Published in Proc Natl Acad Sci U S A on October 01, 1986
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Identification of more than 500 RFLPs by screening random genomic clones. Am J Hum Genet (1988) 3.01
Genetic linkage map of human chromosome 7 with 63 DNA markers. Proc Natl Acad Sci U S A (1987) 2.91
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Joint linkage of multiple loci for a complex disorder. Am J Hum Genet (1993) 2.20
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Dietary obesity linked to genetic loci on chromosomes 9 and 15 in a polygenic mouse model. J Clin Invest (1994) 1.16
Mapping quantitative trait loci in humans: achievements and limitations. J Clin Invest (2005) 1.08
Two-hit model for sporadic congenital anomalies in mice with the disorganization mutation. Am J Hum Genet (1993) 1.06
Full-genome scan for linkage in 50 families segregating the bipolar affective disease phenotype. Am J Hum Genet (2000) 1.05
Effective testing of gene-disease associations. Am J Hum Genet (1990) 1.05
Association mapping of spot blotch resistance in wild barley. Mol Breed (2010) 1.02
Strategies for mapping heterogeneous recessive traits by allele-sharing methods. Am J Hum Genet (1997) 1.02
Genetic linkage map of 46 DNA markers on human chromosome 16. Proc Natl Acad Sci U S A (1990) 0.97
Next-generation sequencing in genetic hearing loss. Genet Test Mol Biomarkers (2013) 0.93
Detection of linkage for heterogeneous disorders by using multipoint linkage analysis. Am J Hum Genet (1991) 0.89
Polymorphic Hh genes in the HLA-B(C) region control natural killer cell frequency and activity. J Exp Med (1994) 0.85
A variant insulin promoter in non-insulin-dependent diabetes mellitus. J Clin Invest (1992) 0.78
Genome-wide conditional search for epistatic disease-predisposing variants in human association studies. Hum Hered (2010) 0.77
A clinically homogeneous group of families with facioscapulohumeral (Landouzy-Déjérine) muscular dystrophy: linkage analysis of six autosomes. Am J Hum Genet (1990) 0.75
Construction of a genetic linkage map in man using restriction fragment length polymorphisms. Am J Hum Genet (1980) 75.25
Sequential tests for the detection of linkage. Am J Hum Genet (1955) 43.74
Linkage analysis of two cloned DNA sequences flanking the Duchenne muscular dystrophy locus on the short arm of the human X chromosome. Nucleic Acids Res (1983) 8.92
A closely linked genetic marker for cystic fibrosis. Nature (1985) 7.85
Localization of cystic fibrosis locus to human chromosome 7cen-q22. Nature (1985) 7.77
A highly polymorphic DNA marker linked to adult polycystic kidney disease on chromosome 16. Nature (1985) 7.34
Construction of linkage maps with DNA markers for human chromosomes. Nature (1985) 6.38
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Cystic fibrosis locus defined by a genetically linked polymorphic DNA marker. Science (1985) 5.81
A polymorphic DNA marker linked to cystic fibrosis is located on chromosome 7. Nature (1985) 5.07
Genetic mapping of the human X chromosome by using restriction fragment length polymorphisms. Proc Natl Acad Sci U S A (1984) 4.22
Linkage analysis and family classification under heterogeneity. Ann Hum Genet (1983) 3.76
Detecting linkage for genetically heterogeneous diseases and detecting heterogeneity with linkage data. Am J Hum Genet (1986) 3.16
Complementation analysis of ataxia-telangiectasia. Kroc Found Ser (1985) 1.58
Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nat Genet (2000) 336.52
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Molecular portraits of human breast tumours. Nature (2000) 94.14
Molecular classification of cancer: class discovery and class prediction by gene expression monitoring. Science (1999) 83.27
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Construction of a genetic linkage map in man using restriction fragment length polymorphisms. Am J Hum Genet (1980) 75.25
Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci U S A (2001) 71.82
Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature (2000) 64.32
Comprehensive identification of cell cycle-regulated genes of the yeast Saccharomyces cerevisiae by microarray hybridization. Mol Biol Cell (1998) 62.20
The Gene Ontology (GO) database and informatics resource. Nucleic Acids Res (2004) 54.37
A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms. Nature (2001) 42.18
Parametric and nonparametric linkage analysis: a unified multipoint approach. Am J Hum Genet (1996) 39.80
Interpreting patterns of gene expression with self-organizing maps: methods and application to hematopoietic differentiation. Proc Natl Acad Sci U S A (1999) 39.79
The transcriptional program of sporulation in budding yeast. Science (1998) 37.23
Genomic expression programs in the response of yeast cells to environmental changes. Mol Biol Cell (2000) 36.09
Construction of multilocus genetic linkage maps in humans. Proc Natl Acad Sci U S A (1987) 35.83
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature (2002) 28.79
Two differentially regulated mRNAs with different 5' ends encode secreted with intracellular forms of yeast invertase. Cell (1982) 25.10
Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses. Proc Natl Acad Sci U S A (2001) 24.34
Characterization of single-nucleotide polymorphisms in coding regions of human genes. Nat Genet (1999) 24.24
Systematic variation in gene expression patterns in human cancer cell lines. Nat Genet (2000) 24.22
Dissecting the regulatory circuitry of a eukaryotic genome. Cell (1998) 23.62
Resolution of quantitative traits into Mendelian factors by using a complete linkage map of restriction fragment length polymorphisms. Nature (1988) 23.48
Genomic binding sites of the yeast cell-cycle transcription factors SBF and MBF. Nature (2001) 21.55
Genetic and physical maps of Saccharomyces cerevisiae. Nature (1997) 21.48
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High-resolution haplotype structure in the human genome. Nat Genet (2001) 20.51
Genetic engineering in vivo using translocatable drug-resistance elements. New methods in bacterial genetics. J Mol Biol (1977) 20.29
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A Saccharomyces cerevisiae genomic plasmid bank based on a centromere-containing shuttle vector. Gene (1987) 19.68
Sterile host yeasts (SHY): a eukaryotic system of biological containment for recombinant DNA experiments. Gene (1979) 19.39
Multiclass cancer diagnosis using tumor gene expression signatures. Proc Natl Acad Sci U S A (2001) 19.30
The transcriptional program in the response of human fibroblasts to serum. Science (1999) 19.19
An SNP map of the human genome generated by reduced representation shotgun sequencing. Nature (2000) 19.19
Exploring the new world of the genome with DNA microarrays. Nat Genet (1999) 19.05
Integrating functional genomic information into the Saccharomyces genome database. Nucleic Acids Res (2000) 18.52
Singular value decomposition for genome-wide expression data processing and modeling. Proc Natl Acad Sci U S A (2000) 18.42
Large-scale identification, mapping, and genotyping of single-nucleotide polymorphisms in the human genome. Science (1998) 18.23
An STS-based map of the human genome. Science (1995) 17.72
Mendelian factors underlying quantitative traits in tomato: comparison across species, generations, and environments. Genetics (1991) 17.40
Diversity of gene expression in adenocarcinoma of the lung. Proc Natl Acad Sci U S A (2001) 17.36
A common language for physical mapping of the human genome. Science (1989) 17.36
Linkage disequilibrium in the human genome. Nature (2001) 17.24
On the allelic spectrum of human disease. Trends Genet (2001) 16.26
The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes. Nat Genet (2000) 15.19
Genome-wide analysis of DNA copy-number changes using cDNA microarrays. Nat Genet (1999) 14.96
A gene map of the human genome. Science (1996) 14.32
Distinctive gene expression patterns in human mammary epithelial cells and breast cancers. Proc Natl Acad Sci U S A (1999) 14.16
Restriction fragment length polymorphism linkage map for Arabidopsis thaliana. Proc Natl Acad Sci U S A (1988) 13.85
Using the Saccharomyces Genome Database (SGD) for analysis of protein similarities and structure. Nucleic Acids Res (1999) 13.65
Identification of genetic factors contributing to heterosis in a hybrid from two elite maize inbred lines using molecular markers. Genetics (1992) 13.63
A genetic linkage map of the human genome. Cell (1987) 13.37
A gene expression database for the molecular pharmacology of cancer. Nat Genet (2000) 13.31
Promoter-specific binding of Rap1 revealed by genome-wide maps of protein-DNA association. Nat Genet (2001) 13.05
Complete multipoint sib-pair analysis of qualitative and quantitative traits. Am J Hum Genet (1995) 12.78
Positive natural selection in the human lineage. Science (2006) 12.55
A physical map of 30,000 human genes. Science (1998) 12.43
Homozygosity mapping: a way to map human recessive traits with the DNA of inbred children. Science (1987) 12.20
Mutagenesis by insertion of a drug-resistance element carrying an inverted repetition. J Mol Biol (1975) 11.14
Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn disease. Nat Genet (2001) 11.12
Genomic analysis of metastasis reveals an essential role for RhoC. Nature (2000) 10.11
Structure and function of the yeast URA3 gene: expression in Escherichia coli. Gene (1984) 10.07
Systematic detection of errors in genetic linkage data. Genomics (1992) 10.06
Genetic mapping of a gene causing hypertension in the stroke-prone spontaneously hypertensive rat. Cell (1991) 9.99
Ploidy regulation of gene expression. Science (1999) 9.98
Recognition of related proteins by iterative template refinement (ITR). Protein Sci (1994) 9.67
Remodeling of yeast genome expression in response to environmental changes. Mol Biol Cell (2001) 9.63
Phenotypic analysis of temperature-sensitive yeast actin mutants. Cell (1985) 8.53
A genetic map of the mouse suitable for typing intraspecific crosses. Genetics (1992) 8.53
Human and mouse gene structure: comparative analysis and application to exon prediction. Genome Res (2000) 8.28
Mapping complex genetic traits in humans: new methods using a complete RFLP linkage map. Cold Spring Harb Symp Quant Biol (1986) 8.22
The Stanford Microarray Database. Nucleic Acids Res (2001) 7.77
Chemosensitivity prediction by transcriptional profiling. Proc Natl Acad Sci U S A (2001) 7.51
The yeast GTP-binding YPT1 protein and a mammalian counterpart are associated with the secretion machinery. Cell (1988) 7.39
Plasmid construction by homologous recombination in yeast. Gene (1987) 7.26
Diverse effects of beta-tubulin mutations on microtubule formation and function. J Cell Biol (1988) 6.88
Lethal disruption of the yeast actin gene by integrative DNA transformation. Science (1982) 6.88
Evidence for transcriptional regulation of orotidine-5'-phosphate decarboxylase in yeast by hybridization of mRNA to the yeast structural gene cloned in Escherichia coli. Proc Natl Acad Sci U S A (1979) 6.81
Properties of the translocatable tetracycline-resistance element Tn10 in Escherichia coli and bacteriophage lambda. Genetics (1978) 6.73
Rapid multipoint linkage analysis of recessive traits in nuclear families, including homozygosity mapping. Am J Hum Genet (1995) 6.51
Genomic expression responses to DNA-damaging agents and the regulatory role of the yeast ATR homolog Mec1p. Mol Biol Cell (2001) 6.39
Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesion. Proc Natl Acad Sci U S A (2000) 6.30
Comparison of the complete protein sets of worm and yeast: orthology and divergence. Science (1998) 6.28
Isolation of the beta-tubulin gene from yeast and demonstration of its essential function in vivo. Cell (1983) 6.22
Specialized transduction of tetracycline resistance by phage P22 in Salmonella typhimurium. II. Properties of a high-frequency-transducing lysate. Virology (1972) 6.21
Mutants of yeast defective in sucrose utilization. Genetics (1981) 6.20
DNA topoisomerase II is required at the time of mitosis in yeast. Cell (1985) 6.08
The plasticity of dendritic cell responses to pathogens and their components. Science (2001) 5.58
Yeast actin-binding proteins: evidence for a role in morphogenesis. J Cell Biol (1988) 5.46
Systematic changes in gene expression patterns following adaptive evolution in yeast. Proc Natl Acad Sci U S A (1999) 5.45
'Gene shaving' as a method for identifying distinct sets of genes with similar expression patterns. Genome Biol (2000) 5.29
Research on DNA typing catching up with courtroom application. Am J Hum Genet (1991) 5.28
A rapid, efficient method for isolating DNA from yeast. Gene (1986) 5.20
Ultrastructure of the yeast actin cytoskeleton and its association with the plasma membrane. J Cell Biol (1994) 5.14
Secretion of beta-lactamase requires the carboxy end of the protein. Cell (1980) 5.03
Systematic mutational analysis of the yeast ACT1 gene. Genetics (1992) 5.02
Diverse signaling pathways activated by growth factor receptors induce broadly overlapping, rather than independent, sets of genes. Cell (1999) 4.97
Simple Mendelian inheritance of the reiterated ribosomal DNA of yeast. Proc Natl Acad Sci U S A (1977) 4.86