An interaction map of circulating metabolites, immune gene networks, and their genetic regulation.

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Published in Genome Biol on August 01, 2017

Authors

Artika P Nath1,2, Scott C Ritchie2,3, Sean G Byars3,4, Liam G Fearnley3,4, Aki S Havulinna5,6, Anni Joensuu5, Antti J Kangas7, Pasi Soininen7,8, Annika Wennerström5, Lili Milani9, Andres Metspalu9, Satu Männistö5, Peter Würtz7,10, Johannes Kettunen5,7,8,11, Emma Raitoharju12, Mika Kähönen13, Markus Juonala14,15, Aarno Palotie6,16,17,18, Mika Ala-Korpela7,8,11,19,20, Samuli Ripatti6,21, Terho Lehtimäki12, Gad Abraham2,3,4, Olli Raitakari22,23, Veikko Salomaa5, Markus Perola5,6,9, Michael Inouye24,25,26,27

Author Affiliations

1: Department of Microbiology and Immunology, The University of Melbourne, Parkville, 3010, Victoria, Australia.
2: Systems Genomics Lab, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.
3: Department of Pathology, The University of Melbourne, Parkville, 3010, Victoria, Australia.
4: School of BioSciences, The University of Melbourne, Parkville, 3010, Victoria, Australia.
5: National Institute for Health and Welfare, Helsinki, 00271, Finland.
6: Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, 00014, Finland.
7: Computational Medicine, Faculty of Medicine, University of Oulu, Oulu, 90014, Finland.
8: NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, 70211, Finland.
9: University of Tartu, Estonian Genome Center, Tartu, 51010, Estonia.
10: Diabetes and Obesity Research Program, University of Helsinki, Helsinki, Finland.
11: Biocenter Oulu, University of Oulu, Oulu, 90014, Finland.
12: Department of Clinical Chemistry, Fimlab Laboratories and Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Life Sciences, University of Tampere, 33014, Tampere, Finland.
13: Department of Clinical Physiology, University of Tampere and Tampere University Hospital, FI-33521, Tampere, Finland.
14: Department of Medicine, University of Turku and Division of Medicine, Turku University Hospital, FI-20520, Turku, Finland.
15: Murdoch Childrens Research Institute, Parkville, 3052, Victoria, Australia.
16: Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
17: Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.
18: Psychiatric & Neurodevelopmental Genetics Unit, Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA.
19: Computational Medicine, School of Social and Community Medicine, University of Bristol, Bristol, BS8 1TH, UK.
20: Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, BS8 2BN, UK.
21: Department of Public Health, University of Helsinki, Helsinki, 00014, Finland.
22: Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, 20520, Finland.
23: Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, 20520, Finland.
24: Department of Microbiology and Immunology, The University of Melbourne, Parkville, 3010, Victoria, Australia. minouye@baker.edu.au.
25: Systems Genomics Lab, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia. minouye@baker.edu.au.
26: Department of Pathology, The University of Melbourne, Parkville, 3010, Victoria, Australia. minouye@baker.edu.au.
27: School of BioSciences, The University of Melbourne, Parkville, 3010, Victoria, Australia. minouye@baker.edu.au.

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