The MEK inhibitor selumetinib complements CTLA-4 blockade by reprogramming the tumor immune microenvironment.

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Published in J Immunother Cancer on August 15, 2017

Authors

Edmund Poon1, Stefanie Mullins1, Amanda Watkins1, Geoffrey S Williams1, Jens-Oliver Koopmann1, Gianfranco Di Genova2, Marie Cumberbatch2,3, Margaret Veldman-Jones2, Shaun E Grosskurth4,5, Vasu Sah4, Alwin Schuller4, Corrine Reimer4, Simon J Dovedi1, Paul D Smith2, Ross Stewart1, Robert W Wilkinson6

Author Affiliations

1: MedImmune Ltd, Granta Park, Cambridge, UK.
2: AstraZeneca Ltd, Cambridge, UK.
3: New address: Immune Insight Ltd, Biohub, Alderley Park, Cheshire, UK.
4: AstraZeneca Ltd, 35 Gatehouse Lane, Waltham, USA.
5: New address: Abbvie Inc, 1 North Waukegan Road, North Chicago, IL, 60064, USA.
6: MedImmune Ltd, Granta Park, Cambridge, UK. Wilkinsonr@MedImmune.com.

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