Published in Nanotechnology on August 25, 2017
The sequence of the human genome. Science (2001) 101.55
Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature (1995) 13.80
Genetic enhancement of learning and memory in mice. Nature (1999) 8.06
In vivo localization of DNA sequences and visualization of large-scale chromatin organization using lac operator/repressor recognition. J Cell Biol (1996) 6.78
A genome-wide search for human non-insulin-dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2. Nat Genet (1996) 6.58
Staphylococcus aureus sortase, an enzyme that anchors surface proteins to the cell wall. Science (1999) 5.98
Carrying passengers as a risk factor for crashes fatal to 16- and 17-year-old drivers. JAMA (2000) 5.67
CENP-E is a putative kinetochore motor that accumulates just before mitosis. Nature (1992) 5.54
Identification of the platelet ADP receptor targeted by antithrombotic drugs. Nature (2001) 5.51
Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines. Endocrinology (1992) 5.45
Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow. Nat Cell Biol (2001) 4.38
Smoking cessation with and without assistance: a population-based analysis. Am J Prev Med (2000) 3.92
Regulation of dendritic spine morphology and synaptic function by Shank and Homer. Neuron (2001) 3.91
Purification and characterization of sortase, the transpeptidase that cleaves surface proteins of Staphylococcus aureus at the LPXTG motif. Proc Natl Acad Sci U S A (1999) 3.90
A regulatory role for ARF6 in receptor-mediated endocytosis. Science (1995) 3.82
PACS-1 defines a novel gene family of cytosolic sorting proteins required for trans-Golgi network localization. Cell (1998) 3.79
Staphylococcus aureus sortase mutants defective in the display of surface proteins and in the pathogenesis of animal infections. Proc Natl Acad Sci U S A (2000) 3.46
Signal transduction in neuronal migration: roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway. Cell (2001) 3.44
Extensive neurite outgrowth and active synapse formation on self-assembling peptide scaffolds. Proc Natl Acad Sci U S A (2000) 3.41
Prevalence and genetic diversity of coronaviruses in bats from China. J Virol (2006) 3.37
A formalin-inactivated whole SIV vaccine confers protection in macaques. Science (1989) 3.37
Development and evaluation of functional gene arrays for detection of selected genes in the environment. Appl Environ Microbiol (2001) 3.36
Epitope mapping of CCR5 reveals multiple conformational states and distinct but overlapping structures involved in chemokine and coreceptor function. J Biol Chem (1999) 3.35
Pyrazole ligands: structure-affinity/activity relationships and estrogen receptor-alpha-selective agonists. J Med Chem (2000) 3.34
Wildtype Kras2 can inhibit lung carcinogenesis in mice. Nat Genet (2001) 3.27
Estrogen receptor-beta potency-selective ligands: structure-activity relationship studies of diarylpropionitriles and their acetylene and polar analogues. J Med Chem (2001) 3.24
Biomarkers of oxidative stress study II: are oxidation products of lipids, proteins, and DNA markers of CCl4 poisoning? Free Radic Biol Med (2005) 3.13
Risk factors for seizure-related motor vehicle crashes in patients with epilepsy. Neurology (1999) 3.10
A family of peptidoglycan recognition proteins in the fruit fly Drosophila melanogaster. Proc Natl Acad Sci U S A (2000) 3.08
Nanostructured high-strength molybdenum alloys with unprecedented tensile ductility. Nat Mater (2013) 2.90
Distinct mechanism for antidepressant activity by blockade of central substance P receptors. Science (1998) 2.83
Structural and magnetic phase diagram of CeFeAsO(1- x)F(x) and its relation to high-temperature superconductivity. Nat Mater (2008) 2.83
A peptidoglycan recognition protein in innate immunity conserved from insects to humans. Proc Natl Acad Sci U S A (1998) 2.81
Superconductivity at 41 K and its competition with spin-density-wave instability in layered CeO1-xFxFeAs. Phys Rev Lett (2008) 2.72
Surgical complications secondary to decompressive craniectomy in patients with a head injury: a series of 108 consecutive cases. Acta Neurochir (Wien) (2008) 2.59
Molecular characterization and transcriptional analysis of type 8 capsule genes in Staphylococcus aureus. J Bacteriol (1997) 2.58
Clinical manifestations and diagnosis of acute pyrethroid poisoning. Arch Toxicol (1989) 2.50
The receptor binding site for the methyltransferase of bacterial chemotaxis is distinct from the sites of methylation. Biochemistry (1996) 2.44
Biomarker risk assessment and bladder cancer detection in a cohort exposed to benzidine. J Natl Cancer Inst (2001) 2.41
The skeletal muscle calcium release channel: coupled O2 sensor and NO signaling functions. Cell (2000) 2.41
A new ultrasound instrument for in vivo microimaging of mice. Ultrasound Med Biol (2002) 2.34
Epidemiological link between exposure to poultry and all influenza A(H7N9) confirmed cases in Huzhou city, China, March to May 2013. Euro Surveill (2013) 2.34
Heme mediates derepression of Maf recognition element through direct binding to transcription repressor Bach1. EMBO J (2001) 2.32
Microelectrode-guided pallidotomy: technical approach and its application in medically intractable Parkinson's disease. J Neurosurg (1998) 2.31
A comparison of batch effect removal methods for enhancement of prediction performance using MAQC-II microarray gene expression data. Pharmacogenomics J (2010) 2.30
alpha1-Antitrypsin Portland, a bioengineered serpin highly selective for furin: application as an antipathogenic agent. Proc Natl Acad Sci U S A (1998) 2.28
Effects of high school driver education on motor vehicle crashes, violations, and licensure. Am J Prev Med (1999) 2.25
Disruption of CD40-CD40 ligand interactions results in an enhanced susceptibility to Leishmania amazonensis infection. Immunity (1996) 2.24
Increased risk of hepatocellular carcinoma in male hepatitis B surface antigen carriers with chronic hepatitis who have detectable urinary aflatoxin metabolite M1. Hepatology (1999) 2.16
An updatable holographic three-dimensional display. Nature (2008) 2.14
Transcriptional regulation of the HIV-1 promoter by NF-kappa B in vitro. Genes Dev (1992) 2.12
The phenylalanine ammonia-lyase gene family in Arabidopsis thaliana. Plant Mol Biol (1995) 2.11
Mitotic regulation of microtubule cross-linking activity of CENP-E kinetochore protein. Science (1994) 2.11
The vascular actions of insulin control its delivery to muscle and regulate the rate-limiting step in skeletal muscle insulin action. Diabetologia (2009) 2.11
Modulation of folding pathways of exported proteins by the leader sequence. Science (1988) 2.10
Predictors of smoking cessation in U.S. adolescents. Am J Prev Med (1999) 2.09
Effect of calcium or 25OH vitamin D3 dietary supplementation on bone loss at the hip in men and women over the age of 60. J Clin Endocrinol Metab (2000) 2.09
IMPACT trial results should not change current standard of care of 100 days for cytomegalovirus prophylaxis. Am J Transplant (2010) 2.05
Normal hip joint contact pressure distribution in single-leg standing--effect of gender and anatomic parameters. J Biomech (2001) 2.05
Activation of HER4 by heparin-binding EGF-like growth factor stimulates chemotaxis but not proliferation. EMBO J (1997) 2.02
Lightwand-guided nasotracheal intubation in oromaxillofacial surgery patients with anticipated difficult airways: a comparison with blind nasal intubation. Int J Oral Maxillofac Surg (2013) 2.00
Further characterization of endometrial integrins during the menstrual cycle and in pregnancy. Fertil Steril (1994) 1.99
Mammalian peptidoglycan recognition protein binds peptidoglycan with high affinity, is expressed in neutrophils, and inhibits bacterial growth. J Biol Chem (2000) 1.99
Smoking, air pollution, and the high rates of lung cancer in Shenyang, China. J Natl Cancer Inst (1989) 1.99
Evaluation of Binax NOW, an assay for the detection of pneumococcal antigen in urine samples, performed among pediatric patients. Clin Infect Dis (2001) 1.96
The cytoplasmic domain of FtsK protein is required for resolution of chromosome dimers. Mol Microbiol (1999) 1.95
Mice lacking complex gangliosides develop Wallerian degeneration and myelination defects. Proc Natl Acad Sci U S A (1999) 1.95
Indoor radon and lung cancer in China. J Natl Cancer Inst (1990) 1.95
Human factors in crashes of commuter airplanes. Aviat Space Environ Med (1993) 1.93
Rofecoxib: no effect on Alzheimer's disease in a 1-year, randomized, blinded, controlled study. Neurology (2004) 1.92
Pseudomonas aeruginosa ExoS and ExoT. Rev Physiol Biochem Pharmacol (2004) 1.91
DNA/DNA hybridization to microarrays reveals gene-specific differences between closely related microbial genomes. Proc Natl Acad Sci U S A (2001) 1.90
Reverse transcriptase in a clinical strain of Escherichia coli: production of branched RNA-linked msDNA. Science (1989) 1.89
A phospholipid acts as a chaperone in assembly of a membrane transport protein. J Biol Chem (1996) 1.89
Transformation of NIH 3T3 cells by HER3 or HER4 receptors requires the presence of HER1 or HER2. J Biol Chem (1996) 1.87
Effects of pyrethroid insecticides on subjects engaged in packaging pyrethroids. Br J Ind Med (1988) 1.87
Cancer incidence and risk estimation among medical x-ray workers in China, 1950-1995. Health Phys (2002) 1.85
Human herpesvirus 7 is a T-lymphotropic virus and is related to, but significantly different from, human herpesvirus 6 and human cytomegalovirus. Proc Natl Acad Sci U S A (1992) 1.85
Harvesting the genome's bounty: integrative genomics. Cold Spring Harb Symp Quant Biol (2003) 1.84
Patterns of risk in first-degree relatives of patients with Alzheimer's disease. Arch Gen Psychiatry (1994) 1.84
Visual attention to the periphery is enhanced in congenitally deaf individuals. J Neurosci (2000) 1.83
Comparison of active treatment and placebo in older Chinese patients with isolated systolic hypertension. Systolic Hypertension in China (Syst-China) Collaborative Group. J Hypertens (1998) 1.83
A humoral stress response in Drosophila. Curr Biol (2001) 1.82
Prevention of metastasis by inhibition of the urokinase receptor. Proc Natl Acad Sci U S A (1993) 1.82
Nanometer size diesel exhaust particles are selectively toxic to dopaminergic neurons: the role of microglia, phagocytosis, and NADPH oxidase. FASEB J (2004) 1.79
Digit tip regeneration correlates with regions of Msx1 (Hox 7) expression in fetal and newborn mice. Development (1995) 1.79
Local anesthesia for functional endoscopic sinus surgery employing small volumes of epinephrine-containing solutions of lidocaine produces profound hypotension. Acta Anaesthesiol Scand (2005) 1.77
High-resolution EEG: a new realistic geometry spline Laplacian estimation technique. Clin Neurophysiol (2001) 1.76
Insulin-like growth factor-1 induces survival and growth of biologically early melanoma cells through both the mitogen-activated protein kinase and beta-catenin pathways. Cancer Res (2001) 1.75
Ras CAAX peptidomimetic FTI-277 selectively blocks oncogenic Ras signaling by inducing cytoplasmic accumulation of inactive Ras-Raf complexes. J Biol Chem (1995) 1.75
An integrated approach utilizing artificial neural networks and SELDI mass spectrometry for the classification of human tumours and rapid identification of potential biomarkers. Bioinformatics (2002) 1.73
Blockage of NF-kappa B signaling by selective ablation of an mRNA target by 2-5A antisense chimeras. Science (1994) 1.72
Long-term T cell memory requires the surface expression of self-peptide/major histocompatibility complex molecules. Proc Natl Acad Sci U S A (1998) 1.71
Valproate protects dopaminergic neurons in midbrain neuron/glia cultures by stimulating the release of neurotrophic factors from astrocytes. Mol Psychiatry (2006) 1.71
Increased Expression of MicroRNA-221 in gastric cancer and its clinical significance. J Int Med Res (2012) 1.71
Design of peptides, proteins, and peptidomimetics in chi space. Biopolymers (1997) 1.69
Overexpression of transforming growth factor-beta1 and insulin-like growth factor-I in patients with idiopathic hypertrophic cardiomyopathy. Circulation (1997) 1.69
Biological functions of the ING family tumor suppressors. Cell Mol Life Sci (2004) 1.69
Long-term effects of a randomised trial of a 6-year lifestyle intervention in impaired glucose tolerance on diabetes-related microvascular complications: the China Da Qing Diabetes Prevention Outcome Study. Diabetologia (2010) 1.68