Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival.

PubWeight™: 0.76‹?›

🔗 View Article (PMID 28843279)

Published in Cancer Cell on December 14, 2015

Authors

Berna C Özdemir, Tsvetelina Pentcheva-Hoang, Julienne L Carstens, Xiaofeng Zheng, Chia-Chin Wu, Tyler R Simpson, Hanane Laklai, Hikaru Sugimoto, Christoph Kahlert, Sergey V Novitskiy, Ana De Jesus-Acosta, Padmanee Sharma, Pedram Heidari, Umar Mahmood, Lynda Chin, Harold L Moses, Valerie M Weaver, Anirban Maitra, James P Allison, Valerie S LeBleu, Raghu Kalluri

Articles citing this

Adrenergic-mediated increases in INHBA drive CAF phenotype and collagens. JCI Insight (2017) 0.75

Articles by these authors

Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science (2008) 36.02

Restoring function in exhausted CD8 T cells during chronic viral infection. Nature (2005) 28.04

A comprehensive catalogue of somatic mutations from a human cancer genome. Nature (2009) 24.27

International network of cancer genome projects. Nature (2010) 20.35

Tensional homeostasis and the malignant phenotype. Cancer Cell (2005) 19.30

Malignant astrocytic glioma: genetics, biology, and paths to treatment. Genes Dev (2007) 17.20

Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. Cancer Cell (2003) 15.43

Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis. Mol Cell (2007) 14.58

Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers. Nat Med (2008) 14.47

Matrix crosslinking forces tumor progression by enhancing integrin signaling. Cell (2009) 14.40

The genomic complexity of primary human prostate cancer. Nature (2011) 14.06

Elucidation of a universal size-control mechanism in Drosophila and mammals. Cell (2007) 13.04

Nivolumab versus Everolimus in Advanced Renal-Cell Carcinoma. N Engl J Med (2015) 12.74

A landscape of driver mutations in melanoma. Cell (2012) 12.61

The somatic genomic landscape of glioblastoma. Cell (2013) 11.73

Stromal fibroblasts in cancer initiation and progression. Nature (2004) 11.69

The epithelial-mesenchymal transition: new insights in signaling, development, and disease. J Cell Biol (2006) 11.16

Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma. Proc Natl Acad Sci U S A (2003) 10.71

Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies. Science (2007) 10.60

DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors. Science (2011) 10.26

TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia. Science (2004) 10.23

Endothelial-to-mesenchymal transition contributes to cardiac fibrosis. Nat Med (2007) 9.51

Molecular characterization of the tumor microenvironment in breast cancer. Cancer Cell (2004) 9.41

EMT and dissemination precede pancreatic tumor formation. Cell (2012) 9.27

FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis. Cell (2007) 8.94

Tumour microenvironment: TGFbeta: the molecular Jekyll and Hyde of cancer. Nat Rev Cancer (2006) 8.59

Immunologic correlates of the abscopal effect in a patient with melanoma. N Engl J Med (2012) 8.46

Highly recurrent TERT promoter mutations in human melanoma. Science (2013) 8.40

Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes. Nature (2012) 8.31

Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours. Nature (2003) 8.14

BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury. Nat Med (2003) 7.91

A tense situation: forcing tumour progression. Nat Rev Cancer (2009) 7.80

Melanoma genome sequencing reveals frequent PREX2 mutations. Nature (2012) 7.77

Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting. Nature (2012) 7.76

Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene. Science (2009) 7.39

Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism. Cell (2012) 7.36

Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis. Nat Genet (2011) 6.89

The prioritization of cancer antigens: a national cancer institute pilot project for the acceleration of translational research. Clin Cancer Res (2009) 6.83

Hedgehog signalling in prostate regeneration, neoplasia and metastasis. Nature (2004) 6.82

Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis. Cancer Cell (2008) 6.78

High-resolution genomic profiles of human lung cancer. Proc Natl Acad Sci U S A (2005) 6.52

Novel cancer immunotherapy agents with survival benefit: recent successes and next steps. Nat Rev Cancer (2011) 6.44

Telomere dysfunction induces metabolic and mitochondrial compromise. Nature (2011) 6.36

PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors. Proc Natl Acad Sci U S A (2010) 6.20

Gemcitabine plus nab-paclitaxel is an active regimen in patients with advanced pancreatic cancer: a phase I/II trial. J Clin Oncol (2011) 6.16

The extracellular matrix: a dynamic niche in cancer progression. J Cell Biol (2012) 6.07

Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse. Proc Natl Acad Sci U S A (2006) 5.90

Fibroblasts in kidney fibrosis emerge via endothelial-to-mesenchymal transition. J Am Soc Nephrol (2008) 5.83

Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas. N Engl J Med (2015) 5.71

Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers. Nature (2007) 5.65

CTLA4 blockade and GM-CSF combination immunotherapy alters the intratumor balance of effector and regulatory T cells. J Clin Invest (2006) 5.62

A genetic screen for candidate tumor suppressors identifies REST. Cell (2005) 5.61

TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function. Nat Genet (2005) 5.53

An in vivo platform for translational drug development in pancreatic cancer. Clin Cancer Res (2006) 5.52

Biologic activity of cytotoxic T lymphocyte-associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients. Proc Natl Acad Sci U S A (2003) 5.49

Fibroblasts derive from hepatocytes in liver fibrosis via epithelial to mesenchymal transition. J Biol Chem (2007) 5.37

Notch mediates TGF alpha-induced changes in epithelial differentiation during pancreatic tumorigenesis. Cancer Cell (2003) 5.36

The impact of human EGFR kinase domain mutations on lung tumorigenesis and in vivo sensitivity to EGFR-targeted therapies. Cancer Cell (2006) 5.34

Arthritis critically dependent on innate immune system players. Immunity (2002) 5.31

Epitope landscape in breast and colorectal cancer. Cancer Res (2008) 5.29

Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: a new paradigm for combination therapy in solid cancers. Cancer Res (2007) 5.12

Recurrent GNAS mutations define an unexpected pathway for pancreatic cyst development. Sci Transl Med (2011) 5.03

High-resolution genomic profiles define distinct clinico-pathogenetic subgroups of multiple myeloma patients. Cancer Cell (2006) 5.01

p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation. Nature (2008) 5.00

Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression. Proc Natl Acad Sci U S A (2010) 4.97

Tumor-reactive CD4(+) T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts. J Exp Med (2010) 4.90

Conversion of vascular endothelial cells into multipotent stem-like cells. Nat Med (2010) 4.88

Pathology of genetically engineered mouse models of pancreatic exocrine cancer: consensus report and recommendations. Cancer Res (2006) 4.83

Marked genomic differences characterize primary and secondary glioblastoma subtypes and identify two distinct molecular and clinical secondary glioblastoma entities. Cancer Res (2006) 4.80

An illustrated consensus on the classification of pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasms. Am J Surg Pathol (2004) 4.74

Feedback circuit among INK4 tumor suppressors constrains human glioblastoma development. Cancer Cell (2008) 4.71

Comparative oncogenomics identifies NEDD9 as a melanoma metastasis gene. Cell (2006) 4.68

Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti-CTLA-4 antibodies. J Exp Med (2009) 4.68

Induction of B7-1 in podocytes is associated with nephrotic syndrome. J Clin Invest (2004) 4.65

The organizing principle: microenvironmental influences in the normal and malignant breast. Differentiation (2002) 4.64

Expression of Yes-associated protein in common solid tumors. Hum Pathol (2008) 4.61

Altered telomeres in tumors with ATRX and DAXX mutations. Science (2011) 4.60

SMAD4-dependent barrier constrains prostate cancer growth and metastatic progression. Nature (2011) 4.57

BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1. Nat Immunol (2003) 4.56

Origin and function of myofibroblasts in kidney fibrosis. Nat Med (2013) 4.55

CTLA-4: new insights into its biological function and use in tumor immunotherapy. Nat Immunol (2002) 4.48

Immunologic and clinical effects of antibody blockade of cytotoxic T lymphocyte-associated antigen 4 in previously vaccinated cancer patients. Proc Natl Acad Sci U S A (2008) 4.43

Mechanics, malignancy, and metastasis: the force journey of a tumor cell. Cancer Metastasis Rev (2009) 4.36

Immune-mediated inhibition of metastases after treatment with local radiation and CTLA-4 blockade in a mouse model of breast cancer. Clin Cancer Res (2005) 4.23

Identification of fibroblast heterogeneity in the tumor microenvironment. Cancer Biol Ther (2006) 4.20

Checkpoint blockade in cancer immunotherapy. Adv Immunol (2006) 4.09

Modification of kidney barrier function by the urokinase receptor. Nat Med (2007) 4.01

An X chromosome gene, WTX, is commonly inactivated in Wilms tumor. Science (2007) 4.00

Cell growth and size homeostasis in proliferating animal cells. Science (2009) 3.89

Balancing forces: architectural control of mechanotransduction. Nat Rev Mol Cell Biol (2011) 3.87