GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates.

PubWeight™: 0.86‹?›

🔗 View Article (PMID 28846097)

Published in Nat Med on August 28, 2017

Authors

Shannon E Mullican1, Xiefan Lin-Schmidt2, Chen-Ni Chin2, Jose A Chavez1, Jennifer L Furman3, Anthony A Armstrong2, Stephen C Beck1, Victoria J South2, Thai Q Dinh3, Tanesha D Cash-Mason1, Cassandre R Cavanaugh1, Serena Nelson3, Chichi Huang2, Michael J Hunter3, Shamina M Rangwala1

Author Affiliations

1: Cardiovascular and Metabolism Therapeutic Area, Janssen Research and Development, Spring House, Pennsylvania, USA.
2: Janssen BioTherapeutics, Janssen Research and Development, Spring House, Pennsylvania, USA.
3: Janssen BioTherapeutics, Janssen Research and Development, La Jolla, California, USA.

Articles cited by this

Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet (2014) 22.33

The GDNF family: signalling, biological functions and therapeutic value. Nat Rev Neurosci (2002) 5.93

Targeting the TGFβ signalling pathway in disease. Nat Rev Drug Discov (2012) 4.30

Mechanisms, Pathophysiology, and Management of Obesity. N Engl J Med (2017) 4.02

Severe malaria is associated with parasite binding to endothelial protein C receptor. Nature (2013) 2.86

Tumor-induced anorexia and weight loss are mediated by the TGF-beta superfamily cytokine MIC-1. Nat Med (2007) 2.20

An efficient route to human bispecific IgG. Nat Biotechnol (1998) 1.93

Structure of the ternary signaling complex of a TGF-beta superfamily member. Proc Natl Acad Sci U S A (2006) 1.88

Association of Pharmacological Treatments for Obesity With Weight Loss and Adverse Events: A Systematic Review and Meta-analysis. JAMA (2016) 1.78

The BMP7/ActRII extracellular domain complex provides new insights into the cooperative nature of receptor assembly. Mol Cell (2003) 1.72

Caudal brainstem processing is sufficient for behavioral, sympathetic, and parasympathetic responses driven by peripheral and hindbrain glucagon-like-peptide-1 receptor stimulation. Endocrinology (2008) 1.68

Concentration in plasma of macrophage inhibitory cytokine-1 and risk of cardiovascular events in women: a nested case-control study. Lancet (2002) 1.46

Growth-differentiation factor-15 improves risk stratification in ST-segment elevation myocardial infarction. Eur Heart J (2007) 1.40

Identification of macrophage inhibitory cytokine-1 in adipose tissue and its secretion as an adipokine by human adipocytes. Endocrinology (2008) 1.34

BMP-3 and BMP-6 structures illuminate the nature of binding specificity with receptors. Biochemistry (2007) 1.27

Growth differentiation factor 15 predicts future insulin resistance and impaired glucose control in obese nondiabetic individuals: results from the XENDOS trial. Eur J Endocrinol (2012) 1.18

TGF-b superfamily cytokine MIC-1/GDF15 is a physiological appetite and body weight regulator. PLoS One (2013) 1.12

Macrophage inhibitory cytokine 1 (MIC-1/GDF15) decreases food intake, body weight and improves glucose tolerance in mice on normal & obesogenic diets. PLoS One (2012) 1.12

Growth differentiation factor 15 deficiency protects against atherosclerosis by attenuating CCR2-mediated macrophage chemotaxis. J Exp Med (2011) 1.10

The propeptide of macrophage inhibitory cytokine (MIC-1), a TGF-beta superfamily member, acts as a quality control determinant for correctly folded MIC-1. EMBO J (2000) 1.05

Anorexia/cachexia of chronic diseases: a role for the TGF-β family cytokine MIC-1/GDF15. J Cachexia Sarcopenia Muscle (2012) 1.02

NAG-1/GDF-15 prevents obesity by increasing thermogenesis, lipolysis and oxidative metabolism. Int J Obes (Lond) (2014) 0.98

hNAG-1 increases lifespan by regulating energy metabolism and insulin/IGF-1/mTOR signaling. Aging (Albany NY) (2014) 0.94

The anorectic actions of the TGFβ cytokine MIC-1/GDF15 require an intact brainstem area postrema and nucleus of the solitary tract. PLoS One (2014) 0.93

Loss of neurturin in frog--comparative genomics study of GDNF family ligand-receptor pairs. Mol Cell Neurosci (2006) 0.88

Identification, expression and functional characterization of the GRAL gene. J Neurochem (2005) 0.87

Tissue distribution of Ret, GFRalpha-1, GFRalpha-2 and GFRalpha-3 receptors in the human brainstem at fetal, neonatal and adult age. Brain Res (2007) 0.86

GDF-15 inhibits integrin activation and mouse neutrophil recruitment through the ALK-5/TGF-βRII heterodimer. Blood (2016) 0.86

GDF15 regulates Kv2.1-mediated outward K+ current through the Akt/mTOR signalling pathway in rat cerebellar granule cells. Biochem J (2014) 0.83

RET recognition of GDNF-GFRα1 ligand by a composite binding site promotes membrane-proximal self-association. Cell Rep (2014) 0.80

Selective inhibition of RET mediated cell proliferation in vitro by the kinase inhibitor SPP86. BMC Cancer (2014) 0.80

Comparison of GFL-GFRalpha complexes: further evidence relating GFL bend angle to RET signalling. Acta Crystallogr Sect F Struct Biol Cryst Commun (2009) 0.79

Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis. J Cell Biol (2016) 0.79

Serum Levels of Human MIC-1/GDF15 Vary in a Diurnal Pattern, Do Not Display a Profile Suggestive of a Satiety Factor and Are Related to BMI. PLoS One (2015) 0.79

Brown Adipose YY1 Deficiency Activates Expression of Secreted Proteins Linked to Energy Expenditure and Prevents Diet-Induced Obesity. Mol Cell Biol (2015) 0.78

Internalization of glial cell-derived neurotrophic factor receptor GFR alpha 1 in the absence of the ret tyrosine kinase coreceptor. Cell Mol Neurobiol (2003) 0.77

Mitochondrial energy deficiency leads to hyperproliferation of skeletal muscle mitochondria and enhanced insulin sensitivity. Proc Natl Acad Sci U S A (2017) 0.75

Bone morphogenetic protein-binding endothelial regulator of liver sinusoidal endothelial cells induces iron overload in a fatty liver mouse model. J Gastroenterol (2016) 0.75