Toxoplasma Modulates Signature Pathways of Human Epilepsy, Neurodegeneration & Cancer.

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Published in Sci Rep on September 13, 2017

Authors

Huân M Ngô1,2,3, Ying Zhou1, Hernan Lorenzi4, Kai Wang5, Taek-Kyun Kim5, Yong Zhou5, Kamal El Bissati1, Ernest Mui1, Laura Fraczek1, Seesandra V Rajagopala4, Craig W Roberts6, Fiona L Henriquez1,7, Alexandre Montpetit8, Jenefer M Blackwell9,10, Sarra E Jamieson10, Kelsey Wheeler1, Ian J Begeman1, Carlos Naranjo-Galvis1, Ney Alliey-Rodriguez1, Roderick G Davis11, Liliana Soroceanu12, Charles Cobbs12, Dennis A Steindler13, Kenneth Boyer14, A Gwendolyn Noble2, Charles N Swisher2, Peter T Heydemann14, Peter Rabiah15, Shawn Withers1, Patricia Soteropoulos16, Leroy Hood5, Rima McLeod17

Author Affiliations

1: The University of Chicago, Chicago, IL, 60637, USA.
2: Northwestern University, Feinberg School of Medicine, Chicago, IL, 60611, USA.
3: BrainMicro LLC, New Haven, CT, 06511, USA.
4: J Craig Venter Institute, Rockville, MD, 20850, USA.
5: Institute for Systems Biology, Seattle, WA, 98109, USA.
6: University of Strathclyde, Glasgow, G1 1XQ, United Kingdom.
7: FLH, IBEHR School of Science and Sport, University of the West of Scotland, Paisley, PA1 2BE, UK.
8: Genome Quebec, Montréal, QC H3B 1S6, Canada; McGill University, Montréal, QC H3A 0G4, Canada.
9: Department of Pathology, University of Cambridge, Cambridge, CB2 1QP, United Kingdom.
10: Telethon Kids Institute, The University of Western Australia, Perth, Australia.
11: University of Illinois-Chicago, Chicago, IL, 60607, USA.
12: California Pacific Medical Center, San Francisco, CA, 94114, USA.
13: JM USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, 02111, USA.
14: Rush University Medical Center, Chicago, IL, 60612, USA.
15: Northshore University Health System, Evanston, IL, 60201, USA.
16: Rutgers University, Newark, New Jersey, 07101, USA.
17: The University of Chicago, Chicago, IL, 60637, USA. rmcleod@uchicago.edu.

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A mass accuracy sensitive probability based scoring algorithm for database searching of tandem mass spectrometry data. BMC Bioinformatics (2007) 2.48

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HLA-class II genes modify outcome of Toxoplasma gondii infection. Int J Parasitol (1999) 1.39

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Incidence of adult brain cancers is higher in countries where the protozoan parasite Toxoplasma gondii is common. Biol Lett (2011) 1.06

Human innate immunity to Toxoplasma gondii is mediated by host caspase-1 and ASC and parasite GRA15. MBio (2013) 1.05

Towards an immunosense vaccine to prevent toxoplasmosis: protective Toxoplasma gondii epitopes restricted by HLA-A*0201. Vaccine (2010) 1.04

Derivation and large-scale expansion of multipotent astroglial neural progenitors from adult human brain. Development (2006) 1.04

Converging miRNA functions in diverse brain disorders: a case for miR-124 and miR-126. Exp Neurol (2011) 1.04

Protein phosphatase X interacts with c-Rel and stimulates c-Rel/nuclear factor kappaB activity. J Biol Chem (1998) 1.03

Evidence for associations between the purinergic receptor P2X(7) (P2RX7) and toxoplasmosis. Genes Immun (2010) 1.03

Brain cancer mortality rates increase with Toxoplasma gondii seroprevalence in France. Infect Genet Evol (2012) 1.03

Oral oocyst-induced mouse model of toxoplasmosis: effect of infection with Toxoplasma gondii strains of different genotypes, dose, and mouse strains (transgenic, out-bred, in-bred) on pathogenesis and mortality. Parasitology (2011) 1.02

Common astrocytic programs during brain development, injury and cancer. Trends Neurosci (2009) 1.01

Symptoms of depression and anxiety in anorexia nervosa: links with plasma tryptophan and serotonin metabolism. Psychoneuroendocrinology (2013) 0.99