The role of heat shock proteins and co-chaperones in heart failure.

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Published in Philos Trans R Soc Lond B Biol Sci on January 19, 2018

Authors

Mark J Ranek1, Marisa J Stachowski2, Jonathan A Kirk1, Monte S Willis3,4

Author Affiliations

1: Division of Cardiology, Johns Hopkins Medical Institutions, Baltimore, MD 212015.
2: Department of Cell and Molecular Physiology, Stritch School of Medicine, Loyola University, Chicago, IL 60302, USA.
3: Department of Pathology & Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
4: McAllister Heart Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

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Autophagy in the pathogenesis of disease. Cell (2008) 34.68

Autophagy fights disease through cellular self-digestion. Nature (2008) 33.83

The heat-shock proteins. Annu Rev Genet (1988) 22.28

Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation (1986) 19.82

Forecasting the future of cardiovascular disease in the United States: a policy statement from the American Heart Association. Circulation (2011) 14.00

Molecular chaperones in cellular protein folding. Nature (1996) 14.00

The Hsp70 and Hsp60 chaperone machines. Cell (1998) 13.79

An Hsp70-like protein in the ER: identity with the 78 kd glucose-regulated protein and immunoglobulin heavy chain binding protein. Cell (1986) 10.38

Heart Disease and Stroke Statistics-2016 Update: A Report From the American Heart Association. Circulation (2015) 10.14

Regulation of signaling protein function and trafficking by the hsp90/hsp70-based chaperone machinery. Exp Biol Med (Maywood) (2003) 8.04

Cardiac hypertrophy: the good, the bad, and the ugly. Annu Rev Physiol (2003) 6.99

Protein synthesis in salivary glands of Drosophila melanogaster: relation to chromosome puffs. J Mol Biol (1974) 6.60

Three-dimensional structure of the ATPase fragment of a 70K heat-shock cognate protein. Nature (1990) 6.45

The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins. Nat Cell Biol (2001) 6.10

Structure and mechanism of the Hsp90 molecular chaperone machinery. Annu Rev Biochem (2006) 5.82

Folding of newly translated proteins in vivo: the role of molecular chaperones. Annu Rev Biochem (2001) 5.74

Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions. Mol Cell Biol (1999) 4.98

Navigating the chaperone network: an integrative map of physical and genetic interactions mediated by the hsp90 chaperone. Cell (2005) 4.95

Structure and expression of the human gene encoding major heat shock protein HSP70. Mol Cell Biol (1985) 4.79

Folding of nascent polypeptide chains in a high molecular mass assembly with molecular chaperones. Nature (1994) 4.75

A missense mutation in the alphaB-crystallin chaperone gene causes a desmin-related myopathy. Nat Genet (1998) 4.75

Modulation of Akt kinase activity by binding to Hsp90. Proc Natl Acad Sci U S A (2000) 4.55

Hsp90: a specialized but essential protein-folding tool. J Cell Biol (2001) 4.51

Heat-shock protein 90, a chaperone for folding and regulation. Cell Mol Life Sci (2002) 4.24

The heat shock protein 70 family: Highly homologous proteins with overlapping and distinct functions. FEBS Lett (2007) 4.23

Proteotoxicity and cardiac dysfunction--Alzheimer's disease of the heart? N Engl J Med (2013) 3.41

Dynein mutations impair autophagic clearance of aggregate-prone proteins. Nat Genet (2005) 3.39

Hsp70 and Hsp90--a relay team for protein folding. Rev Physiol Biochem Pharmacol (2004) 3.29

Cardiac stress protein elevation 24 hours after brief ischemia or heat stress is associated with resistance to myocardial infarction. Circulation (1993) 3.27

The role of Hsp70 in conferring unidirectionality on protein translocation into mitochondria. Science (1994) 3.26

Cooperation of a ubiquitin domain protein and an E3 ubiquitin ligase during chaperone/proteasome coupling. Curr Biol (2001) 3.21

Domain mapping studies reveal that the M domain of hsp90 serves as a molecular scaffold to regulate Akt-dependent phosphorylation of endothelial nitric oxide synthase and NO release. Circ Res (2002) 3.01

Protein quality control: U-box-containing E3 ubiquitin ligases join the fold. Trends Biochem Sci (2002) 3.01

An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators. J Biol Chem (1999) 2.97

Overexpression of the rat inducible 70-kD heat stress protein in a transgenic mouse increases the resistance of the heart to ischemic injury. J Clin Invest (1995) 2.97

BAG-1 modulates the chaperone activity of Hsp70/Hsc70. EMBO J (1997) 2.91

Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3. EMBO J (2009) 2.83

The U box is a modified RING finger - a common domain in ubiquitination. Curr Biol (2000) 2.73

A hitchhiker's guide to the human Hsp70 family. Cell Stress Chaperones (1996) 2.70

The ubiquitin-related BAG-1 provides a link between the molecular chaperones Hsc70/Hsp70 and the proteasome. J Biol Chem (2000) 2.66

Role of the J-domain in the cooperation of Hsp40 with Hsp70. Proc Natl Acad Sci U S A (1998) 2.66

Molecular distinction between physiological and pathological cardiac hypertrophy: experimental findings and therapeutic strategies. Pharmacol Ther (2010) 2.65

From the cradle to the grave: molecular chaperones that may choose between folding and degradation. EMBO Rep (2001) 2.55

Heat-shock response and limitation of tissue necrosis during occlusion/reperfusion in rabbit hearts. Circulation (1993) 2.51

Chaperone-assisted selective autophagy is essential for muscle maintenance. Curr Biol (2010) 2.45

Genome-wide studies of copy number variation and exome sequencing identify rare variants in BAG3 as a cause of dilated cardiomyopathy. Am J Hum Genet (2011) 2.38

A zinc finger-like domain of the molecular chaperone DnaJ is involved in binding to denatured protein substrates. EMBO J (1996) 2.33

Desmin-related cardiomyopathy in transgenic mice: a cardiac amyloidosis. Proc Natl Acad Sci U S A (2004) 2.32

The insulin-like growth factor 1 receptor induces physiological heart growth via the phosphoinositide 3-kinase(p110alpha) pathway. J Biol Chem (2003) 2.28

Role of the cytosolic chaperones Hsp70 and Hsp90 in maturation of the cardiac potassium channel HERG. Circ Res (2003) 2.27

Hsp90 isoforms: functions, expression and clinical importance. FEBS Lett (2004) 2.26

Identification of the key structural motifs involved in HspB8/HspB6-Bag3 interaction. Biochem J (2009) 2.19

Mutation R120G in alphaB-crystallin, which is linked to a desmin-related myopathy, results in an irregular structure and defective chaperone-like function. Proc Natl Acad Sci U S A (1999) 2.18

Missense mutations in desmin associated with familial cardiac and skeletal myopathy. Nat Genet (1998) 2.17

A stress-inducible 72-kDa heat-shock protein (HSP72) is expressed on the surface of human tumor cells, but not on normal cells. Int J Cancer (1995) 2.12

Structure and expression of a human gene coding for a 71 kd heat shock 'cognate' protein. Nucleic Acids Res (1987) 2.05

Desmin myopathy, a skeletal myopathy with cardiomyopathy caused by mutations in the desmin gene. N Engl J Med (2000) 2.04

Mutation in BAG3 causes severe dominant childhood muscular dystrophy. Ann Neurol (2009) 2.03

Transgenic mice expressing the human heat shock protein 70 have improved post-ischemic myocardial recovery. J Clin Invest (1995) 1.96

BAG3 deficiency results in fulminant myopathy and early lethality. Am J Pathol (2006) 1.90

Biology of cardiac arrhythmias: ion channel protein trafficking. Circ Res (2004) 1.87

The co-chaperone carboxyl terminus of Hsp70-interacting protein (CHIP) mediates alpha-synuclein degradation decisions between proteasomal and lysosomal pathways. J Biol Chem (2005) 1.85

Dilated cardiomyopathy-associated BAG3 mutations impair Z-disc assembly and enhance sensitivity to apoptosis in cardiomyocytes. Hum Mutat (2011) 1.85

Myofibrillar myopathy caused by novel dominant negative alpha B-crystallin mutations. Ann Neurol (2003) 1.77

BAG3 mediates chaperone-based aggresome-targeting and selective autophagy of misfolded proteins. EMBO Rep (2011) 1.73

CHIP: a quality-control E3 ligase collaborating with molecular chaperones. Int J Biochem Cell Biol (2003) 1.72

Mitochondrial dysfunction and apoptosis underlie the pathogenic process in alpha-B-crystallin desmin-related cardiomyopathy. Circulation (2005) 1.72

Hsp90's secrets unfold: new insights from structural and functional studies. Trends Cell Biol (1999) 1.68

A genome-wide association study identifies two loci associated with heart failure due to dilated cardiomyopathy. Eur Heart J (2011) 1.67

Akt and CHIP coregulate tau degradation through coordinated interactions. Proc Natl Acad Sci U S A (2008) 1.66

Hsp70 and Hsp40 chaperone activities in the cytoplasm and the nucleus of mammalian cells. J Biol Chem (1997) 1.63

A dysfunctional desmin mutation in a patient with severe generalized myopathy. Proc Natl Acad Sci U S A (1998) 1.61

Mammalian target of rapamycin signaling in cardiac physiology and disease. Circ Res (2014) 1.59

The kinetic parameters and energy cost of the Hsp70 chaperone as a polypeptide unfoldase. Nat Chem Biol (2010) 1.59

Heat shock protein induction in rat hearts. A role for improved myocardial salvage after ischemia and reperfusion? Circulation (1992) 1.57

The human heat-shock protein family. Expression of a novel heat-inducible HSP70 (HSP70B') and isolation of its cDNA and genomic DNA. Biochem J (1990) 1.55

Bis, a Bcl-2-binding protein that synergizes with Bcl-2 in preventing cell death. Oncogene (1999) 1.54

The small-molecule BGP-15 protects against heart failure and atrial fibrillation in mice. Nat Commun (2014) 1.54

Respiratory insufficiency in desminopathy patients caused by introduction of proline residues in desmin c-terminal alpha-helical segment. Muscle Nerve (2003) 1.50

Cloning and subcellular localization of human mitochondrial hsp70. J Biol Chem (1995) 1.50

Cardiomyocyte expression of a polyglutamine preamyloid oligomer causes heart failure. Circulation (2008) 1.49

Heat-shock protein induction in rat hearts. A direct correlation between the amount of heat-shock protein induced and the degree of myocardial protection. Circulation (1994) 1.49

Cell surface expression of heat shock proteins and the immune response. Cell Stress Chaperones (1996) 1.48

Rapid expression of heat shock protein in the rabbit after brief cardiac ischemia. J Clin Invest (1991) 1.48

BAG-1, a negative regulator of Hsp70 chaperone activity, uncouples nucleotide hydrolysis from substrate release. EMBO J (1998) 1.48

How BAD phosphorylation is good for survival. Nat Cell Biol (1999) 1.45

CHIP, a cochaperone/ubiquitin ligase that regulates protein quality control, is required for maximal cardioprotection after myocardial infarction in mice. Am J Physiol Heart Circ Physiol (2005) 1.43

Molecular chaperones and the art of recognizing a lost cause. Nat Cell Biol (2001) 1.43

Hsp90 ensures the transition from the early Ca2+-dependent to the late phosphorylation-dependent activation of the endothelial nitric-oxide synthase in vascular endothelial growth factor-exposed endothelial cells. J Biol Chem (2001) 1.42

Hsp90 and caveolin are key targets for the proangiogenic nitric oxide-mediated effects of statins. Circ Res (2001) 1.42

Build it up-Tear it down: protein quality control in the cardiac sarcomere. Cardiovasc Res (2008) 1.42

HSP40 binding is the first step in the HSP90 chaperoning pathway for the progesterone receptor. J Biol Chem (2002) 1.41

BAG3 and Hsc70 interact with actin capping protein CapZ to maintain myofibrillar integrity under mechanical stress. Circ Res (2010) 1.41

Essential roles of Her2/erbB2 in cardiac development and function. Recent Prog Horm Res (2004) 1.39

Regulation by heavy metals and temperature of the human BAG-3 gene, a modulator of Hsp70 activity. FEBS Lett (2003) 1.37

The anti-apoptotic protein BAG-3 is overexpressed in pancreatic cancer and induced by heat stress in pancreatic cancer cell lines. FEBS Lett (2001) 1.37

Cardioprotective effects of 70-kDa heat shock protein in transgenic mice. Proc Natl Acad Sci U S A (1996) 1.32

Chaperone-assisted degradation: multiple paths to destruction. Biol Chem (2010) 1.32

The protective role of heat stress in the ischaemic and reperfused rabbit myocardium. J Mol Cell Cardiol (1992) 1.31

Dual function of membrane-bound heat shock protein 70 (Hsp70), Bag-4, and Hsp40: protection against radiation-induced effects and target structure for natural killer cells. Cell Death Differ (2005) 1.28