Cytoplasmic genetics of mammalian cells: conditional sensitivity to mitochondrial inhibitors and isolation of new mutant phenotypes.

PubWeight™: 1.00‹?› | Rank: Top 15%

🔗 View Article (PMID 296586)

Published in Somatic Cell Genet on November 01, 1979

Authors

N Howell, R Sager

Articles by these authors

Reanalysis and revision of the Cambridge reference sequence for human mitochondrial DNA. Nat Genet (1999) 18.22

Maspin, a serpin with tumor-suppressing activity in human mammary epithelial cells. Science (1994) 5.37

Distinctive traits of normal and tumor-derived human mammary epithelial cells expressed in a medium that supports long-term growth of both cell types. Proc Natl Acad Sci U S A (1989) 4.81

Constitutive overexpression of a growth-regulated gene in transformed Chinese hamster and human cells. Proc Natl Acad Sci U S A (1987) 3.74

Human papilloma virus DNAs immortalize normal human mammary epithelial cells and reduce their growth factor requirements. Proc Natl Acad Sci U S A (1990) 3.40

Differential display and cloning of messenger RNAs from human breast cancer versus mammary epithelial cells. Cancer Res (1992) 3.12

Social deprivation and prognostic benefits of cardiac surgery: observational study of 44 902 patients from five hospitals over 10 years. BMJ (2009) 2.95

Selective silencing of eukaryotic DNA. Science (1975) 2.90

The epidemiology of Leber hereditary optic neuropathy in the North East of England. Am J Hum Genet (2002) 2.67

Mammalian mitochondrial genetics: heredity, heteroplasmy and disease. Trends Genet (1997) 2.45

Positive selection of candidate tumor-suppressor genes by subtractive hybridization. Proc Natl Acad Sci U S A (1991) 2.43

Amplification of specific DNA sequences correlates with multi-drug resistance in Chinese hamster cells. Nature (1984) 2.39

Oxygen and Light Induced Oxidations of Cytochrome, Flavoprotein, and Pyridine Nucleotide in a Chlamydomonas Mutant. Plant Physiol (1957) 2.28

Maspin acts at the cell membrane to inhibit invasion and motility of mammary and prostatic cancer cells. Proc Natl Acad Sci U S A (1996) 2.20

The inheritance of mitochondrial DNA heteroplasmy: random drift, selection or both? Trends Genet (2000) 2.19

Loss of p53 protein in human papillomavirus type 16 E6-immortalized human mammary epithelial cells. J Virol (1991) 2.14

Molecular basis of maternal inheritance. Proc Natl Acad Sci U S A (1972) 2.11

A variant of Leber hereditary optic neuropathy characterized by recovery of vision and by an unusual mitochondrial genetic etiology. Am J Hum Genet (1992) 2.10

Molecular pathology of MELAS and MERRF. The relationship between mutation load and clinical phenotypes. Brain (1997) 2.09

Functional diversity of gro gene expression in human fibroblasts and mammary epithelial cells. Proc Natl Acad Sci U S A (1988) 2.07

Biparental inheritance of nonchromosomal genes induced by ultraviolet irradiation. Proc Natl Acad Sci U S A (1967) 2.00

Genomic rearrangements in a mouse cell line containing integrated SV40 DNA. Cell (1981) 1.94

Identification of three related human GRO genes encoding cytokine functions. Proc Natl Acad Sci U S A (1990) 1.86

Keratins as markers that distinguish normal and tumor-derived mammary epithelial cells. Proc Natl Acad Sci U S A (1990) 1.81

Mutations in mitochondrial cytochrome c oxidase genes segregate with late-onset Alzheimer disease. Proc Natl Acad Sci U S A (1997) 1.80

Tumor progression in four mammary epithelial cell lines derived from the same patient. Cancer Res (1990) 1.80

Resistance of human cells to tumorigenesis induced by cloned transforming genes. Proc Natl Acad Sci U S A (1983) 1.79

Evolution of maternofetal transport of immunoglobulins during human pregnancy. Am J Reprod Immunol (1996) 1.79

Leber hereditary optic neuropathy. Electron microscopy and molecular genetic analysis of a case. Ophthalmology (1995) 1.74

Gap junction genes Cx26 and Cx43 individually suppress the cancer phenotype of human mammary carcinoma cells and restore differentiation potential. Cell Growth Differ (1996) 1.73

Regulation of the Chlamydomonas cell cycle by light and dark. J Cell Biol (1980) 1.73

A genetic map of non-Mandelian genes in Chlamydomonas. Proc Natl Acad Sci U S A (1970) 1.72

Suppression of tumor growth by senescence in virally transformed human fibroblasts. Proc Natl Acad Sci U S A (1986) 1.70

Recombination of nonchromosomal genes in Chlamydomonas. Proc Natl Acad Sci U S A (1965) 1.65

Genetic analysis of tumorigenesis: I. Expression of tumor-forming ability in hamster hybrid cell lines. Somatic Cell Genet (1978) 1.60

Role of methylation in the modification and restriction of chloroplast DNA in Chlamydomonas. Proc Natl Acad Sci U S A (1979) 1.55

Expression of growth factors and oncogenes in normal and tumor-derived human mammary epithelial cells. Cancer Res (1988) 1.52

Analysis of European mtDNAs for recombination. Am J Hum Genet (2000) 1.51

Denaturation and the renaturation kinetics of chloroplast DNA from Chlamydomonas reinhardi. J Mol Biol (1971) 1.46

Chloroplast Genetics of Chlamydomonas. III. Closing the Circle. Genetics (1976) 1.46

Mutations that alter the transmission of chloroplast genes in Chlamydomonas. Proc Natl Acad Sci U S A (1974) 1.42

Pre-adipocyte determination either by insulin or by 5-azacytidine. Proc Natl Acad Sci U S A (1982) 1.42

An NF-kappa B-like transcription factor mediates IL-1/TNF-alpha induction of gro in human fibroblasts. J Immunol (1991) 1.42

Identification of Native American founder mtDNAs through the analysis of complete mtDNA sequences: some caveats. Ann Hum Genet (2003) 1.41

Azacytidine-induced tumorigenesis of CHEF/18 cells: correlated DNA methylation and chromosome changes. Proc Natl Acad Sci U S A (1983) 1.41

Linking gene expression patterns to therapeutic groups in breast cancer. Cancer Res (2000) 1.40

High-level, unstable adriamycin resistance in a Chinese hamster mutant cell line with double minute chromosomes. Cancer Res (1984) 1.40

A heteroplasmic LHON family: tissue distribution and transmission of the 11778 mutation. Am J Hum Genet (1994) 1.39

Production, purification, and characterization of recombinant maspin proteins. J Biol Chem (1994) 1.38

Transcriptional downregulation of gap-junction proteins blocks junctional communication in human mammary tumor cell lines. J Cell Biol (1992) 1.36

Genetic analysis of chloroplast DNA in Chlamydomonas. Adv Genet (1977) 1.36

Localization of five antibiotic resistances at the subunit level in chloroplast ribosomes of Chlamydomonas. Proc Natl Acad Sci U S A (1974) 1.35

Methylation of chloroplast DNAs in the life cycle of Chlamydomonas. Proc Natl Acad Sci U S A (1979) 1.34

Down-regulation of a member of the S100 gene family in mammary carcinoma cells and reexpression by azadeoxycytidine treatment. Proc Natl Acad Sci U S A (1992) 1.34

maspin suppresses the invasive phenotype of human breast carcinoma. Cancer Res (1998) 1.32

Tissue specificity and clustering of methylated cystosines in bovine satellite I DNA. Proc Natl Acad Sci U S A (1982) 1.31

Abnormal RNA processing associated with a novel tRNA mutation in mitochondrial DNA. A potential disease mechanism. J Biol Chem (1993) 1.31

Suppression of tumorigenicity in hybrids of normal and oncogene-transformed CHEF cells. Proc Natl Acad Sci U S A (1985) 1.31

Cytoplasmic and chloroplast ribosomes of Chlamydomonas: ultracentrifugal characterization. Science (1967) 1.30

Estrogen inhibits the growth of estrogen receptor-negative, but not estrogen receptor-positive, human mammary epithelial cells expressing a recombinant estrogen receptor. Cancer Res (1993) 1.27

MELAS and MERRF. The relationship between maternal mutation load and the frequency of clinically affected offspring. Brain (1998) 1.26

Suppression of tumor-forming ability and related traits in MCF-7 human breast cancer cells by fusion with immortal mammary epithelial cells. Proc Natl Acad Sci U S A (1990) 1.24

Leber's hereditary optic neuropathy: the etiological role of a mutation in the mitochondrial cytochrome b gene. Genetics (1993) 1.23

Mitochondrial DNA haplogroups and susceptibility to AD and dementia with Lewy bodies. Neurology (2000) 1.22

Nonrandom tissue distribution of mutant mtDNA. Am J Med Genet (1999) 1.22

Enhanced expression of an insulin growth factor-like binding protein (mac25) in senescent human mammary epithelial cells and induced expression with retinoic acid. Proc Natl Acad Sci U S A (1995) 1.22

The mat-1 gene in Chlamydomonas regulates DNA methylation during gametogenesis. Cell (1981) 1.21

The surface of prostate carcinoma DU145 cells mediates the inhibition of urokinase-type plasminogen activator by maspin. Cancer Res (2000) 1.21

Sequence variation in mitochondrial complex I genes: mutation or polymorphism? J Med Genet (2005) 1.20

A novel protease homolog differentially expressed in breast and ovarian cancer. Mol Med (1996) 1.20

Expression of maspin in prostate cells is regulated by a positive ets element and a negative hormonal responsive element site recognized by androgen receptor. Proc Natl Acad Sci U S A (1997) 1.20

Genetic suppression of tumor formation: a new frontier in cancer research. Cancer Res (1986) 1.19

Identification, cloning, and characterization of cystatin M, a novel cysteine proteinase inhibitor, down-regulated in breast cancer. J Biol Chem (1997) 1.19

Gene amplification: an example of accelerated evolution in tumorigenic cells. Proc Natl Acad Sci U S A (1985) 1.19

Transactivation through Ets and Ap1 transcription sites determines the expression of the tumor-suppressing gene maspin. Cell Growth Differ (1997) 1.19

Down-regulation of a calmodulin-related gene during transformation of human mammary epithelial cells. Proc Natl Acad Sci U S A (1990) 1.19

The tumor suppressor maspin does not undergo the stressed to relaxed transition or inhibit trypsin-like serine proteases. Evidence that maspin is not a protease inhibitory serpin. J Biol Chem (1995) 1.18

The mitochondrial ND6 gene is a hot spot for mutations that cause Leber's hereditary optic neuropathy. Brain (2001) 1.18

Down-regulation of retinoic acid receptor beta in mammary carcinoma cell lines and its up-regulation in senescing normal mammary epithelial cells. Cell Growth Differ (1994) 1.17

mtDNA mutations that cause optic neuropathy: how do we know? Am J Hum Genet (1998) 1.16

The sequence of human mtDNA: the question of errors versus polymorphisms. Am J Hum Genet (1992) 1.15

Epicardial adipose tissue as a source of nuclear factor-kappaB and c-Jun N-terminal kinase mediated inflammation in patients with coronary artery disease. J Clin Endocrinol Metab (2008) 1.15

Specificity of gap junction communication among human mammary cells and connexin transfectants in culture. J Cell Biol (1993) 1.14

Differential activity of DNA methyltransferase in the life cycle of Chlamydomonas reinhardi. Proc Natl Acad Sci U S A (1981) 1.14

Mitochondrial biogenesis in Neurospora crassa. I. An ultrastructural and biochemical investigation of the effects of anaerobiosis and chloramphenicol inhibition. J Cell Biol (1971) 1.14

A newly established metastatic breast tumor cell line with integrated amplified copies of ERBB2 and double minute chromosomes. Genes Chromosomes Cancer (1989) 1.14

Mutation of a cytoplasmic gene in Chlamydomonas alters chlorplast ribosome function. Proc Natl Acad Sci U S A (1972) 1.13

A cautionary note on reaction tubes for differential display and cDNA amplification in thermal cycling. Biotechniques (1994) 1.13

Mitochondrial DNA analysis: polymorphisms and pathogenicity. J Med Genet (1999) 1.12

The human papilloma virus 16E6 gene sensitizes human mammary epithelial cells to apoptosis induced by DNA damage. Proc Natl Acad Sci U S A (1995) 1.12

Regulation of nuclear DNA replication by thechloroplast in Chlamydomonas. Proc Natl Acad Sci U S A (1974) 1.11

A site-specific single-strand endonuclease from the eukaryote Chlamydomonas. Proc Natl Acad Sci U S A (1977) 1.10

Leptin production and release in the dually in vitro perfused human placenta. J Clin Endocrinol Metab (2000) 1.09

Clinical mitochondrial genetics. J Med Genet (1999) 1.08

Identification of 5-methylcytosine in DNA fragments immobilized on nitrocellulose paper. Proc Natl Acad Sci U S A (1980) 1.08

Longitudinal study of a heteroplasmic 3460 Leber hereditary optic neuropathy family by multiplexed primer-extension analysis and nucleotide sequencing. Am J Hum Genet (1996) 1.08

Down-regulation of laminin-5 in breast carcinoma cells. Mol Med (1998) 1.07

Tumorigenicity and its suppression in cybrids of mouse and Chinese hamster cell lines. Proc Natl Acad Sci U S A (1978) 1.06

Maspin plays an important role in mammary gland development. Dev Biol (1999) 1.06