Published in Science on March 22, 1985
Improved tools for biological sequence comparison. Proc Natl Acad Sci U S A (1988) 193.60
SSAHA: a fast search method for large DNA databases. Genome Res (2001) 48.64
Multiple sequence alignment with hierarchical clustering. Nucleic Acids Res (1988) 32.89
ZOOM! Zillions of oligos mapped. Bioinformatics (2008) 29.78
KAAS: an automatic genome annotation and pathway reconstruction server. Nucleic Acids Res (2007) 29.46
Profile analysis: detection of distantly related proteins. Proc Natl Acad Sci U S A (1987) 29.26
Automated generation of heuristics for biological sequence comparison. BMC Bioinformatics (2005) 24.54
A tool for multiple sequence alignment. Proc Natl Acad Sci U S A (1989) 17.09
A two-component regulatory system (phoP phoQ) controls Salmonella typhimurium virulence. Proc Natl Acad Sci U S A (1989) 9.79
A large family of bacterial activator proteins. Proc Natl Acad Sci U S A (1988) 8.19
Streptococcal M protein: molecular design and biological behavior. Clin Microbiol Rev (1989) 7.80
Finding sequence motifs in groups of functionally related proteins. Proc Natl Acad Sci U S A (1990) 7.65
Molecular characterization of the 50-kD subunit of dynactin reveals function for the complex in chromosome alignment and spindle organization during mitosis. J Cell Biol (1996) 7.65
Predictive motifs derived from cytosine methyltransferases. Nucleic Acids Res (1989) 7.63
A gene activated by growth factors is related to the oncogene v-jun. Proc Natl Acad Sci U S A (1988) 7.47
Identification of new eukaryotic tRNA genes in genomic DNA databases by a multistep weight matrix analysis of transcriptional control regions. Nucleic Acids Res (1994) 7.44
Characterization of Tn1546, a Tn3-related transposon conferring glycopeptide resistance by synthesis of depsipeptide peptidoglycan precursors in Enterococcus faecium BM4147. J Bacteriol (1993) 6.96
Structural and transcriptional analysis of human papillomavirus type 16 sequences in cervical carcinoma cell lines. J Virol (1987) 6.65
DDBJ in the stream of various biological data. Nucleic Acids Res (2004) 6.24
Mapping single molecule sequencing reads using basic local alignment with successive refinement (BLASR): application and theory. BMC Bioinformatics (2012) 6.16
Super-resolution biomolecular crystallography with low-resolution data. Nature (2010) 6.14
Characterization, sequence determination, and immunogenicity of a 64-kilodalton protein of Mycobacterium bovis BCG expressed in escherichia coli K-12. Infect Immun (1987) 6.00
Chromosomal beta-lactamase of Klebsiella oxytoca, a new class A enzyme that hydrolyzes broad-spectrum beta-lactam antibiotics. Antimicrob Agents Chemother (1989) 5.98
Evolutionary families of peptidases. Biochem J (1993) 5.81
A gene essential for Agrobacterium virulence is homologous to a family of positive regulatory loci. Proc Natl Acad Sci U S A (1986) 5.61
Protein database searches for multiple alignments. Proc Natl Acad Sci U S A (1990) 5.52
The Polycomb protein shares a homologous domain with a heterochromatin-associated protein of Drosophila. Proc Natl Acad Sci U S A (1991) 5.47
Complete nucleotide sequence of the Drosophila transposable element copia: homology between copia and retroviral proteins. Mol Cell Biol (1985) 5.44
Analysis of the complete DNA sequence of murine cytomegalovirus. J Virol (1996) 5.44
Structural, functional, and evolutionary relationships among extracellular solute-binding receptors of bacteria. Microbiol Rev (1993) 5.36
An interspersed repeated sequence specific for human subtelomeric regions. EMBO J (1990) 5.30
Characterization of VPS34, a gene required for vacuolar protein sorting and vacuole segregation in Saccharomyces cerevisiae. Mol Cell Biol (1990) 5.25
The protein identification resource (PIR). Nucleic Acids Res (1986) 5.18
Nucleotide sequences of mRNAs encoding Epstein-Barr virus nuclear proteins: a probable transcriptional initiation site. Proc Natl Acad Sci U S A (1986) 5.12
Purification and characterization of a newly identified growth factor specific for epithelial cells. Proc Natl Acad Sci U S A (1989) 5.10
Dynactin, a conserved, ubiquitously expressed component of an activator of vesicle motility mediated by cytoplasmic dynein. J Cell Biol (1991) 5.02
Identification and characterization of genes for a second anthranilate synthase in Pseudomonas aeruginosa: interchangeability of the two anthranilate synthases and evolutionary implications. J Bacteriol (1990) 5.01
The VanS-VanR two-component regulatory system controls synthesis of depsipeptide peptidoglycan precursors in Enterococcus faecium BM4147. J Bacteriol (1992) 4.99
Poliovirus mutant that does not selectively inhibit host cell protein synthesis. Mol Cell Biol (1985) 4.94
Identification and cloning of TCF-1, a T lymphocyte-specific transcription factor containing a sequence-specific HMG box. EMBO J (1991) 4.90
The sequence of a large L1Md element reveals a tandemly repeated 5' end and several features found in retrotransposons. Mol Cell Biol (1986) 4.83
Transcription, organization, and sequence of an auxin-regulated gene cluster in soybean. Plant Cell (1989) 4.79
Sequences required for expression of Bordetella pertussis virulence factors share homology with prokaryotic signal transduction proteins. Proc Natl Acad Sci U S A (1989) 4.78
Isolation of Listeria monocytogenes small-plaque mutants defective for intracellular growth and cell-to-cell spread. Infect Immun (1990) 4.74
Primary structure and binding activity of the hnRNP U protein: binding RNA through RGG box. EMBO J (1992) 4.73
Identification of a gene that positively regulates expression of listeriolysin, the major virulence factor of listeria monocytogenes. Proc Natl Acad Sci U S A (1990) 4.52
Analysis of cloned cDNA and genomic sequences for phytochrome: complete amino acid sequences for two gene products expressed in etiolated Avena. Nucleic Acids Res (1985) 4.45
Cloning and characterization of a cDNA encoding the rat brain glucose-transporter protein. Proc Natl Acad Sci U S A (1986) 4.40
Characterization of osmotin : a thaumatin-like protein associated with osmotic adaptation in plant cells. Plant Physiol (1987) 4.36
The identification of a novel synaptosomal-associated protein, SNAP-25, differentially expressed by neuronal subpopulations. J Cell Biol (1989) 4.36
Nucleotide sequence of the lecithinase operon of Listeria monocytogenes and possible role of lecithinase in cell-to-cell spread. Infect Immun (1992) 4.35
The 3-D structure of a zinc metallo-beta-lactamase from Bacillus cereus reveals a new type of protein fold. EMBO J (1995) 4.30
A novel GTP-binding protein, Sar1p, is involved in transport from the endoplasmic reticulum to the Golgi apparatus. J Cell Biol (1989) 4.29
The yeast ubiquitin genes: a family of natural gene fusions. EMBO J (1987) 4.25
Characterization of the virA locus of Agrobacterium tumefaciens: a transcriptional regulator and host range determinant. EMBO J (1987) 4.22
The structure of human thrombospondin, an adhesive glycoprotein with multiple calcium-binding sites and homologies with several different proteins. J Cell Biol (1986) 4.16
Nucleotide sequence of the regulatory locus controlling expression of bacterial genes for bioluminescence. Nucleic Acids Res (1987) 4.12
Saccharomyces cerevisiae STE6 gene product: a novel pathway for protein export in eukaryotic cells. EMBO J (1989) 4.10
Tracheal antimicrobial peptide, a cysteine-rich peptide from mammalian tracheal mucosa: peptide isolation and cloning of a cDNA. Proc Natl Acad Sci U S A (1991) 3.98
MIPS: a database for protein sequences, homology data and yeast genome information. Nucleic Acids Res (1997) 3.97
Surface presentation of Shigella flexneri invasion plasmid antigens requires the products of the spa locus. J Bacteriol (1992) 3.91
Bacillus sporulation gene spo0H codes for sigma 30 (sigma H). J Bacteriol (1988) 3.88
Identification and characterization of macrophage inflammatory protein 2. Proc Natl Acad Sci U S A (1989) 3.88
DNA Data Bank of Japan (DDBJ) in XML. Nucleic Acids Res (2003) 3.87
A 1-deoxy-D-xylulose 5-phosphate reductoisomerase catalyzing the formation of 2-C-methyl-D-erythritol 4-phosphate in an alternative nonmevalonate pathway for terpenoid biosynthesis. Proc Natl Acad Sci U S A (1998) 3.86
Genetic competence in Bacillus subtilis. Microbiol Rev (1991) 3.77
Bacteriophage PRD1 DNA polymerase: evolution of DNA polymerases. Proc Natl Acad Sci U S A (1987) 3.77
A system to generate chromosomal mutations in Lactococcus lactis which allows fast analysis of targeted genes. J Bacteriol (1995) 3.76
Characterization of a component of the yeast secretion machinery: identification of the SEC18 gene product. Mol Cell Biol (1988) 3.74
Nucleotide sequence and transcriptional regulation of the yeast recombinational repair gene RAD51. Mol Cell Biol (1992) 3.74
Similar organization of the sigB and spoIIA operons encoding alternate sigma factors of Bacillus subtilis RNA polymerase. J Bacteriol (1990) 3.73
Homologies between the Salmonella typhimurium CheY protein and proteins involved in the regulation of chemotaxis, membrane protein synthesis, and sporulation. Proc Natl Acad Sci U S A (1985) 3.72
Deletions of a DNA sequence in retinoblastomas and mesenchymal tumors: organization of the sequence and its encoded protein. Proc Natl Acad Sci U S A (1987) 3.72
A unified statistical framework for sequence comparison and structure comparison. Proc Natl Acad Sci U S A (1998) 3.68
Deduced products of C4-dicarboxylate transport regulatory genes of Rhizobium leguminosarum are homologous to nitrogen regulatory gene products. Nucleic Acids Res (1987) 3.66
Sequence of PSE-2 beta-lactamase. Antimicrob Agents Chemother (1988) 3.65
Isolation and characterization of a cDNA encoding a human liver/bone/kidney-type alkaline phosphatase. Proc Natl Acad Sci U S A (1986) 3.62
Calcineurin-dependent growth control in Saccharomyces cerevisiae mutants lacking PMC1, a homolog of plasma membrane Ca2+ ATPases. J Cell Biol (1994) 3.59
Evolutionary families of peptidase inhibitors. Biochem J (2004) 3.57
The Saccharomyces cerevisiae SEC14 gene encodes a cytosolic factor that is required for transport of secretory proteins from the yeast Golgi complex. J Cell Biol (1989) 3.55
Regulation of mitochondrial morphology and inheritance by Mdm10p, a protein of the mitochondrial outer membrane. J Cell Biol (1994) 3.53
PDBe: Protein Data Bank in Europe. Nucleic Acids Res (2009) 3.48
Transcriptional regulation of the virA and virG genes of Agrobacterium tumefaciens. J Bacteriol (1988) 3.48
An 'equalized cDNA library' by the reassociation of short double-stranded cDNAs. Nucleic Acids Res (1990) 3.47
Salmonella typhimurium mutants defective in flagellar filament regrowth and sequence similarity of FliI to F0F1, vacuolar, and archaebacterial ATPase subunits. J Bacteriol (1991) 3.45
Structural similarity among Escherichia coli FtsW and RodA proteins and Bacillus subtilis SpoVE protein, which function in cell division, cell elongation, and spore formation, respectively. J Bacteriol (1989) 3.41
Sequence motifs characteristic of DNA[cytosine-N4]methyltransferases: similarity to adenine and cytosine-C5 DNA-methylases. Nucleic Acids Res (1989) 3.39
A membrane glycoprotein, Sec12p, required for protein transport from the endoplasmic reticulum to the Golgi apparatus in yeast. J Cell Biol (1988) 3.37
Alternative membrane forms of Fc gamma RIII(CD16) on human natural killer cells and neutrophils. Cell type-specific expression of two genes that differ in single nucleotide substitutions. J Exp Med (1989) 3.36
Characterization of Saccharomyces cerevisiae genes encoding subunits of cyclic AMP-dependent protein kinase. Mol Cell Biol (1987) 3.34
prrA, a putative response regulator involved in oxygen regulation of photosynthesis gene expression in Rhodobacter sphaeroides. J Bacteriol (1994) 3.30
DNA sequence of mip, a Legionella pneumophila gene associated with macrophage infectivity. Infect Immun (1989) 3.29
The algR gene, which regulates mucoidy in Pseudomonas aeruginosa, belongs to a class of environmentally responsive genes. J Bacteriol (1989) 3.28
Molecular characterization of two proteins involved in the excision of the conjugative transposon Tn1545: homologies with other site-specific recombinases. EMBO J (1989) 3.26
Nucleotide sequence of the type A staphylococcal enterotoxin gene. J Bacteriol (1988) 3.26
Nucleotide sequence of the Shiga-like toxin genes of Escherichia coli. Proc Natl Acad Sci U S A (1987) 3.25
Isolation and characterization of a vascular endothelial cell mitogen produced by pituitary-derived folliculo stellate cells. Proc Natl Acad Sci U S A (1989) 3.24
Isolation of the gene encoding the Saccharomyces cerevisiae centromere-binding protein CP1. Mol Cell Biol (1990) 3.24
Comparison of flavivirus universal primer pairs and development of a rapid, highly sensitive heminested reverse transcription-PCR assay for detection of flaviviruses targeted to a conserved region of the NS5 gene sequences. J Clin Microbiol (2001) 3.24
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res (1997) 665.31
Basic local alignment search tool. J Mol Biol (1990) 659.07
Improved tools for biological sequence comparison. Proc Natl Acad Sci U S A (1988) 193.60
Rapid similarity searches of nucleic acid and protein data banks. Proc Natl Acad Sci U S A (1983) 53.12
A genomic perspective on protein families. Science (1997) 50.51
GenBank. Nucleic Acids Res (2000) 36.75
Protein sequence similarity searches using patterns as seeds. Nucleic Acids Res (1998) 23.87
GenBank. Nucleic Acids Res (1999) 21.47
Aligning two sequences within a specified diagonal band. Comput Appl Biosci (1992) 19.31
On the statistical significance of nucleic acid similarities. Nucleic Acids Res (1984) 18.21
Rapid and sensitive sequence comparison with FASTP and FASTA. Methods Enzymol (1990) 17.64
A workbench for multiple alignment construction and analysis. Proteins (1991) 16.96
Weights for data related by a tree. J Mol Biol (1989) 12.63
GenBank. Nucleic Acids Res (1997) 11.73
GenBank. Nucleic Acids Res (1998) 9.36
GenBank. Nucleic Acids Res (1993) 9.06
GenBank. Nucleic Acids Res (1996) 7.06
GenBank. Nucleic Acids Res (1994) 5.63
Protein database searches for multiple alignments. Proc Natl Acad Sci U S A (1990) 5.52
Hereditary differences in the expression of the human glutathione transferase active on trans-stilbene oxide are due to a gene deletion. Proc Natl Acad Sci U S A (1988) 3.75
Lineage-specific loss and divergence of functionally linked genes in eukaryotes. Proc Natl Acad Sci U S A (2000) 3.27
Extracting protein alignment models from the sequence database. Nucleic Acids Res (1997) 3.17
A program for least squares analysis of reassociation and hybridization data. Nucleic Acids Res (1977) 3.13
Nomenclature for human glutathione transferases. Biochem J (1992) 2.71
Contextual constraints on synonymous codon choice. J Mol Biol (1983) 2.47
Equal animals. Nature (1990) 2.09
Automatic construction of restriction site maps. Nucleic Acids Res (1982) 1.92
Empirical determination of effective gap penalties for sequence comparison. Bioinformatics (2002) 1.78
Increased synthesis of glutathione S-transferases in response to anticarcinogenic antioxidants. Cloning and measurement of messenger RNA. J Biol Chem (1983) 1.68
Evolution of protein sequences and structures. J Mol Biol (1999) 1.65
Cloning, expression, and characterization of a class-mu glutathione transferase from human muscle, the product of the GST4 locus. Proc Natl Acad Sci U S A (1991) 1.46
The origin of nuclear receptor proteins: a single precursor distinct from other transcription factors. Mol Endocrinol (1992) 1.21
Regulation of synthesis of amyloid A-related protein. Ann N Y Acad Sci (1982) 1.20
Heterologous expression of the allelic variant mu-class glutathione transferases mu and psi. Biochem J (1991) 1.18
Interaction of silent and replacement changes in eukaryotic coding sequences. J Mol Evol (1985) 1.18
A platform for biological sequence comparison on parallel computers. Comput Appl Biosci (1991) 1.16
Analysis of rat repetitive DNA sequences. Biochemistry (1978) 1.16
Absence of short period interspersion of repetitive and non-repetitive sequences in the DNA of Drosophila melanogaster. Chromosoma (1976) 1.14
Characterization of the human class Mu glutathione S-transferase gene cluster and the GSTM1 deletion. J Biol Chem (1998) 1.11
Structural organization of Escherichia coli tRNAtyr gene clusters in four different transducing bacteriophages. J Mol Biol (1979) 1.10
Repeated DNA sequences near the 5'-end of the silk fibroin gene. J Biol Chem (1981) 1.10
Use of site-directed mutagenesis of allele-specific PCR primers to identify the GSTM1 A, GSTM1 B, GSTM1 A,B and GSTM1 null polymorphisms at the glutathione S-transferase, GSTM1 locus. Biochem J (1993) 1.08
Stoichiometry of chromatin proteins. Biochem Biophys Res Commun (1974) 1.06
Molecular characterization of alpha 1- and alpha 2-adrenoceptors. Trends Pharmacol Sci (1991) 1.02
Comparative analysis of nucleic acid sequences by their general constraints. Nucleic Acids Res (1982) 1.00
Training for bioinformatics and computational biology. Bioinformatics (2001) 0.96
The structure of two murine class-mu glutathione transferase genes coordinately induced by butylated hydroxyanisole. Arch Biochem Biophys (1993) 0.96
Long and short repeats of sea urchin DNA and their evolution. Chromosoma (1981) 0.93
Rapid identification of protein phosphatase 1-binding proteins by mixed peptide sequencing and data base searching. Characterization of a novel holoenzymic form of protein phosphatase 1. J Biol Chem (1998) 0.90
Sequence relationship between long and short repetitive DNA of the rat: a preliminary report. Proc Natl Acad Sci U S A (1977) 0.87
Aligning a DNA sequence with a protein sequence. J Comput Biol (1997) 0.86
Homozygous deletion of gene for glutathione S-transferase M1 in bladder cancer. BMJ (1993) 0.85
Computer programs for analysis of nucleic acid hybridization, thermal denaturation, and gel electrophoresis data. Nucleic Acids Res (1979) 0.82
Discrete-length repeated sequences in eukaryotic genomes. Proc Natl Acad Sci U S A (1981) 0.81
Differences in induction by xenobiotics in murine tissues and the Hepa1c1c7 cell line of mRNAs encoding glutathione transferase, quinone reductase, and CYP1A P450s. Pharmacogenetics (1993) 0.81
Sequence organization of the rat genome by electron microscopy. Biochemistry (1978) 0.80
Panning for genes--A visual strategy for identifying novel gene orthologs and paralogs. Genome Res (1999) 0.80
Distinctive structure of the human GSTM3 gene-inverted orientation relative to the mu class glutathione transferase gene cluster. Arch Biochem Biophys (1999) 0.77
Local sequence patterns of hydrophobicity and solvent accessibility in soluble globular proteins. Biopolymers (1987) 0.76
Hierarchical analysis of influenza A hemagglutinin gene sequences. Nucleic Acids Res (1982) 0.75
Programming languages III. MD Comput (1986) 0.75
Tracking the stock market. MD Comput (1984) 0.75
Primary structure of avian H+/K(+)-ATPase beta-subunit. Biochim Biophys Acta (1994) 0.75
Comparing machine-independent versus machine-specific parallelization of a software platform for biological sequence comparison. Comput Appl Biosci (1992) 0.75
Programming languages. II. MD Comput (1987) 0.75