Published in J Biol Chem on February 15, 1986
Phospholipase A2 and phospholipase C are activated by distinct GTP-binding proteins in response to alpha 1-adrenergic stimulation in FRTL5 thyroid cells. Proc Natl Acad Sci U S A (1986) 2.45
Dissociation of bradykinin-induced prostaglandin formation from phosphatidylinositol turnover in Swiss 3T3 fibroblasts: evidence for G protein regulation of phospholipase A2. Proc Natl Acad Sci U S A (1987) 2.17
Occurrence in Saccharomyces cerevisiae of a gene homologous to the cDNA coding for the alpha subunit of mammalian G proteins. Proc Natl Acad Sci U S A (1987) 2.15
RGS4 and GAIP are GTPase-activating proteins for Gq alpha and block activation of phospholipase C beta by gamma-thio-GTP-Gq alpha. Proc Natl Acad Sci U S A (1997) 2.14
Specific binding of [alpha-32P]GTP to cytosolic and membrane-bound proteins of human platelets correlates with the activation of phospholipase C. Proc Natl Acad Sci U S A (1987) 1.99
Phosphoinositide hydrolysis by guanosine 5'-[gamma-thio]triphosphate-activated phospholipase C of turkey erythrocyte membranes. Biochem J (1988) 1.88
Two G-proteins act in series to control stimulus-secretion coupling in mast cells: use of neomycin to distinguish between G-proteins controlling polyphosphoinositide phosphodiesterase and exocytosis. J Cell Biol (1987) 1.75
Identification of a GTP-binding protein alpha subunit that lacks an apparent ADP-ribosylation site for pertussis toxin. Proc Natl Acad Sci U S A (1988) 1.55
Guanine-nucleotide and hormone regulation of polyphosphoinositide phospholipase C activity of rat liver plasma membranes. Bivalent-cation and phospholipid requirements. Biochem J (1987) 1.44
Guanine nucleotides stimulate polyphosphoinositide phosphodiesterase and exocytotic secretion from HL60 cells permeabilized with streptolysin O. Biochem J (1988) 1.39
Sequence analysis of cDNA and genomic DNA for a putative pertussis toxin-insensitive guanine nucleotide-binding regulatory protein alpha subunit. Proc Natl Acad Sci U S A (1988) 1.32
Angiotensin II induces oscillations of intracellular calcium and blocks anomalous inward rectifying potassium current in mouse renal juxtaglomerular cells. Proc Natl Acad Sci U S A (1989) 1.22
How far does phospholipase C activity depend on the cell calcium concentration? A study in intact cells. Biochem J (1987) 1.16
Effects of glucagon and Ca2+ on the metabolism of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate in isolated rat hepatocytes and plasma membranes. Biochem J (1987) 1.16
The dependence on Ca2+ of the guanine-nucleotide-activated polyphosphoinositide phosphodiesterase in neutrophil plasma membranes. Biochem J (1986) 1.09
Regulation of bombesin-stimulated inositol 1,4,5-trisphosphate generation in Swiss 3T3 fibroblasts by a guanine-nucleotide-binding protein. Biochem J (1990) 1.08
Phospholipase C associated with particulate fractions of bovine brain. Proc Natl Acad Sci U S A (1987) 1.07
G-proteins of fat-cells. Role in hormonal regulation of intracellular inositol 1,4,5-trisphosphate. Biochem J (1986) 1.05
Guanine nucleotide and NaF stimulation of phospholipase C activity in rat cerebral-cortical membranes. Studies on substrate specificity. Biochem J (1987) 1.02
Bacterial toxins affect early events of T lymphocyte activation. J Clin Invest (1989) 1.02
Polyphosphoinositide Phospholipase C in Plasma Membranes of Wheat (Triticum aestivum L.) : Orientation of Active Site and Activation by Ca and Mg. Plant Physiol (1992) 1.01
Guanine nucleotide binding regulatory proteins and adenylate cyclase in livers of streptozotocin- and BB/Wor-diabetic rats. Immunodetection of Gs and Gi with antisera prepared against synthetic peptides. J Clin Invest (1989) 0.98
Different effects of phorbol ester on angiotensin II- and stable GTP analogue-induced activation of polyphosphoinositide phosphodiesterase in membranes isolated from rat renal mesangial cells. Biochem J (1987) 0.97
Epidermal growth factor-stimulated phosphoinositide hydrolysis in cultured rat inner medullary collecting tubule cells. Regulation by G protein, calcium, and protein kinase C. J Clin Invest (1990) 0.96
Cholera-toxin and corticotropin modulation of inositol phosphate accumulation induced by vasopressin and angiotensin II in rat glomerulosa cells. Biochem J (1988) 0.96
Dissociation of inositol trisphosphate from diacylglycerol production in Rous sarcoma virus-transformed fibroblasts. J Cell Biol (1989) 0.94
Thrombin-induced phosphoinositide hydrolysis in platelets. Receptor occupancy and desensitization. Biochem J (1987) 0.93
Thyroid-stimulating hormone stimulates increases in inositol phosphates as well as cyclic AMP in the FRTL-5 rat thyroid cell line. Biochem J (1987) 0.92
The stimulation by sodium fluoride of plasma-membrane Ca2+ inflow in isolated hepatocytes. Evidence that a GTP-binding regulatory protein is involved in the hormonal stimulation of Ca2+ inflow. Biochem J (1987) 0.92
Stimulation of polyphosphoinositide hydrolysis by thrombin in membranes from human fibroblasts. Biochem J (1987) 0.91
Activation of the phospholipase C pathway by ATP is mediated exclusively through nucleotide type P2-purinoceptors in C2C12 myotubes. Br J Pharmacol (1993) 0.91
Oxytocin receptor couples to the 80 kDa Gh alpha family protein in human myometrium. Biochem J (1996) 0.89
Biochemical and functional responses stimulated by platelet-activating factor in murine peritoneal macrophages. J Cell Biol (1988) 0.89
Activation of phospholipase C associated with isolated rabbit platelet membranes by guanosine 5'-[gamma-thio]triphosphate and by thrombin in the presence of GTP. Biochem J (1987) 0.87
Role of G-proteins in T cell activation: non-hydrolysable GTP analogues induce early ornithine decarboxylase activity in human T lymphocytes. EMBO J (1986) 0.87
Bradykinin-activated membrane-associated phospholipase C in Madin-Darby canine kidney cells. J Clin Invest (1988) 0.85
Epidermal growth factor-induced phosphoinositide hydrolysis in permeabilized 3T3 cells: lack of guanosine triphosphate dependence and inhibition by tyrosine-containing peptides. Cell Regul (1990) 0.83
Cholera toxin modulation of angiotensin II-stimulated inositol phosphate production in cultured vascular smooth muscle cells. Biochem J (1990) 0.83
The roles of phospholipase D and a GTP-binding protein in guanosine 5'-[gamma-thio]triphosphate-stimulated hydrolysis of phosphatidylcholine in rat liver plasma membranes. Biochem J (1990) 0.83
Phospholipase C-delta1 and oxytocin receptor signalling: evidence of its role as an effector. Biochem J (1998) 0.82
Guanine nucleotide regulation of [3H]vasopressin binding to liver plasma membranes and solubilized receptors. Evidence for the involvement of a guanine nucleotide regulatory protein. Biochem J (1986) 0.82
Muscarinic cholinergic stimulation of inositol phosphate production in cultured embryonic chick atrial cells. Evidence for a role of two guanine-nucleotide-binding proteins. Biochem J (1990) 0.82
Guanine nucleotides mediate stimulatory and inhibitory effects on cerebral-cortical membrane phospholipase C activity. Biochem J (1989) 0.81
Influence of bacterial toxins and forskolin upon vasopressin-induced inositol phosphate accumulation in WRK 1 cells. Biochem J (1989) 0.81
Characterization of partially purified phospholipase C from human platelet membranes. Biochem J (1987) 0.81
Evidence from studies employing radioactively labelled fatty acids that the stimulation of flux through the diacylglycerol pool is an early action of vasopressin on hepatocytes. Biochem J (1987) 0.81
Purification of two distinct types of phosphoinositide-specific phospholipase C from rat liver. Enzymological and structural studies. Biochem J (1988) 0.81
Action of guanosine 5'-[beta-thio]diphosphate on thrombin-induced activation and Ca2+ mobilization in saponin-permeabilized and intact human platelets. Biochem J (1988) 0.80
Inhibition of prostaglandin E2-induced phosphoinositide metabolism by phorbol ester in bovine adrenal chromaffin cells. Biochem J (1988) 0.79
Lack of translocation of protein kinase C from the cytosol to the membranes in vasopressin-stimulated hepatocytes. Biochem J (1990) 0.79
Ca2+-induced changes in the secondary structure of a 60 kDa phosphoinositide-specific phospholipase C from bovine brain cytosol. Biochem J (1988) 0.78
Evidence that guanosine 5'-[gamma-thio]triphosphate stimulates plasma membrane Ca2+ inflow when introduced into hepatocytes. Biochem J (1989) 0.78
Interaction of cerebral-cortical membranes with exogenously added phosphatidylinositol 4,5-bisphosphate. Effects on measured phospholipase C activity. Biochem J (1989) 0.77
Properties of phosphatidate phosphohydrolase in rat adipose tissue. Biochem J (1994) 0.77
G-protein inhibition of phospholipase C-beta 1 in membranes: role of G-protein beta gamma subunits. Biochem J (1996) 0.77
G-proteins are not directly involved in the CD3-antigen-mediated production of inositol phosphates in HPB-ALL T-leukaemia cells expressing phospholipase C isoforms gamma 1 and beta 3. Biochem J (1993) 0.77
Ca2+ inhibits guanine nucleotide-activated phospholipase D in neural-derived NG108-15 cells. Cell Regul (1991) 0.76
Effect of guanine nucleotides on polyphosphoinositide synthesis in rat liver plasma membranes. Biochem J (1990) 0.76
Different mechanisms of Ca2(+)-handling following nicotinic acetylcholine receptor stimulation, P2U-purinoceptor stimulation and K(+)-induced depolarization in C2C12 myotubes. Br J Pharmacol (1996) 0.76
Characterization of Ca2+ fluxes in rat liver plasma-membrane vesicles. Biochem J (1988) 0.76
Effects of GTP gamma S on muscarinic receptor-stimulated inositol phospholipid hydrolysis in permeabilized smooth muscle from the small intestine. Br J Pharmacol (1995) 0.76
Oxytocin receptors on cultured astroglial cells. Regulation by a guanine-nucleotide-binding protein and effect of Mg2+. Biochem J (1992) 0.76
Reduced high-affinity alpha 1-adrenoceptors in liver of senescent rats: implications of assessment at various temperatures. Br J Pharmacol (1990) 0.75
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Activation of the zeta isozyme of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem (1993) 4.23
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Changes in free cytosolic Ca2+ in hepatocytes following alpha 1-adrenergic stimulation. Studies on Quin-2-loaded hepatocytes. J Biol Chem (1983) 2.73
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First analysis of cancer incidence and occupational radiation exposure based on the National Dose Registry of Canada. Am J Epidemiol (2001) 2.44
Phosphatidate accumulation in hormone-treated hepatocytes via a phospholipase D mechanism. J Biol Chem (1987) 2.40
The carriage of Escherichia coli resistant to antimicrobial agents by healthy children in Boston, in Caracas, Venezuela, and in Qin Pu, China. N Engl J Med (1990) 2.40
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A rapid method for the determination of glycogen content and radioactivity in small quantities of tissue or isolated hepatocytes. Anal Biochem (1976) 2.36
Characterization of responses of isolated rat hepatocytes to ATP and ADP. J Biol Chem (1985) 2.27
DMC1 functions in a Saccharomyces cerevisiae meiotic pathway that is largely independent of the RAD51 pathway. Genetics (1997) 2.26
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A novel gene causing a mendelian audiogenic mouse epilepsy. Neuron (2001) 2.05
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Estimating cancer risk in relation to tritium exposure from routine operation of a nuclear-generating station in Pickering, Ontario. Chronic Dis Inj Can (2013) 1.97
Vasopressin-, angiotensin II-, and alpha 1-adrenergic-induced inhibition of Ca2+ transport by rat liver plasma membrane vesicles. J Biol Chem (1984) 1.95
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