Sequence and domain relationships of ntrC and nifA from Klebsiella pneumoniae: homologies to other regulatory proteins.

PubWeight™: 5.20‹?› | Rank: Top 1%

🔗 View Article (PMC 1166750)

Published in EMBO J on February 01, 1986

Authors

M Drummond, P Whitty, J Wootton

Articles citing this

(truncated to the top 100)

Protein phosphorylation and regulation of adaptive responses in bacteria. Microbiol Rev (1989) 20.50

PAS domains: internal sensors of oxygen, redox potential, and light. Microbiol Mol Biol Rev (1999) 10.69

A large family of bacterial activator proteins. Proc Natl Acad Sci U S A (1988) 8.19

Control site location and transcriptional regulation in Escherichia coli. Microbiol Rev (1991) 8.11

Expression of sigma 54 (ntrA)-dependent genes is probably united by a common mechanism. Microbiol Rev (1989) 7.22

Two-component regulatory systems responsive to environmental stimuli share strongly conserved domains with the nitrogen assimilation regulatory genes ntrB and ntrC. Proc Natl Acad Sci U S A (1986) 7.01

Improved detection of helix-turn-helix DNA-binding motifs in protein sequences. Nucleic Acids Res (1990) 6.99

Protein kinase and phosphoprotein phosphatase activities of nitrogen regulatory proteins NTRB and NTRC of enteric bacteria: roles of the conserved amino-terminal domain of NTRC. Proc Natl Acad Sci U S A (1988) 5.62

A gene essential for Agrobacterium virulence is homologous to a family of positive regulatory loci. Proc Natl Acad Sci U S A (1986) 5.61

The sigma 54 bacterial enhancer-binding protein family: mechanism of action and phylogenetic relationship of their functional domains. J Bacteriol (1993) 4.34

Nitrogen control in bacteria. Microbiol Rev (1995) 3.99

Rhizobium meliloti ntrA (rpoN) gene is required for diverse metabolic functions. J Bacteriol (1987) 3.68

Deduced products of C4-dicarboxylate transport regulatory genes of Rhizobium leguminosarum are homologous to nitrogen regulatory gene products. Nucleic Acids Res (1987) 3.66

Genetic regulation of nitrogen fixation in rhizobia. Microbiol Rev (1994) 3.42

VpsR, a Member of the Response Regulators of the Two-Component Regulatory Systems, Is Required for Expression of vps Biosynthesis Genes and EPS(ETr)-Associated Phenotypes in Vibrio cholerae O1 El Tor. J Bacteriol (2001) 2.77

Isolation of the gene encoding the Hin recombinational enhancer binding protein. Proc Natl Acad Sci U S A (1988) 2.76

Analysis of the Kluyveromyces lactis positive regulatory gene LAC9 reveals functional homology to, but sequence divergence from, the Saccharomyces cerevisiae GAL4 gene. Nucleic Acids Res (1986) 2.76

Deduced polypeptides encoded by the Bacillus subtilis sacU locus share homology with two-component sensor-regulator systems. J Bacteriol (1988) 2.65

Physical and genetic map of the major nif gene cluster from Azotobacter vinelandii. J Bacteriol (1989) 2.60

P(II) signal transduction proteins, pivotal players in microbial nitrogen control. Microbiol Mol Biol Rev (2001) 2.56

Cloning and nucleotide sequence of phoP, the regulatory gene for alkaline phosphatase and phosphodiesterase in Bacillus subtilis. J Bacteriol (1987) 2.52

A family of positive regulators related to the Pseudomonas putida TOL plasmid XylS and the Escherichia coli AraC activators. Nucleic Acids Res (1990) 2.48

Role of integration host factor in the regulation of the glnHp2 promoter of Escherichia coli. Proc Natl Acad Sci U S A (1991) 2.42

Prokaryotic enhancer-binding proteins reflect eukaryote-like modularity: the puzzle of nitrogen regulatory protein C. J Bacteriol (1993) 2.32

Identification and characterization of the Rhizobium meliloti ntrC gene: R. meliloti has separate regulatory pathways for activation of nitrogen fixation genes in free-living and symbiotic cells. J Bacteriol (1987) 2.23

Pseudomonas aeruginosa AlgB, a two-component response regulator of the NtrC family, is required for algD transcription. J Bacteriol (1991) 2.13

NifA-dependent in vivo protection demonstrates that the upstream activator sequence of nif promoters is a protein binding site. Proc Natl Acad Sci U S A (1988) 2.10

The central domain of Rhizobium meliloti NifA is sufficient to activate transcription from the R. meliloti nifH promoter. J Bacteriol (1989) 2.02

Activation of the Bradyrhizobium japonicum nifH and nifDK operons is dependent on promoter-upstream DNA sequences. Nucleic Acids Res (1986) 2.00

The predicted protein product of a pathogenicity locus from Pseudomonas syringae pv. phaseolicola is homologous to a highly conserved domain of several procaryotic regulatory proteins. J Bacteriol (1989) 1.95

Beryllofluoride mimics phosphorylation of NtrC and other bacterial response regulators. Proc Natl Acad Sci U S A (1999) 1.90

The DNA-binding domain of the transcriptional activator protein NifA resides in its carboxy terminus, recognises the upstream activator sequences of nif promoters and can be separated from the positive control function of NifA. Nucleic Acids Res (1988) 1.89

Cloning and phenotypic characterization of fleS and fleR, new response regulators of Pseudomonas aeruginosa which regulate motility and adhesion to mucin. Infect Immun (1995) 1.87

Role of uhp genes in expression of the Escherichia coli sugar-phosphate transport system. J Bacteriol (1988) 1.85

Binding of transcriptional activators to sigma 54 in the presence of the transition state analog ADP-aluminum fluoride: insights into activator mechanochemical action. Genes Dev (2001) 1.84

In vitro transcription of the nitrogen fixation regulatory operon nifLA of Klebsiella pneumoniae. J Bacteriol (1987) 1.84

Cloning and nucleotide sequence of the gene encoding the positive regulator (DmpR) of the phenol catabolic pathway encoded by pVI150 and identification of DmpR as a member of the NtrC family of transcriptional activators. J Bacteriol (1993) 1.80

Sensing of aromatic compounds by the DmpR transcriptional activator of phenol-catabolizing Pseudomonas sp. strain CF600. J Bacteriol (1994) 1.78

Initial cloning and sequencing of hydHG, an operon homologous to ntrBC and regulating the labile hydrogenase activity in Escherichia coli K-12. J Bacteriol (1989) 1.78

The transcriptional regulator LevR of Bacillus subtilis has domains homologous to both sigma 54- and phosphotransferase system-dependent regulators. Proc Natl Acad Sci U S A (1991) 1.76

The narX and narL genes encoding the nitrate-sensing regulators of Escherichia coli are homologous to a family of prokaryotic two-component regulatory genes. Nucleic Acids Res (1989) 1.75

Essential and non-essential domains in the Bradyrhizobium japonicum NifA protein: identification of indispensable cysteine residues potentially involved in redox reactivity and/or metal binding. Nucleic Acids Res (1988) 1.73

The complete nucleotide sequence of the glnALG operon of Escherichia coli K12. Nucleic Acids Res (1987) 1.73

Nucleotide sequence and genetic analysis of the nifB-nifQ region from Azotobacter vinelandii. J Bacteriol (1988) 1.69

In vitro activity of the nitrogen fixation regulatory protein NIFA. Proc Natl Acad Sci U S A (1989) 1.69

FlbD of Caulobacter crescentus is a homologue of the NtrC (NRI) protein and activates sigma 54-dependent flagellar gene promoters. Proc Natl Acad Sci U S A (1990) 1.64

Identification of pilR, which encodes a transcriptional activator of the Pseudomonas aeruginosa pilin gene. J Bacteriol (1992) 1.62

Transcriptional regulation of the spo0F gene of Bacillus subtilis. J Bacteriol (1986) 1.61

The presence of five nifH-like sequences in Clostridium pasteurianum: sequence divergence and transcription properties. Nucleic Acids Res (1988) 1.60

The central domain of Rhizobium leguminosarum DctD functions independently to activate transcription. J Bacteriol (1992) 1.60

Sequencing, chromosomal inactivation, and functional expression in Escherichia coli of ppsR, a gene which represses carotenoid and bacteriochlorophyll synthesis in Rhodobacter sphaeroides. J Bacteriol (1994) 1.60

Activity of purified NIFA, a transcriptional activator of nitrogen fixation genes. Proc Natl Acad Sci U S A (1993) 1.59

Complementation of nitrogen-regulatory (ntr-like) mutations in Rhodobacter capsulatus by an Escherichia coli gene: cloning and sequencing of the gene and characterization of the gene product. J Bacteriol (1987) 1.57

Conservation between coding and regulatory elements of Rhizobium meliloti and Rhizobium leguminosarum dct genes. J Bacteriol (1989) 1.56

The effect on the function of the transcriptional activator NtrC from Klebsiella pneumoniae of mutations in the DNA-recognition helix. Nucleic Acids Res (1988) 1.54

The isolated catalytic domain of NIFA, a bacterial enhancer-binding protein, activates transcription in vitro: activation is inhibited by NIFL. Proc Natl Acad Sci U S A (1994) 1.49

Detection of protein similarities using nucleotide sequence databases. Nucleic Acids Res (1988) 1.45

Regulation of expression of the Escherichia coli K-12 mtr gene by TyrR protein and Trp repressor. J Bacteriol (1991) 1.43

Modulation of NifA activity by PII in Azospirillum brasilense: evidence for a regulatory role of the NifA N-terminal domain. J Bacteriol (1996) 1.43

Three trans-acting regulatory functions control hydrogenase synthesis in Alcaligenes eutrophus. J Bacteriol (1991) 1.41

Transcriptional activation of the Klebsiella pneumoniae nifLA promoter by NTRC is face-of-the-helix dependent and the activator stabilizes the interaction of sigma 54-RNA polymerase with the promoter. EMBO J (1989) 1.40

Molecular characterization of the virD operon from Agrobacterium tumefaciens. Nucleic Acids Res (1987) 1.39

A genetic analysis of various functions of the TyrR protein of Escherichia coli. J Bacteriol (1993) 1.39

Mutations in the RNA polymerase recognition sequence of the Klebsiella pneumoniae nifH promoter permitting transcriptional activation in the absence of NifA binding to upstream activator sequences. Nucleic Acids Res (1989) 1.34

Purification and in vitro activities of the native nitrogen fixation control proteins NifA and NifL. J Bacteriol (1994) 1.34

The signal transduction protein GlnK is required for NifL-dependent nitrogen control of nif gene expression in Klebsiella pneumoniae. J Bacteriol (1999) 1.31

The product of the nitrogen fixation regulatory gene nfrX of Azotobacter vinelandii is functionally and structurally homologous to the uridylyltransferase encoded by glnD in enteric bacteria. J Bacteriol (1991) 1.28

Activation of the Klebsiella pneumoniae nifU promoter: identification of multiple and overlapping upstream NifA binding sites. Nucleic Acids Res (1990) 1.28

Two nifA-like genes required for expression of alternative nitrogenases by Azotobacter vinelandii. J Bacteriol (1989) 1.26

Organization and partial sequence of a DNA region of the Rhizobium leguminosarum symbiotic plasmid pRL6JI containing the genes fixABC, nifA, nifB and a novel open reading frame. Nucleic Acids Res (1987) 1.25

In vitro activity of NifL, a signal transduction protein for biological nitrogen fixation. J Bacteriol (1993) 1.25

Mutations in the glnG gene of Escherichia coli that result in increased activity of nitrogen regulator I. J Bacteriol (1989) 1.23

Transcriptional activation of the nitrogenase promoter in vitro: adenosine nucleotides are required for inhibition of NIFA activity by NIFL. J Bacteriol (1995) 1.23

Identification and sequence analysis of the hupR1 gene, which encodes a response regulator of the NtrC family required for hydrogenase expression in Rhodobacter capsulatus. J Bacteriol (1991) 1.21

Genetic regulation of formate hydrogenlyase of Escherichia coli: role of the fhlA gene product as a transcriptional activator for a new regulatory gene, fhlB. J Bacteriol (1990) 1.20

Role of the Bradyrhizobium japonicum ntrC gene product in differential regulation of the glutamine synthetase II gene (glnII). J Bacteriol (1988) 1.20

Expression and functional analysis of the Rhizobium meliloti nifA gene. EMBO J (1988) 1.18

Influence of oxygen on DNA binding, positive control, and stability of the Bradyrhizobium japonicum NifA regulatory protein. J Bacteriol (1991) 1.16

Mutational analysis of upstream sequences required for transcriptional activation of the Klebsiella pneumoniae nifH promoter. Nucleic Acids Res (1987) 1.12

Effector-mediated stimulation of ATPase activity by the sigma 54-dependent transcriptional activator FHLA from Escherichia coli. J Bacteriol (1995) 1.11

Cascade regulation of the toluene-3-monooxygenase operon (tbuA1UBVA2C) of Burkholderia pickettii PKO1: role of the tbuA1 promoter (PtbuA1) in the expression of its cognate activator, TbuT. J Bacteriol (1996) 1.11

Use of PCR to isolate genes encoding sigma54-dependent activators from diverse bacteria. J Bacteriol (1996) 1.09

Control of Herbaspirillum seropedicae NifA activity by ammonium ions and oxygen. J Bacteriol (1999) 1.07

Influence of a mutation in the putative nucleotide binding site of the nitrogen regulatory protein NTRC on its positive control function. Nucleic Acids Res (1991) 1.07

Phosphorylation-induced signal propagation in the response regulator ntrC. J Bacteriol (2000) 1.06

Comparative analysis of the replicon regions of eleven ColE2-related plasmids. J Bacteriol (1994) 1.05

The Azorhizobium caulinodans nifA gene: identification of upstream-activating sequences including a new element, the 'anaerobox'. Nucleic Acids Res (1988) 1.02

Rhizobium meliloti and Rhizobium leguminosarum dctD gene products bind to tandem sites in an activation sequence located upstream of sigma 54-dependent dctA promoters. J Bacteriol (1990) 1.01

The C-terminal domain of NifL is sufficient to inhibit NifA activity. J Bacteriol (1995) 1.01

Mutations affecting motifs of unknown function in the central domain of nitrogen regulatory protein C. J Bacteriol (1999) 1.01

Active contribution of two domains to cooperative DNA binding of the enhancer-binding protein nitrogen regulator I (NtrC) of Escherichia coli: stimulation by phosphorylation and the binding of ATP. J Bacteriol (1995) 0.99

Aromatic effector activation of the NtrC-like transcriptional regulator PhhR limits the catabolic potential of the (methyl)phenol degradative pathway it controls. J Bacteriol (1995) 0.99

Effects of insertions and deletions in glnG (ntrC) of Escherichia coli on nitrogen regulator I-dependent DNA binding and transcriptional activation. J Bacteriol (1993) 0.98

Characterization of fhlA mutations resulting in ligand-independent transcriptional activation and ATP hydrolysis. J Bacteriol (1997) 0.98

"Switch I" mutant forms of the bacterial enhancer-binding protein NtrC that perturb the response to DNA. Proc Natl Acad Sci U S A (1999) 0.95

In vitro studies of the domains of the nitrogen fixation regulatory protein NIFA. J Bacteriol (1995) 0.91

The basis of ammonium release in nifL mutants of Azotobacter vinelandii. J Bacteriol (1999) 0.90

Interactive regulation of Azorhizobium nifA transcription via overlapping promoters. J Bacteriol (1995) 0.88

Secondary structure and DNA binding by the C-terminal domain of the transcriptional activator NifA from Klebsiella pneumoniae. Nucleic Acids Res (2002) 0.87

Chimeric transcriptional activators generated in vivo from VnfA and AnfA of Azotobacter vinelandii: N-terminal domain of AnfA is responsible for dependence on nitrogenase Fe protein. J Bacteriol (1994) 0.87

Articles cited by this

DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci U S A (1977) 790.54

A simple method for displaying the hydropathic character of a protein. J Mol Biol (1982) 150.65

Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins. J Mol Biol (1978) 33.47

Prediction of the secondary structure of proteins from their amino acid sequence. Adv Enzymol Relat Areas Mol Biol (1978) 29.77

Protein-DNA recognition. Annu Rev Biochem (1984) 22.02

Computer methods to locate signals in nucleic acid sequences. Nucleic Acids Res (1984) 21.53

pEMBL: a new family of single stranded plasmids. Nucleic Acids Res (1983) 19.19

An interactive graphics program for comparing and aligning nucleic acid and amino acid sequences. Nucleic Acids Res (1982) 12.58

Characterization of translational initiation sites in E. coli. Nucleic Acids Res (1982) 11.91

Structure-independent nucleotide sequence analysis. Proc Natl Acad Sci U S A (1979) 8.65

Genetic analysis of the ompB locus in Escherichia coli K-12. J Mol Biol (1981) 8.18

Physical map of chromosomal nitrogen fixation (nif) genes of Klebsiella pneumoniae. Proc Natl Acad Sci U S A (1979) 5.93

The helical hydrophobic moment: a measure of the amphiphilicity of a helix. Nature (1982) 5.01

Characterization of the spo0A locus and its deduced product. Proc Natl Acad Sci U S A (1985) 4.86

Complex glnA-glnL-glnG operon of Escherichia coli. J Bacteriol (1982) 4.25

Osmoregulation of gene expression. I. DNA sequence of the ompR gene of the ompB operon of Escherichia coli and characterization of its gene product. J Biol Chem (1982) 3.89

The nif promoters of Klebsiella pneumoniae have a characteristic primary structure. Cell (1983) 3.88

Repressor structure and the mechanism of positive control. Cell (1983) 3.82

Isolation of the nitrogen assimilation regulator NR(I), the product of the glnG gene of Escherichia coli. Proc Natl Acad Sci U S A (1983) 3.80

Random sequences. J Mol Biol (1983) 3.72

Deduced product of the stage 0 sporulation gene spo0F shares homology with the Spo0A, OmpR, and SfrA proteins. Proc Natl Acad Sci U S A (1985) 3.60

Developmentally regulated transcription in a cloned segment of the Bacillus subtilis chromosome. J Bacteriol (1981) 3.58

Positive control and autogenous regulation of the nifLA promoter in Klebsiella pneumoniae. Nature (1983) 3.43

Analysis of regulation of Klebsiella pneumoniae nitrogen fixation (nif) gene cluster with gene fusions. Nature (1980) 3.38

Nitrogen fixation specific regulatory genes of Klebsiella pneumoniae and Rhizobium meliloti share homology with the general nitrogen regulatory gene ntrC of K. pneumoniae. Nucleic Acids Res (1985) 3.38

Role of the nifA gene product in the regulation of nif expression in Klebsiella pneumoniae. Nature (1981) 3.33

DNA sequence analysis of the dye gene of Escherichia coli reveals amino acid homology between the dye and OmpR proteins. J Biol Chem (1985) 3.33

Regulation of nitrogen metabolism genes by nifA gene product in Klebsiella pneumoniae. Nature (1983) 3.24

Identification and regulation of the glnL operator-promoter of the complex glnALG operon of Escherichia coli. J Bacteriol (1984) 3.18

Tandem promoters determine regulation of the Klebsiella pneumoniae glutamine synthetase (glnA) gene. Nucleic Acids Res (1984) 2.94

Identification of the transcriptional suppressor sof-1 as an alteration in the spo0A protein. J Bacteriol (1985) 2.89

The genetic complexity of nitrogen fixation. The ninth Fleming lecture. J Gen Microbiol (1984) 2.73

Interaction of the sigma factor and the nusA gene protein of E. coli with RNA polymerase in the initiation-termination cycle of transcription. Cell (1981) 2.57

Nitrogen regulation in Salmonella typhimurium. Identification of an ntrC protein-binding site and definition of a consensus binding sequence. EMBO J (1985) 2.48

Nitrogen control of the nif regulon in Klebsiella pneumoniae: involvement of the ntrA gene and analogies between ntrC and nifA. EMBO J (1983) 2.47

Nitrogen fixation gene (nifL) involved in oxygen regulation of nitrogenase synthesis in K. pneumoniae. Nature (1981) 2.42

Regulation of the F conjugation genes studied by hybridization and tra-lacZ fusion. J Mol Biol (1983) 2.21

Protein folding. Annu Rev Biochem (1981) 2.21

The products of glnL and glnG are bifunctional regulatory proteins. Mol Gen Genet (1982) 2.00

The nucleotide sequence of the nitrogen regulation gene ntrB and the glnA-ntrBC intergenic region of Klebsiella pneumoniae. Nucleic Acids Res (1985) 1.91

The cloning and transposon Tn5 mutagenesis of the glnA region of Klebsiella pneumoniae: identification of glnR, a gene involved in the regulation of the nif and hut operons. Mol Gen Genet (1981) 1.89

The nucleotide sequence of the cloned nusA gene and its flanking region of Escherichia coli. Nucleic Acids Res (1984) 1.87

Cloning of the glnA, ntrB and ntrC genes of Klebsiella pneumoniae and studies of their role in regulation of the nitrogen fixation (nif) gene cluster. Mol Gen Genet (1982) 1.77

Site-directed mutagenesis of the Klebsiella pneumoniae nifL and nifH promoters and in vivo analysis of promoter activity. Nucleic Acids Res (1985) 1.73

Evidence that a nucleotide sequence, "boxA," is involved in the action of the NusA protein. Cell (1983) 1.72

Mutations affecting regulation of the Klebsiella pneumoniae nifH (nitrogenase reductase) promotor. J Bacteriol (1984) 1.64

Glutamine auxotrophs with mutations in a nitrogen regulatory gene, ntrC, that is near glnA. Mol Gen Genet (1981) 1.62

Regulation of nitrogen metabolism in glutamine auxotrophs of Klebsiella pneumoniae. J Bacteriol (1980) 1.61

Interaction of purified NtrC protein with nitrogen regulated promoters from Klebsiella pneumoniae. Mol Gen Genet (1985) 1.43

Studies on the regulation and function of the Klebsiella pneumoniae ntrA gene. Gene (1985) 1.40

Positive and negative control of the glnA ntrBC regulon in Klebsiella pneumoniae. EMBO J (1984) 1.38

Homology in protein sequences expressed by correlation coefficients. J Theor Biol (1981) 1.12

Molecular genetic analysis of Klebsiella pneumoniae nitrogen-fixation (nif) genes. Cold Spring Harb Symp Quant Biol (1981) 1.11

Studies on the control of development: isolation of Bacillus subtilis mutants blocked early in sporulation and defective in synthesis of highly phosphorylated nucleotides. Proc Natl Acad Sci U S A (1977) 1.05

Structural homology of lens crystallins. A method to detect protein structural homology from primary sequences. Eur J Biochem (1983) 0.97

Articles by these authors

(truncated to the top 100)

Effectiveness and efficiency of guideline dissemination and implementation strategies. Health Technol Assess (2004) 29.45

General practice fundholding. BMJ (1990) 6.43

Positive control and autogenous regulation of the nifLA promoter in Klebsiella pneumoniae. Nature (1983) 3.43

Effectiveness, efficiency, and NICE. BMJ (2001) 3.03

Use of complementary medicine by adult patients participating in cancer clinical trials. Oncol Nurs Forum (2000) 2.41

A framework for clinical evaluation of diagnostic technologies. CMAJ (1986) 2.26

Some guidelines on the use of cost effectiveness league tables. BMJ (1993) 2.16

Results of selective early operation in myelomeningocele. Arch Dis Child (1973) 2.12

When is it cost-effective to change the behavior of health professionals? JAMA (2001) 2.08

Efficiency in the National Health Service: lessons from abroad. Health Policy (1988) 1.79

Should clinical trials with concurrent economic analyses be blinded? JAMA (1997) 1.76

Sequence and molecular analysis of the nifL gene of Azotobacter vinelandii. Mol Microbiol (1993) 1.69

Nucleotide sequence, organisation and structural analysis of the products of genes in the nirB-cysG region of the Escherichia coli K-12 chromosome. Eur J Biochem (1990) 1.66

Clinical effectiveness, tolerability and cost-effectiveness of newer drugs for epilepsy in adults: a systematic review and economic evaluation. Health Technol Assess (2005) 1.64

Reporting guidelines for economic studies. Health Econ (1995) 1.62

Estimating the long-term impact of a prophylactic human papillomavirus 16/18 vaccine on the burden of cervical cancer in the UK. Br J Cancer (2006) 1.57

The effect on the function of the transcriptional activator NtrC from Klebsiella pneumoniae of mutations in the DNA-recognition helix. Nucleic Acids Res (1988) 1.54

The economics of femorocrural reconstruction for critical leg ischemia with and without autologous vein. J Vasc Surg (1992) 1.51

Absence of DNA sequences homologous to transposable element Tn5 (Kan) in the chromosome of Escherichia coli K-12. J Bacteriol (1978) 1.49

A systematic review and economic model of the effectiveness and cost-effectiveness of methylphenidate, dexamfetamine and atomoxetine for the treatment of attention deficit hyperactivity disorder in children and adolescents. Health Technol Assess (2006) 1.49

The cost of treatment for post-herpetic neuralgia in the UK. Pharmacoeconomics (1994) 1.48

Calculation of the need for paediatric intensive care beds. Arch Dis Child (1995) 1.48

Prescription for error. Nurs Times (1975) 1.48

Guidelines for the clinical and economic evaluation of health care technologies. Soc Sci Med (1986) 1.47

Cost-of-illness studies: a major headache? Pharmacoeconomics (1992) 1.44

A randomized trial of Evidence-based OutReach (EBOR): rationale and design. Control Clin Trials (1999) 1.42

Evaluating the BMJ guidelines for economic submissions: prospective audit of economic submissions to BMJ and The Lancet. JAMA (1998) 1.42

Developing guidance for budget impact analysis. Pharmacoeconomics (2001) 1.40

Paradoxical reaction of blood pressure on sleep apnoea patients treated with Positive Airway Pressure. Rev Port Pneumol (2011) 1.39

The product of the nitrogen fixation regulatory gene nfrX of Azotobacter vinelandii is functionally and structurally homologous to the uridylyltransferase encoded by glnD in enteric bacteria. J Bacteriol (1991) 1.28

The cost-effectiveness of population Helicobacter pylori screening and treatment: a Markov model using economic data from a randomized controlled trial. Aliment Pharmacol Ther (2002) 1.27

Comparison of alternative sources of data on health service encounters. J Health Serv Res Policy (1999) 1.25

The iterative use of economic evaluation as part of the process of health technology assessment. J Health Serv Res Policy (1997) 1.23

Stapled haemorrhoidectomy (haemorrhoidopexy) for the treatment of haemorrhoids: a systematic review and economic evaluation. Health Technol Assess (2008) 1.22

Redundancy of the conserved His residue in Azotobacter vinelandii NifL, a histidine autokinase homologue which regulates transcription of nitrogen fixation genes. Mol Microbiol (1994) 1.14

Cost effectiveness of photodynamic therapy with verteporfin for age related macular degeneration: the UK case. Br J Ophthalmol (2004) 1.12

Prevalence of new-onset insomnia in patients with obstructive sleep apnoea syndrome treated with nocturnal ventilatory support. Rev Port Pneumol (2011) 1.12

Early insight predicts depression and attempted suicide after 4 years in first-episode schizophrenia and schizophreniform disorder. Acta Psychiatr Scand (2005) 1.10

Cost-effectiveness guidelines for reimbursement of pharmaceuticals: is economic evaluation ready for its enhanced status? Health Econ (1992) 1.09

Propranolol treatment of assaultive patients with organic brain disease. A double-blind crossover, placebo-controlled study. J Nerv Ment Dis (1986) 1.07

Control of Herbaspirillum seropedicae NifA activity by ammonium ions and oxygen. J Bacteriol (1999) 1.07

Resource costing for multinational neurologic clinical trials: methods and results. Health Econ (1998) 1.06

A counterselectable pACYC184-based lacZ alpha-complementing plasmid vector with novel multiple cloning sites; construction of chromosomal deletions in Klebsiella pneumoniae. Gene (1993) 1.05

The U.K. NHS economic evaluation database. Economic issues in evaluations of health technology. Int J Technol Assess Health Care (2000) 1.04

A systematic review of the effectiveness and cost-effectiveness of different models of community-based respite care for frail older people and their carers. Health Technol Assess (2007) 1.03

Translation of Berlin Questionnaire to Portuguese language and its application in OSA identification in a sleep disordered breathing clinic. Rev Port Pneumol (2011) 1.01

Pharmacoeconomics: integrating economic evaluation into clinical trials. Br J Clin Pharmacol (1997) 0.99

Two-hybrid analysis of domain interactions involving NtrB and NtrC two-component regulators. Mol Microbiol (2001) 0.96

Carboplatin and gemcitabine in metastatic transitional cell carcinoma of the urothelium: effective treatment of patients with poor prognostic features. Ann Oncol (2001) 0.94

Positional requirements for the function of nif-specific upstream activator sequences. Mol Gen Genet (1987) 0.93

Economic evaluation of gastric ulcer prophylaxis in patients with arthritis receiving non-steroidal anti-inflammatory drugs. Postgrad Med J (1990) 0.92

Calcium accumulation and cyclic AMP-stimulated phosphorylation in plasma membrane-enriched preparations of myocardium. Arch Biochem Biophys (1976) 0.92

Construction of chimeric proteins from the sigma N-associated transcriptional activators VnfA and AnfA of Azotobacter vinelandii shows that the determinants of promoter specificity lie outside the 'recognition' helix of the HTH motif in the C-terminal domain. Mol Microbiol (1993) 0.91

The basis of ammonium release in nifL mutants of Azotobacter vinelandii. J Bacteriol (1999) 0.90

A framework for incorporating cost-effectiveness in evidence-based clinical practice guidelines. Health Policy (1999) 0.90

The DH register of cost-effectiveness studies: content and quality. Health Trends (1995) 0.90

Does expenditure on pharmaceuticals give good value for money?: current evidence and policy implications. Health Policy (1993) 0.88

Domiciliary physiotherapy for old people who have fallen. Int Rehabil Med (1983) 0.88

Detecting radiolabeled lipid-modified proteins in polyacrylamide gels. Methods Enzymol (1995) 0.88

Spina bifida as an obstetric problem. Dev Med Child Neurol Suppl (1970) 0.87

Properties of the Escherichia coli rhodanese-like protein SseA: contribution of the active-site residue Ser240 to sulfur donor recognition. FEBS Lett (2001) 0.87

Chimeric transcriptional activators generated in vivo from VnfA and AnfA of Azotobacter vinelandii: N-terminal domain of AnfA is responsible for dependence on nitrogenase Fe protein. J Bacteriol (1994) 0.87

Health economics: an introduction for clinicians. Ann Intern Med (1987) 0.86

Gestational diabetes mellitus. BMJ (1993) 0.85

Report of the OMERACT task force on economic evaluation. Outcome Measures in Rheumatology. J Rheumatol (1999) 0.85

Cloning, sequence analysis and overexpression of the rhodanese gene of Azotobacter vinelandii. Eur J Biochem (1996) 0.84

Acceptance for chronic dialysis treatment: insufficient and unequal. Nephrol Dial Transplant (1996) 0.84

Erectile dysfunction in obstructive sleep apnea syndrome--prevalence and determinants. Rev Port Pneumol (2012) 0.83

The economic evaluation of cancer treatments and programmes. Eur J Cancer (1991) 0.82

National Institutes of Health Consensus Development Statement on Acupuncture. J Altern Complement Med (1997) 0.82

Hemophagocytosis and relapsed peripheral T-cell lymphoma. Eur J Haematol (2008) 0.81

Incidence and management of gynaecological-related ureteric injuries. Aust N Z J Obstet Gynaecol (1999) 0.81

Prioritizing investments in health technology assessment. Can we assess potential value for money? Int J Technol Assess Health Care (2000) 0.81

Treating AIDS: the economic issues. Health Policy (1988) 0.81

Consolidated Health Economic Evaluation Reporting Standards (CHEERS) statement. BJOG (2013) 0.81

Low doses vs. high doses of the angiotensin converting-enzyme inhibitor lisinopril in chronic heart failure: a cost-effectiveness analysis based on the Assessment of Treatment with Lisinopril and Survival (ATLAS) study. The ATLAS Study Group. Eur J Heart Fail (2000) 0.80

The economic burden of glaucoma in the UK. The need for a far-sighted policy. Pharmacoeconomics (1995) 0.80

Is disease management relevant in Europe: some evidence from the United Kingdom. Health Policy (1999) 0.80

Cys184 and Cys187 of NifL protein of Klebsiella pneumoniae are not absolutely required for inhibition of NifA activity. Gene (1991) 0.79

Topiramate relieves refractory intercostal neuralgia. Neurology (1999) 0.78

An economic evaluation of propofol/fentanyl compared with midazolam/fentanyl on recovery in the ICU following cardiac surgery. Anaesthesia (1996) 0.78

Two cases of trisomy 12p due to rcpt (12;21)(p11;p11) inherited through three generations. Hum Genet (1979) 0.78

Satranidazole: mechanism of action on DNA and structure-activity correlations. J Antimicrob Chemother (1986) 0.77

Intussusception of the ureter by a polypoid transitional cell carcinoma. Br J Urol (1986) 0.77

Cost effectiveness of antituberculosis interventions. Pharmacoeconomics (1995) 0.77

Economic appraisal in health care: 1. A guide to the methodology of economic appraisal. Hosp Health Serv Rev (1981) 0.77

Economic analysis alongside clinical trials: practical considerations. The Economics Workgroup. J Rheumatol (1995) 0.77

Economic appraisal in health care 2. Economic appraisal and health service decision-making. Hosp Health Serv Rev (1982) 0.77

Optometrist screening for diabetic retinopathy: evidence and environment. Ophthalmic Physiol Opt (1996) 0.76

Current status of economic appraisal of health technology in the European Community: report of the network. The EC Network on the Methodology of Economic Appraisal of Health Technology. Soc Sci Med (1994) 0.76

Is evidence based medicine neglected by royal college examinations? A descriptive study of their syllabi. BMJ (2000) 0.75

Prevalence and age of onset of type 1 diabetes in adult Asians. Diabet Med (1990) 0.75

Developing a district diabetes register. BMJ (1992) 0.75

Patients' perception of the anaesthetist and anaesthesia. Anaesthesia (1994) 0.75

Air travel and hypoxaemia in real life. Eur Respir J (2008) 0.75

Aspirin in acute myocardial infarction. Br J Gen Pract (1996) 0.75

Successful use of National Cancer Registry data to monitor the effective use of imatinib for treating chronic myeloid leukaemia. Scott Med J (2008) 0.75

Biotechnology: a special case for health technology assessment? Health Policy (1997) 0.75

[Access to chronic dialysis treatment: deficient and unequal]. Rev Assoc Med Bras (1997) 0.75

Economic evaluations of drug therapy: attitudes of primary care prescribing advisers in Great Britain. Health Policy (1997) 0.75