Published in Nucleic Acids Res on August 26, 1986
Cell type-specificity elements of the immunoglobulin heavy chain gene enhancer. EMBO J (1987) 4.58
Targeting of an inducible toxic phenotype in animal cells. Proc Natl Acad Sci U S A (1988) 1.78
Thymidine kinase obliteration: creation of transgenic mice with controlled immune deficiency. Proc Natl Acad Sci U S A (1989) 1.74
Negative regulation contributes to tissue specificity of the immunoglobulin heavy-chain enhancer. Mol Cell Biol (1987) 1.71
The importance of the 3'-enhancer region in immunoglobulin kappa gene expression. Nucleic Acids Res (1990) 1.56
Functional analysis of defined mutations in the immunoglobulin heavy-chain enhancer in transgenic mice. Nucleic Acids Res (1992) 0.86
Lymphoid-specific transcriptional activation by components of the IgH enhancer: studies on the E2/E3 and octanucleotide elements. Nucleic Acids Res (1990) 0.77
Purification of mouse immunoglobulin heavy-chain messenger RNAs from total myeloma tumor RNA. Eur J Biochem (1980) 26.55
A lymphocyte-specific cellular enhancer is located downstream of the joining region in immunoglobulin heavy chain genes. Cell (1983) 20.32
The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice. Nature (1986) 14.56
Cell-type specificity of immunoglobulin gene expression is regulated by at least three DNA sequence elements. Cell (1985) 8.16
Factors affecting the efficiency of introducing foreign DNA into mice by microinjecting eggs. Proc Natl Acad Sci U S A (1985) 7.32
Comparison of total sequence of a cloned rabbit beta-globin gene and its flanking regions with a homologous mouse sequence. Science (1979) 6.94
The SV40 72 bp repeat preferentially potentiates transcription starting from proximal natural or substitute promoter elements. Cell (1983) 5.67
Differences in human alpha- and beta-globin gene expression in mouse erythroleukemia cells: the role of intragenic sequences. Cell (1984) 5.12
Differential regulation of metallothionein-thymidine kinase fusion genes in transgenic mice and their offspring. Cell (1982) 4.60
Multiple immunoglobulin heavy-chain gene transcripts in Abelson murine leukemia virus-transformed lymphoid cell lines. Mol Cell Biol (1982) 4.26
Introduction of a mu immunoglobulin gene into the mouse germ line: specific expression in lymphoid cells and synthesis of functional antibody. Cell (1984) 3.24
Cell-type specific expression of a transfected immunoglobulin gene. Nature (1983) 2.56
The immunoglobulin heavy-chain B-lymphocyte enhancer efficiently stimulates transcription in non-lymphoid cells. EMBO J (1986) 2.56
An immunoglobulin promoter displays cell-type specificity independently of the enhancer. Nature (1985) 2.39
Short and long range activation by the SV40 enhancer. Nucleic Acids Res (1984) 2.35
Transgenic mice. Cell (1985) 2.30
Promoter elements of genes coding for proteins and modulation of transcription by estrogens and progesterone. Recent Prog Horm Res (1984) 2.04
Expression of a microinjected immunoglobulin gene in the spleen of transgenic mice. Nature (1984) 2.00
Expression of the chicken transferrin gene in transgenic mice. Cell (1983) 1.59
Novel developmental specificity in the nervous system of transgenic animals expressing growth hormone fusion genes. Nature (1985) 1.31
Expression of immunoglobulin and globin genes in B and T lymphocytes and other cells. Biochemistry (1977) 1.14
Promoter sequences of eukaryotic protein-coding genes. Science (1980) 19.96
The SV40 72 base repair repeat has a striking effect on gene expression both in SV40 and other chimeric recombinants. Nucleic Acids Res (1981) 15.12
Specific in vitro transcription of conalbumin gene is drastically decreased by single-point mutation in T-A-T-A box homology sequence. Proc Natl Acad Sci U S A (1980) 10.27
Specific in vitro initiation of transcription on conalbumin and ovalbumin genes and comparison with adenovirus-2 early and late genes. Nature (1980) 10.22
neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas. Proc Natl Acad Sci U S A (2000) 8.34
Ligand-activated site-specific recombination in mice. Proc Natl Acad Sci U S A (1996) 6.48
The SV40 72 bp repeat preferentially potentiates transcription starting from proximal natural or substitute promoter elements. Cell (1983) 5.67
Gastric mucosa abnormalities and tumorigenesis in mice lacking the pS2 trefoil protein. Science (1996) 5.55
Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells. Proc Natl Acad Sci U S A (1997) 5.24
The c-ets proto-oncogenes encode transcription factors that cooperate with c-Fos and c-Jun for transcriptional activation. Nature (1990) 3.74
Function of the retinoic acid receptors (RARs) during development (II). Multiple abnormalities at various stages of organogenesis in RAR double mutants. Development (1994) 3.53
Disruption of the Hox-1.6 homeobox gene results in defects in a region corresponding to its rostral domain of expression. Cell (1991) 3.53
Molecular cloning of extensive sequences of the in vitro synthesized chicken ovalbumin structural gene. Nucleic Acids Res (1977) 3.32
Genetic analysis of RXR alpha developmental function: convergence of RXR and RAR signaling pathways in heart and eye morphogenesis. Cell (1994) 3.16
Mice deficient for delta- and mu-opioid receptors exhibit opposing alterations of emotional responses. Nat Genet (2000) 3.10
Hoxa-13 and Hoxd-13 play a crucial role in the patterning of the limb autopod. Development (1996) 2.96
The ovalbumin gene family: hormonal control of X and Y gene transcription and mRNA accumulation. Cell (1981) 2.91
The bHLH protein NEUROGENIN 2 is a determination factor for epibranchial placode-derived sensory neurons. Neuron (1998) 2.87
Function of retinoic acid receptor gamma in the mouse. Cell (1993) 2.83
Distinct functions of the two isoforms of dopamine D2 receptors. Nature (2000) 2.83
High postnatal lethality and testis degeneration in retinoic acid receptor alpha mutant mice. Proc Natl Acad Sci U S A (1993) 2.78
Spermiogenesis deficiency and germ-cell apoptosis in CREM-mutant mice. Nature (1996) 2.74
The collagenase gene promoter contains a TPA and oncogene-responsive unit encompassing the PEA3 and AP-1 binding sites. EMBO J (1990) 2.73
Organization of coding and intervening sequences in the chicken ovalbumin split gene. Cell (1978) 2.61
The immunoglobulin heavy-chain B-lymphocyte enhancer efficiently stimulates transcription in non-lymphoid cells. EMBO J (1986) 2.56
Transcription from the SV40 early-early and late-early overlapping promoters in the absence of DNA replication. EMBO J (1983) 2.55
Impairing follicle-stimulating hormone (FSH) signaling in vivo: targeted disruption of the FSH receptor leads to aberrant gametogenesis and hormonal imbalance. Proc Natl Acad Sci U S A (1998) 2.50
A Harvey-ras responsive transcription element is also responsive to a tumour-promoter and to serum. Nature (1988) 2.48
Stimulation of in vitro transcription from heterologous promoters by the simian virus 40 enhancer. Proc Natl Acad Sci U S A (1984) 2.44
The ovalbumin gene region: common features in the organisation of three genes expressed in chicken oviduct under hormonal control. Nature (1979) 2.35
Short and long range activation by the SV40 enhancer. Nucleic Acids Res (1984) 2.35
Defective platelet aggregation and increased resistance to thrombosis in purinergic P2Y(1) receptor-null mice. J Clin Invest (1999) 2.34
Enhanced aggressive behavior in mice lacking 5-HT1B receptor. Science (1994) 2.32
A T to A base substitution and small deletions in the conalbumin TATA box drastically decrease specific in vitro transcription. Nucleic Acids Res (1981) 2.31
The c-Ets oncoprotein activates the stromelysin promoter through the same elements as several non-nuclear oncoproteins. EMBO J (1991) 2.30
The c-Ha-ras oncogene and a tumor promoter activate the polyoma virus enhancer. Cell (1987) 2.24
Ha-ras oncogene expression directed by a milk protein gene promoter: tissue specificity, hormonal regulation, and tumor induction in transgenic mice. Proc Natl Acad Sci U S A (1987) 2.23
Transforming but not immortalizing oncogenes activate the transcription factor PEA1. EMBO J (1988) 2.14
Net, a new ets transcription factor that is activated by Ras. Genes Dev (1994) 2.12
Disruption of the Hoxd-13 gene induces localized heterochrony leading to mice with neotenic limbs. Cell (1993) 2.09
Compartmentalization of MHC class II gene expression in transgenic mice. Cell (1988) 2.08
Electron microscopy and restriction enzyme mapping reveal additional intervening sequences in the chicken ovalbumin split gene. Cell (1978) 2.08
Pax-5 (BSAP) recruits Ets proto-oncogene family proteins to form functional ternary complexes on a B-cell-specific promoter. Genes Dev (1996) 1.98
PEA3 is a nuclear target for transcription activation by non-nuclear oncogenes. EMBO J (1989) 1.97
A novel modulator domain of Ets transcription factors. Genes Dev (1992) 1.97
In vivo evidence that the stromelysin-3 metalloproteinase contributes in a paracrine manner to epithelial cell malignancy. J Cell Biol (1998) 1.95
Transformation suppressor activity of a Jun transcription factor lacking its activation domain. Nature (1991) 1.92
The influence of human immunodeficiency virus coinfection on chronic hepatitis C in injection drug users: a long-term retrospective cohort study. Hepatology (2001) 1.87
Net, a negative Ras-switchable TCF, contains a second inhibition domain, the CID, that mediates repression through interactions with CtBP and de-acetylation. EMBO J (1999) 1.76
Homeotic transformation of the occipital bones of the skull by ectopic expression of a homeobox gene. Nature (1992) 1.74
Developmental analysis of the retinoic acid-inducible RAR-beta 2 promoter in transgenic animals. Development (1991) 1.74
Negative regulation contributes to tissue specificity of the immunoglobulin heavy-chain enhancer. Mol Cell Biol (1987) 1.71
Correcting an immune-response deficiency by creating E alpha gene transgenic mice. Nature (1985) 1.67
Negative and positive factors determine the activity of the polyoma virus enhancer alpha domain in undifferentiated and differentiated cell types. Proc Natl Acad Sci U S A (1988) 1.66
Expression of raf oncogenes activates the PEA1 transcription factor motif. Mol Cell Biol (1989) 1.66
Inactivation of the Friedreich ataxia mouse gene leads to early embryonic lethality without iron accumulation. Hum Mol Genet (2000) 1.66
Prediction of future metastasis and molecular characterization of head and neck squamous-cell carcinoma based on transcriptome and genome analysis by microarrays. Oncogene (2008) 1.63
The M-twist gene of Mus is expressed in subsets of mesodermal cells and is closely related to the Xenopus X-twi and the Drosophila twist genes. Dev Biol (1991) 1.60
Nuclear targets for transcription regulation by oncogenes. Trends Genet (1991) 1.60
The contribution of the acidic domain of MDM2 to p53 and MDM2 stability. Oncogene (2001) 1.57
Head and neck squamous cell carcinoma transcriptome analysis by comprehensive validated differential display. Oncogene (2006) 1.56
CREB activation induced by mitochondrial dysfunction is a new signaling pathway that impairs cell proliferation. EMBO J (2002) 1.55
The breast cancer-associated stromelysin-3 gene is expressed during mouse mammary gland apoptosis. J Cell Biol (1992) 1.55
Termination of the ovalbumin gene transcription. EMBO J (1984) 1.53
Point mutation in the TATA box curtails expression of sea urchin H2A histone gene in vivo. Nature (1981) 1.51
Allele-specific amplification for preimplantation genetic diagnosis (PGD) of spinal muscular atrophy. Prenat Diagn (2001) 1.50
Tumour prevention and rejection with recombinant vaccinia. Nature (1987) 1.47
Effect of histone acetylation on structure and in vitro transcription of chromatin. Nucleic Acids Res (1978) 1.43
B-cell control region at the 5' end of a major histocompatibility complex class II gene: sequences and factors. Mol Cell Biol (1988) 1.41
Conserved mechanisms of Ras regulation of evolutionary related transcription factors, Ets1 and Pointed P2. Oncogene (1997) 1.41
Targeted c-myc gene expression in mammary glands of transgenic mice induces mammary tumours with constitutive milk protein gene transcription. EMBO J (1988) 1.41
Preferential in vitro assembly of nucleosome cores on some AT-rich regions of SV40 DNA. Nucleic Acids Res (1979) 1.41
Nucleotide sequence at the 5' extremity of tobacco-mosaic-virus RNA. 2. The coding region (nucleotides 69-236). Eur J Biochem (1978) 1.40
The immunoglobulin heavy chain enhancer is stimulated by the adenovirus type 2 E1A products in mouse fibroblasts. Proc Natl Acad Sci U S A (1986) 1.39
ANO1 amplification and expression in HNSCC with a high propensity for future distant metastasis and its functions in HNSCC cell lines. Br J Cancer (2010) 1.38
Ha-ras and c-myc oncogene expression interferes with morphological and functional differentiation of mammary epithelial cells in single and double transgenic mice. Genes Dev (1988) 1.35
Functional interactions between p53 and the TFIIH complex are affected by tumour-associated mutations. EMBO J (1996) 1.34
The chicken conalbumin gene: studies of the organization of cloned DNAs. Nucleic Acids Res (1979) 1.31
Reactive oxygen species, lipid peroxidation and enzymatic defence systems in human spermatozoa. J Reprod Fertil (1995) 1.30
Ligand-dependent interaction of the glucocorticoid receptor with p53 enhances their degradation by Hdm2. Genes Dev (2001) 1.30
Characterization of the human CD4 gene promoter: transcription from the CD4 gene core promoter is tissue-specific and is activated by Ets proteins. Proc Natl Acad Sci U S A (1993) 1.29
Transgenic mice with I-A on islet cells are normoglycemic but immunologically intolerant. Science (1989) 1.28
Mutational analysis of the contribution of sequence motifs within the IgH enhancer to tissue specific transcriptional activation. Nucleic Acids Res (1988) 1.26
Do morphological anomalies reflect chromosomal aneuploidies?: case report. Hum Reprod (2000) 1.25
Two independent activation domains in c-Ets-1 and c-Ets-2 located in non-conserved sequences of the ets gene family. Oncogene (1992) 1.25