Published in Mol Pharmacol on April 01, 1987
Adenylyl cyclase inhibition and altered G protein subunit expression and ADP-ribosylation patterns in tissues and cells from Gi2 alpha-/-mice. Proc Natl Acad Sci U S A (1996) 1.14
Natural polyamines stimulate G-proteins. Biochem J (1992) 1.10
Coupling of the alpha 2-adrenergic receptor to the inhibitory G-protein Gi and adenylate cyclase in HT29 cells. Biochem J (1993) 1.01
Characterization and distribution of alpha 2-adrenergic receptors in the human intestinal mucosa. J Clin Invest (1993) 1.00
Close association of the alpha subunits of Gq and G11 G proteins with actin filaments in WRK1 cells: relation to G protein-mediated phospholipase C activation. Proc Natl Acad Sci U S A (1995) 0.94
The adipocyte Go alpha-immunoreactive polypeptide is different from the alpha subunit of the brain Go protein. Biochem J (1989) 0.91
Concurrent up-regulation of guanine-nucleotide-binding proteins Gi1 alpha, Gi2 alpha and Gi3 alpha in adipocytes of hypothyroid rats. Biochem J (1990) 0.89
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Molecular cloning of the receptor for human antidiuretic hormone. Nature (1992) 2.44
G protein activation: a receptor-independent mode of action for cationic amphiphilic neuropeptides and venom peptides. Trends Pharmacol Sci (1990) 2.32
The gastrointestinal prokinetic benzamide derivatives are agonists at the non-classical 5-HT receptor (5-HT4) positively coupled to adenylate cyclase in neurons. Naunyn Schmiedebergs Arch Pharmacol (1989) 2.31
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Glutamate stimulates inositol phosphate formation in striatal neurones. Nature (1985) 2.02
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Functional coupling between ryanodine receptors and L-type calcium channels in neurons. Nature (1996) 1.81
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Participation of the molecular chaperone DnaK in intracellular growth of Brucella suis within U937-derived phagocytes. Mol Microbiol (1996) 1.74
Multiple neurological abnormalities in mice deficient in the G protein Go. Proc Natl Acad Sci U S A (1998) 1.70
Localization and mechanisms of action of cannabinoid receptors at the glutamatergic synapses of the mouse nucleus accumbens. J Neurosci (2001) 1.69
An alpha 40 subunit of a GTP-binding protein immunologically related to Go mediates a dopamine-induced decrease of Ca2+ current in snail neurons. Neuron (1988) 1.68
Regulation of apoptosis and cell cycle arrest by Zac1, a novel zinc finger protein expressed in the pituitary gland and the brain. EMBO J (1997) 1.60
Pituitary adenylate cyclase-activating polypeptide (PACAP-38) protects cerebellar granule neurons from apoptosis by activating the mitogen-activated protein kinase (MAP kinase) pathway. J Neurosci (1997) 1.58
NMDA receptors activate the arachidonic acid cascade system in striatal neurons. Nature (1988) 1.55
Multiple topogenic sequences in bovine opsin. Proc Natl Acad Sci U S A (1987) 1.54
Pharmacological and functional characteristics of metabotropic excitatory amino acid receptors. Trends Pharmacol Sci (1990) 1.53
Species- and age-dependent changes in the relative amounts of cardiac myosin isoenzymes in mammals. Dev Biol (1981) 1.53
Specific binding of (3H) lysine-vasopressin to pig kidney plasma membranes. Relationship of receptor occupancy to adenylate cyclase activation. J Biol Chem (1973) 1.52
The cytotoxin YopT of Yersinia enterocolitica induces modification and cellular redistribution of the small GTP-binding protein RhoA. J Biol Chem (1999) 1.52
Expression and bactericidal activity of nitric oxide synthase in Brucella suis-infected murine macrophages. Infect Immun (1998) 1.48
Evidence for a direct negative coupling between dopamine-D2 receptors and PLC by heterotrimeric Gi1/2 proteins in rat anterior pituitary cell membranes. Endocrinology (2002) 1.48
Complex interactions between mGluRs, intracellular Ca2+ stores and ion channels in neurons. Trends Neurosci (2000) 1.45
Dendritic and axonal targeting of type 5 metabotropic glutamate receptor is regulated by homer1 proteins and neuronal excitation. J Neurosci (2000) 1.43
A 5-HT receptor in the central nervous system, positively coupled with adenylate cyclase, is antagonized by ICS 205 930. Eur J Pharmacol (1988) 1.43
Cytokine signals propagate through the brain. Mol Psychiatry (2000) 1.42
BAY36-7620: a potent non-competitive mGlu1 receptor antagonist with inverse agonist activity. Mol Pharmacol (2001) 1.41
Yersinia outer protein P of Yersinia enterocolitica simultaneously blocks the nuclear factor-kappa B pathway and exploits lipopolysaccharide signaling to trigger apoptosis in macrophages. J Immunol (2001) 1.41
An electrophoretic study of native myosin isozymes and of their subunit content. Eur J Biochem (1979) 1.39
hZAC encodes a zinc finger protein with antiproliferative properties and maps to a chromosomal region frequently lost in cancer. Proc Natl Acad Sci U S A (1998) 1.38
Physical interaction between the serotonin transporter and neuronal nitric oxide synthase underlies reciprocal modulation of their activity. Proc Natl Acad Sci U S A (2007) 1.38
Direct activation of GTP-binding regulatory proteins (G-proteins) by substance P and compound 48/80. FEBS Lett (1990) 1.37
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Nitric oxide-induced blockade of NMDA receptors. Neuron (1992) 1.35
Hormone-stimulated desensitization of hormone-dependent adenylyl cyclase. Dual action of luteninizing hormone on pig graafian follicle membranes. J Biol Chem (1976) 1.33
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Molecular, functional, and pharmacological characterization of the metabotropic glutamate receptor type 5 splice variants: comparison with mGluR1. J Neurosci (1995) 1.29
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The vasopressin-sensitive adenylate cyclase of the rat kidney. Effect of adrenalectomy and corticosteroids on hormonal receptor-enzyme coupling. J Biol Chem (1974) 1.25
A new mechanism for glutamate receptor action: phosphoinositide hydrolysis. Trends Neurosci (1988) 1.24
Presence of three pertussis toxin substrates and Go alpha immunoreactivity in both plasma and granule membranes of chromaffin cells. FEBS Lett (1987) 1.24
Domains involved in the specificity of G protein activation in phospholipase C-coupled metabotropic glutamate receptors. EMBO J (1994) 1.24
Novel brain-specific 5-HT4 receptor splice variants show marked constitutive activity: role of the C-terminal intracellular domain. Mol Pharmacol (1999) 1.24
Oxytocin-sensitive adenylate cyclase in frog bladder epithelial cells. Role of calcium, nucleotides, and other factors in hormonal stimulation. J Biol Chem (1972) 1.23
Pharmacological characterization of the D2 dopamine receptor negatively coupled with adenylate cyclase in rat anterior pituitary. Mol Pharmacol (1983) 1.22
Changes in the carboxyl-terminal domain of metabotropic glutamate receptor 1 by alternative splicing generate receptors with differing agonist-independent activity. Mol Pharmacol (1996) 1.21
Major outer membrane protein Omp25 of Brucella suis is involved in inhibition of tumor necrosis factor alpha production during infection of human macrophages. Infect Immun (2001) 1.21
PAC1 receptor-deficient mice display impaired insulinotropic response to glucose and reduced glucose tolerance. J Clin Invest (2000) 1.19
Loss of expression of the candidate tumor suppressor gene ZAC in breast cancer cell lines and primary tumors. Oncogene (1999) 1.19
Arachidonic acid released from striatal neurons by joint stimulation of ionotropic and metabotropic quisqualate receptors. Nature (1990) 1.18
5-HT1B receptors are negatively coupled with adenylate cyclase in rat substantia nigra. Eur J Pharmacol (1988) 1.17
A simple method to transfer plasmid DNA into neuronal primary cultures: functional expression of the mGlu5 receptor in cerebellar granule cells. Neuropharmacology (1999) 1.16
Differential G protein-mediated coupling of D2 dopamine receptors to K+ and Ca2+ currents in rat anterior pituitary cells. Neuron (1992) 1.15
Central 5-HT4 receptors. Trends Pharmacol Sci (1995) 1.15
Intracellular survival of Brucella spp. in human monocytes involves conventional uptake but special phagosomes. Infect Immun (2001) 1.15
Dissociation between light-induced phase shift of the circadian rhythm and clock gene expression in mice lacking the pituitary adenylate cyclase activating polypeptide type 1 receptor. J Neurosci (2001) 1.14
Effects of N-aralkyl substitution of beta-agonists on alpha- and beta-adrenoceptor subtypes: pharmacological studies and binding assays. J Pharm Pharmacol (1982) 1.14
The second intracellular loop of metabotropic glutamate receptor 1 cooperates with the other intracellular domains to control coupling to G-proteins. J Biol Chem (1996) 1.12
Expression of a new G protein-coupled receptor X-msr is associated with an endothelial lineage in Xenopus laevis. Mech Dev (1996) 1.12
Cloning and functional expression of a Drosophila metabotropic glutamate receptor expressed in the embryonic CNS. J Neurosci (1996) 1.11
Alternative splicing generates metabotropic glutamate receptors inducing different patterns of calcium release in Xenopus oocytes. Proc Natl Acad Sci U S A (1992) 1.11
Glutamate stimulates glucagon secretion via an excitatory amino acid receptor of the AMPA subtype in rat pancreas. Eur J Pharmacol (1993) 1.11
D2-dopamine receptor-mediated inhibition of cyclic AMP formation in striatal neurons in primary culture. Mol Pharmacol (1985) 1.11
The heterotrimeric protein Go is required for the formation of heart epithelium in Drosophila. J Cell Biol (1999) 1.10
Visualization of cyclic AMP-regulated presynaptic activity at cerebellar granule cells. Neuron (1998) 1.10
Gi2 alpha protein deficiency: a model of inflammatory bowel disease. J Clin Immunol (1995) 1.10
Pharmacology of 5-hydroxytryptamine-1A receptors which inhibit cAMP production in hippocampal and cortical neurons in primary culture. Mol Pharmacol (1988) 1.10
Structure and chromosomal localization of the human antidiuretic hormone receptor gene. Am J Hum Genet (1992) 1.10
Metabotropic glutamate receptors in the rat nucleus accumbens. Eur J Neurosci (1997) 1.09
Studies on some para-substituted clonidine derivatives that exhibit an alpha-adrenoceptor stimulant activity. Br J Pharmacol (1980) 1.08
The Ca2+/C1- dependent L-[3H]glutamate binding: a new receptor or a particular transport process? FEBS Lett (1984) 1.08
Adenylyl cyclase activities in ovarian tissues. I. Homogenization and conditions of assay in graafian follicles and corpora lutea of rabbits, rats, and pigs: regulation by ATP, and some comparative properties. Endocrinology (1976) 1.08
Amino acid sequence and embryonic expression of msr/apj, the mouse homolog of Xenopus X-msr and human APJ. Mech Dev (1999) 1.07
Comparative effect of L-CCG-I, DCG-IV and gamma-carboxy-L-glutamate on all cloned metabotropic glutamate receptor subtypes. Neuropharmacology (1998) 1.07
Selective blockade of P/Q-type calcium channels by the metabotropic glutamate receptor type 7 involves a phospholipase C pathway in neurons. J Neurosci (2000) 1.07
Synaptogenesis of cultured striatal neurons in serum-free medium: a morphological and biochemical study. Proc Natl Acad Sci U S A (1986) 1.07
Use of (-)-[3H]dihydroalprenolol to study beta adrenergic receptor-adenylate cyclase coupling in C6 glioma cells: role of 5'-guanylylimidodiphosphate. Mol Pharmacol (1977) 1.07
Apelin is a potent activator of tumour neoangiogenesis. Oncogene (2007) 1.06