Published in Environ Health Perspect on October 01, 1978
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Anesthesia and the responsiveness of individual neurons of the caudate nucleus of the cat to acetylcholine, norepinephrine and dopamine administered by microelectrophoresis. J Pharmacol Exp Ther (1965) 2.31
Effects of some antidepressant drugs on the depletion of intraneuronal brain catecholamine stores caused by 4,alpha-dimethyl-meta-tyramine. Eur J Pharmacol (1969) 2.26
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Molecular geometry of inhibitors of the uptake of catecholamines and serotonin in synaptosomal preparations of rat brain. J Pharmacol Exp Ther (1976) 1.80
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Biogenic amines and depression. Biochemical and pharmacological separation of two types of depression. Arch Gen Psychiatry (1975) 1.17
Caudate nucleus neurones: correlation of the effects of substantia nigra stimulaton with iontophoretic dopamine. J Physiol (1970) 1.12
Accumulation of tritiated 5-hydroxytryptamine in brain slices. Life Sci (1967) 1.06
Gas chromatographic evaluation of the influence of oxotremorine upon the regional distribution of acetylcholine in rat brain. J Neurochem (1970) 0.96
Selective depletion of caudate nucleus dopamine and serotonin during chronic manganese dioxide administration to squirrel monkeys. Experientia (1969) 0.96
Neurotoxic effects of mercury--a review. Environ Res (1977) 0.89
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Cholinergic imbalance hypotheses of psychoses and movement disorders: strategies for evaluation. Psychopharmacol Commun (1975) 0.78
3-Methoxy-4-hydroxyphenethylene glycol in plasma. Clin Chim Acta (1974) 0.78
The behavioral toxicology of metals. Fed Proc (1978) 0.78
Brain concentrations and synthesis rates of biogenic amines during chronic cobalt experimental epilepsy in the rat. Neuropharmacology (1973) 0.77
The pharmacological treatment of delusional depression. Am J Psychiatry (1985) 1.33
The Gulf War, stress and a leaky blood-brain barrier. Nat Med (1996) 1.09
Choline and lecithin in the treatment of neurologic disorders. N Engl J Med (1979) 0.97
Amitriptyline plasma levels and clinical response in primary depression. Clin Pharmacol Ther (1977) 0.95
Thalamic and subcortical gliosis with dementia. Arch Neurol (1987) 0.92
The influence of pH on the muscarinic action of oxotremorine, arecoline, pilocarpine, and their quaternary ammonium analogs. Mol Pharmacol (1966) 0.91
Adjustment of lithium dose during lithium-chlorothiazide therapy. Clin Pharmacol Ther (1977) 0.91
Vinblastine and vincristine: a study of their action on tissue concentrations of epinephrine, norephinephrine and acetylcholine. Neuropharmacology (1973) 0.91
Choline analogs as potential tools in developing selective animal models of central cholinergic hypofunction. Life Sci (1980) 0.90
A brain regional analysis of morphologic and cholinergic abnormalities in Alzheimer's disease. Arch Neurol (1989) 0.88
Caffeinism complicating hypersomnic depressive episodes. Compr Psychiatry (1978) 0.87
Estimation of choline esters in brain by a new gas chromatographic procedure. Biochem Pharmacol (1969) 0.87
Identification of acetylcholine in fresh rat brain by combined gas chromatography-mass spectrometry. Nature (1968) 0.87
Sex differences and estrous cycle-variations in the AF64A-induced cholinergic deficit in the rat hippocampus. Brain Res Bull (1993) 0.87
An approach to the in vivo study of acetylcholine turnover in rat salivary glands by radio gas chromatography. J Pharmacol Exp Ther (1972) 0.86
Mechanism of lithium-induced elevation in red blood cell choline content: an in vitro analysis. Commun Psychopharmacol (1980) 0.86
CSF and urinary biogenic amines and metabolites in depression and mania. A controlled, univariate analysis. Arch Gen Psychiatry (1983) 0.86
Lateralization of brain morphologic and cholinergic abnormalities in Alzheimer's disease. Arch Neurol (1989) 0.84
Red-cell/plasma choline ratio in dementia. N Engl J Med (1982) 0.84
Acute and chronic studies with the anticholinesterase Huperzine A: effect on central nervous system cholinergic parameters. Neuropharmacology (1991) 0.84
Long-term central cholinergic hypofunction induced in mice by ethylcholine aziridinium ion (AF64A) in vivo. J Pharmacol Exp Ther (1982) 0.84
Comparison of the effects of natural and synthetic huperzine-A on rat brain cholinergic function in vitro and in vivo. J Ethnopharmacol (1994) 0.83
Red-cell choline and Gilles de la Tourette syndrome. N Engl J Med (1979) 0.83
Choline deficiency associated with total parenteral nutrition. Lancet (1980) 0.82
The pattern of physical symptom changes in major depressive disorder following treatment with amitriptyline or imipramine. J Affect Disord (1994) 0.82
Chronic lead exposure in immature animals: neurochemical correlates. Life Sci (1978) 0.82
Erythrocyte choline concentrations in psychiatric disorders. Biol Psychiatry (1991) 0.82
Effects of chronic lead exposure on levels of acetylcholine and choline and on acetylcholine turnover rate in rat brain areas in vivo. Psychopharmacology (Berl) (1978) 0.82
Acetylcholine concentrations in rat brain: diurnal oscillation. Science (1970) 0.82
RBC and plasma choline levels in control and depressed individuals: a critical evaluation. Psychiatry Res (1980) 0.81
Effects of amitriptyline and imipramine on brain amine neurotransmitter metabolites in cerebrospinal fluid. Clin Pharmacol Ther (1985) 0.81
Stimulation of cell membrane sodium transport activity by lithium: possible relationship to therapeutic action. Psychiatry Res (1987) 0.81
The AF64a-treated mouse: possible model for central cholinergic hypofunction. Science (1981) 0.81
Glycosaminoglycan C3 protects against AF64A-induced cholinotoxicity in a dose-dependent and time-dependent manner. Brain Res (2004) 0.81
Protective effect of the heparin-derived oligosaccharide C3, on AF64A-induced cholinergic lesion in rats. Neurobiol Aging (2003) 0.81
The cholinergic-adrenergic hypothesis of depression reexamined using clonidine, metoprolol, and physostigmine in an animal model. Biol Psychiatry (1991) 0.80
Oral and subcutaneous administration of the glycosaminoglycan C3 attenuates Abeta(25-35)-induced abnormal tau protein immunoreactivity in rat brain. Neurobiol Aging (2001) 0.80
Gas chromatographic evaluation of the effects of some muscarinic and antimuscarinic drugs on acetylcholine levels in rat brain. Biochem Pharmacol (1970) 0.80
Lipid composition of different areas of murine brain: effects of lipid extraction procedures. Lipids (1985) 0.80
Neuroprotective properties of glycosaminoglycans: potential treatment for neurodegenerative disorders. Neurodegener Dis (2008) 0.80
CSF monoamine metabolites in mania. Am J Psychiatry (1983) 0.80
High affinity choline uptake in striatum and hippocampus: differential effects of treatments which release acetylcholine. Life Sci (1978) 0.80
Lithium treatment during pregnancy: a case study of erythrocyte choline content and lithium transport. J Clin Psychiatry (1983) 0.79
AF64A, a cholinergic neurotoxin, selectively depletes acetylcholine in hippocampus and cortex, and produces long-term passive avoidance and radial-arm maze deficits in the rat. Brain Res (1984) 0.79
Cholinergic lesion of the striatum impairs acquisition and retention of a passive avoidance response. Behav Neurosci (1984) 0.79
Regional differences in ethylcholine mustard aziridinium ion (AF64A)-induced deficits in presynaptic cholinergic markers for the rat central nervous system. J Pharmacol Exp Ther (1985) 0.79
Biological component of the NIMH clinical research branch collaborative program on the psychobiology of depression: II. Methodology and data analysis. Psychol Med (1980) 0.79
Cholinomimetic effects of aqueous extracts from Carum copticum seeds. Br J Pharmacol (1974) 0.79
Erythrocyte and plasma choline in bipolar psychiatric patients: a followup study. Psychopharmacol Bull (1982) 0.79
Behavioural and histological effects of low concentrations of intraventricular AF64A. Eur J Pharmacol (1989) 0.78
Blood choline and response to clonazepam and haloperidol in Tourette's syndrome. Acta Psychiatr Scand (1985) 0.78
AF64A: an active site directed irreversible inhibitor of choline acetyltransferase. J Neurochem (1985) 0.78
Red blood cell abnormalities in Alzheimer disease. J Am Geriatr Soc (1985) 0.78
Selective cholinergic neurotoxin: AF64A's effects in rat striatum. Brain Res (1984) 0.78
Bilateral symmetry of cholinergic deficits in Alzheimer's disease. Arch Neurol (1988) 0.78
A pharmacokinetic approach to the study of cell membrane lithium transport in vivo. J Clin Psychopharmacol (1985) 0.78
Time course of ethylcholine aziridinium ion (AF64A)-induced cholinotoxicity in vivo. Neuropharmacology (1987) 0.78
Lumbar cerebrospinal fluid choline in healthy aging and in Down's syndrome. Arch Neurol (1990) 0.78
Potential animal models for senile dementia of Alzheimer's type, with emphasis on AF64A-induced cholinotoxicity. Annu Rev Pharmacol Toxicol (1986) 0.77
AF64A-induced changes in N-myc expression in the LA-N-2 human neuroblastoma cell line are modulated by choline and hemicholinium-3. Neurochem Res (1998) 0.77
Development of a sensitive and inexpensive micropush-pull technique for the continuous analysis of brain neurotransmitters and metabolites in vivo. J Neurosci Methods (1992) 0.77
Cholinergic and noradrenergic toxicity of intraventricular aluminum chloride in the rat hippocampus. Brain Res (1989) 0.77
Selective inhibition of peripheral cholinergic transmission in the cat produced by AF64A. J Pharmacol Exp Ther (1983) 0.77
Behavioural, biochemical and histological effects of AF64A following injection into the third ventricle of the mouse. Behav Brain Res (1992) 0.77
Electroencephalographic sleep, aging, and psychopathology: new data and state of the art. Biol Psychiatry (1983) 0.77
Effect of cholinergic deficit induced by ethylcholine aziridinium (AF64A) on noradrenergic and dopaminergic parameters in rat brain. Brain Res (1987) 0.77
Cerebrospinal fluid free choline in movement disorders of paediatric onset. Eur J Paediatr Neurol (1998) 0.77
Selective presynaptic cholinergic neurotoxicity following intrahippocampal AF64A injection in rats. J Neurochem (1983) 0.77
Application of principles of steady-state kinetics to the estimation of brain acetylcholine turnover rate: effects of oxotremorine and physostigmine. J Pharmacol Exp Ther (1975) 0.77
Effects of postnatal trimethyltin or triethyltin treatment on CNS catecholamine, GABA, and acetylcholine systems in the rat. J Neurochem (1983) 0.77
Absolute availability of lithium. J Pharm Sci (1977) 0.77
Pre-treatment neurotransmitter metabolites and response to imipramine or amitriptyline treatment. Psychol Med (1982) 0.76
AF64A affects septal choline acetyltransferase but not parvalbumin immunoreactive cells. Brain Res Bull (1994) 0.76
Within-subject decline in delayed-non-match-to-sample radial arm maze performance in aging Sprague-Dawley rats. Behav Neurosci (1995) 0.76
Imipramine and amitriptyline plasma concentrations and clinical response in major depression. Br J Psychiatry (1986) 0.76
Long-term exposure to high levels of corticosterone aggravates AF64A-induced cholinergic hypofunction in rat hippocampus in vivo. Brain Res (1994) 0.76
Acute in vivo exposure to ethylcholine aziridinium (AF64A) depresses the secretion of quanta from motor nerve terminals. Eur J Pharmacol (1986) 0.76
Treating delusional depressives with amitriptyline. J Clin Psychiatry (1986) 0.76
Intracerebroventricular administration of ethylcholine mustard aziridinium ion (AF64A) reduces release of acetylcholine from rat hippocampal slices. Neuropharmacology (1985) 0.76
Inhibition of high affinity choline transport attenuates both cholinergic and non-cholinergic effects of ethylcholine aziridinium (AF64A). Brain Res (1989) 0.76
AF64A (ethylcholine aziridinium ion), a cholinergic neurotoxin, selectively impairs working memory in a multiple component T-maze task. Brain Res (1987) 0.76
Morphine dependence and in vivo turnover of acetylcholine in whole mouse brain. J Pharmacol Exp Ther (1975) 0.76
Labelling of acetylcholine in the brain of mice fed on a diet containing deuterium labelled choline: studies utilizing gas chromatography--mass spectrometry. J Neurochem (1974) 0.76
AF64A-induced working memory impairment: behavioral, neurochemical and histological correlates. Brain Res (1988) 0.75
Letter: Side effects of lithium carbonate. Br Med J (1974) 0.75
Effect of tetrahydrocannabinols on 3H-acetylcholine biosynthesis in various rat brain slices. J Pharmacol Exp Ther (1976) 0.75
The pharmacology of basal forebrain involvement in cognition. Adv Exp Med Biol (1991) 0.75
Age-dependent effect of AF64A on cholinergic activity in the septo-hippocampal pathway of the rat brain: decreased responsiveness in aged rats. Neurosci Lett (1996) 0.75
Analysis of microquantities of choline and its esters utilizing gas chromatography-chemical ionization mass spectrometry. Anal Biochem (1975) 0.75
The use of the rat iris as a model system to evaluate the effect of the cholinotoxin, AF64A, in vivo. J Neurosci Methods (1995) 0.75
Application of principles of steady-state kinetics to the in vivo estimation of acetylcholine turnover rate in mouse brain. J Pharmacol Exp Ther (1975) 0.75
Choline esters in brain--estimation by a new gas chromatographic procedure. Proc West Pharmacol Soc (1968) 0.75
On the uses of research consultation. Psychiatr Commun (1975) 0.75
The effect of perchlorate ion and some pharmacological agents on the sensitivity of the frog (Rana pipiens) rectus abdominis to acetylcholine. Experientia (1966) 0.75
An approach to the study of the biochemical pharmacology of cholinergic function. Adv Biochem Psychopharmacol (1972) 0.75
In vitro and in vivo transport of lithium by human erythrocytes. Clin Pharmacol Ther (1975) 0.75
A specific gas chromatographic method for assaying tissue acetylcholine: present status. Adv Biochem Psychopharmacol (1969) 0.75
Application of principles of steady-state kinetics to measure acetylcholine turnover rate in rat salivary glands: effect of deafferentation and duct ligation. J Pharmacol Exp Ther (1973) 0.75
A gas chromatographic study of brain acetylcholine: influence of muscarinic and antimuscarinic agents. Proc West Pharmacol Soc (1969) 0.75
Gas chromatographic microestimation of acetylcholine and related compounds. Anal Chem (1968) 0.75