Compassionate Use of Remdesivir for Patients with Severe Covid-19.

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🔗 View Article (PMID 32275812)

Published in N Engl J Med on April 10, 2020

Authors

Jonathan Grein1, Norio Ohmagari1, Daniel Shin1, George Diaz1, Erika Asperges1, Antonella Castagna1, Torsten Feldt1, Gary Green1, Margaret L Green1, François-Xavier Lescure1, Emanuele Nicastri1, Rentaro Oda1, Kikuo Yo1, Eugenia Quiros-Roldan1, Alex Studemeister1, John Redinski1, Seema Ahmed1, Jorge Bernett1, Daniel Chelliah1, Danny Chen1, Shingo Chihara1, Stuart H Cohen1, Jennifer Cunningham1, Antonella D'Arminio Monforte1, Saad Ismail1, Hideaki Kato1, Giuseppe Lapadula1, Erwan L'Her1, Toshitaka Maeno1, Sumit Majumder1, Marco Massari1, Marta Mora-Rillo1, Yoshikazu Mutoh1, Duc Nguyen1, Ewa Verweij1, Alexander Zoufaly1, Anu O Osinusi1, Adam DeZure1, Yang Zhao1, Lijie Zhong1, Anand Chokkalingam1, Emon Elboudwarej1, Laura Telep1, Leighann Timbs1, Ilana Henne1, Scott Sellers1, Huyen Cao1, Susanna K Tan1, Lucinda Winterbourne1, Polly Desai1, Robertino Mera1, Anuj Gaggar1, Robert P Myers1, Diana M Brainard1, Richard Childs1, Timothy Flanigan1

Author Affiliations

1: From Cedars-Sinai Medical Center, Los Angeles (J.G.), El Camino Hospital, Mountain View (D.S., D. Chelliah), Sutter Santa Rosa Regional Hospital, Santa Rosa (G.G.), Regional Medical Center (A.S., J.R.) and Good Samaritan Hospital (S.M.), San Jose, John Muir Health, Walnut Creek (J.B.), UC Davis Health, Sacramento (S.H.C.), NorthBay Medical Center, Fairfield (S.I.), and Gilead Sciences, Foster City (A.O.O., A.D., Y.Z., L.Z., A. Chokkalingam, E.E., L. Telep, L. Timbs, I.H., S.S., H.C., S.K.T., L.W., P.D., R.M., A.G., R.P.M., D.M.B.) - all in California; the National Center for Global Health and Medicine, Tokyo (N.O.), Tokyo Bay Urayasu Ichikawa Medical Center, Urayasu City (R.O.), Hiratsuka City Hospital, Hiratsuka (K.Y.), Yokohama City University Hospital, Yokohama (H.K.), Gunma University Hospital, Gunma (T.M.), and Tosei General Hospital, Seto (Y.M.) - all in Japan; Providence Regional Medical Center Everett, Everett (G.D.), and University of Washington Medical Center-Northwest (M.L.G.) and Virginia Mason Medical Center (S. Chihara), Seattle - all in Washington; Fondazione IRCCS Policlinico San Matteo, Pavia (E.A.), IRCCS, San Raffaele Scientific Institute (A. Castagna) and Azienda Socio Sanitaria Territoriale Spedali (ASST) Santi Paolo e Carlo, Department of Health Services, University of Milan (A.D.M.), Milan, National Institute for Infectious Diseases, IRCCS, L. Spallanzani, Rome (E.N.), Università degli Study of Brescia, ASST Civili di Brescia, Brescia (E.Q.-R.), San Gerardo Hospital, ASST Monza, University of Milan-Bicocca, Monza (G.L.), and Azienda Unite Sanitarie Locali-IRCCS, Reggio Emilia (M.M.) - all in Italy; Universitätsklinikum Düsseldorf, Düsseldorf, Germany (T. Feldt); Université de Paris, Infection, Antimicrobiens, Modélisation, Evolution (IAME), INSERM, and Assistance Publique-Hôpitaux de Paris, Department of Infectious Diseases, Bichat Hospital, Paris (F.-X.L.), Centre Hospitalier Régional et Universitaire de Brest-La Cavale Blanche, Brest (E.L.), and Division of Infectious Diseases and Tropical Medicine, University Hospital of Bordeaux, Bordeaux (D.N.) - all in France; St. Alexius Medical Center, Hoffman Estates, IL (S.A.); Mackenzie Health, Richmond Hill, ON, Canada (D. Chen); Columbia University Irving Medical Center, New York (J.C.); Hospital Universitario La Paz-Carlos III, Instituto de Investigación Hospital Universitario La Paz, Madrid (M.M.-R.); Bernhoven Hospital, Uden, the Netherlands (E.V.); Kaiser Franz Josef Hospital, Vienna (A.Z.); the U.S. Public Health Service Commissioned Corps, Washington, DC (R.C.); and Miriam Hospital, Providence, RI (T. Flanigan).

Associated clinical trials:

Prophylactic Corticosteroid to Prevent COVID-19 Cytokine Storm | NCT04355247

Multicenter, Retrospective Study of the Effects of Remdesivir in the Treatment of Severe Covid-19 Infections (REMDECO-19) | NCT04365725

Tocilizumab Versus Methylprednisolone in the Cytokine Release Syndrome of Patients With COVID-19 | NCT04377503

Clinical Characteristics and Outcomes of 187 Critically Ill Patients With Coronavirus Disease 2019 (COVID-19) | NCT04454372

Decitabine for Coronavirus (COVID-19) Pneumonia- Acute Respiratory Distress Syndrome (ARDS) Treatment: DART Trial (DART) | NCT04482621