ERK-Mediated Loss of miR-199a-3p and Induction of EGR1 Act as a "Toggle Switch" of GBM Cell Dedifferentiation into NANOG- and OCT4-Positive Cells.

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Published in Cancer Res on May 04, 2020

Authors

Fabien Almairac1,2, Laurent Turchi1,3, Nathalie Sakakini1, David Nicolas Debruyne1, Sarah Elkeurti1, Elisabet Gjernes1, Beatrice Polo1, Laurence Bianchini4, Denys Fontaine2, Philippe Paquis1,2, Herve Chneiweiss5,6,7, Marie-Pierre Junier5,6,7, Patrick Verrando1, Fanny Burel-Vandenbos1,8, Thierry Virolle9

Author Affiliations

1: Université Côte D'Azur, CNRS, INSERM, Institut de Biologie Valrose, Nice, France.
2: Service de Neurochirurgie, Hôpital Pasteur, CHU de Nice, France.
3: DRCI, CHU de Nice, France.
4: Laboratory of Solid Tumor Genetics, Université Côte d'Azur (UCA), CNRS UMR7284, INSERM U1081, Institute for Research on Cancer and Aging, Nice (IRCAN), Nice, France.
5: CNRS UMR8246 Neuroscience Paris Seine - IBPS; Team Glial Plasticity; 7 quai Saint-Bernard, Paris, France.
6: Inserm U1130, Neuroscience Paris Seine - IBPS; Team Glial Plasticity; 7 quai Saint-Bernard, Paris, France.
7: Sorbonne University, Neuroscience Paris Seine - IBPS; Team Glial Plasticity; 7 quai Saint-Bernard, Paris, France.
8: Service d'Anatomopathologie, Hôpital Pasteur, CHU de Nice, France.
9: Université Côte D'Azur, CNRS, INSERM, Institut de Biologie Valrose, Nice, France. Thierry.VIROLLE@univ-cotedazur.fr.

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