DNA typing from single hairs.

A general method of in vitro preparation and specific mutagenesis of DNA fragments: study of protein and DNA interactions. Nucleic Acids Res (1988) 26.70

DNA sequencing with Thermus aquaticus DNA polymerase and direct sequencing of polymerase chain reaction-amplified DNA. Proc Natl Acad Sci U S A (1988) 14.20

Dynamics of mitochondrial DNA evolution in animals: amplification and sequencing with conserved primers. Proc Natl Acad Sci U S A (1989) 12.95

Inhibition and facilitation of nucleic acid amplification. Appl Environ Microbiol (1997) 9.00

Amplification of human minisatellites by the polymerase chain reaction: towards DNA fingerprinting of single cells. Nucleic Acids Res (1988) 8.33

Genetic analysis of amplified DNA with immobilized sequence-specific oligonucleotide probes. Proc Natl Acad Sci U S A (1989) 7.79

Mitochondrial DNA sequences in single hairs from a southern African population. Proc Natl Acad Sci U S A (1989) 6.92

Rapid method for separation of bacterial DNA from humic substances in sediments for polymerase chain reaction. Appl Environ Microbiol (1992) 6.54

Evidence that a point mutation in dihydrofolate reductase-thymidylate synthase confers resistance to pyrimethamine in falciparum malaria. Proc Natl Acad Sci U S A (1988) 5.92

Ancient DNA: extraction, characterization, molecular cloning, and enzymatic amplification. Proc Natl Acad Sci U S A (1989) 5.50

Optimal conditions for directly sequencing double-stranded PCR products with sequenase. Nucleic Acids Res (1990) 3.90

Transcription-based amplification system and detection of amplified human immunodeficiency virus type 1 with a bead-based sandwich hybridization format. Proc Natl Acad Sci U S A (1989) 3.56

Mitochondrial DNA sequences from a 7000-year old brain. Nucleic Acids Res (1988) 3.38

Detection of viable Legionella pneumophila in water by polymerase chain reaction and gene probe methods. Appl Environ Microbiol (1991) 3.22

Rapid typing of tandemly repeated hypervariable loci by the polymerase chain reaction: application to the apolipoprotein B 3' hypervariable region. Proc Natl Acad Sci U S A (1989) 2.92

Population variation of human mtDNA control region sequences detected by enzymatic amplification and sequence-specific oligonucleotide probes. Am J Hum Genet (1991) 2.56

Identification of individuals by analysis of biallelic DNA markers, using PCR and solid-phase minisequencing. Am J Hum Genet (1993) 2.46

mtDNA analysis of Nile River Valley populations: A genetic corridor or a barrier to migration? Am J Hum Genet (1999) 2.25

Collection of genomic DNA by buccal swabs for polymerase chain reaction-based biomarker assays. Environ Health Perspect (1999) 2.21

Detection of Epstein-Barr virus DNA by polymerase chain reaction in blood and tissue biopsies from patients with Sjogren's syndrome. J Exp Med (1989) 2.15

Cloning of the gamma-aminobutyric acid (GABA) rho 1 cDNA: a GABA receptor subunit highly expressed in the retina. Proc Natl Acad Sci U S A (1991) 2.10

Testing migration patterns and estimating founding population size in Polynesia by using human mtDNA sequences. Proc Natl Acad Sci U S A (1998) 2.04

Mitochondrial sequences show diverse evolutionary histories of African hominoids. Proc Natl Acad Sci U S A (1999) 2.02

Development of a polymerase chain reaction-based diagnosis of Trichomonas vaginalis. J Clin Microbiol (1992) 1.91

Use of a signature nucleotide sequence of hepatitis C virus for detection of viral RNA in human serum and plasma. J Clin Microbiol (1991) 1.87

Alterations in the p53 gene and the clonal evolution of the blast crisis of chronic myelocytic leukemia. Proc Natl Acad Sci U S A (1989) 1.86

Amplification of bacterial genomic DNA by the polymerase chain reaction and direct sequencing after asymmetric amplification: application to the study of periplasmic permeases. J Bacteriol (1989) 1.77

The efficiency of multilocus DNA fingerprint probes for individualization and establishment of family relationships, determined from extensive casework. Am J Hum Genet (1991) 1.76

Rapid sequencing of rDNA from single worms and eggs of parasitic helminths. Nucleic Acids Res (1993) 1.74

HLA-DQ alpha allele and genotype frequencies in various human populations, determined by using enzymatic amplification and oligonucleotide probes. Am J Hum Genet (1990) 1.72

Pelizaeus-Merzbacher disease: an X-linked neurologic disorder of myelin metabolism with a novel mutation in the gene encoding proteolipid protein. Am J Hum Genet (1989) 1.64

Phylogeography and genetic ancestry of tigers (Panthera tigris). PLoS Biol (2004) 1.60

Splice-mediated insertion of an Alu sequence inactivates ornithine delta-aminotransferase: a role for Alu elements in human mutation. Proc Natl Acad Sci U S A (1991) 1.56

Ancient roots for polymorphism at the HLA-DQ alpha locus in primates. Proc Natl Acad Sci U S A (1989) 1.46

High mitochondrial sequence diversity in linguistic isolates of the Alps. Am J Hum Genet (1996) 1.40

Molecular basis for H blood group deficiency in Bombay (Oh) and para-Bombay individuals. Proc Natl Acad Sci U S A (1994) 1.36

Directly repeated sequences associated with pathogenic mitochondrial DNA deletions. Proc Natl Acad Sci U S A (1989) 1.35

mtDNA affinities of the peoples of North-Central Mexico. Am J Hum Genet (2000) 1.34

Mutation of the proteolipid protein gene PLP in a human X chromosome-linked myelin disorder. Proc Natl Acad Sci U S A (1989) 1.32

An E1M--E2C fusion protein encoded by human papillomavirus type 11 is asequence-specific transcription repressor. J Virol (1991) 1.24

Forensic trace DNA: a review. Investig Genet (2010) 1.21

Forensic medicine and the polymerase chain reaction technique. J Med Genet (1993) 1.18

Direct genomic fluorescent on-line sequencing and analysis using in vitro amplification of DNA. Nucleic Acids Res (1989) 1.17

Ancient and modern environmental DNA. Philos Trans R Soc Lond B Biol Sci (2015) 1.16

Neutron radiation can activate K-ras via a point mutation in codon 146 and induces a different spectrum of ras mutations than does gamma radiation. Mol Cell Biol (1990) 1.16

PCR amplification of alleles at the DIS80 locus: comparison of a Finnish and a North American Caucasian population sample, and forensic casework evaluation. Am J Hum Genet (1992) 1.13

A simple method of genomic DNA extraction from human samples for PCR-RFLP analysis. J Biomol Tech (2013) 1.11

Phenotypic heterogeneity in osteogenesis imperfecta: the mildly affected mother of a proband with a lethal variant has the same mutation substituting cysteine for alpha 1-glycine 904 in a type I procollagen gene (COL1A1). Am J Hum Genet (1990) 1.10

Tandem direct duplications of mitochondrial DNA in mitochondrial myopathy: analysis of nucleotide sequence and tissue distribution. Nucleic Acids Res (1989) 1.07

Pelizaeus-Merzbacher disease: a valine to phenylalanine point mutation in a putative extracellular loop of myelin proteolipid. Proc Natl Acad Sci U S A (1991) 1.06

Oncogene activation in human benign tumors of the skin (keratoacanthomas): is HRAS involved in differentiation as well as proliferation? Proc Natl Acad Sci U S A (1989) 1.04

Translocation t(14;18) in B cell lymphomas as a cause for defective immunoglobulin production. J Exp Med (1989) 1.03

Albumin Redhill (-1 Arg, 320 Ala----Thr): a glycoprotein variant of human serum albumin whose precursor has an aberrant signal peptidase cleavage site. Proc Natl Acad Sci U S A (1990) 1.02

Amplification of the ribonucleotide reductase small subunit gene: analysis of novel joints and the mechanism of gene duplication in vaccinia virus. Nucleic Acids Res (1989) 1.00

LytF, a novel competence-regulated murein hydrolase in the genus Streptococcus. J Bacteriol (2011) 0.97

Reduced CAG repeats length in androgen receptor gene is associated with violent criminal behavior. Int J Legal Med (2008) 0.96

Second generation sequencing allows for mtDNA mixture deconvolution and high resolution detection of heteroplasmy. Croat Med J (2011) 0.95

ras activation in human tumors and in animal model systems. Environ Health Perspect (1991) 0.93

Single-molecule LATE-PCR analysis of human mitochondrial genomic sequence variations. PLoS One (2009) 0.92

Rapid epidemiologic analysis of cytomegalovirus by using polymerase chain reaction amplification of the L-S junction region. J Clin Microbiol (1992) 0.92

Mitochondrial DNA heteroplasmy in the emerging field of massively parallel sequencing. Forensic Sci Int Genet (2015) 0.90

Mitochondrial DNA sequencing of cat hair: an informative forensic tool. J Forensic Sci (2010) 0.89

Genetic analysis using fingernail DNA. Nucleic Acids Res (1992) 0.86

Feather barbs as a good source of mtDNA for bird species identification in forensic wildlife investigations. Investig Genet (2011) 0.85

Detection of human papillomavirus genes in human oral tissue biopsies and cultures by polymerase chain reaction. Br J Cancer (1989) 0.85

Methanol for preparing hair bulbs for PCR. Nucleic Acids Res (1992) 0.84

Genetic Kinship Investigation from Blood Groups to DNA Markers. Transfus Med Hemother (2012) 0.83

An evaluation of the transfer of saliva-derived DNA. Int J Legal Med (2012) 0.83

Peptide-regulated gene depletion system developed for use in Streptococcus pneumoniae. J Bacteriol (2011) 0.81

The polymerase chain reaction: current and future clinical applications. J Med Genet (1990) 0.81

Variation at 16 STR loci in Rwandans (Hutu) and implications on profile frequency estimation in Bantu-speakers. Int J Legal Med (2003) 0.79

The polymerase chain reaction in pathology. J Clin Pathol (1997) 0.77

Structural DNA analysis from a single hair root by standard or pulsed field gel electrophoresis. Nucleic Acids Res (1990) 0.75

PCR amplification of genomic DNA from a 24 year old lysate derived from washed human erythrocytes. J Med Genet (1991) 0.75

A simple method to extract DNA from hair shafts using enzymatic laundry powder. PLoS One (2013) 0.75

Genotype: A Crucial but Not Unique Factor Affecting the Clinical Phenotypes in Fabry Disease. PLoS One (2016) 0.75

The Leaderless Bacteriocin Enterocin K1 Is Highly Potent against Enterococcus faecium: A Study on Structure, Target Spectrum and Receptor. Front Microbiol (2017) 0.75

Detection of enzymatically amplified human immunodeficiency virus DNA by oligonucleotide solution hybridization and by incorporation of radiolabeled deoxynucleotides. J Clin Microbiol (1989) 0.75

Analysis of beta3 adrenergic receptor gene polymorphism using noninvasive samples obtained at scheduled infant health checkups. Environ Health Prev Med (2000) 0.75

Digital DNA detection based on a compact optofluidic laser with ultra-low sample consumption. Lab Chip (2016) 0.75

Evidence of Subdivisions on Evolutionary Timescales in a Large, Declining Marsupial Distributed across a Phylogeographic Barrier. PLoS One (2016) 0.75

Prospects for gene therapy now and in the future. J Inherit Metab Dis (1989) 0.75

Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. Science (1988) 220.77

Enzymatic amplification of beta-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia. Science (1985) 95.08

Direct cloning and sequence analysis of enzymatically amplified genomic sequences. Science (1986) 19.54

Generation of single-stranded DNA by the polymerase chain reaction and its application to direct sequencing of the HLA-DQA locus. Proc Natl Acad Sci U S A (1988) 18.72

Analysis of enzymatically amplified beta-globin and HLA-DQ alpha DNA with allele-specific oligonucleotide probes. Nature (1986) 17.77

Amplification and analysis of DNA sequences in single human sperm and diploid cells. Nature (1988) 10.84

Length mutations in human mitochondrial DNA: direct sequencing of enzymatically amplified DNA. Nucleic Acids Res (1987) 10.38

Phenotypic expression in E. coli of a DNA sequence coding for mouse dihydrofolate reductase. Nature (1978) 8.76

Characterization of beta-thalassaemia mutations using direct genomic sequencing of amplified single copy DNA. Nature (1987) 8.58

Genetic analysis of amplified DNA with immobilized sequence-specific oligonucleotide probes. Proc Natl Acad Sci U S A (1989) 7.79

Allelic sequence variation of the HLA-DQ loci: relationship to serology and to insulin-dependent diabetes susceptibility. Proc Natl Acad Sci U S A (1988) 4.19

Analysis of DNA extracted from formalin-fixed, paraffin-embedded tissues by enzymatic amplification and hybridization with sequence-specific oligonucleotides. Biochem Biophys Res Commun (1987) 4.05

The polymerase chain reaction. Trends Genet (1989) 3.95

Nomenclature for the major histocompatibility complexes of different species: a proposal. Immunogenetics (1990) 3.53

Western Blot analysis of the antigens of Toxoplasma gondii recognized by human IgM and IgG antibodies. J Immunol (1983) 3.53

Lack of association between early exposure to cow's milk protein and beta-cell autoimmunity. Diabetes Autoimmunity Study in the Young (DAISY) JAMA (1996) 3.52

Rapid prenatal diagnosis of sickle cell anemia by a new method of DNA analysis. N Engl J Med (1987) 3.44

A sensitive radioimmunoassay for detecting products translated from cloned DNA fragments. Cell (1978) 3.30

Limited heterogeneity of rearranged T-cell receptor V alpha transcripts in brains of multiple sclerosis patients. Nature (1990) 3.30

Newborn screening for HLA markers associated with IDDM: diabetes autoimmunity study in the young (DAISY). Diabetologia (1996) 3.23

Nomenclature for factors of the HLA system, 2010. Tissue Antigens (2010) 3.22

Analysis of RAS gene mutations in acute myeloid leukemia by polymerase chain reaction and oligonucleotide probes. Proc Natl Acad Sci U S A (1988) 2.99

The role of HLA class II genes in insulin-dependent diabetes mellitus: molecular analysis of 180 Caucasian, multiplex families. Am J Hum Genet (1996) 2.90

HLA class II allelic variation and susceptibility to pemphigus vulgaris. Proc Natl Acad Sci U S A (1988) 2.72

High-resolution, high-throughput HLA genotyping by next-generation sequencing. Tissue Antigens (2009) 2.64

Diagnosis of sickle cell anemia and beta-thalassemia with enzymatically amplified DNA and nonradioactive allele-specific oligonucleotide probes. N Engl J Med (1988) 2.64

Population variation of human mtDNA control region sequences detected by enzymatic amplification and sequence-specific oligonucleotide probes. Am J Hum Genet (1991) 2.56

Preferential PCR amplification of alleles: mechanisms and solutions. PCR Methods Appl (1992) 2.47

Polymorphism, recombination, and linkage disequilibrium within the HLA class II region. J Immunol (1992) 2.39

Structure, sequence and polymorphism in the HLA-D region. Immunol Rev (1985) 2.16

A multilocus genotyping assay for candidate markers of cardiovascular disease risk. Genome Res (1999) 2.13

Selection for T-cell receptor V beta-D beta-J beta gene rearrangements with specificity for a myelin basic protein peptide in brain lesions of multiple sclerosis. Nature (1993) 2.01

Nomenclature for factors of the HLA system, 1990. Tissue Antigens (1991) 1.98

Nomenclature for factors of the HLA system, 2002. Tissue Antigens (2002) 1.89

Recent origin of HLA-DRB1 alleles and implications for human evolution. Nat Genet (1998) 1.89

Integrated portable genetic analysis microsystem for pathogen/infectious disease detection. Anal Chem (2004) 1.87

A multi-site study using high-resolution HLA genotyping by next generation sequencing. Tissue Antigens (2011) 1.81

Relative predispositional effects of HLA class II DRB1-DQB1 haplotypes and genotypes on type 1 diabetes: a meta-analysis. Tissue Antigens (2007) 1.77

A diabetes-susceptible HLA haplotype is best defined by a combination of HLA-DR and -DQ alleles. J Clin Invest (1989) 1.72

The HLA class II locus DPB1 can influence susceptibility to type 1 diabetes. Diabetes (2000) 1.69

Quantitative determination of bone marrow transplant engraftment using fluorescent polymerase chain reaction primers for human identity markers. Blood (1995) 1.68

Isolation of a cDNA clone for the human HLA-DR antigen alpha chain by using a synthetic oligonucleotide as a hybridization probe. Proc Natl Acad Sci U S A (1982) 1.64

Multi-locus candidate gene polymorphisms and risk of myocardial infarction: a population-based, prospective genetic analysis. J Thromb Haemost (2006) 1.61

Nomenclature for factors of the HLA system, 1991. WHO Nomenclature Committee for factors of the HLA system. Tissue Antigens (1992) 1.58

Nomenclature for factors of the HLA system, 2004. Tissue Antigens (2005) 1.57

Multifactor dimensionality reduction reveals gene-gene interactions associated with multiple sclerosis susceptibility in African Americans. Genes Immun (2006) 1.56

HLA DR-DQ associations with cervical carcinoma show papillomavirus-type specificity. Nat Genet (1994) 1.52

Initiation of protein synthesis in bacteria at a translational start codon of mamalian cDNA: effects of the preceding nucleotide sequence. Proc Natl Acad Sci U S A (1980) 1.51

A method for typing polymorphism at the HLA-A locus using PCR amplification and immobilized oligonucleotide probes. Tissue Antigens (1994) 1.49

T-cell receptor V alpha and C alpha alleles associated with multiple and myasthenia gravis. Proc Natl Acad Sci U S A (1989) 1.47

The association of specific HLA class I and II alleles with type 1 diabetes among Filipinos. Tissue Antigens (2002) 1.47

Ancient roots for polymorphism at the HLA-DQ alpha locus in primates. Proc Natl Acad Sci U S A (1989) 1.46

Rapid typing of HLA-DQB1 DNA polymorphism using nonradioactive oligonucleotide probes and amplified DNA. Immunogenetics (1991) 1.45

Postcoital detection of a male-specific semen protein. Application to the investigation of rape. N Engl J Med (1985) 1.44

Nomenclature for factors of the HLA system, 1998. Tissue Antigens (1999) 1.40

HLA sequence polymorphism and the origin of humans. Science (1996) 1.39

DNA sequence and characterization of human class II major histocompatibility complex beta chains from the DR1 haplotype. Proc Natl Acad Sci U S A (1985) 1.39

High-throughput genetic analysis using microfabricated 96-sample capillary array electrophoresis microplates. Proc Natl Acad Sci U S A (1998) 1.37

Molecular genetic analysis of 178 I-Abm12-reactive T cells. J Exp Med (1989) 1.36

Nomenclature for factors of the HLA system, 1995. Tissue Antigens (1995) 1.34

High throughput HLA genotyping using 454 sequencing and the Fluidigm Access Array™ System for simplified amplicon library preparation. Tissue Antigens (2013) 1.34

Genetic relationships among Neisseria species assessed by comparative enzyme electrophoresis. J Gen Microbiol (1985) 1.29

16(th) IHIW : review of HLA typing by NGS. Int J Immunogenet (2013) 1.27

HLA diversity, differentiation, and haplotype evolution in Mesoamerican Natives. Hum Immunol (2001) 1.27

Analysis of HLA-DP allelic sequence polymorphism using the in vitro enzymatic DNA amplification of DP-alpha and DP-beta loci. J Immunol (1988) 1.26

Immunosuppressive activity of human seminal plasma. I. Inhibition of in vitro lymphocyte activation. J Immunol (1977) 1.26

Isolation and characterization of a semen-specific protein from human seminal plasma: a potential new marker for semen identification. J Forensic Sci (1978) 1.26

Extended DR3-D6S273-HLA-B haplotypes are associated with increased susceptibility to type 1 diabetes in US Caucasians. Tissue Antigens (2005) 1.25

Rapid HLA-DPB typing using enzymatically amplified DNA and nonradioactive sequence-specific oligonucleotide probes. Immunogenetics (1990) 1.25

Immunological detection and characterization of products translated from cloned DNA fragments. Methods Enzymol (1979) 1.25

High-resolution HLA class I typing in the CEPH families: analysis of linkage disequilibrium among HLA loci. Tissue Antigens (2000) 1.23

Transcriptional regulation of HLA class II and invariant chain genes. J Immunol (1985) 1.23

Multi-locus HLA class I and II allele and haplotype associations with follicular lymphoma. Tissue Antigens (2012) 1.22

Nomenclature for factors of the HLA system, 2000. Tissue Antigens (2001) 1.21

High-speed DNA genotyping using microfabricated capillary array electrophoresis chips. Anal Chem (1997) 1.21

Identification of an antigen-specific immunoglobulin M antibody associated with acute Toxoplasma infection. Infect Immun (1983) 1.21

Nomenclature for factors of the HLA system, 1994. Tissue Antigens (1994) 1.19

Allelic diversification at the class II DQB locus of the mammalian major histocompatibility complex. Proc Natl Acad Sci U S A (1990) 1.18

Nomenclature for factors of the HLA system, 1996. Tissue Antigens (1997) 1.18

HLA-DQB1*0602 is associated with dominant protection from diabetes even among islet cell antibody-positive first-degree relatives of patients with IDDM. Diabetes (1995) 1.16

Nomenclature for factors of the HLA system, 1995. Hum Immunol (1995) 1.16

Next-generation sequencing can reveal in vitro-generated PCR crossover products: some artifactual sequences correspond to HLA alleles in the IMGT/HLA database. Tissue Antigens (2014) 1.15

Human leukocyte antigen class I and II alleles and risk of cervical neoplasia: results from a population-based study in Costa Rica. J Infect Dis (2001) 1.14

DRB1*04 and DQ alleles: expression of 21-hydroxylase autoantibodies and risk of progression to Addison's disease. J Clin Endocrinol Metab (1999) 1.14

Association between type 1 diabetes age of onset and HLA among sibling pairs. Diabetes (1999) 1.12

Sequence analysis of the HLA-DR beta and HLA-DQ beta loci from three Pemphigus vulgaris patients. Hum Immunol (1988) 1.12

A specific HLA-DP beta allele is associated with pauciarticular juvenile rheumatoid arthritis but not adult rheumatoid arthritis. Proc Natl Acad Sci U S A (1989) 1.11

DNA sequencing using a four-color confocal fluorescence capillary array scanner. Electrophoresis (1996) 1.11

Evolution of HLA class II molecules: Allelic and amino acid site variability across populations. Genetics (1999) 1.10

Nomenclature for factors of the HLA system, 1989. Tissue Antigens (1990) 1.10

Rapid typing of DNA sequence polymorphism at the HLA-DRB1 locus using the polymerase chain reaction and nonradioactive oligonucleotide probes. Hum Immunol (1991) 1.09

Use of synthetic oligonucleotide probes complementary to genes for human HLA-DR alpha and beta as extension primers for the isolation of 5'-specific genomic clones. Proc Natl Acad Sci U S A (1983) 1.09

Modeling of HLA class II susceptibility to Type I diabetes reveals an effect associated with DPB1. Genet Epidemiol (2001) 1.09

Biochemical characterization of an invariant polypeptide associated with Ia antigens in human and mouse. Mol Immunol (1983) 1.08

Nomenclature for factors of the HLA system, 2000. Eur J Immunogenet (2001) 1.08

Mapping of the genes encoding the HLA-DR alpha chain and the HLA-related antigens to a chromosome 6 deletion by using genomic blotting. Proc Natl Acad Sci U S A (1983) 1.06

Beta-cell autoantibodies in infants and toddlers without IDDM relatives: diabetes autoimmunity study in the young (DAISY). J Autoimmun (1996) 1.05

Association of susceptibility to multiple sclerosis in Sweden with HLA class II DRB1 and DQB1 alleles. Hum Immunol (1994) 1.03

HLA-D alleles associated with generalized disease, localized disease, and putative immunity in Onchocerca volvulus infection. Proc Natl Acad Sci U S A (1994) 1.03

Allelic diversity is generated by intraexon sequence exchange at the DRB1 locus of primates. Proc Natl Acad Sci U S A (1991) 1.03