Published in EMBO J on May 01, 1987
A 3D map of the human genome at kilobase resolution reveals principles of chromatin looping. Cell (2014) 8.79
How do site-specific DNA-binding proteins find their targets? Nucleic Acids Res (2004) 6.17
DNA-looping and enhancer activity: association between DNA-bound NtrC activator and RNA polymerase at the bacterial glnA promoter. Proc Natl Acad Sci U S A (1990) 3.48
A stochastic single-molecule event triggers phenotype switching of a bacterial cell. Science (2008) 3.46
Probing the Escherichia coli glnALG upstream activation mechanism in vivo. Proc Natl Acad Sci U S A (1988) 3.01
Conversion of the lac repressor into an allosterically regulated transcriptional activator for mammalian cells. Mol Cell Biol (1990) 3.00
Quality and position of the three lac operators of E. coli define efficiency of repression. EMBO J (1994) 2.90
Screening for receptor ligands using large libraries of peptides linked to the C terminus of the lac repressor. Proc Natl Acad Sci U S A (1992) 2.67
DNA looping. Microbiol Rev (1992) 2.63
DNA looping and Sp1 multimer links: a mechanism for transcriptional synergism and enhancement. Proc Natl Acad Sci U S A (1991) 2.51
DNA bending creates favored sites for retroviral integration: an explanation for preferred insertion sites in nucleosomes. EMBO J (1994) 2.48
Helical phase dependent action of CRP: effect of the distance between the CRP site and the -35 region on promoter activity. Nucleic Acids Res (1990) 2.40
Broad-host-range expression vectors with tightly regulated promoters and their use to examine the influence of TraR and TraM expression on Ti plasmid quorum sensing. Appl Environ Microbiol (2008) 2.36
Use of gel retardation to analyze protein-nucleic acid interactions. Microbiol Rev (1992) 2.35
DNA looping generated by DNA bending protein IHF and the two domains of lambda integrase. Science (1989) 2.34
Biological consequences of tightly bent DNA: the other life of a macromolecular celebrity. Biopolymers (2007) 2.19
Alternative DNA loops regulate the arabinose operon in Escherichia coli. Proc Natl Acad Sci U S A (1988) 1.95
Repressor induced site-specific binding of HU for transcriptional regulation. EMBO J (1997) 1.94
Structure of peptide sex pheromone receptor PrgX and PrgX/pheromone complexes and regulation of conjugation in Enterococcus faecalis. Proc Natl Acad Sci U S A (2005) 1.85
Modeling the Lac repressor-operator assembly: the influence of DNA looping on Lac repressor conformation. Proc Natl Acad Sci U S A (2006) 1.75
DNA supercoiling changes the spacing requirement of two lac operators for DNA loop formation with lac repressor. EMBO J (1988) 1.70
Closing the loop: the PmrA/PmrB two-component system negatively controls expression of its posttranscriptional activator PmrD. Proc Natl Acad Sci U S A (2003) 1.66
Epstein-Barr nuclear antigen 1 mediates a DNA loop within the latent replication origin of Epstein-Barr virus. Proc Natl Acad Sci U S A (1991) 1.66
Control of gal transcription through DNA looping: inhibition of the initial transcribing complex. Proc Natl Acad Sci U S A (1992) 1.65
DNA curvature and flexibility in vitro and in vivo. Q Rev Biophys (2010) 1.63
Glucocorticoid receptor binds cooperatively to adjacent recognition sites. EMBO J (1989) 1.61
The dihedral symmetry of the p53 tetramerization domain mandates a conformational switch upon DNA binding. EMBO J (1995) 1.58
Interaction of spatially separated protein-DNA complexes for control of gene expression: operator conversions. Proc Natl Acad Sci U S A (1988) 1.58
The gamma delta resolvase bends the res site into a recombinogenic complex. EMBO J (1988) 1.49
Lac repressor hinge flexibility and DNA looping: single molecule kinetics by tethered particle motion. Nucleic Acids Res (2006) 1.48
Multiple sequence-specific transcription factors modulate cytomegalovirus enhancer activity in vitro. Mol Cell Biol (1988) 1.47
Regulation of aroL expression by TyrR protein and Trp repressor in Escherichia coli K-12. J Bacteriol (1994) 1.46
Concentration and length dependence of DNA looping in transcriptional regulation. PLoS One (2009) 1.46
Mechanism for specificity by HMG-1 in enhanceosome assembly. Mol Cell Biol (2000) 1.44
Purification and characterization of the deoR repressor of Escherichia coli. EMBO J (1989) 1.42
Activation of distant replication origins in vivo by DNA looping as revealed by a novel mutant form of an initiator protein defective in cooperativity at a distance. EMBO J (1992) 1.40
DNA-binding specificity of the cut repeats from the human cut-like protein. Mol Cell Biol (1995) 1.39
Cooperative binding of an Ultrabithorax homeodomain protein to nearby and distant DNA sites. Mol Cell Biol (1993) 1.38
No strict alignment is required between a transcriptional activator binding site and the "TATA box" of a yeast gene. Proc Natl Acad Sci U S A (1988) 1.35
Dual mechanism of repression at a distance in the lac operon. Proc Natl Acad Sci U S A (1988) 1.34
Molecular geometry of CsrA (RsmA) binding to RNA and its implications for regulated expression. J Mol Biol (2009) 1.33
Looping dynamics of linear DNA molecules and the effect of DNA curvature: a study by Brownian dynamics simulation. Biophys J (1998) 1.31
Genetic analysis of the leucine heptad repeats of Lac repressor: evidence for a 4-helical bundle. EMBO J (1993) 1.27
Three binding sites for AraC protein are required for autoregulation of araC in Escherichia coli. Proc Natl Acad Sci U S A (1988) 1.26
Autoregulation of Escherichia coli purR requires two control sites downstream of the promoter. J Bacteriol (1990) 1.25
Recombination by resolvase to analyse DNA communications by the SfiI restriction endonuclease. EMBO J (1996) 1.25
RNA polymerase and gal repressor bind simultaneously and with DNA bending to the control region of the Escherichia coli galactose operon. EMBO J (1989) 1.24
The class E floral homeotic protein SEPALLATA3 is sufficient to loop DNA in 'floral quartet'-like complexes in vitro. Nucleic Acids Res (2008) 1.23
Interconvertible lac repressor-DNA loops revealed by single-molecule experiments. PLoS Biol (2008) 1.23
Coordinate control of gene expression noise and interchromosomal interactions in a MAP kinase pathway. Nat Cell Biol (2010) 1.22
Operator-bound GalR dimers close DNA loops by direct interaction: tetramerization and inducer binding. EMBO J (2002) 1.21
Ligand-induced conformational changes and conformational dynamics in the solution structure of the lactose repressor protein. J Mol Biol (2007) 1.20
First-principles calculation of DNA looping in tethered particle experiments. Phys Biol (2009) 1.20
Reconstitution of 'floral quartets' in vitro involving class B and class E floral homeotic proteins. Nucleic Acids Res (2009) 1.17
Structural characterization and corepressor binding of the Escherichia coli purine repressor. J Bacteriol (1992) 1.13
Single-molecule manipulation reveals supercoiling-dependent modulation of lac repressor-mediated DNA looping. Nucleic Acids Res (2008) 1.12
Sequence dependence of transcription factor-mediated DNA looping. Nucleic Acids Res (2012) 1.11
Sliding and intermolecular transfer of the lac repressor: kinetic perturbation of a reaction intermediate by a distant DNA sequence. Proc Natl Acad Sci U S A (1992) 1.10
Effects of DNA looping on pyrimidine dimer formation. Nucleic Acids Res (1992) 1.09
Molecular sequestration stabilizes CAP-DNA complexes during polyacrylamide gel electrophoresis. Nucleic Acids Res (1994) 1.08
Sequence analysis of rsk, a portion of the 95-kilobase plasmid of Salmonella typhimurium associated with resistance to the bactericidal activity of serum. Infect Immun (1989) 1.07
Rationally designed insulator-like elements can block enhancer action in vitro. EMBO J (2003) 1.06
DNA looping in prokaryotes: experimental and theoretical approaches. J Bacteriol (2013) 1.03
Coregulation of the Kluyveromyces lactis lactose permease and beta-galactosidase genes is achieved by interaction of multiple LAC9 binding sites in a 2.6 kbp divergent promoter. Nucleic Acids Res (1991) 1.02
Potent stimulation of transcription-coupled DNA supercoiling by sequence-specific DNA-binding proteins. Proc Natl Acad Sci U S A (2002) 1.01
Control of the arabinose regulon in Bacillus subtilis by AraR in vivo: crucial roles of operators, cooperativity, and DNA looping. J Bacteriol (2001) 1.01
Renaturation and DNA looping promoted by the SV40 large tumour antigen. EMBO J (1990) 0.99
DNA bending and expression of the divergent nagE-B operons. Nucleic Acids Res (1998) 0.99
Tetramer opening in LacI-mediated DNA looping. Proc Natl Acad Sci U S A (2009) 0.99
DNA binding sites of the LysR-type regulator GcvA in the gcv and gcvA control regions of Escherichia coli. J Bacteriol (1995) 0.97
Helical-repeat dependence of integrative recombination of bacteriophage lambda: role of the P1 and H1 protein binding sites. Proc Natl Acad Sci U S A (1988) 0.97
Quantitative methods for measuring DNA flexibility in vitro and in vivo. Methods Enzymol (2011) 0.97
The CTCF insulator protein forms an unusual DNA structure. BMC Mol Biol (2010) 0.96
Interaction of the Bacillus subtilis phage phi 105 repressor DNA: a genetic analysis. EMBO J (1988) 0.96
Single-molecule approaches to probe the structure, kinetics, and thermodynamics of nucleoprotein complexes that regulate transcription. J Biol Chem (2010) 0.96
EspR, a key regulator of Mycobacterium tuberculosis virulence, adopts a unique dimeric structure among helix-turn-helix proteins. Proc Natl Acad Sci U S A (2011) 0.96
Novel insights from hybrid LacI/GalR proteins: family-wide functional attributes and biologically significant variation in transcription repression. Nucleic Acids Res (2012) 0.91
FRET studies of a landscape of Lac repressor-mediated DNA loops. Nucleic Acids Res (2012) 0.91
Mechanism of promoter repression by Lac repressor-DNA loops. Nucleic Acids Res (2012) 0.90
Enhancement of DNA flexibility in vitro and in vivo by HMGB box A proteins carrying box B residues. Biochemistry (2009) 0.90
Mass spectrometric study of the Escherichia coli repressor proteins, Ic1R and Gc1R, and their complexes with DNA. Protein Sci (2001) 0.90
Computational analysis of looping of a large family of highly bent DNA by LacI. Biophys J (2008) 0.90
Eukaryotic HMGB proteins as replacements for HU in E. coli repression loop formation. Nucleic Acids Res (2008) 0.90
Design and analysis of LacI-repressed promoters and DNA-looping in a cyanobacterium. J Biol Eng (2014) 0.90
P22 repressor mutants deficient in co-operative binding and DNA loop formation. EMBO J (1989) 0.89
Binding sites of different geometries for the 16-3 phage repressor. Proc Natl Acad Sci U S A (2002) 0.89
Stereospecific relationships between elements in an SV40/adenovirus-2 heterologous promoter. Nucleic Acids Res (1989) 0.87
Analysis of kinetics in noisy systems: application to single molecule tethered particle motion. Biophys J (2007) 0.87
Fine-structure mutational analysis of a stage- and tissue-specific promoter element of the Drosophila glue gene Sgs-3. Mol Cell Biol (1990) 0.87
Bacterial promoter repression by DNA looping without protein-protein binding competition. Nucleic Acids Res (2014) 0.86
Two closely spaced promoters are equally activated by a remote enhancer: evidence against a scanning model for enhancer action. Nucleic Acids Res (1989) 0.86
Arabidopsis SEPALLATA proteins differ in cooperative DNA-binding during the formation of floral quartet-like complexes. Nucleic Acids Res (2014) 0.86
DNA linking number change induced by sequence-specific DNA-binding proteins. Nucleic Acids Res (2010) 0.85
Role of the imp operon of the Streptomyces coelicolor genetic element SLP1: two imp-encoded proteins interact to autoregulate imp expression and control plasmid maintenance. J Bacteriol (1993) 0.85
The quaternary structure of Tet repressors bound to the Tn10-encoded tet gene control region determined by neutron solution scattering. EMBO J (1989) 0.85
Bending the rules of transcriptional repression: tightly looped DNA directly represses T7 RNA polymerase. Biophys J (2010) 0.84
Direct analysis of native and chimeric GATA specific DNA binding proteins from Aspergillus nidulans. Nucleic Acids Res (1994) 0.84
Weak operator binding enhances simulated lac repressor-mediated DNA looping. Biopolymers (2013) 0.83
Engineered interphase chromosome loops guide intrachromosomal recombination. EMBO J (2001) 0.83
DNA modeling reveals an extended lac repressor conformation in classic in vitro binding assays. Biophys J (2011) 0.83
A new method for sequencing DNA. Proc Natl Acad Sci U S A (1977) 250.51
Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mp18 and pUC19 vectors. Gene (1985) 213.67
Supercoil sequencing: a fast and simple method for sequencing plasmid DNA. DNA (1985) 40.01
Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis. Nucleic Acids Res (1981) 35.39
DNAse footprinting: a simple method for the detection of protein-DNA binding specificity. Nucleic Acids Res (1978) 30.43
A gel electrophoresis method for quantifying the binding of proteins to specific DNA regions: application to components of the Escherichia coli lactose operon regulatory system. Nucleic Acids Res (1981) 24.41
The lac repressor-operator interaction. 3. Kinetic studies. J Mol Biol (1970) 10.07
Gene regulation by proteins acting nearby and at a distance. Nature (1986) 9.71
Sequence of the lactose permease gene. Nature (1980) 9.67
DNA bending at adenine . thymine tracts. Nature (1986) 9.25
DNA bending and its relation to nucleosome positioning. J Mol Biol (1985) 6.18
Cooperative binding of lambda repressors to sites separated by integral turns of the DNA helix. Cell (1986) 5.81
DNA flexibility studied by covalent closure of short fragments into circles. Proc Natl Acad Sci U S A (1981) 5.44
An operator at -280 base pairs that is required for repression of araBAD operon promoter: addition of DNA helical turns between the operator and promoter cyclically hinders repression. Proc Natl Acad Sci U S A (1984) 5.42
Requirement of stereospecific alignments for initiation from the simian virus 40 early promoter. Nature (1986) 4.77
A new preparation method for dark-field electron microscopy of biomacromolecules. J Ultrastruct Res (1971) 4.32
Transcription from efficient promoters can interfere with plasmid replication and diminish expression of plasmid specified genes. EMBO J (1982) 4.26
A perfectly symmetric lac operator binds the lac repressor very tightly. Proc Natl Acad Sci U S A (1983) 4.24
Energetics of DNA twisting. I. Relation between twist and cyclization probability. J Mol Biol (1983) 4.05
Torsional rigidity of DNA and length dependence of the free energy of DNA supercoiling. J Mol Biol (1984) 4.03
Curved DNA: design, synthesis, and circularization. Proc Natl Acad Sci U S A (1986) 3.72
A control element within a structural gene: the gal operon of Escherichia coli. Cell (1983) 3.62
The DNA loop model for ara repression: AraC protein occupies the proposed loop sites in vivo and repression-negative mutations lie in these same sites. Proc Natl Acad Sci U S A (1986) 3.18
Lac repressor and lac operator. Prog Biophys Mol Biol (1975) 3.08
Diffusion-driven mechanisms of protein translocation on nucleic acids. 2. The Escherichia coli repressor--operator interaction: equilibrium measurements. Biochemistry (1981) 2.98
One-step purification of hybrid proteins which have beta-galactosidase activity. Gene (1984) 2.77
Energetics of DNA twisting. II. Topoisomer analysis. J Mol Biol (1983) 2.65
Possible ideal lac operator: Escherichia coli lac operator-like sequences from eukaryotic genomes lack the central G X C pair. Proc Natl Acad Sci U S A (1984) 2.64
The location of the repressor binding sites in the lac operon. Proc Natl Acad Sci U S A (1974) 2.64
Upstream operators enhance repression of the lac promoter. Science (1986) 2.58
Demonstration of two operator elements in gal: in vitro repressor binding studies. Proc Natl Acad Sci U S A (1984) 2.54
DNA loops induced by cooperative binding of lambda repressor. Nature (1986) 2.50
Kinetics and mechanism in the reaction of gene regulatory proteins with DNA. J Mol Biol (1984) 2.43
On the different binding affinities of CRP at the lac, gal and malT promoter regions. Nucleic Acids Res (1983) 2.34
Construction, isolation and implications of repressor-galactosidase - beta-galactosidase hybrid molecules. Eur J Biochem (1977) 2.24
Thermodynamic origins of specificity in the lac repressor-operator interaction. Adaptability in the recognition of mutant operator sites. J Mol Biol (1985) 2.00
The functional repressor parts of a tetrameric lac repressor-beta-galactosidase chimaera are organized as dimers. Proc Natl Acad Sci U S A (1976) 1.92
Synthetic lac operator mediates repression through lac repressor when introduced upstream and downstream from lac promoter. EMBO J (1986) 1.80
Two operator sites separated by 599 base pairs are required for deoR repression of the deo operon of Escherichia coli. EMBO J (1985) 1.75
Characterization of two mutations in the Escherichia coli galE gene inactivating the second galactose operator and comparative studies of repressor binding. EMBO J (1983) 1.72
Lac repressor - lac operator interaction. Circular dichroism study. Nucleic Acids Res (1981) 1.56
DNA binding characteristics of lactose repressor and the trypsin-resistant core repressor. J Biol Chem (1980) 1.51
Regulation of the operon encoding ribonucleotide reductase in Escherichia coli: evidence for both positive and negative control. EMBO J (1986) 1.28
The upstream operator of the Escherichia coli galactose operon is sufficient for repression of transcription initiated at the cyclic AMP-stimulated promoter. EMBO J (1986) 1.27
Role of DNA regions flanking the tryptophan promoter of Escherichia coli. II. Insertion of lac operator fragments. Gene (1984) 1.11
Escherichia coli lac repressor is elongated with its operator DNA binding domains located at both ends. J Mol Biol (1982) 1.01
Thermodynamic analysis of the lactose repressor-operator DNA interaction. Biochemistry (1986) 0.97
Studies on the lactose operon. III. Visualization and physical mapping of the lactose repressor-operator complex. J Mol Biol (1976) 0.92
Filamentous coliphage M13 as a cloning vehicle: insertion of a HindII fragment of the lac regulatory region in M13 replicative form in vitro. Proc Natl Acad Sci U S A (1977) 18.85
The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature (1987) 17.08
Isolation of the lac repressor. Proc Natl Acad Sci U S A (1966) 10.20
Sequence of the lactose permease gene. Nature (1980) 9.67
Easy identification of cDNA clones. EMBO J (1983) 9.18
pUR222, a vector for cloning and rapid chemical sequencing of DNA. Nucleic Acids Res (1981) 6.55
Sequence of the lacZ gene of Escherichia coli. EMBO J (1983) 6.46
Mutants that make more lac repressor. Proc Natl Acad Sci U S A (1968) 6.26
Lac repressor can be fused to beta-galactosidase. Nature (1974) 5.84
The three operators of the lac operon cooperate in repression. EMBO J (1990) 5.45
The lac operator is DNA. Proc Natl Acad Sci U S A (1967) 5.24
How lac repressor binds to DNA. Nature (1972) 3.72
Lac repressor and lac operator. Prog Biophys Mol Biol (1975) 3.08
Repression of lac promoter as a function of distance, phase and quality of an auxiliary lac operator. J Mol Biol (1996) 3.08
Genetic studies of the Lac repressor. XV: 4000 single amino acid substitutions and analysis of the resulting phenotypes on the basis of the protein structure. J Mol Biol (1996) 2.98
Quality and position of the three lac operators of E. coli define efficiency of repression. EMBO J (1994) 2.90
Sequence of galR gene indicates a common evolutionary origin of lac and gal repressor in Escherichia coli. Proc Natl Acad Sci U S A (1982) 2.77
Possible ideal lac operator: Escherichia coli lac operator-like sequences from eukaryotic genomes lack the central G X C pair. Proc Natl Acad Sci U S A (1984) 2.64
Amplification of the lactose carrier protein in Escherichia coli using a plasmid vector. Mol Gen Genet (1978) 2.48
Suppressible regulator constitutive mutants of the lactose system in Escherichia coli. J Mol Biol (1966) 2.36
A role for the deep orange and carnation eye color genes in lysosomal delivery in Drosophila. Mol Cell (1999) 2.34
Immunoenzymatic detection of expressed gene fragments cloned in the lac Z gene of E. coli. EMBO J (1982) 2.29
Construction, isolation and implications of repressor-galactosidase - beta-galactosidase hybrid molecules. Eur J Biochem (1977) 2.24
Inhibition of the synthesis of beta-galactosidase in Escherichia coli by 2-nitrophenyl-beta-D-fucoside. J Mol Biol (1966) 2.24
Identification, transmembrane orientation and biogenesis of the amyloid A4 precursor of Alzheimer's disease. EMBO J (1988) 2.23
The interaction of the recognition helix of lac repressor with lac operator. EMBO J (1987) 2.19
Who uses sunbeds? A systematic literature review of risk groups in developed countries. J Eur Acad Dermatol Venereol (2009) 2.10
Exon cloning: immunoenzymatic identification of exons of the chicken lysozyme gene. Proc Natl Acad Sci U S A (1982) 2.07
Nucleotide sequences of the gal E gene and the gal T gene of E. coli. Nucleic Acids Res (1986) 2.00
On the conservation of protein sequences in evolution. Trends Biochem Sci (2000) 1.91
Synthetic lac operator mediates repression through lac repressor when introduced upstream and downstream from lac promoter. EMBO J (1986) 1.80
Mutant lac repressors with new specificities hint at rules for protein--DNA recognition. EMBO J (1990) 1.77
The Golgi-associated hook3 protein is a member of a novel family of microtubule-binding proteins. J Cell Biol (2001) 1.75
Not just pretty eyes: Drosophila eye-colour mutations and lysosomal delivery. Trends Cell Biol (1998) 1.74
The bride of sevenless and sevenless interaction: internalization of a transmembrane ligand. Cell (1992) 1.73
DNA supercoiling changes the spacing requirement of two lac operators for DNA loop formation with lac repressor. EMBO J (1988) 1.70
Recognition helices of lac and lambda repressor are oriented in opposite directions and recognize similar DNA sequences. Proc Natl Acad Sci U S A (1988) 1.64
Four dimers of lambda repressor bound to two suitably spaced pairs of lambda operators form octamers and DNA loops over large distances. Curr Biol (1999) 1.63
Specific destruction of the second lac operator decreases repression of the lac operon in Escherichia coli fivefold. J Mol Biol (1987) 1.62
beta-Galactosidase chimeras: primary structure of a lac repressor-beta-galactosidase protein. Proc Natl Acad Sci U S A (1978) 1.60
Induction in the developing compound eye of Drosophila: multiple mechanisms restrict R7 induction to a single retinal precursor cell. Cell (1991) 1.59
Synthetic multifunctional proteins: isolation of covalently linked tryptophan synthetase alpha-subunit-lac-repressor-beta-galactosidase chimeras. Mol Gen Genet (1977) 1.57
How Trp repressor binds to its operator. EMBO J (1990) 1.53
Human antisera detect a Plasmodium falciparum genomic clone encoding a nonapeptide repeat. Nature (1984) 1.51
Identification of three residues in the basic regions of the bZIP proteins GCN4, C/EBP and TAF-1 that are involved in specific DNA binding. EMBO J (1993) 1.46
Interaction of the histone (H3-H4)2 tetramer of the nucleosome with positively supercoiled DNA minicircles: Potential flipping of the protein from a left- to a right-handed superhelical form. Proc Natl Acad Sci U S A (1996) 1.42
Molecular characterization of mammalian homologues of class C Vps proteins that interact with syntaxin-7. J Biol Chem (2001) 1.37
Dimer-to-tetramer assembly of Lac repressor involves a leucine heptad repeat. New Biol (1991) 1.35
[Comparative study of the DNA of phages 2C, SP8*, SP82, phi e, SP01 and SP50]. Eur J Biochem (1970) 1.33
lac repressor forms stable loops in vitro with supercoiled wild-type lac DNA containing all three natural lac operators. J Mol Biol (1990) 1.31
Genetic analysis of transpositions in the lac region of Escherichia coli. J Mol Biol (1980) 1.29
Induction of cell fate in the Drosophila retina: the bride of sevenless protein is predicted to contain a large extracellular domain and seven transmembrane segments. Genes Dev (1990) 1.28
Isolation, genetic analysis, and characterization of Escherichia coli mutants with defects in the lacY gene. J Bacteriol (1977) 1.28
Genetic analysis of the leucine heptad repeats of Lac repressor: evidence for a 4-helical bundle. EMBO J (1993) 1.27
Genetic dissection of endocytic trafficking in Drosophila using a horseradish peroxidase-bride of sevenless chimera: hook is required for normal maturation of multivesicular endosomes. Mol Biol Cell (1999) 1.24
How AraC interacts specifically with its target DNAs. J Mol Biol (1996) 1.24
Cloning and characterization of the MboII restriction-modification system. Nucleic Acids Res (1991) 1.19
lac repressor mutants with double or triple exchanges in the recognition helix bind specifically to lac operator variants with multiple exchanges. EMBO J (1989) 1.18
Cloning of the cDNA encoding human brain trypsinogen and characterization of its product. Gene (1993) 1.18
Lac repressor. Angew Chem Int Ed Engl (1971) 1.17
Mutations in the lacY gene of Escherichia coli define functional organization of lactose permease. Proc Natl Acad Sci U S A (1981) 1.16
Different Z DNA forming sequences are revealed in phi X174 RFI by high resolution darkfield immuno-electron microscopy. EMBO J (1984) 1.15
High local protein concentrations at promoters: strategies in prokaryotic and eukaryotic cells. Bioessays (2001) 1.15
How Lac repressor finds lac operator in vitro. J Mol Biol (1992) 1.13
A versatile phage lambda expression vector system for cloning in Escherichia coli. Gene (1989) 1.13
A change of threonine 266 to isoleucine in the lac permease of Escherichia coli diminishes the transport of lactose and increases the transport of maltose. Mol Gen Genet (1985) 1.12
Chromatin reconstitution on small DNA rings. II. DNA supercoiling on the nucleosome. J Mol Biol (1988) 1.10
Molecular cloning and characterization of human VPS18, VPS 11, VPS16, and VPS33. Gene (2001) 1.10
The 11-1 gene of Plasmodium falciparum codes for distinct fast evolving repeats. EMBO J (1988) 1.08
Dimeric lac repressors exhibit phase-dependent co-operativity. J Mol Biol (1998) 1.07
Does the lactose carrier of Escherichia coli function as a monomer? FEBS Lett (1983) 1.07
The PreA4(695) precursor protein of Alzheimer's disease A4 amyloid is encoded by 16 exons. Nucleic Acids Res (1989) 1.07
Investigation of structure and function of lactose permease of Escherichia coli. Biochem Soc Trans (1980) 1.04
Replacement of invariant bZip residues within the basic region of the yeast transcriptional activator GCN4 can change its DNA binding specificity. Nucleic Acids Res (1994) 1.03
Chromatin reconstitution on small DNA rings. I. J Mol Biol (1988) 1.03
72 residues of gal repressor fused to beta-galactosidase repress the gal operon of E. coli. EMBO J (1983) 1.03
The sequence of the two extra exons in rat preA4. Nucleic Acids Res (1989) 1.01
Cross-reactive antigenic determinants present on different Plasmodium falciparum blood-stage antigens. Parasite Immunol (1989) 1.01
Lactose permease of Escherichia coli: properties of mutants defective in substrate translocation. Proc Natl Acad Sci U S A (1987) 1.00
A model of the lac repressor-operator complex based on physical and genetic data. Eur J Biochem (1991) 0.99