| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
Taxonomy of four marine bacterial strains that produce tetrodotoxin.
|
Int J Syst Bacteriol
|
1990
|
1.91
|
|
2
|
Detection of sodium channel toxins: directed cytotoxicity assays of purified ciguatoxins, brevetoxins, saxitoxins, and seafood extracts.
|
J AOAC Int
|
1995
|
1.63
|
|
3
|
Production of tetrodotoxin and its derivatives by Pseudomonas sp. isolated from the skin of a pufferfish.
|
Toxicon
|
1987
|
1.47
|
|
4
|
Two analogs of azaspiracid isolated from mussels, Mytilus edulis, involved in human intoxication in Ireland.
|
Nat Toxins
|
1999
|
1.38
|
|
5
|
The structure elucidation and biological activities of high molecular weight algal toxins: maitotoxin, prymnesins and zooxanthellatoxins.
|
Nat Prod Rep
|
2000
|
1.31
|
|
6
|
New saxitoxin analogues from the freshwater filamentous cyanobacterium Lyngbya wollei.
|
Nat Toxins
|
1997
|
1.28
|
|
7
|
Inhibition of specific binding of okadaic acid to protein phosphatase 2A by microcystin-LR, calyculin-A and tautomycin: method of analysis of interactions of tight-binding ligands with target protein.
|
Biochem J
|
1995
|
1.25
|
|
8
|
Multiple organ damage caused by a new toxin azaspiracid, isolated from mussels produced in Ireland.
|
Toxicon
|
2000
|
1.23
|
|
9
|
Structures of azaspiracid analogs, azaspiracid-4 and azaspiracid-5, causative toxins of azaspiracid poisoning in Europe.
|
Biosci Biotechnol Biochem
|
2001
|
1.20
|
|
10
|
Inhibitory effect of okadaic acid derivatives on protein phosphatases. A study on structure-affinity relationship.
|
Biochem J
|
1992
|
1.18
|
|
11
|
Maitotoxin, a Ca2+ channel activator candidate.
|
J Biol Chem
|
1982
|
1.18
|
|
12
|
First occurrence of tetrodotoxin in a dendrobatid frog (Colostethus inguinalis), with further reports for the bufonid genus Atelopus.
|
Toxicon
|
1994
|
1.17
|
|
13
|
A protein phosphatase 2A inhibition assay for a fast and sensitive assessment of okadaic acid contamination in mussels.
|
Toxicon
|
1996
|
1.16
|
|
14
|
Comparison of oral and intraperitoneal toxicity of yessotoxin towards mice.
|
Toxicon
|
2002
|
1.16
|
|
15
|
Histopathological studies on experimental marine toxin poisoning. I. Ultrastructural changes in the small intestine and liver of suckling mice induced by dinophysistoxin-1 and pectenotoxin-1.
|
Toxicon
|
1986
|
1.10
|
|
16
|
Origins of ciguatera fish poisoning: a new dinoflagellate, Gambierdiscus toxicus Adachi and Fukuyo, definitively involved as a causal agent.
|
Toxicon
|
1980
|
1.09
|
|
17
|
Dinoflagellate Gymnodinium catenatum as the source of paralytic shellfish toxins in Tasmanian shellfish.
|
Toxicon
|
1987
|
1.07
|
|
18
|
Electrospray ionization mass spectrometry of tetrodotoxin and its analogs: liquid chromatography/mass spectrometry, tandem mass spectrometry, and liquid chromatography/tandem mass spectrometry.
|
Anal Biochem
|
2001
|
1.07
|
|
19
|
Diarrhetic shellfish toxin, dinophysistoxin-1, is a potent tumor promoter on mouse skin.
|
Jpn J Cancer Res
|
1988
|
1.06
|
|
20
|
Aplysiatoxin and debromoaplysiatoxin as the causative agents of a red alga Gracilaria coronopifolia poisoning in Hawaii.
|
Toxicon
|
1996
|
1.06
|
|
21
|
Some chemical properties of maitotoxin, a putative calcium channel agonist isolated from a marine dinoflagellate.
|
J Biochem
|
1988
|
1.05
|
|
22
|
Ca2+ channel activating function of maitotoxin, the most potent marine toxin known, in clonal rat pheochromocytoma cells.
|
J Biol Chem
|
1983
|
1.02
|
|
23
|
Preparation of monoclonal antibodies against okadaic acid prepared from the sponge Halichondria okadai.
|
Toxicon
|
1989
|
1.01
|
|
24
|
Oral and intraperitoneal acute toxicity studies of yessotoxin and homoyessotoxins in mice.
|
Toxicon
|
2003
|
1.00
|
|
25
|
Toxicologic evaluation of yessotoxin.
|
Nat Toxins
|
1997
|
0.99
|
|
26
|
Tetrodotoxin derivatives in puffer fish.
|
Toxicon
|
1985
|
0.99
|
|
27
|
Brevetoxin B4 isolated from greenshell mussels Perna canaliculus, the major toxin involved in neurotoxic shellfish poisoning in New Zealand.
|
Nat Toxins
|
1999
|
0.99
|
|
28
|
Short-term oral toxicity of homoyessotoxins, yessotoxin and okadaic acid in mice.
|
Toxicon
|
2004
|
0.99
|
|
29
|
Identification of Protoceratium reticulatum as the biogenetic origin of yessotoxin.
|
Nat Toxins
|
1997
|
0.98
|
|
30
|
Structure-activity relationship within a series of okadaic acid derivatives.
|
Carcinogenesis
|
1990
|
0.97
|
|
31
|
Affinity of okadaic acid to type-1 and type-2A protein phosphatases is markedly reduced by oxidation of its 27-hydroxyl group.
|
Biochem J
|
1994
|
0.96
|
|
32
|
Effects of ciguatoxin and maitotoxin on the isolated guinea pig atria.
|
Res Commun Chem Pathol Pharmacol
|
1979
|
0.96
|
|
33
|
Distribution of tetrodotoxin, 6-epitetrodotoxin, and 11-deoxytetrodotoxin in newts.
|
Toxicon
|
1990
|
0.95
|
|
34
|
Human fatality due to ingestion of the crab Demania reynaudii that contained a palytoxin-like toxin.
|
Toxicon
|
1988
|
0.94
|
|
35
|
The occurrence of paralytic shellfish toxins in two species of xanthid crab from Suva barrier reef, Fiji Islands.
|
Toxicon
|
1983
|
0.94
|
|
36
|
Identification of putative palytoxin as the cause of clupeotoxism.
|
Toxicon
|
1999
|
0.94
|
|
37
|
Effects of specific modifications of several hydroxyls of tetrodotoxin on its affinity to rat brain membrane.
|
J Pharmacol Exp Ther
|
1999
|
0.94
|
|
38
|
Histopathological studies on experimental marine toxin poisoning--5. The effects in mice of yessotoxin isolated from Patinopecten yessoensis and of a desulfated derivative.
|
Toxicon
|
1990
|
0.93
|
|
39
|
Purification, characterization, and cDNA cloning of a novel soluble saxitoxin and tetrodotoxin binding protein from plasma of the puffer fish, Fugu pardalis.
|
Eur J Biochem
|
2001
|
0.92
|
|
40
|
Excitatory effect of the most potent marine toxin, maitotoxin, on the guinea-pig vas deferens.
|
J Pharmacol Exp Ther
|
1983
|
0.92
|
|
41
|
Contractile response of the rabbit aorta to maitotoxin, the most potent marine toxin.
|
J Physiol
|
1983
|
0.92
|
|
42
|
Selective stimulation of Ca2+ flux in cells by maitotoxin.
|
Eur J Pharmacol
|
1992
|
0.92
|
|
43
|
Suitability of the MTT-based cytotoxicity assay to detect okadaic acid contamination of mussels.
|
Toxicon
|
1996
|
0.92
|
|
44
|
Quantitative determination of marine toxins associated with diarrhetic shellfish poisoning by liquid chromatography coupled with mass spectrometry.
|
J Chromatogr A
|
2001
|
0.91
|
|
45
|
Azaspiracid shellfish poisoning: unusual toxin dynamics in shellfish and the increased risk of acute human intoxications.
|
Food Addit Contam
|
2002
|
0.90
|
|
46
|
Manauealides, some of the causative agents of a red alga Gracilaria coronopifolia poisoning in Hawaii.
|
J Nat Prod
|
1997
|
0.90
|
|
47
|
Sensitive detection of apoptogenic toxins in suspension cultures of rat and salmon hepatocytes.
|
Toxicon
|
1998
|
0.90
|
|
48
|
Clinical and laboratory findings implicating palytoxin as cause of ciguatera poisoning due to Decapterus macrosoma (mackerel).
|
Toxicon
|
1989
|
0.90
|
|
49
|
Estimation of the rate constants associated with the inhibitory effect of okadaic acid on type 2A protein phosphatase by time-course analysis.
|
Biochem J
|
1992
|
0.89
|
|
50
|
Binding properties of (3)H-PbTx-3 and (3)H-saxitoxin to brain membranes and to skeletal muscle membranes of puffer fish Fugu pardalis and the primary structure of a voltage-gated Na(+) channel alpha-subunit (fMNa1) from skeletal muscle of F. pardalis.
|
Biochem Biophys Res Commun
|
2000
|
0.89
|
|
51
|
Actions of 4-epitetrodotoxin and anhydrotetrodotoxin on the squid axon.
|
Toxicon
|
1985
|
0.89
|
|
52
|
Interspecies distribution and possible origin of tetrodotoxin.
|
Ann N Y Acad Sci
|
1986
|
0.89
|
|
53
|
Multiresidue method for determination of algal toxins in shellfish: single-laboratory validation and interlaboratory study.
|
J AOAC Int
|
2005
|
0.88
|
|
54
|
A sensitive and specific determination method for azaspiracids by liquid chromatography mass spectrometry.
|
Nat Toxins
|
1999
|
0.88
|
|
55
|
Toxicities and distribution of tetrodotoxin in the tissues of puffer fish found in the coast of the Baja California Peninsula, Mexico.
|
Toxicon
|
2000
|
0.88
|
|
56
|
Further report of the occurrence of tetrodotoxin in Atelopus species (family: Bufonidae).
|
Toxicon
|
1995
|
0.87
|
|
57
|
Maitotoxin effects are blocked by SK&F 96365, an inhibitor of receptor-mediated calcium entry.
|
Mol Pharmacol
|
1992
|
0.86
|
|
58
|
Maitotoxin stimulates hormonal release and calcium flux in rat anterior pituitary cells in vitro.
|
Am J Physiol
|
1984
|
0.86
|
|
59
|
New insights into maitotoxin action.
|
Eur J Biochem
|
1988
|
0.86
|
|
60
|
Structure elucidation of ostreocin D, a palytoxin analog isolated from the dinoflagellate Ostreopsis siamensis.
|
Biosci Biotechnol Biochem
|
2001
|
0.86
|
|
61
|
Confirmation of anatoxin-a(s), in the cyanobacterium Anabaena lemmermannii, as the cause of bird kills in Danish lakes.
|
Toxicon
|
1997
|
0.85
|
|
62
|
Maitotoxin-induced free Ca changes in single rat hepatocytes.
|
Cell Signal
|
1999
|
0.85
|
|
63
|
Isolation and structural assignment of 5-deoxytetrodotoxin from the puffer fish Fugu poecilonotus.
|
Biosci Biotechnol Biochem
|
1999
|
0.85
|
|
64
|
Actin cytoskeleton of rabbit intestinal cells is a target for potent marine phycotoxins.
|
J Exp Biol
|
2005
|
0.85
|
|
65
|
The mechanism of action of maitotoxin in relation to Ca2+ movements in guinea-pig and rat cardiac muscles.
|
Br J Pharmacol
|
1985
|
0.85
|
|
66
|
Actions of 6-epitetrodotoxin and 11-deoxytetrodotoxin on the frog skeletal muscle fiber.
|
Toxicon
|
1992
|
0.84
|
|
67
|
Liquid chromatography-electrospray ionization mass spectrometry of the diarrhetic shellfish-poisoning toxins okadaic acid, dinophysistoxin-1 and pectenotoxin-6 in bivalves.
|
J Chromatogr A
|
2000
|
0.84
|
|
68
|
Isolation and structure of ciguatoxin-4A, a new ciguatoxin precursor, from cultures of dinoflagellate Gambierdiscus toxicus and parrotfish Scarus gibbus.
|
Biosci Biotechnol Biochem
|
1996
|
0.84
|
|
69
|
Ultrastructural damage to heart tissue from repeated oral exposure to yessotoxin resolves in 3 months.
|
Toxicon
|
2008
|
0.83
|
|
70
|
The 1990 United States-Japan seminar on bioorganic marine chemistry, meeting report.
|
J Nat Prod
|
1992
|
0.82
|
|
71
|
Monthly variations in diarrhetic toxins and yessotoxin in shellfish from coast to the inner part of the Sognefjord, Norway.
|
Toxicon
|
2001
|
0.82
|
|
72
|
Na(+)-permeable channels induced by maitotoxin in guinea-pig single ventricular cells.
|
Eur J Pharmacol
|
1996
|
0.82
|
|
73
|
Maitotoxin: effects on calcium channels, phosphoinositide breakdown, and arachidonate release in pheochromocytoma PC12 cells.
|
Mol Pharmacol
|
1990
|
0.82
|
|
74
|
Stimulatory effects of maitotoxin on insulin release in insulinoma HIT cells: role of calcium uptake and phosphoinositide breakdown.
|
J Pharmacol Exp Ther
|
1990
|
0.82
|
|
75
|
Yessotoxin in mussels of the northern Adriatic Sea.
|
Toxicon
|
1997
|
0.82
|
|
76
|
Occurrence of toxic crabs in Ryukyu and Amami Islands.
|
Toxicon
|
1967
|
0.82
|
|
77
|
Maitotoxin, a potent, general activator of phosphoinositide breakdown.
|
FEBS Lett
|
1989
|
0.82
|
|
78
|
Maitotoxin-induced calcium entry in human lymphocytes: modulation by yessotoxin, Ca(2+) channel blockers and kinases.
|
Cell Signal
|
2001
|
0.82
|
|
79
|
Contraction and increase in tissue calcium content induced by maitotoxin, the most potent known marine toxin, in intestinal smooth muscle.
|
Br J Pharmacol
|
1983
|
0.81
|
|
80
|
Cardiotoxic effects of maitotoxin, a principal toxin of seafood poisoning, on guinea pig and rat cardiac muscle.
|
J Pharmacol Exp Ther
|
1986
|
0.81
|
|
81
|
Occurrence of saxitoxin in puffer fish.
|
Toxicon
|
1984
|
0.81
|
|
82
|
Biological activities of prymnesin-2 isolated from a red tide alga Prymnesium parvum.
|
Nat Toxins
|
1998
|
0.80
|
|
83
|
Maitotoxin activates quantal transmitter release at the neuromuscular junction: evidence for elevated intraterminal Ca2+ in the motor nerve terminal.
|
Brain Res
|
1985
|
0.80
|
|
84
|
Liquid chromatographic methods for the isolation and identification of new pectenotoxin-2 analogues from marine phytoplankton and shellfish.
|
J Chromatogr A
|
1999
|
0.80
|
|
85
|
Cytoskeletal toxicity of pectenotoxins in hepatic cells.
|
Br J Pharmacol
|
2008
|
0.80
|
|
86
|
Repeated oral co-exposure to yessotoxin and okadaic acid: a short term toxicity study in mice.
|
Toxicon
|
2013
|
0.80
|
|
87
|
[Actin depolymerizing action by marine toxin, pectenotoxin-2].
|
Nihon Yakurigaku Zasshi
|
1999
|
0.80
|
|
88
|
Assessment of potential activation of gonyautoxin V in the stomach of mice and rats.
|
Toxicon
|
1984
|
0.80
|
|
89
|
11-Oxo-tetrodotoxin and a specifically labelled 3H-tetrodotoxin.
|
Toxicon
|
1996
|
0.80
|
|
90
|
Mechanisms underlying the hemolytic and ichthyotoxic activities of maitotoxin.
|
Nat Toxins
|
1999
|
0.80
|
|
91
|
Detection and quantification of maitotoxin-like compounds using a neuroblastoma (Neuro-2a) cell based assay. Application to the screening of maitotoxin-like compounds in Gambierdiscus spp.
|
Toxicon
|
2010
|
0.80
|
|
92
|
The effects of maitotoxin on 45Ca2+ flux and hormone release in GH3 rat pituitary cells.
|
Endocrinology
|
1985
|
0.80
|
|
93
|
Fluorometric analysis of pectenotoxin-2 in microalgal samples by high performance liquid chromatography.
|
Nat Toxins
|
1999
|
0.80
|
|
94
|
Fatal mass poisoning in Madagascar following ingestion of a shark (Carcharhinus leucas): clinical and epidemiological aspects and isolation of toxins.
|
Toxicon
|
1995
|
0.80
|
|
95
|
Mechanism of maitotoxin-stimulated phosphoinositide breakdown in HL-60 cells.
|
J Pharmacol Exp Ther
|
1990
|
0.79
|
|
96
|
Biological activities of novel polyether antifungals, gambieric acids A and B from a marine dinoflagellate Gambierdiscus toxicus.
|
J Antibiot (Tokyo)
|
1993
|
0.79
|
|
97
|
Progress on chemical knowledge of ciguatoxins.
|
Bull Soc Pathol Exot
|
1992
|
0.79
|
|
98
|
Maitotoxin-induced intracellular calcium rise in PC12 cells: involvement of dihydropyridine-sensitive and omega-conotoxin-sensitive calcium channels and phosphoinositide breakdown.
|
J Neurochem
|
1992
|
0.78
|
|
99
|
Homologous desensitization with gonadotropin-releasing hormone (GnRH) also diminishes gonadotrope responsiveness to maitotoxin: a role for the GnRH receptor-regulated calcium ion channel in mediation of cellular desensitization.
|
Mol Endocrinol
|
1987
|
0.78
|
|
100
|
Two new analogs of yessotoxin, homoyessotoxin and 45-hydroxyhomoyessotoxin, isolated from mussels of the Adriatic Sea.
|
Nat Toxins
|
1997
|
0.78
|
|
101
|
Isolation of Prorocentrum lima (Syn. Exuviaella lima) and diarrhetic shellfish poisoning (DSP) risk assessment in the Gulf of California, Mexico.
|
Toxicon
|
2002
|
0.78
|
|
102
|
Effect of maitotoxin analogues on calcium influx and phosphoinositide breakdown in cultured cells.
|
Toxicon
|
1991
|
0.78
|
|
103
|
[Toxic complex from parrotfish].
|
Biochimie
|
1977
|
0.78
|
|
104
|
Maitotoxin, a novel activator of mediator release from human basophils, induces large increases in cytosolic calcium resulting in histamine, but not leukotriene C4, release.
|
J Pharmacol Exp Ther
|
1992
|
0.78
|
|
105
|
Effects of yessotoxin (YTX) on the skeletal muscle: an update.
|
Food Addit Contam Part A Chem Anal Control Expo Risk Assess
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2008
|
0.78
|
|
106
|
Gene expression of neurotrophins and their receptors in lead nitrate-induced rat liver hyperplasia.
|
Biochem Biophys Res Commun
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2000
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0.78
|
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107
|
Light and scanning electron microscopic studies on effects of marine algal toxins toward freshly prepared hepatocytes.
|
J Toxicol Environ Health
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1991
|
0.78
|
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108
|
Agents that stimulate phosphoinositide turnover also elevate cAMP in SK-N-SH human neuroblastoma cells.
|
Life Sci
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1992
|
0.78
|
|
109
|
Chinese hamster ovary cells resistant to okadaic acid express a multidrug resistant phenotype.
|
Biochem Biophys Res Commun
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1994
|
0.78
|
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110
|
Sandwich ELISA assay for the quantitation of palytoxin and its analogs in natural samples.
|
Environ Sci Technol
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2013
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0.78
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111
|
Calcium-dependent effects of maitotoxin on phosphoinositide breakdown and on cyclic AMP accumulation in PC12 and NCB-20 cells.
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Mol Pharmacol
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1989
|
0.78
|
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112
|
Detection of sodium channel activators by a rapid fluorimetric microplate assay.
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Chem Res Toxicol
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2004
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0.78
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113
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Histopathological studies of experimental marine toxin poisoning. II. The acute effects of maitotoxin on the stomach, heart and lymphoid tissues in mice and rats.
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Toxicon
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1988
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0.77
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114
|
Cross-reactivity of highly purified okadaic acid (OA), synthetic, spiroketal East sphere of OA and ciguatoxin.
|
J Clin Lab Anal
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1992
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0.77
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115
|
The maitotoxin-evoked Ca2+ entry into synaptosomes is enhanced by cholera toxin.
|
Neurosci Lett
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1986
|
0.77
|
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116
|
Intracellular free calcium in rat anterior pituitary cells monitored by fura-2.
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Life Sci
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1987
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0.77
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117
|
Development of a method for the identification of azaspiracid in shellfish by liquid chromatography-tandem mass spectrometry.
|
J Chromatogr A
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2000
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0.77
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118
|
Prokaryotic adenylate cyclase toxin stimulates anterior pituitary cells in culture.
|
Am J Physiol
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1986
|
0.77
|
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119
|
Absolute configuration at C14 and C85 in prymnesin-2, a potent hemolytic and ichthyotoxic glycoside isolated from the red tide alga Prymnesium parvum.
|
Chirality
|
2001
|
0.77
|
|
120
|
Maitotoxin and Bay-K-8644: two putative calcium channel activators with different effects on endogenous dopamine release from tuberoinfundibular neurons.
|
Brain Res
|
1986
|
0.77
|
|
121
|
Ca(2+)- and Na(+)-dependent depolarization induced by maitotoxin in the crayfish giant axon.
|
Gen Pharmacol
|
1993
|
0.77
|
|
122
|
Maitotoxin-induced myocardial cell injury: calcium accumulation followed by ATP depletion precedes cell death.
|
Toxicol Appl Pharmacol
|
1990
|
0.77
|
|
123
|
Dopamine decreases 7315a tumor cell prolactin release induced by calcium mobilization.
|
Endocrinology
|
1985
|
0.77
|
|
124
|
Marine toxins of the Pacific. 8. Ciguatoxin from moray eel livers.
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Toxicon
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1969
|
0.77
|
|
125
|
Histopathological studies on experimental marine toxin poisoning--4. Pathogenesis of experimental maitotoxin poisoning.
|
Toxicon
|
1989
|
0.76
|
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126
|
Maitotoxin-evoked gamma-aminobutyric acid release is due not only to the opening of calcium channels.
|
J Neurochem
|
1988
|
0.76
|
|
127
|
Intestinal injuries caused by experimental palytoxicosis in mice.
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Toxicon
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1996
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0.76
|
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128
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[Fatal ichthyosarcotoxism after eating shark meat. Implications of two new marine toxins].
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Arch Inst Pasteur Madagascar
|
1994
|
0.76
|
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129
|
Partial structures and binding studies of maitotoxin, the most potent marine toxin.
|
Bull Soc Pathol Exot
|
1992
|
0.76
|
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130
|
Structure and fluorometric HPLC determination of 1-desulfoyessotoxin, a new yessotoxin analog isolated from mussels from Norway.
|
Nat Toxins
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1998
|
0.76
|
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131
|
Tetrodotoxin and its analogues in extracts from the toad Atelopus oxyrhynchus (family: Bufonidae).
|
Toxicon
|
1992
|
0.76
|
|
132
|
Transient Ca2+-dependent activation of ERK1 and ERK2 in cytotoxic responses induced by maitotoxin in breast cancer cells.
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