Published in Proc Natl Acad Sci U S A on January 01, 1978
A computer program to search for tRNA genes. Nucleic Acids Res (1980) 17.12
Ovalbumin gene: evidence for a leader sequence in mRNA and DNA sequences at the exon-intron boundaries. Proc Natl Acad Sci U S A (1978) 14.82
Isolation and sequence of the gene for actin in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1980) 11.24
A design for computer nucleic-acid-sequence storage, retrieval, and manipulation. Nucleic Acids Res (1982) 7.79
Has the endosymbiont hypothesis been proven? Microbiol Rev (1982) 3.86
Putative introns in tRNA genes of prokaryotes. Proc Natl Acad Sci U S A (1983) 3.60
Analysis of the regions flanking the human insulin gene and sequence of an Alu family member. Nucleic Acids Res (1980) 3.55
Mechanism of non-spliceosomal mRNA splicing in the unfolded protein response pathway. EMBO J (1999) 2.84
Two control regions for eukaryotic tRNA gene transcription. Proc Natl Acad Sci U S A (1980) 2.83
Gaps and duplicated sequences in the leaders of SV40 16S RNA. Nucleic Acids Res (1978) 2.60
sigma, a repetitive element found adjacent to tRNA genes of yeast. Proc Natl Acad Sci U S A (1982) 2.09
Mammalian tRNA genes: nucleotide sequence of rat genes for tRNAAsp, tRNAGly and tRNAGlu. Nucleic Acids Res (1981) 2.06
Comparison of cloned mouse alpha- and beta-globin genes: conservation of intervening sequence locations and extragenic homology. Proc Natl Acad Sci U S A (1978) 2.03
Specific transcription of eukaryotic tRNA genes in Xenopus germinal vesicle extracts. Proc Natl Acad Sci U S A (1978) 1.99
Apparent involvement of ribonuclease D in the 3' processing of tRNA precursors. Proc Natl Acad Sci U S A (1980) 1.74
Transfer RNA splicing in Saccharomyces cerevisiae: defining the substrates. Nucleic Acids Res (1984) 1.69
Genetic analysis of the processing of a spliced tRNA. EMBO J (1982) 1.67
The anticodon of the maize chloroplast gene for tRNA Leu UAA is split by a large intron. Nucleic Acids Res (1982) 1.66
The role of non-coding DNA sequences in transcription and processing of a yeast tRNA. Nucleic Acids Res (1983) 1.60
Transcription and processing of a yeast tRNA gene containing a modified intervening sequence. Proc Natl Acad Sci U S A (1980) 1.50
The primary transcript of the ribosomal repeating unit in yeast. Nucleic Acids Res (1979) 1.48
Yeast tRNA3Leu gene transcribed and spliced in a HeLa cell extract. Proc Natl Acad Sci U S A (1981) 1.44
Higher-order structure of bovine mitochondrial tRNA(Phe) lacking the 'conserved' GG and T psi CG sequences as inferred by enzymatic and chemical probing. Nucleic Acids Res (1994) 1.43
Nucleotide sequence of the mitochondrial structural genes for cysteine-tRNA and histidine-tRNA of yeast. Nucleic Acids Res (1979) 1.42
Pleiotropic effects of intron removal on base modification pattern of yeast tRNAPhe: an in vitro study. Nucleic Acids Res (1997) 1.40
Transfer RNA genes in pieces. EMBO Rep (2008) 1.35
Sigma elements are position-specific for many different yeast tRNA genes. Nucleic Acids Res (1988) 1.32
Preparation of synthetic tRNA precursors with tRNA nucleotidyltransferase. Nucleic Acids Res (1978) 1.30
Structural comparison of two yeast tRNA Glu 3 genes. Nucleic Acids Res (1981) 1.30
Isolation and characterization of a human telomere. Nucleic Acids Res (1989) 1.26
Nucleotide sequences of yeast genes for tRNA(2), tRNA(2) and tRNA(1): homology blocks occur in the vicinity of different tRNA genes. EMBO J (1982) 1.21
tRNA synthesis: identification of in vivo precursor tRNAs from parental and mutant yeast strains. Nucleic Acids Res (1981) 1.19
Modulation of transcriptional activity and stable complex formation by 5'-flanking regions of mouse tRNAHis genes. Mol Cell Biol (1986) 1.19
In vitro RNA-RNA splicing in adenovirus 2 mRNA formation. Proc Natl Acad Sci U S A (1978) 1.19
Structure of a yeast non-initiating methionine-tRNA gene. Nucleic Acids Res (1980) 1.19
Diversity and roles of (t)RNA ligases. Cell Mol Life Sci (2012) 1.18
In silico screening of archaeal tRNA-encoding genes having multiple introns with bulge-helix-bulge splicing motifs. RNA (2007) 1.17
Convergence and minimal mutation criteria for evaluating early events in tRNA evolution. Proc Natl Acad Sci U S A (1980) 1.16
Yeast tRNA precursor mutated at a splice junction is correctly processed in vivo. Proc Natl Acad Sci U S A (1981) 1.15
A phenylalanine tRNA gene from Neurospora crassa: conservation of secondary structure involving an intervening sequence. Nucleic Acids Res (1980) 1.12
tau, a repeated DNA sequence in yeast. Proc Natl Acad Sci U S A (1984) 1.11
Variable and constant regions are separated in the 10-kbase transcription unit coding for immunoglobulin kappa light chains. Proc Natl Acad Sci U S A (1978) 1.10
The nucleotide sequence of the major glutamate transfer RNA from Schizosaccharomyces pombe. Nucleic Acids Res (1979) 1.08
Structural organization of a 17 KB segment of the alpha 2 collagen gene: evaluation by R loop mapping. Nucleic Acids Res (1980) 1.08
Glutamate tRNA genes are adjacent to 5S RNA genes in Drosophila and reveal a conserved upstream sequence (the ACT-TA box). Nucleic Acids Res (1982) 1.06
Comparison of rat liver and Walker 256 carcinosarcoma tRNAs. Nucleic Acids Res (1979) 1.03
Six Schizosaccharomyces pombe tRNA genes including a gene for a tRNALys with an intervening sequence which cannot base-pair with the anticodon. Nucleic Acids Res (1983) 1.02
Ariadne: a database search engine for identification and chemical analysis of RNA using tandem mass spectrometry data. Nucleic Acids Res (2009) 1.00
Isolation and nucleotide sequence of a plant tRNA gene: petunia asparagine tRNA. Nucleic Acids Res (1983) 0.99
On origin of genetic code and tRNA before translation. Biol Direct (2011) 0.97
The nucleotide sequence of glutamate tRNA4 of Drosophila melanogaster. Nucleic Acids Res (1980) 0.96
Disrupted tRNA gene diversity and possible evolutionary scenarios. J Mol Evol (2009) 0.93
Secondary structures for splice junctions in eukaryotic and viral messenger RNA precursors. Nucleic Acids Res (1980) 0.92
Crystal structure and assembly of the functional Nanoarchaeum equitans tRNA splicing endonuclease. Nucleic Acids Res (2009) 0.89
Transfer RNA processing in archaea: unusual pathways and enzymes. FEBS Lett (2010) 0.89
Expression of a set of synthetic suppressor tRNA(Phe) genes in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1987) 0.88
Nuclear ligation of RNA 5'-OH kinase products in tRNA. Mol Cell Biol (1982) 0.87
Conserved sequences in both coding and 5' flanking regions of mammalian opal suppressor tRNA genes. Nucleic Acids Res (1985) 0.87
Isolation and structure of a yeast initiator tRNAmet gene. Nucleic Acids Res (1982) 0.84
A methods review on use of nonsense suppression to study 3' end formation and other aspects of tRNA biogenesis. Gene (2014) 0.80
Comparison of theoretical denaturation maps of phiX174 and SV40 with their gene maps. Nucleic Acids Res (1979) 0.80
Genomic heterogeneity in a natural archaeal population suggests a model of tRNA gene disruption. PLoS One (2012) 0.80
The nucleotide sequence of phenylalanine tRNA from the cytoplasm of Neurospora crassa. Nucleic Acids Res (1980) 0.80
New genes for tRNA(Phe), tRNA(Leu), and tRNA(Thr) from Saccharomyces cerevisiae. Nucleic Acids Res (1991) 0.79
In vitro splicing of SV40 late mRNA in isolated nuclei from CV-1 cells. Nucleic Acids Res (1980) 0.78
Avatar pre-tRNAs help elucidate the properties of tRNA-splicing endonucleases that produce tRNA from permuted genes. Proc Natl Acad Sci U S A (2012) 0.76
Cloning of chicken embryo tRNA genes using single stranded nucleosomal DNA highly enriched for tRNA complementary sequences. Nucleic Acids Res (1979) 0.75
Detection of specific sequences among DNA fragments separated by gel electrophoresis. J Mol Biol (1975) 503.08
A new method for sequencing DNA. Proc Natl Acad Sci U S A (1977) 250.51
Acetylornithinase of Escherichia coli: partial purification and some properties. J Biol Chem (1956) 93.84
Colony hybridization: a method for the isolation of cloned DNAs that contain a specific gene. Proc Natl Acad Sci U S A (1975) 77.46
Plasmid ColEl as a molecular vehicle for cloning and amplification of DNA. Proc Natl Acad Sci U S A (1974) 32.46
A colony bank containing synthetic Col El hybrid plasmids representative of the entire E. coli genome. Cell (1976) 26.20
Spliced segments at the 5' terminus of adenovirus 2 late mRNA. Proc Natl Acad Sci U S A (1977) 14.34
Nucleotide sequence of a mutant eukaryotic gene: the yeast tyrosine-inserting ochre suppressor SUP4-o. Proc Natl Acad Sci U S A (1977) 10.64
Amino acid replacements resulting from super-suppression of nonsense mutants of iso-1-cytochrome c from yeast. J Mol Biol (1971) 7.19
Viral integration and excision: structure of the lambda att sites. Science (1977) 6.66
Structural domains of transfer RNA molecules. Science (1976) 6.07
Transposable genetic elements and plasmid evolution. Nature (1976) 5.58
Processing of RNA. Annu Rev Biochem (1976) 5.28
Cloning specific segments of the mammalian genome: bacteriophage lambda containing mouse globin and surrounding gene sequences. Proc Natl Acad Sci U S A (1977) 5.28
The initiation sites for RNA transcription in Ad2 DNA. Cell (1977) 4.76
Ribosomal RNA genes of Saccharomyces cerevisiae. I. Physical map of the repeating unit and location of the regions coding for 5 S, 5.8 S, 18 S, and 25 S ribosomal RNAs. J Biol Chem (1977) 4.76
A map of cytoplasmic RNA transcripts from lytic adenovirus type 2, determined by electron microscopy of RNA:DNA hybrids. Cell (1977) 4.26
Ribosomal RNA genes of Saccharomyces cerevisiae. II. Physical map and nucleotide sequence of the 5 S ribosomal RNA gene and adjacent intergenic regions. J Biol Chem (1977) 4.03
A novel arrangement of the 18S and 28S sequences in a repeating unit of Drosophila melanogaster rDNA. Cell (1977) 3.99
The redundancy of ribosomal and transfer RNA genes in Saccharomyces cerevisiae. J Mol Biol (1969) 3.54
Cloning of yeast transfer RNA genes in Escherichia coli. Science (1977) 2.73
Studies on polynucleotides, lxviii the primary structure of yeast phenylalanine transfer RNA. Proc Natl Acad Sci U S A (1967) 2.45
Promotor region for yeast 5S ribosomal RNA. Nature (1977) 2.32
A plasmid cloning vehicle allowing regulated expression of eukaryotic DNA in bacteria. Proc Natl Acad Sci U S A (1976) 2.31
Nucleotide sequence of the yeast 5S ribosomal RNA gene and adjacent putative control regions. Nature (1977) 2.15
Transcription and processing of transfer RNA precursors. Prog Nucleic Acid Res Mol Biol (1976) 2.11
Eight transfer RNAs induced by infection of Escherichia coli with bacteriophage T4. Proc Natl Acad Sci U S A (1972) 1.89
Hybridization of 125I-labeled ribonucleic acid. Biochemistry (1973) 1.74
Identification of tRNA precursor molecules made by phage T4. Nat New Biol (1973) 1.61
Three adjacent transfer RNA genes in Escherichia coli. Proc Natl Acad Sci U S A (1973) 1.59
Arangement of transfer-RNA -genes in yeast. Nucleic Acids Res (1976) 1.46
The purification of restriction endonuclease EcoRI by precipitation involving polyethyleneimine. FEBS Lett (1977) 1.42
A comparison of transcriptional linkage of tRNA cistrons in yeast and E. coli by the ultraviolet light technique. Nucleic Acids Res (1977) 0.97
Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry (1979) 180.95
Number and evolutionary conservation of alpha- and beta-tubulin and cytoplasmic beta- and gamma-actin genes using specific cloned cDNA probes. Cell (1980) 17.55
Rat insulin genes: construction of plasmids containing the coding sequences. Science (1977) 17.05
Polymorphic DNA region adjacent to the 5' end of the human insulin gene. Proc Natl Acad Sci U S A (1981) 12.86
Replacement of insulin receptor tyrosine residues 1162 and 1163 compromises insulin-stimulated kinase activity and uptake of 2-deoxyglucose. Cell (1986) 8.87
Cell-specific expression controlled by the 5'-flanking region of insulin and chymotrypsin genes. Nature (1984) 8.65
Cell-specific expression of the rat insulin gene: evidence for role of two distinct 5' flanking elements. Science (1985) 8.44
The highly polymorphic region near the human insulin gene is composed of simple tandemly repeating sequences. Nature (1982) 7.47
Multiple forms of DNA-dependent RNA polymerase in eukaryotic organisms. Nature (1969) 6.98
Specific inhibition of nuclear RNA polymerase II by alpha-amanitin. Science (1970) 6.39
Nucleotide sequence of the gene coding for the major protein of hepatitis B virus surface antigen. Nature (1979) 6.10
Isolation and characterization of a cloned rat insulin gene. Cell (1979) 6.05
Sequence of the human insulin gene. Nature (1980) 5.76
Nucleotide and corresponding amino acid sequences encoded by alpha and beta tubulin mRNAs. Nature (1981) 5.65
Ribosomal RNA genes of Saccharomyces cerevisiae. I. Physical map of the repeating unit and location of the regions coding for 5 S, 5.8 S, 18 S, and 25 S ribosomal RNAs. J Biol Chem (1977) 4.76
Hepatitis B virus gene function: the precore region targets the core antigen to cellular membranes and causes the secretion of the e antigen. Proc Natl Acad Sci U S A (1986) 4.73
Specific nucleolar and nucleoplasmic RNA polymerases. Proc Natl Acad Sci U S A (1970) 4.63
Homology requirements for recombination in Escherichia coli. Proc Natl Acad Sci U S A (1985) 4.46
Vibrio parahaemolyticus infections in the United States, 1973-1998. J Infect Dis (2000) 4.35
Interaction cloning: identification of a helix-loop-helix zipper protein that interacts with c-Fos. Science (1992) 4.17
Ribosomal RNA genes of Saccharomyces cerevisiae. II. Physical map and nucleotide sequence of the 5 S ribosomal RNA gene and adjacent intergenic regions. J Biol Chem (1977) 4.03
A human hepatitis B viral enhancer element. EMBO J (1985) 3.94
Synthesis and assembly of hepatitis B virus surface antigen particles in yeast. Nature (1982) 3.82
Sequence of protein disulphide isomerase and implications of its relationship to thioredoxin. Nature (1985) 3.75
Redesigning trypsin: alteration of substrate specificity. Science (1985) 3.70
Analysis of the regions flanking the human insulin gene and sequence of an Alu family member. Nucleic Acids Res (1980) 3.55
Insulin-like growth factor II receptor as a multifunctional binding protein. Nature (1987) 3.52
Sequence of the human somatostatin I gene. Science (1984) 3.48
Isolation of full-length putative rat lysophospholipase cDNA using improved methods for mRNA isolation and cDNA cloning. Biochemistry (1987) 3.48
Tubulin genes are tandemly linked and clustered in the genome of trypanosoma brucei. Cell (1983) 3.40
Transcription of the hepatitis B surface antigen gene in cultured murine cells initiates within the presurface region. J Virol (1984) 3.30
Primary structure and transcription of an amplified genetic locus: the CUP1 locus of yeast. Proc Natl Acad Sci U S A (1984) 3.28
Synthesis of hepatitis B surface antigen in mammalian cells: expression of the entire gene and the coding region. J Virol (1983) 3.24
Synthesis of hepatitis B surface and core antigens in E. coli. Nature (1981) 3.11
A mutational analysis of the insulin gene transcription control region: expression in beta cells is dependent on two related sequences within the enhancer. Proc Natl Acad Sci U S A (1987) 3.08
An ultrastructural analysis of the developing embryonic pancreas. Dev Biol (1972) 3.00
Replacement of lysine residue 1030 in the putative ATP-binding region of the insulin receptor abolishes insulin- and antibody-stimulated glucose uptake and receptor kinase activity. Proc Natl Acad Sci U S A (1987) 2.99
Structure of a mouse submaxillary messenger RNA encoding epidermal growth factor and seven related proteins. Science (1983) 2.97
Synergistic activation of the insulin gene by a LIM-homeo domain protein and a basic helix-loop-helix protein: building a functional insulin minienhancer complex. Genes Dev (1992) 2.86
A signal peptide encoded within the precore region of hepatitis B virus directs the secretion of a heterogeneous population of e antigens in Xenopus oocytes. Proc Natl Acad Sci U S A (1988) 2.84
Transcription of hepatitis B virus by RNA polymerase II. Mol Cell Biol (1983) 2.81
Integration of hepatitis B virus sequences and their expression in a human hepatoma cell. Nature (1980) 2.74
Alpha-factor-directed synthesis and secretion of mature foreign proteins in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1984) 2.74
Toward molecular mechanisms of developmental processes. Annu Rev Biochem (1973) 2.66
Regulation of rat insulin 1 gene expression: evidence for negative regulation in nonpancreatic cells. Proc Natl Acad Sci U S A (1986) 2.57
Splice junctions: association with variation in protein structure. Science (1983) 2.54
The role of Gulf Coast oysters harvested in warmer months in Vibrio vulnificus infections in the United States, 1988-1996. Vibrio Working Group. J Infect Dis (1998) 2.46
Pan: a transcriptional regulator that binds chymotrypsin, insulin, and AP-4 enhancer motifs. Genes Dev (1990) 2.46
Cryptosporidiosis in hospital patients with gastroenteritis. Am J Trop Med Hyg (1983) 2.45
Cloning, sequencing, and chromosomal localization of human term placental alkaline phosphatase cDNA. Proc Natl Acad Sci U S A (1985) 2.44
The changing epidemiology of salmonella: trends in serotypes isolated from humans in the United States, 1987-1997. J Infect Dis (2001) 2.42
Isolation and nucleotide sequence of a cDNA encoding the precursor of mouse nerve growth factor. Nature (1983) 2.41
Targeting of the hepatitis B virus precore protein to the endoplasmic reticulum membrane: after signal peptide cleavage translocation can be aborted and the product released into the cytoplasm. J Cell Biol (1988) 2.41
Selective regulation of integrin--cytoskeleton interactions by the tyrosine kinase Src. Nat Cell Biol (1999) 2.41
Converting trypsin to chymotrypsin: the role of surface loops. Science (1992) 2.40
Structure and processing of yeast precursor tRNAs containing intervening sequences. Nature (1978) 2.31
Assembly of viral particles in Xenopus oocytes: pre-surface-antigens regulate secretion of the hepatitis B viral surface envelope particle. Proc Natl Acad Sci U S A (1986) 2.28
Structure of two related rat pancreatic trypsin genes. J Biol Chem (1984) 2.24
The subunit structure of mammalian fructose diphosphate aldolase. Biochemistry (1967) 2.24
Structure of a family of rat amylase genes. Nature (1980) 2.19
The minisatellite in the diabetes susceptibility locus IDDM2 regulates insulin transcription. Nat Genet (1995) 2.17
Nucleotide sequence of the yeast 5S ribosomal RNA gene and adjacent putative control regions. Nature (1977) 2.15
Systematic binding analysis of the insulin gene transcription control region: insulin and immunoglobulin enhancers utilize similar transactivators. Mol Cell Biol (1988) 2.13
Cloning and sequence analysis of cDNAs encoding two distinct somatostatin precursors found in the endocrine pancreas of anglerfish. Nature (1980) 2.11
Transactivation by hepatitis B virus X protein is promiscuous and dependent on mitogen-activated cellular serine/threonine kinases. Proc Natl Acad Sci U S A (1993) 2.06
Two related helix-loop-helix proteins participate in separate cell-specific complexes that bind the insulin enhancer. Mol Endocrinol (1991) 2.03
The insulin gene is located on chromosome 11 in humans. Nature (1980) 2.03
Cell-specific enhancers in the rat exocrine pancreas. Proc Natl Acad Sci U S A (1986) 2.02
The insulin gene is located on the short arm of chromosome 11 in humans. Diabetes (1981) 2.00
Leukocyte and fibroblast interferon genes are located on human chromosome 9. Proc Natl Acad Sci U S A (1981) 1.98
The insulin and islet amyloid polypeptide genes contain similar cell-specific promoter elements that bind identical beta-cell nuclear complexes. Mol Cell Biol (1992) 1.97
Onset of cell-specific gene expression in the developing mouse pancreas. Proc Natl Acad Sci U S A (1992) 1.96
Hepatitis B viral DNA in liver and serum of asymptomatic carriers. Proc Natl Acad Sci U S A (1982) 1.96
Comparison of the nucleic acid sequence of anglerfish and mammalian insulin mRNA's from cloned cDNA's. Science (1980) 1.92
Changes in the frequency of specific transcripts during development of the pancreas. J Biol Chem (1977) 1.90
Overexpression of the human insulinlike growth factor I receptor promotes ligand-dependent neoplastic transformation. Mol Cell Biol (1990) 1.90
Lineage-specific morphogenesis in the developing pancreas: role of mesenchymal factors. Development (1996) 1.89
The catalytic role of the active site aspartic acid in serine proteases. Science (1987) 1.88
Isolation of yeast tRNALeu genes. DNA sequence of a cloned tRNALeu3 gene. J Biol Chem (1979) 1.88
Multiple forms of fructose diphosphate aldolase in mammalian tissues. Proc Natl Acad Sci U S A (1966) 1.88
The three-dimensional structure of Asn102 mutant of trypsin: role of Asp102 in serine protease catalysis. Science (1987) 1.87
Genes for growth hormone, chorionic somatommammotropin, and growth hormones-like gene on chromosome 17 in humans. Science (1980) 1.85
Expression and characterization of a functional human insulin-like growth factor I receptor. J Biol Chem (1988) 1.83
Hxt encodes a basic helix-loop-helix transcription factor that regulates trophoblast cell development. Development (1995) 1.82
Regulation of insulin gene expression by glucose and calcium in transfected primary islet cultures. J Biol Chem (1990) 1.81