Published in Science on May 08, 1987
An alternative approach to somatic cell gene therapy. Proc Natl Acad Sci U S A (1988) 1.81
Expression of vascular endothelial growth factor does not promote transformation but confers a growth advantage in vivo to Chinese hamster ovary cells. J Clin Invest (1993) 1.42
Prevention of adoptively transferred diabetes in nonobese diabetic mice with IL-10-transduced islet-specific Th1 lymphocytes. A gene therapy model for autoimmune diabetes. J Clin Invest (1996) 0.97
Long-term production and delivery of human growth hormone in vivo. Proc Natl Acad Sci U S A (1994) 0.95
Surgical implantation of a bioengineered internal anal sphincter. J Pediatr Surg (2010) 0.92
Targeting transforming growth factor alpha expression to discrete loci of the neuroendocrine brain induces female sexual precocity. Proc Natl Acad Sci U S A (1997) 0.83
Cellular transplants. Transplant Proc (1991) 0.82
Adaptation to supraphysiologic levels of insulin gene expression in transgenic mice: evidence for the importance of posttranscriptional regulation. J Clin Invest (1993) 0.77
Cellular transplantation and gene therapy. Clin Transplant (1993) 0.75
High resolution two-dimensional electrophoresis of basic as well as acidic proteins. Cell (1977) 30.04
Analysis of endonuclease R-EcoRI fragments of DNA from lambdoid bacteriophages and other viruses by agarose-gel electrophoresis. J Virol (1974) 23.54
Rat insulin genes: construction of plasmids containing the coding sequences. Science (1977) 17.05
DNA nucleotide sequence restricted by the RI endonuclease. Proc Natl Acad Sci U S A (1972) 15.71
Specificity of substrate recognition by the EcoRI restriction endonuclease. Proc Natl Acad Sci U S A (1975) 11.07
Nucleotide sequence of a mutant eukaryotic gene: the yeast tyrosine-inserting ochre suppressor SUP4-o. Proc Natl Acad Sci U S A (1977) 10.64
Replication and transcription of eukaryotic DNA in Escherichia coli. Proc Natl Acad Sci U S A (1974) 10.51
Nopaline synthase: transcript mapping and DNA sequence. J Mol Appl Genet (1982) 8.73
Isolation of the Arabidopsis ABI3 gene by positional cloning. Plant Cell (1992) 8.36
Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Nature (1999) 8.04
Nucleotide sequence and amplification in bacteria of structural gene for rat growth hormone. Nature (1977) 7.97
Molecular cloning and characterization of avian sarcoma virus circular DNA molecules. J Virol (1980) 7.37
Human growth hormone as a reporter gene in regulation studies employing transient gene expression. Mol Cell Biol (1986) 7.11
Ligation of EcoRI endonuclease-generated DNA fragments into linear and circular structures. J Mol Biol (1975) 6.95
Nucleotide sequence of the gene coding for the major protein of hepatitis B virus surface antigen. Nature (1979) 6.10
Isolation and characterization of a cloned rat insulin gene. Cell (1979) 6.05
Primarily vascularized allografts of hearts in mice. The role of H-2D, H-2K, and non-H-2 antigens in rejection. Transplantation (1973) 6.01
DNA substrate site for the EcoRII restriction endonuclease and modification methylase. Nat New Biol (1973) 5.90
Sequence of the human insulin gene. Nature (1980) 5.76
Studies on heterologous anti-lymphocyte serum in mice. I. In vitro and in vivo properties. J Immunol (1966) 5.59
Synthetic lac operator DNA is functional in vivo. Nature (1976) 5.36
Nucleotide sequence of an avian sarcoma virus oncogene (src) and proposed amino acid sequence for gene product. Nature (1980) 5.22
Effects of ionizing radiation on a plant genome: analysis of two Arabidopsis transparent testa mutations. Plant Cell (1992) 5.16
Nucleotide sequences at the cleavage sites of two restriction endonucleases from Hemophilus parainfluenzae. Biochem Biophys Res Commun (1974) 5.14
Transplantation of small bowel in the rat: technical and immunological considerations. Surgery (1971) 5.05
The Arabidopsis abscisic acid response locus ABI4 encodes an APETALA 2 domain protein. Plant Cell (1998) 4.92
Analysis of Arabidopsis mutants deficient in flavonoid biosynthesis. Plant J (1995) 4.87
Isolation of the Arabidopsis GA4 locus. Plant Cell (1995) 4.86
A cyclic AMP- and phorbol ester-inducible DNA element. Nature (1986) 4.60
Physical identity of the SV40 deoxyribonucleic acid sequence recognized by the Eco RI restriction endonuclease and modification methylase. Biochemistry (1974) 4.58
Molecular cloning and sequence analysis of adult chicken betal globin cDNA. Nucleic Acids Res (1979) 4.49
Studies on heterologous anti-lymphocyte serum in mice. II. Effect on the immune response. J Immunol (1966) 4.49
Tumor DNA structure in plant cells transformed by A. tumefaciens. Science (1980) 4.36
Restriction and modification of a self-complementary octanucleotide containing the EcoRI substrate. J Mol Biol (1975) 4.21
Human growth hormone DNA sequence and mRNA structure: possible alternative splicing. Nucleic Acids Res (1981) 4.03
Transcription of DNA from the 70S RNA of Rous sarcoma virus. I. Identification of a specific 4S RNA which serves as primer. J Virol (1974) 3.90
Cloning and sequence of two different cDNAs encoding 1-aminocyclopropane-1-carboxylate synthase in tomato. Proc Natl Acad Sci U S A (1990) 3.85
Human growth hormone: complementary DNA cloning and expression in bacteria. Science (1979) 3.67
Use of monoclonal antibodies to T-cell subsets for immunologic monitoring and treatment in recipients of renal allografts. N Engl J Med (1981) 3.63
Cloning of hormone genes from a mixture of cDNA molecules. Methods Enzymol (1979) 3.62
CpG methylation inhibits proenkephalin gene expression and binding of the transcription factor AP-2. Nucleic Acids Res (1990) 3.46
RNA-directed DNA polymerase of Rous sarcoma virus: initiation of synthesis with 70 S viral RNA as template. J Mol Biol (1973) 3.32
Tumor induction by Agrobacterium tumefaciens: analysis of the boundaries of T-DNA. J Mol Appl Genet (1982) 3.28
Characterization of the low-molecular-weight RNAs associated with the 70S RNA of Rous sarcoma virus. J Virol (1973) 3.19
The nucleotide sequence of an untranslated but conserved domain at the 3' end of the avian sarcoma virus genome. Nucleic Acids Res (1980) 3.16
Construction and analysis of recombinant DNA for human chorionic somatomammotropin. Nature (1977) 3.13
Synthesis of hepatitis B surface and core antigens in E. coli. Nature (1981) 3.11
Amber suppression: a nucleotide change in the anticodon of a tyrosine transfer RNA. Nature (1968) 2.98
Molecular cloning of the avian myelocytomatosis virus genome and recovery of infectious virus by transfection of chicken cells. J Virol (1981) 2.95
Transcription of DNA from the 70S RNA of Rous sarcoma virus. II. Structure of a 4S RNA primer. J Virol (1974) 2.73
DNA sequence of the rat growth hormone gene: location of the 5' terminus of the growth hormone mRNA and identification of an internal transposon-like element. Nucleic Acids Res (1981) 2.67
Nucleotide sequence at the 5' terminus of the avian sarcoma virus genome. Proc Natl Acad Sci U S A (1977) 2.66
Map-based cloning of a gene controlling omega-3 fatty acid desaturation in Arabidopsis. Science (1992) 2.59
Structure and function of phage RNA. Annu Rev Biochem (1973) 2.50
The gene encoding the common alpha subunit of the four human glycoprotein hormones. J Mol Appl Genet (1981) 2.48
Regulation of growth hormone messenger RNA by thyroid and glucocorticoid hormones. Proc Natl Acad Sci U S A (1977) 2.47
A new locus (NIA 1) in Arabidopsis thaliana encoding nitrate reductase. EMBO J (1988) 2.46
Adult Thymectomy: Effect on Recovery from Immunologic Depression in Mice. Science (1965) 2.41
The Arabidopsis photomorphogenic mutant hy1 is deficient in phytochrome chromophore biosynthesis as a result of a mutation in a plastid heme oxygenase. Plant Cell (1999) 2.38
Resolution of simian virus 40 proteins in whole cell extracts by two-dimensional electrophoresis: heterogeneity of the major capsid protein. Cell (1976) 2.37
Isolation, cloning and sequence analysis of the cDNA for the alpha-subunit of human chorionic gonadotropin. Nature (1979) 2.36
Widespread and selective induction of major histocompatibility complex-determined antigens in vivo by gamma interferon. J Exp Med (1985) 2.34
Structure and processing of yeast precursor tRNAs containing intervening sequences. Nature (1978) 2.31
Nucleotide sequence that binds primer for DNA synthesis to the avian sarcoma virus genome. J Virol (1976) 2.28
Treatment of acute renal allograft rejection with OKT3 monoclonal antibody. Transplantation (1981) 2.22
Identification and map position of YAC clones comprising one-third of the Arabidopsis genome. Plant J (1991) 2.17
The immunologic response to xenografts. Recognition of mouse H-2 histocompatibility antigens by the rat. J Immunol (1971) 2.17
Cloning and nitrate induction of nitrate reductase mRNA. Proc Natl Acad Sci U S A (1986) 2.17
A novel pathway of chronic allograft rejection mediated by NK cells and alloantibody. Am J Transplant (2011) 2.16
Characterization of DNA complementary to nucleotide sequences at the 5'-terminus of the avian sarcoma virus genome. Virology (1977) 2.16
Proteins bound at adjacent DNA elements act synergistically to regulate human proenkephalin cAMP inducible transcription. EMBO J (1988) 2.15
Interaction of bacteriophage T4 RNA and DNA ligases in joining of duplex DNA at base-paired ends. J Biol Chem (1977) 2.13
The nucleotide sequences of tyrosine transfer RNAs of Escherichia coli. Eur J Biochem (1970) 2.13
The cDNA for the beta-subunit of human chorionic gonadotropin suggests evolution of a gene by readthrough into the 3'-untranslated region. Nature (1980) 2.12
Tumor virus ribonucleic acid directed deoxyribonucleic acid synthesis: nucleotide sequence at the 5' terminus of nascent deoxyribonucleic acid. Biochemistry (1974) 2.06
The first intron of the human growth hormone gene contains a binding site for glucocorticoid receptor. Proc Natl Acad Sci U S A (1985) 2.03
The structures and fidelity of replication of mouse mitochondrial DNA-pSC 101 EcoRI recombinant plasmids grown in E. coli K12. Cell (1976) 2.02
Nonviral transfer of the gene encoding coagulation factor VIII in patients with severe hemophilia A. N Engl J Med (2001) 2.01
Infusion of alpha-galactosidase A reduces tissue globotriaosylceramide storage in patients with Fabry disease. Proc Natl Acad Sci U S A (2000) 2.00
Heart transplantation in congenic strains of mice. Transplant Proc (1973) 1.97
Plant enolase: gene structure, expression, and evolution. Plant Cell (1991) 1.97
The Arabidopsis splicing factor SR1 is regulated by alternative splicing. Plant Mol Biol (2000) 1.96
Kidney transplants in mice. An analysis of the immune status of mice bearing long-term, H-2 incompatible transplants. J Exp Med (1978) 1.95
Evidence in favor of the symbiotic origin of chloroplasts: primary structure and evolution of tobacco glyceraldehyde-3-phosphate dehydrogenases. Cell (1986) 1.93
Reaction of human lymphocytes in culture to components of the medium. Nature (1965) 1.92
Intron existence predated the divergence of eukaryotes and prokaryotes. Science (1988) 1.89
Differential expression of the two Arabidopsis nitrate reductase genes. Plant Physiol (1991) 1.88
Sequence of the first 175 nucleotides from the 5' terminus of Qbeta RNA synthesized in vitro. Nature (1969) 1.84
Identification of common cystic fibrosis mutations in African-Americans with cystic fibrosis increases the detection rate to 75%. Am J Hum Genet (1997) 1.84
Specific hybridization of tyrosine transfer ribonucleic acids with DNA from a transducing bacteriophage phi-80 carrying the amber suppressor gene su 3. J Mol Biol (1967) 1.84
Controlled clinical trial of prophylactic human-leukocyte interferon in renal transplantation. Effects on cytomegalovirus and herpes simplex virus infections. N Engl J Med (1979) 1.83
Herbicide-resistant alfalfa cells: an example of gene amplification in plants. J Mol Appl Genet (1984) 1.82
Cloning and chromosomal mapping of nuclear genes encoding chloroplast and cytosolic glyceraldehyde-3-phosphate-dehydrogenase from Arabidopsis thaliana. Gene (1991) 1.82
Antiserum to lymphocytes: prolonged survival of canine renal allografts. Science (1966) 1.81
Nucleotide sequence of part of the gene for human chorionic somatomammotropin: purification of DNA complementary to predominant mRNA species. Cell (1977) 1.81
Human mitochondrial DNA: analysis of 7S DNA from the origin of replication. Proc Natl Acad Sci U S A (1978) 1.80
The glutamine synthetase gene family of Arabidopsis thaliana: light-regulation and differential expression in leaves, roots and seeds. Mol Gen Genet (1991) 1.80