Transforming growth factor-beta: biological function and chemical structure.

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Published in Science on August 01, 1986

Authors

M B Sporn, A B Roberts, L M Wakefield, R K Assoian

Articles citing this

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Some recent advances in the chemistry and biology of transforming growth factor-beta. J Cell Biol (1987) 5.25

Suppressor T cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of transforming growth factor beta after antigen-specific triggering. Proc Natl Acad Sci U S A (1992) 4.94

Transforming growth factor beta modulates the expression of collagenase and metalloproteinase inhibitor. EMBO J (1987) 4.56

Role of transforming growth factor-beta in the development of the mouse embryo. J Cell Biol (1987) 3.48

Transforming growth factor beta specifically enhances IgA production by lipopolysaccharide-stimulated murine B lymphocytes. J Exp Med (1989) 3.06

Inhibition of cytotoxic T cell development by transforming growth factor beta and reversal by recombinant tumor necrosis factor alpha. J Exp Med (1987) 3.03

Tumor reversion: correction of malignant behavior by microenvironmental cues. Int J Cancer (2003) 3.02

Distribution and modulation of the cellular receptor for transforming growth factor-beta. J Cell Biol (1987) 2.87

Innate immunity to Mycobacterium tuberculosis. Clin Microbiol Rev (2002) 2.79

Transforming growth factor beta increases mRNA for matrix proteins both in the presence and in the absence of changes in mRNA stability. Proc Natl Acad Sci U S A (1988) 2.73

Involvement of endogenous tumor necrosis factor alpha and transforming growth factor beta during induction of collagen type II arthritis in mice. Proc Natl Acad Sci U S A (1992) 2.73

Elevated expression of transforming growth factor-beta and proteoglycan production in experimental glomerulonephritis. Possible role in expansion of the mesangial extracellular matrix. J Clin Invest (1990) 2.56

Inhibitory action of transforming growth factor beta on endothelial cells. Proc Natl Acad Sci U S A (1987) 2.50

In vitro and in vivo association of transforming growth factor-beta 1 with hepatic fibrosis. J Cell Biol (1989) 2.47

Annexin II regulates fibrin homeostasis and neoangiogenesis in vivo. J Clin Invest (2004) 2.45

Phenotypic modulation of endothelial cells by transforming growth factor-beta depends upon the composition and organization of the extracellular matrix. J Cell Biol (1988) 2.41

Type 1 transforming growth factor beta: amplified expression and secretion of mature and precursor polypeptides in Chinese hamster ovary cells. Mol Cell Biol (1987) 2.26

Molecular events in the processing of recombinant type 1 pre-pro-transforming growth factor beta to the mature polypeptide. Mol Cell Biol (1988) 2.24

Transforming growth factor beta (TGF beta) causes a persistent increase in steady-state amounts of type I and type III collagen and fibronectin mRNAs in normal human dermal fibroblasts. Biochem J (1987) 2.23

Complementary DNA for human glioblastoma-derived T cell suppressor factor, a novel member of the transforming growth factor-beta gene family. EMBO J (1987) 2.23

Effect of antibody to transforming growth factor beta on bleomycin induced accumulation of lung collagen in mice. Thorax (1993) 2.21

A new type of transforming growth factor-beta, TGF-beta 3. EMBO J (1988) 2.12

Transforming growth factor beta induces IgA production and acts additively with interleukin 5 for IgA production. J Exp Med (1989) 2.12

In vitro angiogenesis on the human amniotic membrane: requirement for basic fibroblast growth factor-induced proteinases. J Cell Biol (1989) 2.05

Growth factors in wound healing. Single and synergistic effects on partial thickness porcine skin wounds. J Clin Invest (1989) 2.04

Osteoblasts synthesize and respond to transforming growth factor-type beta (TGF-beta) in vitro. J Cell Biol (1987) 2.01

Transforming growth factor-beta is a strong and fast acting positive regulator of the level of type-1 plasminogen activator inhibitor mRNA in WI-38 human lung fibroblasts. EMBO J (1987) 1.98

Roles of autocrine TGF-beta receptor and Smad signaling in adipocyte differentiation. J Cell Biol (2000) 1.94

Characterization of the human B cell stimulatory factor 1 receptor. J Exp Med (1987) 1.92

Expression of transforming growth factor-beta 1 is increased in human vascular restenosis lesions. J Clin Invest (1992) 1.82

Transforming growth factor-beta-induced growth inhibition and cellular hypertrophy in cultured vascular smooth muscle cells. J Cell Biol (1988) 1.73

Enhanced jun gene expression is an early genomic response to transforming growth factor beta stimulation. Mol Cell Biol (1989) 1.70

Effects of growth factors in vivo. I. Cell ingrowth into porous subcutaneous chambers. Am J Pathol (1987) 1.67

Isolation of osteogenin, an extracellular matrix-associated, bone-inductive protein, by heparin affinity chromatography. Proc Natl Acad Sci U S A (1987) 1.66

In vivo incisional wound healing augmented by platelet-derived growth factor and recombinant c-sis gene homodimeric proteins. J Exp Med (1988) 1.64

Coordinate regulation of transforming growth factor beta gene expression and cell proliferation in hamster lungs undergoing bleomycin-induced pulmonary fibrosis. J Clin Invest (1989) 1.62

Regulation of fibronectin biosynthesis by dexamethasone, transforming growth factor beta, and cAMP in human cell lines. J Cell Biol (1988) 1.61

T cell suppressor factor from human glioblastoma cells is a 12.5-kd protein closely related to transforming growth factor-beta. EMBO J (1987) 1.59

Transforming growth factors beta 1 and beta 2 are differentially expressed in fibrotic liver disease. Am J Pathol (1991) 1.55

Injury induces in vivo expression of platelet-derived growth factor (PDGF) and PDGF receptor mRNAs in skin epithelial cells and PDGF mRNA in connective tissue fibroblasts. Proc Natl Acad Sci U S A (1991) 1.48

Beta-type transforming growth factor specifies organizational behavior in vascular smooth muscle cell cultures. J Cell Biol (1987) 1.48

Identification of tgh-2, a filarial nematode homolog of Caenorhabditis elegans daf-7 and human transforming growth factor beta, expressed in microfilarial and adult stages of Brugia malayi. Infect Immun (2000) 1.46

Gonadal and extragonadal expression of inhibin alpha, beta A, and beta B subunits in various tissues predicts diverse functions. Proc Natl Acad Sci U S A (1988) 1.40

Beta transforming growth factors are potential regulators of B lymphopoiesis. J Exp Med (1987) 1.39

Cyclosporin A inhibits smooth muscle proliferation in the vascular response to injury. Proc Natl Acad Sci U S A (1988) 1.38

Basic fibroblast growth factor in atria and ventricles of the vertebrate heart. J Cell Biol (1989) 1.36

Role of PDGF-A expression in the control of vascular smooth muscle cell growth by transforming growth factor-beta. J Cell Biol (1990) 1.35

Modulation of JE/MCP-1 expression in dermal wound repair. Am J Pathol (1995) 1.33

Vascular remodeling in primary pulmonary hypertension. Potential role for transforming growth factor-beta. Am J Pathol (1994) 1.32

Molecular characterization of germ-line immunoglobulin A transcripts produced during transforming growth factor type beta-induced isotype switching. Proc Natl Acad Sci U S A (1990) 1.31

Eradication of established intracranial rat gliomas by transforming growth factor beta antisense gene therapy. Proc Natl Acad Sci U S A (1996) 1.30

Modulation of keratinocyte motility. Correlation with production of extracellular matrix molecules in response to growth promoting and antiproliferative factors. Am J Pathol (1988) 1.29

Differential effects of transforming growth factor-beta on the synthesis of extracellular matrix proteins by normal fetal rat calvarial bone cell populations. J Cell Biol (1988) 1.29

Immunoregulatory role of transforming growth factor beta (TGF-beta) in development of killer cells: comparison of active and latent TGF-beta 1. J Exp Med (1990) 1.28

Release of interleukin 1 inhibitory activity (contra-IL-1) by human monocyte-derived macrophages infected with human immunodeficiency virus in vitro and in vivo. J Clin Invest (1988) 1.26

Transforming growth factor beta 1 selectively regulates early murine hematopoietic progenitors and inhibits the growth of IL-3-dependent myeloid leukemia cell lines. J Exp Med (1988) 1.24

Transforming growth factor beta 1 regulates production of acute-phase proteins. Proc Natl Acad Sci U S A (1990) 1.23

Drosophila 60A gene, another transforming growth factor beta family member, is closely related to human bone morphogenetic proteins. Proc Natl Acad Sci U S A (1991) 1.22

Stimulation of rat endothelial cell transforming growth factor-beta production by bleomycin. J Clin Invest (1991) 1.22

Transforming growth factor-beta production in anti-glomerular basement membrane disease in the rabbit. Am J Pathol (1991) 1.21

The coxsackievirus A9 RGD motif is not essential for virus viability. J Virol (1995) 1.20

Transforming growth factor beta inhibits formation of osteoclast-like cells in long-term human marrow cultures. Proc Natl Acad Sci U S A (1988) 1.20

Extracellular fibrillar structure of latent TGF beta binding protein-1: role in TGF beta-dependent endothelial-mesenchymal transformation during endocardial cushion tissue formation in mouse embryonic heart. J Cell Biol (1997) 1.18

Arginine metabolism by macrophages promotes cardiac and muscle fibrosis in mdx muscular dystrophy. PLoS One (2010) 1.16

The increase in bladder carcinoma cell population induced by the free beta subunit of human chorionic gonadotrophin is a result of an anti-apoptosis effect and not cell proliferation. Br J Cancer (2000) 1.15

Phase I trial of "bi-shRNAi(furin)/GMCSF DNA/autologous tumor cell" vaccine (FANG) in advanced cancer. Mol Ther (2011) 1.15

Regulation of mesangial cell growth by polypeptide mitogens. Inhibitory role of transforming growth factor beta. Am J Pathol (1989) 1.14

Nonthermal effects of therapeutic ultrasound: the frequency resonance hypothesis. J Athl Train (2002) 1.13

Transforming growth factor-beta regulates in vitro heart valve repair by activated valve interstitial cells. Am J Pathol (2008) 1.13

Biochemical characterization of the Drosophila dpp protein, a member of the transforming growth factor beta family of growth factors. Mol Cell Biol (1990) 1.12

Active multilayered capsules for in vivo bone formation. Proc Natl Acad Sci U S A (2010) 1.11

Activation of protein breakdown and prostaglandin E2 production in rat skeletal muscle in fever is signaled by a macrophage product distinct from interleukin 1 or other known monokines. J Clin Invest (1988) 1.10

A first or dominant immunization. II. Induced immunoglobulin carries transforming growth factor beta and suppresses cytolytic T cell responses to unrelated alloantigens. J Exp Med (1993) 1.07

Periostin promotes a fibroblastic lineage pathway in atrioventricular valve progenitor cells. Dev Dyn (2009) 1.07

Transforming growth factor beta inhibits bone resorption in fetal rat long bone cultures. J Clin Invest (1988) 1.06

Type II transforming growth factor-beta receptor recycling is dependent upon the clathrin adaptor protein Dab2. Mol Biol Cell (2010) 1.06

Extraction and purification of TGFbeta and its effect on the induction of apoptosis of hepatocytes. World J Gastroenterol (2001) 1.05

Macrophage production of basic fibroblast growth factor in the fibroproliferative disorder of alveolar fibrosis after lung injury. Am J Pathol (1993) 1.01

L-428 nodular sclerosing Hodgkin's cell secretes a unique transforming growth factor-beta active at physiologic pH. J Clin Invest (1988) 1.01

Transforming growth factor-beta 1 is decreased in remodeling hypertensive bovine pulmonary arteries. J Clin Invest (1992) 1.01

Intranasal delivery of transforming growth factor-beta1 in mice after stroke reduces infarct volume and increases neurogenesis in the subventricular zone. BMC Neurosci (2008) 1.00

Interleukin 10 inhibits transforming growth factor-beta (TGF-beta) synthesis required for osteogenic commitment of mouse bone marrow cells. J Cell Biol (1994) 0.99

Reduced growth-factor requirement of keloid-derived fibroblasts may account for tumor growth. Proc Natl Acad Sci U S A (1988) 0.98

Molecular analysis of chemical carcinogenesis in the skin. Br J Cancer Suppl (1988) 0.98

Multistep process of squamous differentiation in tracheobronchial epithelial cells in vitro: analogy with epidermal differentiation. Environ Health Perspect (1989) 0.97

Altered structure of the hybrid cell surface proteoglycan of mammary epithelial cells in response to transforming growth factor-beta. J Cell Biol (1988) 0.96

Role of endothelial to mesenchymal transition in the pathogenesis of the vascular alterations in systemic sclerosis. ISRN Rheumatol (2013) 0.95

Tumour necrosis factor-alpha and transforming growth factor-beta are significantly associated with better prognosis in non-small cell lung carcinoma: putative relation with BCL-2-mediated neovascularization. Br J Cancer (2000) 0.94

Persistence of a reduced-collagen-producing phenotype in cultured scleroderma fibroblasts after short-term exposure to interferons. J Clin Invest (1987) 0.94

Purification and biochemical properties of a human monocyte-derived growth factor. Proc Natl Acad Sci U S A (1988) 0.94

Therapeutic effect of clarithromycin on a transplanted tumor in rats. Antimicrob Agents Chemother (1999) 0.91

Pilot Trial of FANG Immunotherapy in Ewing's Sarcoma. Mol Ther (2015) 0.91

TGF-beta 1 induces phosphorylation of the cyclic AMP responsive element binding protein in ML-CCl64 cells. EMBO J (1991) 0.90

Fibroblast growth factor enhances type beta 1 transforming growth factor gene expression in osteoblast-like cells. J Cell Biol (1989) 0.89

A purpose-synthesised anti-fibrotic agent attenuates experimental kidney diseases in the rat. PLoS One (2012) 0.88

Regulation of adhesion and growth of fibrosarcoma cells by NF-kappa B RelA involves transforming growth factor beta. Mol Cell Biol (1994) 0.88

Spontaneous production of transforming growth factor-beta 2 by primary cultures of bronchial epithelial cells. Effects on cell behavior in vitro. J Clin Invest (1992) 0.88

Targeting the immune system in non-small-cell lung cancer: bridging the gap between promising concept and therapeutic reality. Clin Lung Cancer (2010) 0.88

Application of autologous derived-platelet rich plasma gel in the treatment of chronic wound ulcer: diabetic foot ulcer. J Extra Corpor Technol (2010) 0.87

Changes in serum cytokine concentration: a morphological study of liver cirrhosis induced by common bile duct ligation in rats. Korean J Intern Med (2003) 0.85

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Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro. Proc Natl Acad Sci U S A (1986) 12.14

Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death. Proc Natl Acad Sci U S A (1993) 10.82

Human transforming growth factor-beta complementary DNA sequence and expression in normal and transformed cells. Nature (1985) 10.13

Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth. J Exp Med (1986) 9.86

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Expression and secretion of type beta transforming growth factor by activated human macrophages. Proc Natl Acad Sci U S A (1987) 6.76

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Type beta transforming growth factor: a bifunctional regulator of cellular growth. Proc Natl Acad Sci U S A (1985) 5.93

New class of transforming growth factors potentiated by epidermal growth factor: isolation from non-neoplastic tissues. Proc Natl Acad Sci U S A (1981) 5.89

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Human transforming growth factor-alpha: precursor structure and expression in E. coli. Cell (1984) 5.39

Some recent advances in the chemistry and biology of transforming growth factor-beta. J Cell Biol (1987) 5.25

Transforming growth factor beta is an important immunomodulatory protein for human B lymphocytes. J Immunol (1986) 5.19

Suppressor T cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of transforming growth factor beta after antigen-specific triggering. Proc Natl Acad Sci U S A (1992) 4.94

The mammary pathology of genetically engineered mice: the consensus report and recommendations from the Annapolis meeting. Oncogene (2000) 4.90

Suppression of experimental glomerulonephritis by antiserum against transforming growth factor beta 1. Nature (1990) 4.64

Can dietary beta-carotene materially reduce human cancer rates? Nature (1981) 4.43

Characterization of a membrane receptor for transforming growth factor-beta in normal rat kidney fibroblasts. J Biol Chem (1984) 4.20

Randomized trial of fenretinide to prevent second breast malignancy in women with early breast cancer. J Natl Cancer Inst (1999) 4.04

Accelerated healing of incisional wounds in rats induced by transforming growth factor-beta. Science (1987) 4.03

Latent transforming growth factor-beta from human platelets. A high molecular weight complex containing precursor sequences. J Biol Chem (1988) 3.91

Type beta transforming growth factor in human platelets: release during platelet degranulation and action on vascular smooth muscle cells. J Cell Biol (1986) 3.77

A nuclear factor 1 binding site mediates the transcriptional activation of a type I collagen promoter by transforming growth factor-beta. Cell (1988) 3.72

Role of transforming growth factor-beta signaling in cancer. J Natl Cancer Inst (2000) 3.63

Timing of cyclin D1 expression within G1 phase is controlled by Rho. Nat Cell Biol (2001) 3.63

Immunodetection and quantitation of the two forms of transforming growth factor-beta (TGF-beta 1 and TGF-beta 2) secreted by cells in culture. J Cell Physiol (1989) 3.58

Transforming growth factor-beta 1: histochemical localization with antibodies to different epitopes. J Cell Biol (1989) 3.55

Purification and initial characterization of a type beta transforming growth factor from human placenta. Proc Natl Acad Sci U S A (1983) 3.52

Polypeptide transforming growth factors isolated from bovine sources and used for wound healing in vivo. Science (1983) 3.51

Purification and properties of a type beta transforming growth factor from bovine kidney. Biochemistry (1983) 3.49

Role of transforming growth factor-beta in the development of the mouse embryo. J Cell Biol (1987) 3.48

Evidence that transforming growth factor-beta is a hormonally regulated negative growth factor in human breast cancer cells. Cell (1987) 3.45

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Hepatic expression of mature transforming growth factor beta 1 in transgenic mice results in multiple tissue lesions. Proc Natl Acad Sci U S A (1995) 3.25

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Transforming growth factor-beta: recent progress and new challenges. J Cell Biol (1992) 3.18

Transforming growth factor beta 1 positively regulates its own expression in normal and transformed cells. J Biol Chem (1988) 3.13

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