Published in Proc Natl Acad Sci U S A on October 01, 1986
Life cycle of the budding yeast Saccharomyces cerevisiae. Microbiol Rev (1988) 4.55
Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1. EMBO J (1994) 4.37
Identification and regulation of a gene required for cell fusion during mating of the yeast Saccharomyces cerevisiae. Mol Cell Biol (1987) 4.17
The protein kinase homologue Ste20p is required to link the yeast pheromone response G-protein beta gamma subunits to downstream signalling components. EMBO J (1992) 3.91
MKK1 and MKK2, which encode Saccharomyces cerevisiae mitogen-activated protein kinase-kinase homologs, function in the pathway mediated by protein kinase C. Mol Cell Biol (1993) 3.54
A yeast mitogen-activated protein kinase homolog (Mpk1p) mediates signalling by protein kinase C. Mol Cell Biol (1993) 3.47
The yeast STE12 protein binds to the DNA sequence mediating pheromone induction. Proc Natl Acad Sci U S A (1989) 3.01
Protein-protein interactions in the yeast pheromone response pathway: Ste5p interacts with all members of the MAP kinase cascade. Genetics (1994) 2.83
FUS3 phosphorylates multiple components of the mating signal transduction cascade: evidence for STE12 and FAR1. Mol Biol Cell (1993) 2.82
Activation of MEK family kinases requires phosphorylation of two conserved Ser/Thr residues. EMBO J (1994) 2.76
Signaling in the yeast pheromone response pathway: specific and high-affinity interaction of the mitogen-activated protein (MAP) kinases Kss1 and Fus3 with the upstream MAP kinase kinase Ste7. Mol Cell Biol (1996) 2.57
A dominant truncation allele identifies a gene, STE20, that encodes a putative protein kinase necessary for mating in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1993) 2.48
Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinase. Mol Cell Biol (1991) 2.47
Functional homology of protein kinases required for sexual differentiation in Schizosaccharomyces pombe and Saccharomyces cerevisiae suggests a conserved signal transduction module in eukaryotic organisms. Mol Biol Cell (1993) 2.09
Pheromone-induced signal transduction in Saccharomyces cerevisiae requires the sequential function of three protein kinases. Mol Cell Biol (1993) 2.03
Xenopus MAP kinase activator is a serine/threonine/tyrosine kinase activated by threonine phosphorylation. EMBO J (1992) 1.98
Purification of a murine protein-tyrosine/threonine kinase that phosphorylates and activates the Erk-1 gene product: relationship to the fission yeast byr1 gene product. Proc Natl Acad Sci U S A (1992) 1.97
Pheromone response elements are necessary and sufficient for basal and pheromone-induced transcription of the FUS1 gene of Saccharomyces cerevisiae. Mol Cell Biol (1991) 1.96
Tumor progression locus 2 (Tpl-2) encodes a protein kinase involved in the progression of rodent T-cell lymphomas and in T-cell activation. Proc Natl Acad Sci U S A (1993) 1.95
cDNA cloning of MAP kinase kinase reveals kinase cascade pathways in yeasts to vertebrates. EMBO J (1993) 1.94
The wis1 protein kinase is a dosage-dependent regulator of mitosis in Schizosaccharomyces pombe. EMBO J (1991) 1.94
Molecular structure of a protein-tyrosine/threonine kinase activating p42 mitogen-activated protein (MAP) kinase: MAP kinase kinase. Proc Natl Acad Sci U S A (1993) 1.92
SIMKK, a mitogen-activated protein kinase (MAPK) kinase, is a specific activator of the salt stress-induced MAPK, SIMK. Plant Cell (2000) 1.91
The Schizosaccharomyces pombe mam2 gene encodes a putative pheromone receptor which has a significant homology with the Saccharomyces cerevisiae Ste2 protein. EMBO J (1991) 1.89
Reconstitution of a yeast protein kinase cascade in vitro: activation of the yeast MEK homologue STE7 by STE11. Proc Natl Acad Sci U S A (1994) 1.82
Phorbol ester stimulates a protein-tyrosine/threonine kinase that phosphorylates and activates the Erk-1 gene product. Proc Natl Acad Sci U S A (1992) 1.81
Identification of a Ty1 regulatory sequence responsive to STE7 and STE12. Mol Cell Biol (1988) 1.76
Yeast Gal11 protein mediates the transcriptional activation signal of two different transacting factors, Gal4 and general regulatory factor I/repressor/activator site binding protein 1/translation upstream factor. Proc Natl Acad Sci U S A (1990) 1.74
Yeast STE7, STE11, and STE12 genes are required for expression of cell-type-specific genes. Mol Cell Biol (1988) 1.73
Complete nucleotide sequence of a gene conferring polymyxin B resistance on yeast: similarity of the predicted polypeptide to protein kinases. Proc Natl Acad Sci U S A (1987) 1.73
MAP kinase pathways: the first twenty years. Biochim Biophys Acta (2006) 1.65
Requirement for the MAP kinase kinase/MAP kinase cascade in Xenopus oocyte maturation. EMBO J (1994) 1.61
A role for autophosphorylation revealed by activated alleles of FUS3, the yeast MAP kinase homolog. Mol Biol Cell (1994) 1.49
Mutational activation of the STE5 gene product bypasses the requirement for G protein beta and gamma subunits in the yeast pheromone response pathway. Mol Cell Biol (1994) 1.46
Dominant negative selection of heterologous genes: isolation of Candida albicans genes that interfere with Saccharomyces cerevisiae mating factor-induced cell cycle arrest. Proc Natl Acad Sci U S A (1992) 1.46
Phosphorylation of FAR1 in response to alpha-factor: a possible requirement for cell-cycle arrest. Mol Biol Cell (1992) 1.45
Mating in Saccharomyces cerevisiae: the role of the pheromone signal transduction pathway in the chemotropic response to pheromone. Genetics (1997) 1.38
Phosphorylation and localization of Kss1, a MAP kinase of the Saccharomyces cerevisiae pheromone response pathway. Mol Biol Cell (1995) 1.36
Mot3, a Zn finger transcription factor that modulates gene expression and attenuates mating pheromone signaling in Saccharomyces cerevisiae. Genetics (1998) 1.36
Genetic relationships between the G protein beta gamma complex, Ste5p, Ste20p and Cdc42p: investigation of effector roles in the yeast pheromone response pathway. Genetics (1996) 1.35
Yeast MEK-dependent signal transduction: response thresholds and parameters affecting fidelity. Mol Cell Biol (1995) 1.30
Biochemical and biological analysis of Mek1 phosphorylation site mutants. Mol Biol Cell (1995) 1.28
CDC36 and CDC39 are negative elements in the signal transduction pathway of yeast. Cell Regul (1990) 1.26
MOT2 encodes a negative regulator of gene expression that affects basal expression of pheromone-responsive genes in Saccharomyces cerevisiae. Mol Cell Biol (1994) 1.23
Two yeast genes that encode unusual protein kinases. Proc Natl Acad Sci U S A (1987) 1.18
Renaturation and partial peptide sequencing of mitogen-activated protein kinase (MAP kinase) activator from rabbit skeletal muscle. Biochem J (1992) 1.13
Inhibition of Ty1 transposition by mating pheromones in Saccharomyces cerevisiae. Mol Cell Biol (1991) 1.10
Functional domains of the yeast STE12 protein, a pheromone-responsive transcriptional activator. Mol Cell Biol (1993) 1.09
Functional coupling of a mammalian somatostatin receptor to the yeast pheromone response pathway. Mol Cell Biol (1995) 1.08
The Aspergillus nidulans MAPK module AnSte11-Ste50-Ste7-Fus3 controls development and secondary metabolism. PLoS Genet (2012) 1.08
Molecular cloning, expression, and characterization of the human mitogen-activated protein kinase p44erk1. Mol Cell Biol (1993) 1.07
Mutations in cell division cycle genes CDC36 and CDC39 activate the Saccharomyces cerevisiae mating pheromone response pathway. Mol Cell Biol (1990) 1.07
Schizosaccharomyces pombe Spk1 is a tyrosine-phosphorylated protein functionally related to Xenopus mitogen-activated protein kinase. Mol Cell Biol (1993) 1.01
Schizosaccharomyces pombe zfs1+ encoding a zinc-finger protein functions in the mating pheromone recognition pathway. Mol Biol Cell (1995) 0.99
Expression, purification and characterization of recombinant mitogen-activated protein kinase kinases. Biochem J (1994) 0.97
Tyrosine phosphorylation of a yeast 40 kDa protein occurs in response to mating pheromone. EMBO J (1991) 0.96
Novel members of the mitogen-activated protein kinase activator family in Xenopus laevis. Mol Cell Biol (1993) 0.92
Networking with mitogen-activated protein kinases. Mol Cell Biochem (1993) 0.92
Smooth-muscle mitogen-activated protein (MAP) kinase: purification and characterization, and the phosphorylation of caldesmon. Biochem J (1993) 0.92
A mitogen-activated protein kinase kinase required for induction of cytokinesis and appressorium formation by host signals in the conidia of Colletotrichum gloeosporioides. Plant Cell (2000) 0.90
The yeast G-protein homolog is involved in the mating pheromone signal transduction system. Mol Cell Biol (1989) 0.89
Dominant mutations of Drosophila MAP kinase kinase and their activities in Drosophila and yeast MAP kinase cascades. Genetics (1997) 0.87
The MAP kinase cascade. Discovery of a new signal transduction pathway. Mol Cell Biochem (1993) 0.84
Induction of yeast histone genes by stimulation of stationary-phase cells. Mol Cell Biol (1990) 0.84
DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci U S A (1977) 790.54
Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose. Proc Natl Acad Sci U S A (1972) 83.88
Rapid and sensitive protein similarity searches. Science (1985) 76.83
Buffer gradient gels and 35S label as an aid to rapid DNA sequence determination. Proc Natl Acad Sci U S A (1983) 54.64
A reliable method for the recovery of DNA fragments from agarose and acrylamide gels. Anal Biochem (1981) 15.38
Protein-tyrosine kinases. Annu Rev Biochem (1985) 14.83
Automation of the computer handling of gel reading data produced by the shotgun method of DNA sequencing. Nucleic Acids Res (1982) 14.73
Viral src gene products are related to the catalytic chain of mammalian cAMP-dependent protein kinase. Proc Natl Acad Sci U S A (1982) 7.22
Mutants of Saccharomyces cerevisiae unresponsive to cell division control by polypeptide mating hormone. J Cell Biol (1980) 6.94
Mating signals control expression of mutations resulting from insertion of a transposable repetitive element adjacent to diverse yeast genes. Cell (1980) 5.20
Protein kinase activity associated with the product of the yeast cell division cycle gene CDC28. Proc Natl Acad Sci U S A (1985) 5.03
Primary structure homology between the product of yeast cell division control gene CDC28 and vertebrate oncogenes. Nature (1984) 4.74
Direct evidence that oncogenic tyrosine kinases and cyclic AMP-dependent protein kinase have homologous ATP-binding sites. Nature (1984) 3.91
The action of oncogenes in the cytoplasm and nucleus. Science (1985) 3.62
Studies on the transposable element Ty1 of yeast. I. RNA homologous to Ty1. II. Recombination and expression of Ty1 and adjacent sequences. Cold Spring Harb Symp Quant Biol (1981) 3.27
Yeast mRNA initiation sites are determined primarily by specific sequences, not by the distance from the TATA element. EMBO J (1985) 2.87
Spacer regulation of Xenopus ribosomal gene transcription: competition in oocytes. Cell (1983) 2.85
Rapid and simple removal of contaminating RNA from plasmid DNA without the use of RNase. Anal Biochem (1981) 2.51
Affinity labeling of cAMP-dependent protein kinase with p-fluorosulfonylbenzoyl adenosine. Covalent modification of lysine 71. J Biol Chem (1981) 2.48
Amino acid alterations within a highly conserved region of the Rous sarcoma virus src gene product pp60src inactivate tyrosine protein kinase activity. Mol Cell Biol (1984) 2.18
Identification and mapping of the transcriptional and translational products of the yeast plasmid, 2mu circle. Cell (1979) 2.17
Molecular cloning and characterization of the STE7 and STE11 genes of Saccharomyces cerevisiae. Mol Cell Biol (1985) 1.61
Dideoxy DNA sequencing with end-labeled oligonucleotide primers. Anal Biochem (1984) 1.57
Carbon source dependence of transposable element-associated gene activation in Saccharomyces cerevisiae. Mol Cell Biol (1984) 1.56
Expression of the ROAM mutations in Saccharomyces cerevisiae: involvement of trans-acting regulatory elements and relation with the Ty1 transcription. EMBO J (1982) 1.55
Mutations affecting Ty-mediated expression of the HIS4 gene of Saccharomyces cerevisiae. Genetics (1984) 5.64
Mating signals control expression of mutations resulting from insertion of a transposable repetitive element adjacent to diverse yeast genes. Cell (1980) 5.20
Requirement of either of a pair of ras-related genes of Saccharomyces cerevisiae for spore viability. Nature (1984) 4.23
The origins of gene instability in yeast. Science (1980) 3.85
Constitutive mutants of the protein kinase STE11 activate the yeast pheromone response pathway in the absence of the G protein. Genes Dev (1992) 3.65
Genetic events associated with an insertion mutation in yeast. Cell (1980) 3.40
STE11 is a protein kinase required for cell-type-specific transcription and signal transduction in yeast. Genes Dev (1990) 2.72
The proliferation of MAP kinase signaling pathways in yeast. Curr Opin Cell Biol (1995) 2.60
Structure of the Saccharomyces cerevisiae HO gene and analysis of its upstream regulatory region. Mol Cell Biol (1986) 2.36
MSG5, a novel protein phosphatase promotes adaptation to pheromone response in S. cerevisiae. EMBO J (1994) 2.32
Stimulatory effects of yeast and mammalian 14-3-3 proteins on the Raf protein kinase. Science (1994) 2.21
Activation regions in a yeast transposon have homology to mating type control sequences and to mammalian enhancers. Proc Natl Acad Sci U S A (1985) 2.20
Cooperative binding interactions required for function of the Ty1 sterile responsive element. Mol Cell Biol (1997) 2.12
Pheromone-induced signal transduction in Saccharomyces cerevisiae requires the sequential function of three protein kinases. Mol Cell Biol (1993) 2.03
Studies on transposable elements in yeast. I. ROAM mutations causing increased expression of yeast genes: their activation by signals directed toward conjugation functions and their formation by insertion of Ty1 repetitive elements. II. deletions, duplications, and transpositions of the COR segment that encompasses the structural gene of yeast iso-1-cytochrome c. Cold Spring Harb Symp Quant Biol (1981) 2.02
Coordination of the mating and cell integrity mitogen-activated protein kinase pathways in Saccharomyces cerevisiae. Mol Cell Biol (1997) 1.95
Mid2 is a putative sensor for cell integrity signaling in Saccharomyces cerevisiae. Mol Cell Biol (1999) 1.92
Comparative kinetic studies of cytochromes c in reactions with mitochondrial cytochrome c oxidase and reductase. Biochemistry (1978) 1.90
Identification of a Ty1 regulatory sequence responsive to STE7 and STE12. Mol Cell Biol (1988) 1.76
Yeast STE7, STE11, and STE12 genes are required for expression of cell-type-specific genes. Mol Cell Biol (1988) 1.73
Ty1 sequence with enhancer and mating-type-dependent regulatory activities. Mol Cell Biol (1987) 1.65
Molecular cloning and characterization of the STE7 and STE11 genes of Saccharomyces cerevisiae. Mol Cell Biol (1985) 1.61
Yeast MEK-dependent signal transduction: response thresholds and parameters affecting fidelity. Mol Cell Biol (1995) 1.30
Ash1, a daughter cell-specific protein, is required for pseudohyphal growth of Saccharomyces cerevisiae. Mol Cell Biol (1998) 1.29
MOT2 encodes a negative regulator of gene expression that affects basal expression of pheromone-responsive genes in Saccharomyces cerevisiae. Mol Cell Biol (1994) 1.23
Cell-type-dependent gene activation by yeast transposon Ty1 involves multiple regulatory determinants. Mol Cell Biol (1987) 1.22
Pheromone induction promotes Ste11 degradation through a MAPK feedback and ubiquitin-dependent mechanism. Proc Natl Acad Sci U S A (2002) 1.18
Identification of regulatory regions within the Ty1 transposable element that regulate iso-2-cytochrome c production in the CYC7-H2 yeast mutant. Mol Cell Biol (1984) 1.13
A Ty1 cell-type-specific regulatory sequence is a recognition element for a constitutive binding factor. Mol Cell Biol (1988) 1.10
Frequency and directionality of gene conversion events involving the CYC7-H3 mutation in Saccharomyces cerevisiae. Genetics (1986) 0.95
A yeast-Escherichia coli shuttle vector containing the M13 origin of replication. Plasmid (1990) 0.94
An anomalous Ty1 structure attributed to an error in reverse transcription. Mol Cell Biol (1986) 0.93
Novel members of the mitogen-activated protein kinase activator family in Xenopus laevis. Mol Cell Biol (1993) 0.92
Oxidation of ferrocytochrome c by mitochondrial cytochrome c oxidase. Proc Natl Acad Sci U S A (1976) 0.91
Transcriptional analysis of Ty1 deletion and inversion derivatives at CYC7. Mol Cell Biol (1986) 0.87
Preparation and properties of complex IV (ferrocytochrome c: oxygen oxidoreductase EC 1.9.3.1). Methods Enzymol (1978) 0.87
Prevention of extensor lag after indicis proprius tendon transfer. J Hand Surg Am (1979) 0.84
Identification of novel pheromone-response regulators through systematic overexpression of 120 protein kinases in yeast. J Biol Chem (2001) 0.84
Continuing medical education. How to make the most of your program. Tex Hosp (1982) 0.75
Method for measurement of circumduction of the thumb to evaluate results of opponensplasty. Plast Reconstr Surg (1979) 0.75
Burn syndactyly. Plast Reconstr Surg (1978) 0.75