Published in J Biol Chem on May 25, 1987
Iron-carbonyl bond geometries of carboxymyoglobin and carboxyhemoglobin in solution determined by picosecond time-resolved infrared spectroscopy. Proc Natl Acad Sci U S A (1988) 1.77
Inhomogeneous broadening in spectral bands of carbonmonoxymyoglobin. The connection between spectral and functional heterogeneity. Biophys J (1990) 1.62
Conformational relaxation of a low-temperature protein as probed by photochemical hole burning. Horseradish peroxidase. Biophys J (1991) 1.20
Perturbations of the distal heme pocket in human myoglobin mutants probed by infrared spectroscopy of bound CO: correlation with ligand binding kinetics. Proc Natl Acad Sci U S A (1993) 0.93
Positional cloning of the mouse obese gene and its human homologue. Nature (1994) 38.85
Crystal structure at 3.5 A resolution of HIV-1 reverse transcriptase complexed with an inhibitor. Science (1992) 14.70
Weight-reducing effects of the plasma protein encoded by the obese gene. Science (1995) 13.05
Menopausal estrogen and estrogen-progestin replacement therapy and breast cancer risk. JAMA (2000) 7.77
Abnormal splicing of the leptin receptor in diabetic mice. Nature (1996) 7.71
Alcohol, tobacco and breast cancer--collaborative reanalysis of individual data from 53 epidemiological studies, including 58,515 women with breast cancer and 95,067 women without the disease. Br J Cancer (2002) 5.83
Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor. Cell (2000) 5.73
Structural genomics: beyond the human genome project. Nat Genet (1999) 5.58
Mammographic features and breast cancer risk: effects with time, age, and menopause status. J Natl Cancer Inst (1995) 5.35
Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice. Nat Genet (1996) 4.84
The biological assay of testicular diffusing factor. Biochem J (1940) 4.79
Increased risk of lymphoma in sicca syndrome. Ann Intern Med (1978) 4.63
Incidence of cancer among patients with rheumatoid arthritis. J Natl Cancer Inst (1993) 4.59
Leptin-specific patterns of gene expression in white adipose tissue. Genes Dev (2000) 4.57
Genetic and crystallographic studies of the 3',5'-exonucleolytic site of DNA polymerase I. Science (1988) 4.50
Selective deletion of leptin receptor in neurons leads to obesity. J Clin Invest (2001) 3.82
Physiological response to long-term peripheral and central leptin infusion in lean and obese mice. Proc Natl Acad Sci U S A (1997) 3.81
The risk of breast cancer after estrogen and estrogen-progestin replacement. N Engl J Med (1989) 3.77
RNA folding at millisecond intervals by synchrotron hydroxyl radical footprinting. Science (1998) 3.67
Agricultural herbicide use and risk of lymphoma and soft-tissue sarcoma. JAMA (1986) 3.63
Peroxisome proliferator-activated receptor gamma target gene encoding a novel angiopoietin-related protein associated with adipose differentiation. Mol Cell Biol (2000) 3.60
Diagnostic criteria for schwannomatosis. Neurology (2005) 3.41
Risk of cancer in renal-transplant recipients. Lancet (1973) 3.36
Mortality associated with Down's syndrome in the USA from 1983 to 1997: a population-based study. Lancet (2002) 3.35
Increased expression in adipocytes of ob RNA in mice with lesions of the hypothalamus and with mutations at the db locus. Proc Natl Acad Sci U S A (1995) 3.33
Occupation and cancer of the lower urinary tract. Cancer (1972) 3.25
Acute stimulation of glucose metabolism in mice by leptin treatment. Nature (1997) 3.12
Cocrystal structure of an editing complex of Klenow fragment with DNA. Proc Natl Acad Sci U S A (1988) 3.02
Virus-assisted mapping of neural inputs to a feeding center in the hypothalamus. Science (2001) 2.98
Distinct transcriptional profiles of adipogenesis in vivo and in vitro. J Biol Chem (2001) 2.91
Nucleocapsid zinc fingers detected in retroviruses: EXAFS studies of intact viruses and the solution-state structure of the nucleocapsid protein from HIV-1. Protein Sci (1992) 2.79
Mortality in neurofibromatosis 1: an analysis using U.S. death certificates. Am J Hum Genet (2001) 2.78
Structure of the binding site for nonnucleoside inhibitors of the reverse transcriptase of human immunodeficiency virus type 1. Proc Natl Acad Sci U S A (1994) 2.71
NF1 gene and neurofibromatosis 1. Am J Epidemiol (2000) 2.58
Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues. Proc Natl Acad Sci U S A (1997) 2.57
Insights into the pathogenesis of neurofibromatosis 1 vasculopathy. Clin Genet (2000) 2.49
Menopausal estrogens and breast cancer. N Engl J Med (1976) 2.48
Structural basis of asymmetry in the human immunodeficiency virus type 1 reverse transcriptase heterodimer. Proc Natl Acad Sci U S A (1994) 2.47
Excess incidence of squamous cell esophageal cancer among US Black men: role of social class and other risk factors. Am J Epidemiol (2001) 2.30
Acute leukemia after alkylating-agent therapy of ovarian cancer. N Engl J Med (1977) 2.20
Crystal structures of the Klenow fragment of DNA polymerase I complexed with deoxynucleoside triphosphate and pyrophosphate. Biochemistry (1993) 2.19
Population-based analyses of mortality in trisomy 13 and trisomy 18. Pediatrics (2003) 2.11
A patient with vertebral, cognitive and behavioural abnormalities and a de novo deletion of NRXN1alpha. J Med Genet (2007) 1.94
Drug safety in pregnant women and their babies: ignorance not bliss. Clin Pharmacol Ther (2007) 1.87
Linkage of functional and structural heterogeneity in proteins: dynamic hole burning in carboxymyoglobin. Science (1987) 1.87
Improving the prediction of complex diseases by testing for multiple disease-susceptibility genes. Am J Hum Genet (2003) 1.85
Lipoprotein lipase controls fatty acid entry into adipose tissue, but fat mass is preserved by endogenous synthesis in mice deficient in adipose tissue lipoprotein lipase. Proc Natl Acad Sci U S A (1997) 1.85
Increasing the specificity of diagnostic criteria for schwannomatosis. Neurology (2006) 1.85
Use of "unidentified bright objects" on MRI for diagnosis of neurofibromatosis 1 in children. Neurology (2000) 1.83
Lung cancer after employment in shipyards during World War II. N Engl J Med (1978) 1.82
On the use of population attributable fraction to determine sample size for case-control studies of gene-environment interaction. Epidemiology (2003) 1.82
Use of the national institutes of health criteria for diagnosis of neurofibromatosis 1 in children. Pediatrics (2000) 1.79
Bladder cancer, drinking water source, and tap water consumption: a case-control study. J Natl Cancer Inst (1987) 1.77
Teratogenicity of recently introduced medications in human pregnancy. Obstet Gynecol (2002) 1.76
Assessment of algorithms for high throughput detection of genomic copy number variation in oligonucleotide microarray data. BMC Bioinformatics (2007) 1.75
Cancer mortality in U.S. counties with chemical industries. Environ Res (1975) 1.74
Cellular promoters incorporated into the adenovirus genome: cell specificity of albumin and immunoglobulin expression. Mol Cell Biol (1986) 1.73
Cardiovascular malformations and other cardiovascular abnormalities in neurofibromatosis 1. Am J Med Genet (2000) 1.70
Submicroscopic deletions and duplications in individuals with intellectual disability detected by array-CGH. Am J Med Genet A (2005) 1.68
A reevaluation of risk of in utero exposure to lithium. JAMA (1994) 1.68
Evolving knowledge of the teratogenicity of medications in human pregnancy. Am J Med Genet C Semin Med Genet (2011) 1.68
Epidemiology and factor analysis of obesity, type II diabetes, hypertension, and dyslipidemia (syndrome X) on the Island of Kosrae, Federated States of Micronesia. Hum Hered (2001) 1.67
Association between benign and malignant peripheral nerve sheath tumors in NF1. Neurology (2005) 1.65
Transcriptional and post-transcriptional control of specific messenger RNAs in adult and embryonic liver. J Mol Biol (1984) 1.63
Time-resolved synchrotron X-ray "footprinting", a new approach to the study of nucleic acid structure and function: application to protein-DNA interactions and RNA folding. J Mol Biol (1997) 1.60
Mild head injury increasing the brain's vulnerability to a second concussive impact. J Neurosurg (2001) 1.59
Improvement in stroke mortality in Canada and the United States, 1990 to 2002. Circulation (2006) 1.58
Adhesion of normal and sickle erythrocytes to endothelial monolayer cultures. Blood (1979) 1.58
Folding mechanism of the Tetrahymena ribozyme P4-P6 domain. Biochemistry (2000) 1.56
Millisecond radiolytic modification of peptides by synchrotron X-rays identified by mass spectrometry. Anal Chem (1999) 1.56
Menopausal oestrogens and breast cancer risk: an expanded case-control study. Br J Cancer (1986) 1.55
Evaluation of clinical diagnostic criteria for neurofibromatosis 2. Neurology (2002) 1.53
Comparison of the 15q deletions in Prader-Willi and Angelman syndromes: specific regions, extent of deletions, parental origin, and clinical consequences. Am J Med Genet (1990) 1.53
Population trends in cigarette smoking and bladder cancer. Am J Epidemiol (1971) 1.51
Ordered water molecules as key allosteric mediators in a cooperative dimeric hemoglobin. Proc Natl Acad Sci U S A (1996) 1.51
Cancer risk following pernicious anaemia. Br J Cancer (1989) 1.50
Non-Hodgkin's lymphoma and other cancers among a cohort of patients with systemic lupus erythematosus. Arthritis Rheum (1997) 1.49
Risk of cancer in women receiving hormone replacement therapy. Int J Cancer (1989) 1.49
Associations of cancer mortality with halomethanes in drinking water. J Natl Cancer Inst (1978) 1.49
Update on new developments in the study of human teratogens. Teratology (2002) 1.49
Excited state lifetimes in cytochromes measured from Raman scattering data: evidence for iron-porphyrin interactions. Proc Natl Acad Sci U S A (1977) 1.48
Race-ethnicity differences in folic acid intake in women of childbearing age in the United States after folic acid fortification: findings from the National Health and Nutrition Examination Survey, 2001-2002. Am J Clin Nutr (2007) 1.46
Transient Raman study of CO-haemoprotein photolysis: origin of the quantum yield. Nature (1980) 1.43
Workshop report: evaluation of genetic and epigenetic risks associated with assisted reproductive technologies and infertility. Fertil Steril (2007) 1.42
Lung cancer risk, occupational exposure, and the debrisoquine metabolic phenotype. Cancer Res (1989) 1.41
Descriptive analysis of tibial pseudarthrosis in patients with neurofibromatosis 1. Am J Med Genet (1999) 1.40
Risk of endometrial cancer after treatment with oestrogens alone or in conjunction with progestogens: results of a prospective study. BMJ (1989) 1.39
Cancer mortality among workers exposed to zinc chromate paints. J Occup Med (1980) 1.37
Design and methods in a multi-center case-control interview study. Am J Public Health (1984) 1.37
Effects of mammographic density and benign breast disease on breast cancer risk (United States). Cancer Causes Control (2001) 1.37
Hydroxyl radical probe of protein surfaces using synchrotron X-ray radiolysis and mass spectrometry. Int J Radiat Biol (2002) 1.37
Predictors of the risk of mortality in neurofibromatosis 2. Am J Hum Genet (2002) 1.37
The iron-proximal histidine linkage and protein control of oxygen binding in hemoglobin. A transient Raman study. J Biol Chem (1983) 1.35
del(20p) with manifestations of arteriohepatic dysplasia. Am J Med Genet (1986) 1.35
Saethre-Chotzen syndrome: a broad and variable pattern of skeletal malformations. J Pediatr (1977) 1.35
Site-specific PEGylation of hemoglobin at Cys-93(beta): correlation between the colligative properties of the PEGylated protein and the length of the conjugated PEG chain. Bioconjug Chem (2003) 1.34
Reproductive factors in the aetiology of breast cancer. Br J Cancer (1983) 1.34
Dietary patterns associated with a low-fat diet in the national health examination follow-up study: identification of potential confounders for epidemiologic analyses. Am J Epidemiol (1993) 1.32
Expression of ob gene in adipose cells. Regulation by insulin. J Biol Chem (1996) 1.31