CpG islands in vertebrate genomes.

The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores. Nat Genet (2009) 18.90

DNA methylation profiling of human chromosomes 6, 20 and 22. Nat Genet (2006) 18.08

CpG island methylator phenotype in colorectal cancer. Proc Natl Acad Sci U S A (1999) 13.02

Comprehensive analysis of CpG islands in human chromosomes 21 and 22. Proc Natl Acad Sci U S A (2002) 12.33

A genome-wide analysis of CpG dinucleotides in the human genome distinguishes two distinct classes of promoters. Proc Natl Acad Sci U S A (2006) 10.63

Direct detection of DNA methylation during single-molecule, real-time sequencing. Nat Methods (2010) 9.75

Genomic targets of the human c-Myc protein. Genes Dev (2003) 9.67

Abundant quantitative trait loci exist for DNA methylation and gene expression in human brain. PLoS Genet (2010) 8.74

A novel CpG island set identifies tissue-specific methylation at developmental gene loci. PLoS Biol (2008) 7.95

Targeted bisulfite sequencing reveals changes in DNA methylation associated with nuclear reprogramming. Nat Biotechnol (2009) 7.59

Active chromatin domains are defined by acetylation islands revealed by genome-wide mapping. Genes Dev (2005) 7.21

Number of CpG islands and genes in human and mouse. Proc Natl Acad Sci U S A (1993) 6.79

Analysis of repetitive element DNA methylation by MethyLight. Nucleic Acids Res (2005) 6.49

DNA methylation patterns associate with genetic and gene expression variation in HapMap cell lines. Genome Biol (2011) 6.48

Long noncoding RNAs in mouse embryonic stem cell pluripotency and differentiation. Genome Res (2008) 6.43

A unifying model for the selective regulation of inducible transcription by CpG islands and nucleosome remodeling. Cell (2009) 6.26

Comprehensive methylome map of lineage commitment from haematopoietic progenitors. Nature (2010) 6.06

Comparative isoschizomer profiling of cytosine methylation: the HELP assay. Genome Res (2006) 5.99

Minfi: a flexible and comprehensive Bioconductor package for the analysis of Infinium DNA methylation microarrays. Bioinformatics (2014) 5.93

An abundance of bidirectional promoters in the human genome. Genome Res (2004) 5.90

Genome-wide profiling of DNA methylation reveals a class of normally methylated CpG island promoters. PLoS Genet (2007) 5.16

A beta-mixture quantile normalization method for correcting probe design bias in Illumina Infinium 450 k DNA methylation data. Bioinformatics (2012) 4.95

The UCSC Genome Browser database: 2015 update. Nucleic Acids Res (2014) 4.87

An integrated resource for genome-wide identification and analysis of human tissue-specific differentially methylated regions (tDMRs). Genome Res (2008) 4.84

A human B cell methylome at 100-base pair resolution. Proc Natl Acad Sci U S A (2009) 4.72

Comparative analysis of noncoding regions of 77 orthologous mouse and human gene pairs. Genome Res (1999) 4.50

Analysis of human chromosome 21: correlation of physical and cytogenetic maps; gene and CpG island distributions. EMBO J (1990) 4.49

Large-scale structure of genomic methylation patterns. Genome Res (2005) 4.11

Distinct DNA methylation patterns characterize differentiated human embryonic stem cells and developing human fetal liver. Genome Res (2009) 4.11

Epigenome-wide scans identify differentially methylated regions for age and age-related phenotypes in a healthy ageing population. PLoS Genet (2012) 4.05

Identification and characterization of the potential promoter regions of 1031 kinds of human genes. Genome Res (2001) 4.03

Developmental programming of CpG island methylation profiles in the human genome. Nat Struct Mol Biol (2009) 3.96

Tetrahydrobiopterin biosynthesis, regeneration and functions. Biochem J (2000) 3.91

DNA methylation is the primary silencing mechanism for a set of germ line- and tumor-specific genes with a CpG-rich promoter. Mol Cell Biol (1999) 3.76

The expected equilibrium of the CpG dinucleotide in vertebrate genomes under a mutation model. Proc Natl Acad Sci U S A (1990) 3.56

R-loop formation is a distinctive characteristic of unmethylated human CpG island promoters. Mol Cell (2012) 3.56

A genome-wide screen for normally methylated human CpG islands that can identify novel imprinted genes. Genome Res (2002) 3.50

Cloning of a mammalian transcriptional activator that binds unmethylated CpG motifs and shares a CXXC domain with DNA methyltransferase, human trithorax, and methyl-CpG binding domain protein 1. Mol Cell Biol (2000) 3.44

Antisense transcripts with FANTOM2 clone set and their implications for gene regulation. Genome Res (2003) 3.40

Sperm methylation profiles reveal features of epigenetic inheritance and evolution in primates. Cell (2011) 3.39

Transcription-mediated gene fusion in the human genome. Genome Res (2005) 3.19

Epigenetics and colorectal cancer. Nat Rev Gastroenterol Hepatol (2011) 3.15

Removal of deaminated cytosines and detection of in vivo methylation in ancient DNA. Nucleic Acids Res (2009) 3.09

High definition profiling of mammalian DNA methylation by array capture and single molecule bisulfite sequencing. Genome Res (2009) 3.08

G+C content dominates intrinsic nucleosome occupancy. BMC Bioinformatics (2009) 3.05

CpG island mapping by epigenome prediction. PLoS Comput Biol (2007) 3.02

Methylation matters. J Med Genet (2001) 3.00

Speeding disease gene discovery by sequence based candidate prioritization. BMC Bioinformatics (2005) 2.99

Targeted capture and next-generation sequencing identifies C9orf75, encoding taperin, as the mutated gene in nonsyndromic deafness DFNB79. Am J Hum Genet (2010) 2.95

Additional annotation enhances potential for biologically-relevant analysis of the Illumina Infinium HumanMethylation450 BeadChip array. Epigenetics Chromatin (2013) 2.93

CpG islands recruit a histone H3 lysine 36 demethylase. Mol Cell (2010) 2.86

Cloning and intracellular localization of the U2 small nuclear ribonucleoprotein auxiliary factor small subunit. Proc Natl Acad Sci U S A (1992) 2.82

DNA methylation of the first exon is tightly linked to transcriptional silencing. PLoS One (2011) 2.80

Intra- and interindividual epigenetic variation in human germ cells. Am J Hum Genet (2006) 2.79

Directional DNA methylation changes and complex intermediate states accompany lineage specificity in the adult hematopoietic compartment. Mol Cell (2011) 2.77

Methylation-sensitive high resolution melting (MS-HRM): a new approach for sensitive and high-throughput assessment of methylation. Nucleic Acids Res (2007) 2.69

CpG island methylation in human lymphocytes is highly correlated with DNA sequence, repeats, and predicted DNA structure. PLoS Genet (2006) 2.66

CpG island methylator phenotype associates with low-degree chromosomal abnormalities in colorectal cancer. Clin Cancer Res (2008) 2.65

Locations and contexts of sequences that hybridize to poly(dG-dT).(dC-dA) in mammalian ribosomal DNAs and two X-linked genes. Nucleic Acids Res (1988) 2.64

Identification of putative noncoding RNAs among the RIKEN mouse full-length cDNA collection. Genome Res (2003) 2.63

Distinct DNA methylation changes highly correlated with chronological age in the human brain. Hum Mol Genet (2011) 2.62

Computational analysis of genome-wide DNA methylation during the differentiation of human embryonic stem cells along the endodermal lineage. Genome Res (2010) 2.61

Transcriptionally active genome regions are preferred targets for retrovirus integration. J Virol (1990) 2.59

A comprehensive analysis of allelic methylation status of CpG islands on human chromosome 21q. Genome Res (2004) 2.56

Role for DNA methylation in the regulation of miR-200c and miR-141 expression in normal and cancer cells. PLoS One (2010) 2.55

CAGE Basic/Analysis Databases: the CAGE resource for comprehensive promoter analysis. Nucleic Acids Res (2006) 2.54

The human ARF cell cycle regulatory gene promoter is a CpG island which can be silenced by DNA methylation and down-regulated by wild-type p53. Mol Cell Biol (1998) 2.53

CG dinucleotide clustering is a species-specific property of the genome. Nucleic Acids Res (2007) 2.48

DNA methylation profile of tissue-dependent and differentially methylated regions (T-DMRs) in mouse promoter regions demonstrating tissue-specific gene expression. Genome Res (2008) 2.48

Selection on human genes as revealed by comparisons to chimpanzee cDNA. Genome Res (2003) 2.48

High nucleosome occupancy is encoded at human regulatory sequences. PLoS One (2010) 2.43

De novo methylation of the MyoD1 CpG island during the establishment of immortal cell lines. Proc Natl Acad Sci U S A (1990) 2.42

Analysis of DNA methylation in a three-generation family reveals widespread genetic influence on epigenetic regulation. PLoS Genet (2011) 2.41

H2A.X. a histone isoprotein with a conserved C-terminal sequence, is encoded by a novel mRNA with both DNA replication type and polyA 3' processing signals. Nucleic Acids Res (1989) 2.39

DNA methylation analysis of chromosome 21 gene promoters at single base pair and single allele resolution. PLoS Genet (2009) 2.37

A novel interferon-inducible domain: structural and functional analysis of the human interferon regulatory factor 1 gene promoter. Mol Cell Biol (1993) 2.32

Cancer DNA methylation: molecular mechanisms and clinical implications. Clin Cancer Res (2009) 2.31

Prevalence of the initiator over the TATA box in human and yeast genes and identification of DNA motifs enriched in human TATA-less core promoters. Gene (2006) 2.31

Evidence of selection on silent site base composition in mammals: potential implications for the evolution of isochores and junk DNA. Genetics (1999) 2.29

Features of mammalian microRNA promoters emerge from polymerase II chromatin immunoprecipitation data. PLoS One (2009) 2.29

De novo induction of a cancer/testis antigen by 5-aza-2'-deoxycytidine augments adoptive immunotherapy in a murine tumor model. Cancer Res (2006) 2.27

SAR-dependent mobilization of histone H1 by HMG-I/Y in vitro: HMG-I/Y is enriched in H1-depleted chromatin. EMBO J (1993) 2.27

Predicting aberrant CpG island methylation. Proc Natl Acad Sci U S A (2003) 2.25

Genetics and epigenetics of rheumatoid arthritis. Nat Rev Rheumatol (2013) 2.20

Inter-individual variation of DNA methylation and its implications for large-scale epigenome mapping. Nucleic Acids Res (2008) 2.19

CpGcluster: a distance-based algorithm for CpG-island detection. BMC Bioinformatics (2006) 2.19

Genome-wide analysis of aberrant methylation in human breast cancer cells using methyl-DNA immunoprecipitation combined with high-throughput sequencing. BMC Genomics (2010) 2.19

The UCSC Genome Browser database: 2016 update. Nucleic Acids Res (2015) 2.18

Large conserved domains of low DNA methylation maintained by Dnmt3a. Nat Genet (2013) 2.16

Genome-wide mapping and analysis of active promoters in mouse embryonic stem cells and adult organs. Genome Res (2007) 2.16

Initiation of DNA replication at CpG islands in mammalian chromosomes. EMBO J (1998) 2.13

Simian virus 40 major late promoter: a novel tripartite structure that includes intragenic sequences. Mol Cell Biol (1988) 2.09

DNA methylation. The effect of minor bases on DNA-protein interactions. Biochem J (1990) 2.09

Determinants of CpG islands: expression in early embryo and isochore structure. Genome Res (2001) 2.07

Demethylation of specific sites in the 5' region of the inactive X-linked human phosphoglycerate kinase gene correlates with the appearance of nuclease sensitivity and gene expression. Mol Cell Biol (1988) 2.07

Redefining CpG islands using hidden Markov models. Biostatistics (2010) 2.03

The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. Genome Res (2002) 2.03

Genome-scale approaches to the epigenetics of common human disease. Virchows Arch (2009) 2.02

Prospects for epigenetic epidemiology. Am J Epidemiol (2009) 2.00

Identification of multiple HTF-island associated genes in the human major histocompatibility complex class III region. EMBO J (1989) 1.97

High sensitivity mapping of methylated cytosines. Nucleic Acids Res (1994) 16.62

Criteria for evaluating evidence on public health interventions. J Epidemiol Community Health (2002) 8.16

A fraction of the mouse genome that is derived from islands of nonmethylated, CpG-rich DNA. Cell (1985) 5.63

CpNpG methylation in mammalian cells. Nat Genet (1995) 2.88

Extensive DNA methylation spanning the Rb promoter in retinoblastoma tumors. Cancer Res (1997) 1.95

Sequence relationships of three human satellite DNAs. J Mol Biol (1986) 1.93

[The Würzburg polytrauma algorithm. Concept and first results of a sliding-gantry-based computer tomography diagnostic system]. Anaesthesist (2005) 1.41

Interplasmid transposition of the mariner transposable element in non-drosophilid insects. Mol Gen Genet (1997) 1.39

Bisulfite sequencing in preimplantation embryos: DNA methylation profile of the upstream region of the mouse imprinted H19 gene. Genomics (1998) 1.36

The Bactrocera tryoni homologue of the Drosophila melanogaster sex-determination gene doublesex. Insect Mol Biol (1998) 1.13

Simple repeated sequences in human satellite DNA. Nucleic Acids Res (1982) 1.11

Close genetic similarity between two sympatric species of tephritid fruit fly reproductively isolated by mating time. Evolution (2000) 1.10

Mitochondrial control-region sequence variation in aboriginal Australians. Am J Hum Genet (1998) 1.08

Transcripts and CpG islands associated with the pro-opiomelanocortin gene and other neurally expressed genes. J Mol Endocrinol (1994) 1.07

Sequence-specific methylation of the mouse H19 gene in embryonic cells deficient in the Dnmt-1 gene. Dev Genet (1998) 1.04

Microsatellite analysis of the Queensland fruit fly Bactrocera tryoni (Diptera: Tephritidae) indicates spatial structuring: implications for population control. Bull Entomol Res (2001) 1.03

The transposable element mariner can excise in non-drosophilid insects. Mol Gen Genet (1995) 0.96

Human satellite I sequences include a male specific 2.47 kb tandemly repeated unit containing one Alu family member per repeat. Nucleic Acids Res (1984) 0.96

Comparison of the Glidescope and Airtraq optical laryngoscopes in patients undergoing direct microlaryngoscopy. Anaesthesia (2009) 0.91

The period gene in two species of tephritid fruit fly differentiated by mating behaviour. Insect Mol Biol (2002) 0.90

Phylogenetic relationships between oviparous and viviparous populations of an Australian lizard (Lerista bougainvillii, scincidae). Mol Phylogenet Evol (1998) 0.87

The Microbiome of Field-Caught and Laboratory-Adapted Australian Tephritid Fruit Fly Species with Different Host Plant Use and Specialisation. Microb Ecol (2015) 0.87

Partial purification, from Xenopus laevis oocytes, of an ATP-dependent activity required for nucleosome spacing in vitro. J Biol Chem (1992) 0.87

Tropical tephritid fruit fly community with high incidence of shared Wolbachia strains as platform for horizontal transmission of endosymbionts. Environ Microbiol (2014) 0.85

Genetic and molecular markers of the Queensland fruit fly, Bactrocera tryoni. J Hered (2003) 0.83

Interspecific hybridization as a source of novel genetic markers for the sterile insect technique in Bactrocera tryoni (Diptera: Tephritidae). J Econ Entomol (2010) 0.83

Mitotic and polytene chromosome analyses in the Queensland fruit fly, Bactrocera tryoni (Diptera: Tephritidae). Genome (1998) 0.83

Mitochondrial D-loop diversity in Australian riverine and Australian desert Aborigines. Electrophoresis (1997) 0.82

Polymorphic microsatellite markers for population analysis of a tephritid pest species, Bactrocera tryoni. Mol Ecol (1998) 0.81

Germ-line transformation of the Queensland fruit fly, Bactrocera tryoni, using a piggyBac vector in the presence of endogenous piggyBac elements. Genetica (2010) 0.79

Low birth-weight in NSW, 1987: a population-based study. Aust N Z J Obstet Gynaecol (1993) 0.79

Hox-type and non-Hox homeobox gene sequences in genomic DNA of the sea urchin Holopneustes purpurescens. Gene (1997) 0.79

Expression patterns of sex-determination genes in single male and female embryos of two Bactrocera fruit fly species during early development. Insect Mol Biol (2014) 0.79

The white gene of the tephritid fruit fly Bactrocera tryoni is characterized by a long untranslated 5' leader and a 12kb first intron. Insect Mol Biol (1997) 0.78

Towards a male-only release system for SIT with the Queensland fruit fly, Bactrocera tryoni, using a genetic sexing strain with a temperature-sensitive lethal mutation. Genetica (2002) 0.77

The genome of the Queensland fruit fly Bactrocera tryoni contains multiple representatives of the mariner family of transposable elements. Insect Mol Biol (2001) 0.77

Emergency cricothyrotomy in infants--evaluation of a novel device in an animal model. Paediatr Anaesth (2011) 0.75

Handheld vs. conventional transesophageal echocardiography in non-cardiac surgical intensive care unit patients. Ultraschall Med (2008) 0.75

Binding of proteins from embryonic and differentiated cells to a bidirectional promoter contained within a CpG island. J Mol Biol (1992) 0.75

Termination of pregnancy in New South Wales, 1990. Aust N Z J Public Health (1996) 0.75

The scarlet eye colour gene of the tephritid fruit fly: Bactrocera tryoni and the nature of two eye colour mutations. Insect Mol Biol (2003) 0.75

A New South Wales population-based study of stillbirths weighing 2,500 g or more. Aust N Z J Obstet Gynaecol (1993) 0.75

Legionnaires' disease outbreak, Fairfield 1992: public health aspects. Aust J Public Health (1994) 0.75