Published in Biochemistry on June 03, 1986
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Substitution of an essential adenine in the U1A-RNA complex with a non-polar isostere. Nucleic Acids Res (2002) 0.85
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Improved predictions of secondary structures for RNA. Proc Natl Acad Sci U S A (1989) 11.52
Thermodynamic parameters for an expanded nearest-neighbor model for formation of RNA duplexes with Watson-Crick base pairs. Biochemistry (1998) 9.75
PNA hybridizes to complementary oligonucleotides obeying the Watson-Crick hydrogen-bonding rules. Nature (1993) 8.83
Coaxial stacking of helixes enhances binding of oligoribonucleotides and improves predictions of RNA folding. Proc Natl Acad Sci U S A (1994) 8.06
Predicting optimal and suboptimal secondary structure for RNA. Methods Enzymol (1990) 7.08
Base-stacking and base-pairing contributions to helix stability: thermodynamics of double-helix formation with CCGG, CCGGp, CCGGAp, ACCGGp, CCGGUp, and ACCGGUp. Biochemistry (1983) 6.81
RNA structure prediction. Annu Rev Biophys Biophys Chem (1988) 5.75
Resolving the functions of overlapping viral genes by site-specific mutagenesis at a mRNA splice site. Nature (1982) 5.61
Inhibition of RNA cleavage but not polyadenylation by a point mutation in mRNA 3' consensus sequence AAUAAA. Nature (1983) 5.18
Gene synthesis machines: DNA chemistry and its uses. Science (1985) 4.76
In situ activation of bis-dialkylaminophosphines--a new method for synthesizing deoxyoligonucleotides on polymer supports. Nucleic Acids Res (1984) 4.55
Synthetic peptide homologous to beta protein from Alzheimer disease forms amyloid-like fibrils in vitro. Proc Natl Acad Sci U S A (1987) 4.04
Evaluation of 2'-modified oligonucleotides containing 2'-deoxy gaps as antisense inhibitors of gene expression. J Biol Chem (1993) 3.70
The effect of acceptor oligoribonucleotide sequence on the T4 RNA ligase reaction. Eur J Biochem (1982) 3.51
Predicting thermodynamic properties of RNA. Methods Enzymol (1995) 3.38
Thermodynamics of (dG--dC)3 double-helix formation in water and deuterium oxide. Biochemistry (1981) 3.30
Polymer-supported RNA synthesis and its application to test the nearest-neighbor model for duplex stability. Biochemistry (1986) 3.21
Investigation of the structural basis for thermodynamic stabilities of tandem GU mismatches: solution structure of (rGAGGUCUC)2 by two-dimensional NMR and simulated annealing. Biochemistry (1996) 2.96
Binding of synthetic lactose operator DNAs to lactose represessors. Proc Natl Acad Sci U S A (1977) 2.86
Thermodynamic studies of RNA stability. J Biomol Struct Dyn (1984) 2.75
Contributions of dangling end stacking and terminal base-pair formation to the stabilities of XGGCCp, XCCGGp, XGGCCYp, and XCCGGYp helixes. Biochemistry (1985) 2.70
Predicting oligonucleotide affinity to nucleic acid targets. RNA (1999) 2.67
Antisense oligonucleotides inhibit intercellular adhesion molecule 1 expression by two distinct mechanisms. J Biol Chem (1991) 2.65
Metal ion catalysis in the Tetrahymena ribozyme reaction. Nature (1993) 2.62
Vaporizer overfilling. Can J Anaesth (1993) 2.61
Total synthesis of the gene for an alanine transfer ribonucleic acid from yeast. Nature (1970) 2.51
A comparison of optimal and suboptimal RNA secondary structures predicted by free energy minimization with structures determined by phylogenetic comparison. Nucleic Acids Res (1991) 2.51
Stabilities of consecutive A.C, C.C, G.G, U.C, and U.U mismatches in RNA internal loops: Evidence for stable hydrogen-bonded U.U and C.C.+ pairs. Biochemistry (1991) 2.44
Context dependence of hydrogen bond free energy revealed by substitutions in an RNA hairpin. Science (1992) 2.44
Thermodynamics of single mismatches in RNA duplexes. Biochemistry (1999) 2.36
Uniformly modified 2'-deoxy-2'-fluoro phosphorothioate oligonucleotides as nuclease-resistant antisense compounds with high affinity and specificity for RNA targets. J Med Chem (1993) 2.34
New chemical methods for synthesizing polynucleotides. Nucleic Acids Symp Ser (1980) 2.32
Characterization of fully 2'-modified oligoribonucleotide hetero- and homoduplex hybridization and nuclease sensitivity. Nucleic Acids Res (1995) 2.30
Expanded CUG repeat RNAs form hairpins that activate the double-stranded RNA-dependent protein kinase PKR. RNA (2000) 2.25
Molecular cloning and functional characterization of the receptor for Clostridium perfringens enterotoxin. J Cell Biol (1997) 2.25
Implication of RNA structure on antisense oligonucleotide hybridization kinetics. Biochemistry (1992) 2.17
How lac repressor recognizes lac operator. Proc Natl Acad Sci U S A (1978) 2.15
Thermal unfolding of a group I ribozyme: the low-temperature transition is primarily disruption of tertiary structure. Biochemistry (1993) 2.13
Preference for endpoint measures in clinical trials: results of structured workshops. J Rheumatol (1983) 2.13
Laser temperature-jump, spectroscopic, and thermodynamic study of salt effects on duplex formation by dGCATGC. Biochemistry (1989) 2.13
Laser temperature-jump study of stacking in adenylic acid polymers. Biochemistry (1979) 2.12
Improved parameters for prediction of RNA structure. Cold Spring Harb Symp Quant Biol (1987) 2.08
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Selective inhibition of mutant Ha-ras mRNA expression by antisense oligonucleotides. J Biol Chem (1992) 1.99
Sequence dependence for the energetics of dangling ends and terminal base pairs in ribonucleic acid. Biochemistry (1987) 1.95
Do you relish interesting times? Call for applicants for the 2001 CMAJ Editorial Fellowship. CMAJ (2000) 1.93
Energetics of internal GU mismatches in ribooligonucleotide helixes. Biochemistry (1986) 1.92
Phosphorodithioate DNA as a potential therapeutic drug. Science (1993) 1.92
Free energy contributions of G.U and other terminal mismatches to helix stability. Biochemistry (1986) 1.92
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Inhibitory regulation of Rac activation, membrane ruffling, and cell migration by the G protein-coupled sphingosine-1-phosphate receptor EDG5 but not EDG1 or EDG3. Mol Cell Biol (2000) 1.90
Effects of phosphorothioate capping on antisense oligonucleotide stability, hybridization and antiviral efficacy versus herpes simplex virus infection. Nucleic Acids Res (1991) 1.80
Thermodynamics of three-way multibranch loops in RNA. Biochemistry (2001) 1.78
Outbreak of carbapenem-resistant Pseudomonas aeruginosa producing VIM-8, a novel metallo-beta-lactamase, in a tertiary care center in Cali, Colombia. J Clin Microbiol (2004) 1.77
Effects of GA mismatches on the structure and thermodynamics of RNA internal loops. Biochemistry (1990) 1.76
HTLV-1 infection in tropical spastic paraparesis: lymphocyte culture and serologic response. AIDS Res Hum Retroviruses (1988) 1.74
Solvent effects on the stability of A7U7p. Biochemistry (1985) 1.73
Thermodynamic study of internal loops in oligoribonucleotides: symmetric loops are more stable than asymmetric loops. Biochemistry (1991) 1.71
Oligodeoxynucleotides containing 2'-O-modified adenosine: synthesis and effects on stability of DNA:RNA duplexes. Biochemistry (1993) 1.71
Studies on gene control regions XII. The functional significance of a lac operator constitutive mutation. Nucleic Acids Res (1979) 1.70
Nearest-neighbor parameters for G.U mismatches: [formula; see text] is destabilizing in the contexts [formula; see text] and [formula; see text] but stabilizing in [formula; see text]. Biochemistry (1991) 1.70
Structure of (rGGCGAGCC)2 in solution from NMR and restrained molecular dynamics. Biochemistry (1993) 1.70