Published in Proc Natl Acad Sci U S A on August 01, 1979
Uses of lac fusions for the study of biological problems. Microbiol Rev (1985) 4.38
Genetic and DNA sequence analysis of the kanamycin resistance transposon Tn903. Proc Natl Acad Sci U S A (1980) 3.19
In vivo formation of gene fusions encoding hybrid beta-galactosidase proteins in one step with a transposable Mu-lac transducing phage. Proc Natl Acad Sci U S A (1984) 3.06
Cloning and sequence of the crp gene of Escherichia coli K 12. Nucleic Acids Res (1982) 2.87
Identification of the tetracycline resistance promoter and repressor in transposon Tn10. J Bacteriol (1981) 2.77
Resolution of cointegrates between transposons gamma delta and Tn3 defines the recombination site. Proc Natl Acad Sci U S A (1981) 2.53
Sequence of the site-specific recombinase gene cin and of its substrates serving in the inversion of the C segment of bacteriophage P1. EMBO J (1983) 2.16
Transcriptional bias: a non-Lamarckian mechanism for substrate-induced mutations. Proc Natl Acad Sci U S A (1989) 2.02
Homologies between different procaryotic DNA-binding regulatory proteins and between their sites of action. EMBO J (1982) 1.97
Regulation of Tn5 transposition in Salmonella typhimurium. Proc Natl Acad Sci U S A (1980) 1.76
Introduction of transposon Tn901 into a plasmid of Anacystis nidulans: preparation for cloning in cyanobacteria. Proc Natl Acad Sci U S A (1980) 1.67
Molecular nature of a streptomycin and sulfonamide resistance plasmid (pBP1) prevalent in clinical Escherichia coli strains and integration of an ampicillin resistance transposon (TnA). Antimicrob Agents Chemother (1981) 1.58
Transposon Tn3 encodes a site-specific recombination system: identification of essential sequences, genes, and actual site of recombination. Proc Natl Acad Sci U S A (1981) 1.44
Strategy for the mass spectrometric verification and correction of the primary structures of proteins deduced from their DNA sequences. Proc Natl Acad Sci U S A (1984) 1.41
Transposon-specified site-specific recombination. Proc Natl Acad Sci U S A (1982) 1.28
p2 and inhibition of Tn5 transposition. J Bacteriol (1988) 1.11
Comparison of transcription of beta-lactamase genes specified by various ampicillin transposons. J Bacteriol (1982) 1.08
Intramolecular transposition and inversion in plasmid R6K. J Bacteriol (1980) 1.00
Specific binding of transposase to terminal inverted repeats of transposable element Tn3. Proc Natl Acad Sci U S A (1987) 0.99
New gene cassettes for trimethoprim resistance, dfr13, and Streptomycin-spectinomycin resistance, aadA4, inserted on a class 1 integron. Antimicrob Agents Chemother (2000) 0.97
Nucleotide sequences required for Tn3 transposition immunity. J Bacteriol (1989) 0.91
A facile and reversible method to decrease the copy number of the ColE1-related cloning vectors commonly used in Escherichia coli. J Bacteriol (1989) 0.90
Amino-terminal sequence of the Tn3 transposase protein. J Bacteriol (1982) 0.89
Genetic changes accompanying increased fitness in evolving populations of Escherichia coli. Genetics (1992) 0.85
Temporal self-regulation of transposition through host-independent transposase rodlet formation. Nucleic Acids Res (2016) 0.75
A new method for sequencing DNA. Proc Natl Acad Sci U S A (1977) 250.51
High resolution two-dimensional electrophoresis of proteins. J Biol Chem (1975) 133.45
Construction and characterization of amplifiable multicopy DNA cloning vehicles derived from the P15A cryptic miniplasmid. J Bacteriol (1978) 75.38
The 3'-terminal sequence of Escherichia coli 16S ribosomal RNA: complementarity to nonsense triplets and ribosome binding sites. Proc Natl Acad Sci U S A (1974) 62.91
Nonchromosomal antibiotic resistance in bacteria: genetic transformation of Escherichia coli by R-factor DNA. Proc Natl Acad Sci U S A (1972) 57.06
Detection of two restriction endonuclease activities in Haemophilus parainfluenzae using analytical agarose--ethidium bromide electrophoresis. Biochemistry (1973) 43.61
Culture medium for enterobacteria. J Bacteriol (1974) 37.59
High resolution two-dimensional electrophoresis of basic as well as acidic proteins. Cell (1977) 30.04
Chain length determination of small double- and single-stranded DNA molecules by polyacrylamide gel electrophoresis. Biochemistry (1975) 22.00
Nucleotide sequence of the ampicillin resistance gene of Escherichia coli plasmid pBR322. Proc Natl Acad Sci U S A (1978) 19.34
Nucleotide sequence of an RNA polymerase binding site at an early T7 promoter. Proc Natl Acad Sci U S A (1975) 14.75
The nucleotide sequence of the lac operator. Proc Natl Acad Sci U S A (1973) 11.28
Protein expression in E. coli minicells by recombinant plasmids. Cell (1977) 8.74
Site specific recA--independent recombination between bacterial plasmids: involvement of palindromes at the recombinational loci. Proc Natl Acad Sci U S A (1975) 7.60
The construction in vitro of transducing derivatives of phage lambda. Mol Gen Genet (1976) 6.50
Replication control in a composite plasmid constructed by in vitro linkage of two distinct replicons. Nature (1976) 5.73
Deletions affecting the transposition of an antibiotic resistance gene. Proc Natl Acad Sci U S A (1977) 5.48
A catenated DNA molecule as an intermediate in the replication of the resistance transfer factor R6K in Escherichia coli. Biochem Biophys Res Commun (1973) 5.47
In vitro mutagenesis of a circular DNA molecule by using synthetic restriction sites. Proc Natl Acad Sci U S A (1978) 5.32
Physiological regulation of a decontrolled lac operon. J Bacteriol (1977) 4.80
Control elements in the DNA of bacteriophage lambda. Cold Spring Harb Symp Quant Biol (1974) 4.23
Selected translocation of plasmid genes: frequency and regional specificity of translocation of the Tn3 element. J Bacteriol (1977) 4.08
Analysis of sequences transposed by complementation of two classes of transposition-deficient mutants of Tn3. J Bacteriol (1978) 3.69
Specific binding of CAP factor to lac promoter DNA. Nature (1975) 3.47
Analysis of the proteins synthesized in ultraviolet light-irradiated Escherichia coli following infection with the bacteriophages lambdadrifd 18 and lambdadfus-3. Mol Gen Genet (1976) 2.60
Polypeptides expressed in Escherichia coli K-12 minicells by transposition elements Tn1 and Tn3. J Bacteriol (1979) 2.17
Isolation of temperature-sensitive mutants of R plasmid by in vitro mutagenesis with hydroxylamine. J Bacteriol (1976) 1.86
Site-specific DNA deletions occurring adjacent to the termini of a transposable ampicillin resistance element (Tn3). J Mol Biol (1977) 1.74
Studies of the specificity and control of transposition of the Tn3 element. Cold Spring Harb Symp Quant Biol (1979) 1.45
Construction and characterization of amplifiable multicopy DNA cloning vehicles derived from the P15A cryptic miniplasmid. J Bacteriol (1978) 75.38
Nonchromosomal antibiotic resistance in bacteria: genetic transformation of Escherichia coli by R-factor DNA. Proc Natl Acad Sci U S A (1972) 57.06
Analysis of gene control signals by DNA fusion and cloning in Escherichia coli. J Mol Biol (1980) 41.18
Transposition and fusion of the lac genes to selected promoters in Escherichia coli using bacteriophage lambda and Mu. J Mol Biol (1976) 33.01
Construction of biologically functional bacterial plasmids in vitro. Proc Natl Acad Sci U S A (1973) 25.61
Lactose genes fused to exogenous promoters in one step using a Mu-lac bacteriophage: in vivo probe for transcriptional control sequences. Proc Natl Acad Sci U S A (1979) 22.59
High frequency transformation of Bacillus subtilis protoplasts by plasmid DNA. Mol Gen Genet (1979) 17.16
Transformation of Salmonella typhimurium by plasmid deoxyribonucleic acid. J Bacteriol (1974) 15.89
Beta-galactosidase gene fusions for analyzing gene expression in escherichia coli and yeast. Methods Enzymol (1983) 14.92
Recircularization and autonomous replication of a sheared R-factor DNA segment in Escherichia coli transformants. Proc Natl Acad Sci U S A (1973) 13.45
Plasmid insertion mutagenesis and lac gene fusion with mini-mu bacteriophage transposons. J Bacteriol (1984) 12.63
Uniform nomenclature for bacterial plasmids: a proposal. Bacteriol Rev (1976) 12.28
Non-chromosomal antibiotic resistance in bacteria. II. Molecular nature of R-factors isolated from Proteus mirabilis and Escherichia coli. J Mol Biol (1970) 11.86
Electron microscope heteroduplex studies of sequence relations among plasmids of Escherichia coli. II. Structure of drug resistance (R) factors and F factors. J Mol Biol (1973) 11.40
Replication and transcription of eukaryotic DNA in Escherichia coli. Proc Natl Acad Sci U S A (1974) 10.51
Multiple molecular species of circular R-factor DNA isolated from Escherichia coli. Nature (1969) 9.02
Cloning, isolation, and characterization of replication regions of complex plasmid genomes. Proc Natl Acad Sci U S A (1975) 8.85
Phenotypic expression in E. coli of a DNA sequence coding for mouse dihydrofolate reductase. Nature (1978) 8.76
Site specific recA--independent recombination between bacterial plasmids: involvement of palindromes at the recombinational loci. Proc Natl Acad Sci U S A (1975) 7.60
Decay of mRNA in Escherichia coli: investigation of the fate of specific segments of transcripts. Proc Natl Acad Sci U S A (1983) 6.79
Nucleotide sequence of cloned cDNA for bovine corticotropin-beta-lipotropin precursor. Nature (1979) 6.56
Identification and characterization of recD, a gene affecting plasmid maintenance and recombination in Escherichia coli. J Bacteriol (1986) 6.06
Gene expression in Streptomyces: construction and application of promoter-probe plasmid vectors in Streptomyces lividans. Mol Gen Genet (1982) 5.99
Regulation of the regulatory gene for the arabinose pathway, araC. J Mol Biol (1976) 5.97
Replication control in a composite plasmid constructed by in vitro linkage of two distinct replicons. Nature (1976) 5.73
Transposable genetic elements and plasmid evolution. Nature (1976) 5.58
Revised interpretation of the origin of the pSC101 plasmid. J Bacteriol (1977) 5.51
Genome construction between bacterial species in vitro: replication and expression of Staphylococcus plasmid genes in Escherichia coli. Proc Natl Acad Sci U S A (1974) 5.47
Occurrence of insertion sequence (IS) regions on plasmid deoxyribonucleic acid as direct and inverted nucleotide sequence duplications. J Bacteriol (1975) 5.35
Fusion of the Escherichia coli lac genes to the ara promoter: a general technique using bacteriophage Mu-1 insertions. Proc Natl Acad Sci U S A (1975) 5.06
Nonchromosomal antibiotic resistance in bacteria. V. Isolation and characterization of R factor mutants exhibiting temperature-sensitive repression of fertility. J Bacteriol (1972) 4.85
Molecular and genetic studies of an R factor system consisting of independent transfer and drug resistance plasmids. J Bacteriol (1973) 4.81
Are chlamydial infections the most prevalent venereal disease? JAMA (1975) 4.79
Yeast genes fused to beta-galactosidase in Escherichia coli can be expressed normally in yeast. Proc Natl Acad Sci U S A (1981) 4.79
Transient rates of synthesis of individual polypeptides in E. coli following temperature shifts. Cell (1978) 4.66
Conversion of beta-galactosidase to a membrane-bound state by gene fusion. Proc Natl Acad Sci U S A (1976) 4.61
Alignment of genetic and restriction maps of the photosynthesis region of the Rhodopseudomonas capsulata chromosome by a conjugation-mediated marker rescue technique. J Bacteriol (1983) 4.56
Mini-mu bacteriophage with plasmid replicons for in vivo cloning and lac gene fusing. J Bacteriol (1986) 4.45
Dengue and chikungunya virus infection in man in Thailand, 1962-1964. I. Observations on hospitalized patients with hemorrhagic fever. Am J Trop Med Hyg (1969) 4.41
Cloning and characterization of EcoRI and HindIII restriction endonuclease-generated fragments of antibiotic resistance plasmids R6-5 and R6. Mol Gen Genet (1978) 4.33
Observations related to pathogenesis of dengue hemorrhagic fever. IV. Relation of disease severity to antibody response and virus recovered. Yale J Biol Med (1970) 4.30
Utilization of two distinct modes of replication by a hybrid plasmid constructed in vitro from separate replicons. Proc Natl Acad Sci U S A (1974) 4.27
Structure and genomic organization of the mouse dihydrofolate reductase gene. Cell (1980) 4.25
3'-end labeling of DNA with [alpha-32P]cordycepin-5'-triphosphate. Gene (1980) 4.22
Differential expression of photosynthesis genes in R. capsulata results from segmental differences in stability within the polycistronic rxcA transcript. Cell (1985) 4.15
Selected translocation of plasmid genes: frequency and regional specificity of translocation of the Tn3 element. J Bacteriol (1977) 4.08
Release of surface enzymes in Enterobacteriaceae by osmotic shock. J Bacteriol (1967) 4.05
Partitioning of bacterial plasmids during cell division: a cis-acting locus that accomplishes stable plasmid inheritance. Cell (1980) 4.01
Isolation of catenated forms of R factor DNA from minicells. Nat New Biol (1971) 3.99
Indirect selection of bacterial plasmids lacking identifiable phenotypic properties. J Bacteriol (1975) 3.88
Cloning and analysis of strong promoters is made possible by the downstream placement of a RNA termination signal. Proc Natl Acad Sci U S A (1981) 3.77
Isolation of histone genes from unfractionated sea urchin DNA by subculture cloning in E. coli. Nature (1975) 3.70
Involvement of multiple translocating DNA segments and recombinational hotspots in the structural evolution of bacterial plasmids. J Mol Biol (1976) 3.63
The terminal a sequence of the herpes simplex virus genome contains the promoter of a gene located in the repeat sequences of the L component. J Virol (1986) 3.63
Cloning and endonuclease mapping of the hepatitis B viral genome. Nature (1979) 3.62
Letter: Potential biohazards of recombinant DNA molecules. Science (1974) 3.45
Penicillinase-producing Neisseria gonorrhoeae. Lancet (1976) 3.37
A sensitive radioimmunoassay for detecting products translated from cloned DNA fragments. Cell (1978) 3.30
Hemorrhagic fevers of Southeast Asia and South America: a comparative appraisal. Prog Med Virol (1967) 3.22
In vivo DNA cloning and adjacent gene fusing with a mini-Mu-lac bacteriophage containing a plasmid replicon. Proc Natl Acad Sci U S A (1984) 3.10
In vivo formation of gene fusions encoding hybrid beta-galactosidase proteins in one step with a transposable Mu-lac transducing phage. Proc Natl Acad Sci U S A (1984) 3.06
Growth-rate dependent regulation of mRNA stability in Escherichia coli. Nature (1984) 3.06
Tsg101: a novel tumor susceptibility gene isolated by controlled homozygous functional knockout of allelic loci in mammalian cells. Cell (1996) 2.92
Structure of the malB region in Escherichia coli K12. II. Genetic map of the malE,F,G operon. Mol Gen Genet (1979) 2.83
Studies of mouse mitochondrial DNA in Escherichia coli: structure and function of the eucaryotic-procaryotic chimeric plasmids. Cell (1975) 2.80
The stability of E. coli gene transcripts is dependent on determinants localized to specific mRNA segments. Cell (1986) 2.79
Non-chromosomal antibiotic resistance in bacteria. 3. Isolation of the discrete transfer unit of the R-factor R1. Proc Natl Acad Sci U S A (1970) 2.76
In vivo site-specific genetic recombination promoted by the EcoRI restriction endonuclease. Proc Natl Acad Sci U S A (1977) 2.74
Identification by antibody to a synthetic peptide of a protein specified by a diploid gene located in the terminal repeats of the L component of herpes simplex virus genome. J Virol (1986) 2.71
Nucleotide sequences encoding and promoting expression of three antibiotic resistance genes indigenous to Streptomyces. Mol Gen Genet (1985) 2.71
Coryneform bacterial endocarditis: difficulties in diagnosis and treatment, presentation of three cases, and review of literature. Mayo Clin Proc (1977) 2.63
Functional domains within the a sequence involved in the cleavage-packaging of herpes simplex virus DNA. J Virol (1986) 2.61
Replication, establishment of latency, and induced reactivation of herpes simplex virus gamma 1 34.5 deletion mutants in rodent models. J Clin Invest (1993) 2.59
Expression of a preproinsulin-beta-galactosidase gene fusion in mammalian cells. Proc Natl Acad Sci U S A (1983) 2.57
The usefulness of preoperative laboratory screening. JAMA (1985) 2.55
An intercistronic stem-loop structure functions as an mRNA decay terminator necessary but insufficient for puf mRNA stability. Cell (1988) 2.53
Global analysis of growth phase responsive gene expression and regulation of antibiotic biosynthetic pathways in Streptomyces coelicolor using DNA microarrays. Genes Dev (2001) 2.49
Shock associated with dengue infection. I. Clinical and physiologic manifestations of dengue hemorrhagic fever in Thailand, 1964. J Pediatr (1966) 2.45
Cyanobacterial light-harvesting complex subunits encoded in two red light-induced transcripts. Science (1985) 2.41
A+U content rather than a particular nucleotide order determines the specificity of RNase E cleavage. J Biol Chem (1994) 2.39
Translocation specificity of the Tn3 element: characterization of sites of multiple insertions. Cell (1980) 2.31
Structural and functional analysis of cloned DNA segments containing the replication and incompatibility regions of a miniplasmid derived from a copy number mutant of NR1. J Bacteriol (1979) 2.29
Complete nucleotide sequence of the Streptomyces lividans plasmid pIJ101 and correlation of the sequence with genetic properties. J Bacteriol (1988) 2.29
Filamin A, the Arp2/3 complex, and the morphology and function of cortical actin filaments in human melanoma cells. J Cell Biol (2001) 2.29
The rate of processing and degradation of antisense RNAI regulates the replication of ColE1-type plasmids in vivo. Cell (1991) 2.27
Carotid endarterectomy--an evidence-based review: report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology. Neurology (2005) 2.26
RNA degradation in Escherichia coli regulated by 3' adenylation and 5' phosphorylation. Nature (1995) 2.26
Genes encoding major light-harvesting polypeptides are clustered on the genome of the cyanobacterium Fremyella diplosiphon. Proc Natl Acad Sci U S A (1986) 2.26
Transposition protein of Tn3: identification and characterisation of an essential repressor-controlled gene product. Nature (1980) 2.24