Published in Horm Metab Res on November 01, 1985
Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase. J Biol Chem (1999) 10.14
The role of fatty acids in mediating the effects of peripheral insulin on hepatic glucose production in the conscious dog. Diabetes (1997) 1.64
The role of insulin and glucagon in the regulation of basal glucose production in the postabsorptive dog. J Clin Invest (1976) 1.59
A comparison of the effects of selective increases in peripheral or portal insulin on hepatic glucose production in the conscious dog. Diabetes (1996) 1.53
Effect of glucagon on glucose production during insulin deficiency in the dog. J Clin Invest (1978) 1.52
Gluconeogenesis: methodological approaches in vivo. Fed Proc (1977) 1.47
Clinical evaluation of a portable ultrasonic and a standard optical pachometer. Optom Vis Sci (1994) 1.47
Relationship between the plasma glucose level and glucose uptake in the conscious dog. Metabolism (1978) 1.44
Substrate-induced nuclear export and peripheral compartmentalization of hepatic glucokinase correlates with glycogen deposition. Int J Exp Diabetes Res (2001) 1.44
Effects of increased glucokinase gene copy number on glucose homeostasis and hepatic glucose metabolism. J Biol Chem (1997) 1.43
Role of brain in counterregulation of insulin-induced hypoglycemia in dogs. Diabetes (1989) 1.42
Perfluoro-N-[4-(1H-tetrazol-5-ylmethyl)phenyl]alkanamides. A new class of oral antidiabetic agents. J Med Chem (1989) 1.40
Glycemic improvement in diabetic db/db mice by overexpression of the human insulin-regulatable glucose transporter (GLUT4). J Clin Invest (1995) 1.35
Comparison of the time courses of insulin and the portal signal on hepatic glucose and glycogen metabolism in the conscious dog. J Clin Invest (1996) 1.33
Physiologic action of glucagon on liver glucose metabolism. Diabetes Obes Metab (2011) 1.32
Counterregulation during hypoglycemia is directed by widespread brain regions. Diabetes (1993) 1.28
Hyperglycemia per se (insulin and glucagon withdrawn) can inhibit hepatic glucose production in man. J Clin Endocrinol Metab (1979) 1.28
Biosynthesis of bacterial glycogen: genetic and allosteric regulation of glycogen biosynthesis in Salmonella typhimurium LT-2. J Bacteriol (1977) 1.28
Absorption and disposition of a glucose load in the conscious dog. Am J Physiol (1982) 1.27
Discovery of a human liver glycogen phosphorylase inhibitor that lowers blood glucose in vivo. Proc Natl Acad Sci U S A (1998) 1.27
Glucose disposal during insulinopenia in somatostatin-treated dogs. The roles of glucose and glucagon. J Clin Invest (1978) 1.26
Intraportal glucose delivery alters the relationship between net hepatic glucose uptake and the insulin concentration. J Clin Invest (1991) 1.22
Islet amyloid-associated diabetes in obese A(vy)/a mice expressing human islet amyloid polypeptide. Diabetes (1998) 1.22
Small increases in insulin inhibit hepatic glucose production solely caused by an effect on glycogen metabolism. Diabetes (2001) 1.19
Small amounts of fructose markedly augment net hepatic glucose uptake in the conscious dog. Diabetes (1998) 1.19
Evidence for an important role of glucagon in the regulation of hepatic glucose production in normal man. J Clin Invest (1977) 1.19
Basal hepatic glucose production is regulated by the portal vein insulin concentration. Diabetes (1998) 1.18
Enhanced peripheral glucose utilization in transgenic mice expressing the human GLUT4 gene. J Biol Chem (1994) 1.17
Effects of two treatment regimes with synthetic human parathyroid hormone fragment on bone formation and the tissue balance of trabecular bone in greyhounds. Endocrinology (1983) 1.16
Hypoglycemia in IDDM. Diabetes (1989) 1.15
Sources of carbon for hepatic glycogen synthesis in the conscious dog. J Clin Invest (1991) 1.15
Role of insulin in the regulation of leucine kinetics in the conscious dog. J Clin Invest (1982) 1.15
Effect of glucose, independent of changes in insulin and glucagon secretion, on alanine metabolism in the conscious dog. J Clin Invest (1980) 1.14
Importance of the route of intravenous glucose delivery to hepatic glucose balance in the conscious dog. J Clin Invest (1987) 1.13
Effect of arginine on glucose turnover and plasma free fatty acids in normal dogs. Diabetes (1973) 1.12
The roles of insulin, glucagon, and free fatty acids in the regulation of ketogenesis in dogs. Diabetes (1977) 1.10
GLUT4 overexpression in db/db mice dose-dependently ameliorates diabetes but is not a lifelong cure. Diabetes (2001) 1.09
Differential time course of glucagon's effect on glycogenolysis and gluconeogenesis in the conscious dog. Diabetes (1981) 1.09
The effect of somatostatin on glucose uptake and production by rat tissues in vitro. Diabetes (1977) 1.08
Hepatic fuel metabolism during muscular work: role and regulation. Am J Physiol (1991) 1.07
Acute fructose administration decreases the glycemic response to an oral glucose tolerance test in normal adults. J Clin Endocrinol Metab (2000) 1.06
Effect of interaction between insulin and glucagon on glucose turnover and FFA concentration in normal and depancreatized dogs. Metabolism (1974) 1.06
Impact of chronic stress hormone infusion on hepatic carbohydrate metabolism in the conscious dog. Am J Physiol (1993) 1.06
Glucagon is a primary controller of hepatic glycogenolysis and gluconeogenesis during muscular work. Am J Physiol (1989) 1.06
Control of hepatic glucose output by glucagon and insulin in the intact dog. Biochem Soc Symp (1978) 1.05
Compartmental modeling of glucagon kinetics in the conscious dog. Metabolism (1995) 1.05
Glucokinase gene locus transgenic mice are resistant to the development of obesity-induced type 2 diabetes. Diabetes (2001) 1.04
How to become comfortable talking about sex to your patients. Can Med Assoc J (1983) 1.04
Interaction between insulin and glucose-delivery route in regulation of net hepatic glucose uptake in conscious dogs. Diabetes (1990) 1.03
Insulin as a mediator of hepatic glucose uptake in the conscious dog. Am J Physiol (1982) 1.02
Acute fructose administration improves oral glucose tolerance in adults with type 2 diabetes. Diabetes Care (2001) 1.01
A negative arterial-portal venous glucose gradient decreases skeletal muscle glucose uptake. Am J Physiol (1998) 1.01
Autoregulation of hepatic glucose production. Eur J Endocrinol (1998) 1.00
Insulin-independent effects of GLP-1 on canine liver glucose metabolism: duration of infusion and involvement of hepatoportal region. Am J Physiol Endocrinol Metab (2004) 1.00
Regulation of net hepatic glucose uptake in vivo. Annu Rev Physiol (1992) 0.99
Evidence that the brain of the conscious dog is insulin sensitive. J Clin Invest (1995) 0.99
Arginine infusion in dogs. Model for the roles of insulin and glucagon in regulating glucose turnover and free fatty acid levels. Diabetes (1974) 0.99
Importance of hypoglycemia-induced glucose production during isolated glucagon deficiency. Am J Physiol (1979) 0.98
Drug-induced depletion of acetylcholine in the rabbit corneal epithelium. Biochem Pharmacol (1974) 0.98
Disposition of a mixed meal by the conscious dog. Am J Physiol (1994) 0.97
Exercise-induced fall in insulin and hepatic carbohydrate metabolism during muscular work. Am J Physiol (1989) 0.96
Effect of hyperglycemia independent of changes in insulin or glucagon on lipolysis in the conscious dog. Metabolism (1980) 0.96
Intraportal glucose delivery enhances the effects of hepatic glucose load on net hepatic glucose uptake in vivo. J Clin Invest (1991) 0.95
Use of protease inhibitors to protect subcutaneously injected peptide hormones against local degradation [proceedings]. Br J Pharmacol (1977) 0.95
Effect of hyperglucagonemia on hepatic glycogenolysis and gluconeogenesis after a prolonged fast. Am J Physiol (1990) 0.95
Mechanisms of hormonal regulation of liver metabolism. Adv Cyclic Nucleotide Res (1981) 0.95
Ketone body turnover and net hepatic ketone production in fasted and diabetic dogs. Am J Physiol (1978) 0.95
Hepatic denervation does not significantly change the response of the liver to glucagon in conscious dogs. Am J Physiol (1995) 0.94
Differential effect of amino acid infusion route on net hepatic glucose uptake in the dog. Am J Physiol (1999) 0.94
Importance of intrahepatic mechanisms to gluconeogenesis from alanine during exercise and recovery. Am J Physiol (1988) 0.94
Similar dose responsiveness of hepatic glycogenolysis and gluconeogenesis to glucagon in vivo. Diabetes (1987) 0.94
Effect of a mixed meal on hepatic lactate and gluconeogenic precursor metabolism in dogs. Am J Physiol (1984) 0.94
A negative arterial-portal venous glucose gradient increases net hepatic glucose uptake in euglycemic dogs. Am J Physiol (1999) 0.94
Comparison of the direct and indirect effects of epinephrine on hepatic glucose production. J Clin Invest (1997) 0.93
Insulin, glucagon, and glucose as regulators of hepatic glucose uptake and production in vivo. Diabetes Metab Rev (1987) 0.93
Pulsatility does not alter the response to a physiological increment in glucagon in the conscious dog. Am J Physiol (1994) 0.93
Effects of small changes in glucagon on glucose production during a euglycemic, hyperinsulinemic clamp. Metabolism (1991) 0.93
New potent antihyperglycemic agents in db/db mice: synthesis and structure-activity relationship studies of (4-substituted benzyl) (trifluoromethyl)pyrazoles and -pyrazolones. J Med Chem (1996) 0.93
Effect of epinephrine on glycogenolysis and gluconeogenesis in conscious overnight-fasted dogs. Am J Physiol (1984) 0.92
Role of glucagon suppression on gluconeogenesis during insulin treatment of the conscious diabetic dog. Diabetologia (1987) 0.92
Role of hepatic nerves in response of liver to intraportal glucose delivery in dogs. Am J Physiol (1992) 0.91
Physiological changes in circulating glucagon alter hepatic glucose disposition during portal glucose delivery. Am J Physiol (1997) 0.91
Effects of morphine on glucose homeostasis in the conscious dog. J Clin Invest (1984) 0.90
Evaluation of an inservice training program using the SREB information test. Am J Ment Defic (1966) 0.90
Role of gluconeogenesis in sustaining glucose production during hypoglycemia caused by continuous insulin infusion in conscious dogs. Diabetes (1988) 0.90
Regulation of lipolysis and ketogenesis by norepinephrine in conscious dogs. Am J Physiol (1991) 0.90