Published in Science on May 07, 1971
Partial duplication in the "hinge" region of IgA 1 myeloma proteins. Proc Natl Acad Sci U S A (1972) 1.36
Amino acid sequence of the smaller basic protein from rat brain myelin. Biochem J (1974) 1.24
On the location of palindromes in immunoglobulin genes. Proc Natl Acad Sci U S A (1977) 1.17
Protein Hal: partial deletion of a " " immunoglobulin gene(s) and apparent reinitiation at an internal AUG codon. Proc Natl Acad Sci U S A (1973) 1.09
N-terminal amino-acid sequence of African lungfish immunoglobulin light chains. Proc Natl Acad Sci U S A (1971) 0.85
A comprehensive set of sequence analysis programs for the VAX. Nucleic Acids Res (1984) 181.98
The structure and evolution of the human beta-globin gene family. Cell (1980) 21.24
Charon phages: safer derivatives of bacteriophage lambda for DNA cloning. Science (1977) 20.27
Base substitutions, length differences and DNA strand asymmetries in the human G gamma and A gamma fetal globin gene region. Cell (1981) 16.76
Human fetal G gamma- and A gamma-globin genes: complete nucleotide sequences suggest that DNA can be exchanged between these duplicated genes. Cell (1980) 14.88
Cloning human fetal gamma globin and mouse alpha-type globin DNA: preparation and screening of shotgun collections. Science (1978) 8.24
Normal development of mice deficient in beta 2M, MHC class I proteins, and CD8+ T cells. Science (1990) 8.17
Insertion of DNA sequences into the human chromosomal beta-globin locus by homologous recombination. Nature (1985) 7.95
Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene. Proc Natl Acad Sci U S A (1993) 7.13
Targetted correction of a mutant HPRT gene in mouse embryonic stem cells. Nature (1988) 6.12
Quantitative procedures for use with the Edman-Begg sequenator. Partial sequences of two unusual immunoglobulin light chains, Rzf and Sac. Biochemistry (1971) 6.10
Elevated blood pressures in mice lacking endothelial nitric oxide synthase. Proc Natl Acad Sci U S A (1996) 5.94
Generation and reproductive phenotypes of mice lacking estrogen receptor beta. Proc Natl Acad Sci U S A (1998) 5.86
An animal model for cystic fibrosis made by gene targeting. Science (1992) 5.75
Severe reduction in leukocyte adhesion and monocyte extravasation in mice deficient in CC chemokine receptor 2. Proc Natl Acad Sci U S A (1997) 5.54
Recombinant fragment assay for gene targetting based on the polymerase chain reaction. Nucleic Acids Res (1988) 4.84
Requirement of MIP-1 alpha for an inflammatory response to viral infection. Science (1995) 4.55
Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse. Cell (1995) 4.47
Hybridization of labeled RNA to DNA in agarose gels. Nucleic Acids Res (1975) 4.38
Altering genes in animals by gene targeting. Annu Rev Immunol (1992) 4.22
A history of the human fetal globin gene duplication. Cell (1981) 4.19
Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration. Cell (1995) 4.17
Homologous recombination between plasmids in mammalian cells can be enhanced by treatment of input DNA. Proc Natl Acad Sci U S A (1984) 4.16
A noninvasive computerized tail-cuff system for measuring blood pressure in mice. Hypertension (1995) 4.08
TGF alpha deficiency results in hair follicle and eye abnormalities in targeted and waved-1 mice. Cell (1993) 4.02
Direct evidence for the importance of endothelium-derived nitric oxide in vascular remodeling. J Clin Invest (1998) 3.71
Genetic decreases in atrial natriuretic peptide and salt-sensitive hypertension. Science (1995) 3.61
Unexpected relationships between four large deletions in the human beta-globin gene cluster. Cell (1983) 3.57
Regulation of blood pressure by the type 1A angiotensin II receptor gene. Proc Natl Acad Sci U S A (1995) 3.54
Mice lacking inducible nitric oxide synthase are not resistant to lipopolysaccharide-induced death. Proc Natl Acad Sci U S A (1995) 3.53
Genetic control of blood pressure and the angiotensinogen locus. Proc Natl Acad Sci U S A (1995) 3.46
Male-female differences in fertility and blood pressure in ACE-deficient mice. Nature (1995) 3.23
Analysis of transcription and estrogen insensitivity in the female mouse after targeted disruption of the estrogen receptor gene. Mol Endocrinol (1995) 3.21
Targeted mutation of the Hprt gene in mouse embryonic stem cells. Proc Natl Acad Sci U S A (1988) 3.20
Evidence of functional lymphocytes in some (leaky) scid mice. J Exp Med (1988) 3.09
Inactivating the beta 2-microglobulin locus in mouse embryonic stem cells by homologous recombination. Proc Natl Acad Sci U S A (1989) 3.07
Hypertension, cardiac hypertrophy, and sudden death in mice lacking natriuretic peptide receptor A. Proc Natl Acad Sci U S A (1997) 2.99
A mouse alpha-globin-related pseudogene lacking intervening sequences. Nature (1980) 2.92
Single-copy transgenic mice with chosen-site integration. Proc Natl Acad Sci U S A (1996) 2.84
Genetic linkage studies suggest that Alzheimer's disease is not a single homogeneous disorder. Nature (1990) 2.80
Initiation of protein synthesis at an unusual position in an immunoglobulin gene? Science (1972) 2.74
Germ-line transmission of a planned alteration made in a hypoxanthine phosphoribosyltransferase gene by homologous recombination in embryonic stem cells. Proc Natl Acad Sci U S A (1989) 2.59
The natriuretic peptide clearance receptor locally modulates the physiological effects of the natriuretic peptide system. Proc Natl Acad Sci U S A (1999) 2.48
Mutant immunoglobulin genes have repetitive DNA elements inserted into their intervening sequences. Proc Natl Acad Sci U S A (1982) 2.44
Role of mouse cryptochrome blue-light photoreceptor in circadian photoresponses. Science (1998) 2.38
Pharmacodynamic effects and pharmacokinetics of atorvastatin after administration to normocholesterolemic subjects in the morning and evening. J Clin Pharmacol (1996) 2.37
Antibody responses in bursa-deficient chickens. J Immunol (1966) 2.37
Beta 2-microglobulin-, CD8+ T-cell-deficient mice survive inoculation with high doses of vaccinia virus and exhibit altered IgG responses. Proc Natl Acad Sci U S A (1992) 2.37
Defective epithelial chloride transport in a gene-targeted mouse model of cystic fibrosis. Science (1992) 2.36
A coagulation factor IX-deficient mouse model for human hemophilia B. Blood (1997) 2.36
Evidence for close linkage of a mouse light chain marker with the Ly-2,3 locus. J Immunol (1978) 2.34
Double-strand gap repair in a mammalian gene targeting reaction. Mol Cell Biol (1991) 2.28
Genetic disruption of Ptgs-1, as well as Ptgs-2, reduces intestinal tumorigenesis in Min mice. Cancer Res (2000) 2.28
Impaired mucosal defense to acute colonic injury in mice lacking cyclooxygenase-1 or cyclooxygenase-2. J Clin Invest (2000) 2.27
Cloning human fetal gamma globin and mouse alpha-type globin DNA: characterization and partial sequencing. Science (1978) 2.25
Testing an "in-out" targeting procedure for making subtle genomic modifications in mouse embryonic stem cells. Mol Cell Biol (1991) 2.25
The evolution of multigene families: human haptoglobin genes. Annu Rev Genet (1986) 2.21
Reduced growth, abnormal kidney structure, and type 2 (AT2) angiotensin receptor-mediated blood pressure regulation in mice lacking both AT1A and AT1B receptors for angiotensin II. Proc Natl Acad Sci U S A (1998) 2.17
Recombination and balanced chromosome polymorphism suggested by DNA sequences 5' to the human delta-globin gene. Proc Natl Acad Sci U S A (1983) 2.11
Duplication within the haptoglobin Hp2 gene. Nature (1984) 2.08
Toward an animal model of cystic fibrosis: targeted interruption of exon 10 of the cystic fibrosis transmembrane regulator gene in embryonic stem cells. Proc Natl Acad Sci U S A (1991) 2.04
Pressure-independent enhancement of cardiac hypertrophy in natriuretic peptide receptor A-deficient mice. J Clin Invest (2001) 2.03
Nucleotide sequence of 16-kilobase pairs of DNA 5' to the human epsilon-globin gene. J Biol Chem (1985) 2.02
A mouse model for beta 0-thalassemia. Proc Natl Acad Sci U S A (1995) 2.01
Symposium on microbial changes in foods. Bacteria active in the spoilage of certain sea foods. J Appl Bacteriol (1971) 2.01
Efficient transformation and frequent single-site, single-copy insertion of DNA can be obtained in mouse erythroleukemia cells transformed by electroporation. Exp Hematol (1986) 1.98
Gene conversions and their relation to homologous chromosome pairing. Philos Trans R Soc Lond B Biol Sci (1986) 1.95
Accurate modification of a chromosomal plasmid by homologous recombination in human cells. Proc Natl Acad Sci U S A (1987) 1.93
Extreme hydrops fetalis and cardiovascular abnormalities in mice lacking a functional Adrenomedullin gene. Proc Natl Acad Sci U S A (2001) 1.85
Cotransformation and gene targeting in mouse embryonic stem cells. Mol Cell Biol (1991) 1.84
Enhanced atherosclerosis and kidney dysfunction in eNOS(-/-)Apoe(-/-) mice are ameliorated by enalapril treatment. J Clin Invest (2000) 1.84
Angiotensin II regulates cellular immune responses through a calcineurin-dependent pathway. J Clin Invest (1999) 1.80
A gene deletion ending within a complex array of repeated sequences 3' to the human beta-globin gene cluster. Proc Natl Acad Sci U S A (1986) 1.80
Taxonomic position and seasonal variations in marine neritic environment of some gram-negative antibiotic-producing bacteria. J Gen Microbiol (1975) 1.74
Angiotensin II responses in AT1A receptor-deficient mice: a role for AT1B receptors in blood pressure regulation. Am J Physiol (1997) 1.64
Short-term effects of insulin and glucagon on lipid synthesis in isolated rat hepatocytes. Covariance of acetyl-CoA carboxylase activity and the rate of 3H2O incorporation into fatty acids. FEBS Lett (1978) 1.59
Uncompensated polyuria in a mouse model of Bartter's syndrome. Proc Natl Acad Sci U S A (2000) 1.59
Failure of ductus arteriosus closure and remodeling in neonatal mice deficient in cyclooxygenase-1 and cyclooxygenase-2. Proc Natl Acad Sci U S A (2001) 1.58
Protein phosphatase 2A subunit assembly: the catalytic subunit carboxy terminus is important for binding cellular B subunit but not polyomavirus middle tumor antigen. Oncogene (1997) 1.57
Sequence diversity within a subgroup of mouse immunoglobulin kappa chains controlled by the IgK-Ef2 locus. J Exp Med (1981) 1.55
Extracellular phytase (E.C. 3.1.3.8) from Aspergillus ficuum NRRL 3135: purification and characterization. Prep Biochem (1987) 1.54
Antibody-producing cells in division. Science (1967) 1.53
Regulatory elements in the introns of the human HPRT gene are necessary for its expression in embryonic stem cells. Proc Natl Acad Sci U S A (1990) 1.53
Angiotensin-converting enzyme and male fertility. Proc Natl Acad Sci U S A (1998) 1.52
Antibody variability. Somatic recombination between the elements of "antibody gene pairs" may explain antibody variability. Science (1967) 1.52
Abolition of male sexual behaviors in mice lacking estrogen receptors alpha and beta (alpha beta ERKO). Proc Natl Acad Sci U S A (2000) 1.51
Electronic measurement of bacterial growth. J Phys E (1978) 1.50
Human globin psi B2 is not a globin-related sequence. Nucleic Acids Res (1982) 1.48
Multiple-dose pharmacokinetics, pharmacodynamics, and safety of atorvastatin, an inhibitor of HMG-CoA reductase, in healthy subjects. Clin Pharmacol Ther (1996) 1.48
Purification and partial characterization of four proteins from human parotid saliva. Biochem J (1971) 1.47
Altering mice by homologous recombination using embryonic stem cells. J Biol Chem (1994) 1.47
Homologous recombination with DNA introduced into mammalian cells. Cold Spring Harb Symp Quant Biol (1984) 1.46
Coagulation defects and altered hemodynamic responses in mice lacking receptors for thromboxane A2. J Clin Invest (1998) 1.46
Estrogen receptor alpha is a major mediator of 17beta-estradiol's atheroprotective effects on lesion size in Apoe-/- mice. J Clin Invest (2001) 1.45
The kinetics of taxoid accumulation in cell suspension cultures of Taxus following elicitation with methyl jasmonate. Biotechnol Bioeng (1999) 1.44
Estrogen inhibits the vascular injury response in estrogen receptor beta-deficient female mice. Proc Natl Acad Sci U S A (1999) 1.44
A Chinese G gamma + (A gamma delta beta)zero thalassemia deletion: comparison to other deletions in the human beta-globin gene cluster and sequence analysis of the breakpoints. Nucleic Acids Res (1985) 1.42
Tuberculosis Prevention. Can Med Assoc J (1945) 1.38
Modulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity with cAMP and wth protein fractions of rat liver cytosol. Biochem Biophys Res Commun (1973) 1.38