Published in CRC Crit Rev Toxicol on November 01, 1973
Chemotopic odorant coding in a mammalian olfactory system. J Comp Neurol (2007) 2.13
Cardiovascular and systemic responses to inhaled pollutants in rodents: effects of ozone and particulate matter. Environ Health Perspect (2001) 1.36
Menthol attenuates respiratory irritation responses to multiple cigarette smoke irritants. FASEB J (2011) 1.33
Formation of strong airway irritants in mixtures of isoprene/ozone and isoprene/ozone/nitrogen dioxide. Environ Health Perspect (2001) 0.99
Evaluation and application of the RD50 for determining acceptable exposure levels of airborne sensory irritants for the general public. Environ Health Perspect (2007) 0.95
Review of the upper airway, including olfaction, as mediator of symptoms. Environ Health Perspect (2002) 0.92
Sensory and pulmonary irritation of methyl isocyanate in mice and pulmonary irritation and possible cyanidelike effects of methyl isocyanate in guinea pigs. Environ Health Perspect (1987) 0.91
Health effects of acid aerosols formed by atmospheric mixtures. Environ Health Perspect (1989) 0.91
Contribution of formaldehyde to respiratory cancer. Environ Health Perspect (1986) 0.89
Cardiovascular depression in rats exposed to inhaled particulate matter and ozone: effects of diet-induced metabolic syndrome. Environ Health Perspect (2013) 0.88
Role of metabolic activation and the TRPA1 receptor in the sensory irritation response to styrene and naphthalene. Toxicol Sci (2010) 0.88
Dose-response analysis in animal studies: prediction of human responses. Environ Health Perspect (1981) 0.88
Menthol attenuates respiratory irritation and elevates blood cotinine in cigarette smoke exposed mice. PLoS One (2015) 0.88
A cut-off in ocular chemesthesis from vapors of homologous alkylbenzenes and 2-ketones as revealed by concentration-detection functions. Toxicol Appl Pharmacol (2008) 0.82
Proposal for the assessment of quantitative dermal exposure limits in occupational environments: Part 1. Development of a concept to derive a quantitative dermal occupational exposure limit. Occup Environ Med (1998) 0.82
Re-evaluation of the WHO (2010) formaldehyde indoor air quality guideline for cancer risk assessment. Arch Toxicol (2016) 0.82
Dissecting the role of TRPV1 in detecting multiple trigeminal irritants in three behavioral assays for sensory irritation. F1000Res (2013) 0.79
Stimulus properties of inhaled substances. Environ Health Perspect (1978) 0.79
The biological and toxicological activity of gases and vapors. Toxicol In Vitro (2009) 0.78
Acrolein and asthma attack prevalence in a representative sample of the United States adult population 2000-2009. PLoS One (2014) 0.78
Exposure study to examine chemosensory effects of formaldehyde on hyposensitive and hypersensitive males. Int Arch Occup Environ Health (2012) 0.78
Airway irritation, inflammation, and toxicity in mice following inhalation of metal oxide nanoparticles. Nanotoxicology (2016) 0.78
Effects of Acetaminophen on Oxidant and Irritant Respiratory Tract Responses to Environmental Tobacco Smoke in Female Mice. Environ Health Perspect (2015) 0.75
Acute airway irritation of methyl formate in mice. Arch Toxicol (2011) 0.75
Acute cardiopulmonary toxicity of inhaled aldehydes: role of TRPA1. Ann N Y Acad Sci (2016) 0.75
Role of TRPA1 in acute cardiopulmonary toxicity of inhaled acrolein. Toxicol Appl Pharmacol (2016) 0.75
Methyl methacrylate and respiratory sensitization: a critical review. Crit Rev Toxicol (2011) 0.75
Sensory and pulmonary irritation with exposure to methyl isocyanate. Toxicol Appl Pharmacol (1986) 1.33
Bioassay for evaluating the potency of airborne sensory irritants and predicting acceptable levels of exposure in man. Food Cosmet Toxicol (1981) 1.17
Irritating properties of airborne materials to the upper respiratory tract. Arch Environ Health (1966) 1.16
Computer assisted recognition and quantitation of the effects of airborne chemicals acting at different areas of the respiratory tract in mice. Arch Toxicol (1994) 1.15
An aerosol generator for the resuspension of cotton dust. Toxicol Appl Pharmacol (1984) 1.11
Sensory irritation of the upper airways by airborne chemicals. Toxicol Appl Pharmacol (1973) 1.10
Characteristic modifications of the breathing pattern of mice to evaluate the effects of airborne chemicals on the respiratory tract. Arch Toxicol (1993) 1.09
Toxicologic classification of thermal decomposition products of synthetic and natural polymers. Toxicol Appl Pharmacol (1981) 1.06
Tidal midexpiratory flow as a measure of airway hyperresponsiveness in allergic mice. Am J Physiol Lung Cell Mol Physiol (2001) 1.04
Effects of mono-2-ethylhexyl phthalate on the respiratory tract in BALB/c mice. Hum Exp Toxicol (2004) 1.01
Sensory irritation by toluene diisocyanate in single and repeated exposures. Toxicol Appl Pharmacol (1979) 0.99
Sensory irritation, pulmonary irritation, and acute lethality of a polymeric isocyanate and sensory irritation of 2,6-toleune diisocyanate. Toxicol Appl Pharmacol (1982) 0.99
Sequential development of airway hyperresponsiveness and acute airway obstruction in a mouse model of allergic inflammation. Int Arch Allergy Immunol (2000) 0.99
Long-term continuous exposure to sulfur dioxide in cynomolgus monkeys. Arch Environ Health (1972) 0.98
A recommended occupational exposure limit for formaldehyde based on irritation. J Toxicol Environ Health (1997) 0.97
A method for repeated evaluation of pulmonary performance in unanesthetized, unrestrained guinea pigs and its application to detect effects of sulfuric acid mist inhalation. Toxicol Appl Pharmacol (1982) 0.97
Acute airway effects of formaldehyde and ozone in BALB/c mice. Hum Exp Toxicol (1999) 0.96
A short-term test to predict acceptable levels of exposure to airborne sensory irritants. Am Ind Hyg Assoc J (1979) 0.93
Uptake and distribution of 14C during and following inhalation exposure to radioactive toluene diisocyanate. Toxicol Appl Pharmacol (1989) 0.93
Sensory and pulmonary irritation of methyl isocyanate in mice and pulmonary irritation and possible cyanidelike effects of methyl isocyanate in guinea pigs. Environ Health Perspect (1987) 0.91
Longitudinal study of tolyl-reactive IgE antibodies in workers hypersensitive to TDI. J Occup Med (1979) 0.90
Sensory irritating potency of some microbial volatile organic compounds (MVOCs) and a mixture of five MVOCs. Arch Environ Health (1999) 0.89
Comparison of the sensory irritation response in mice to chlorine and hydrogen chloride. Arch Environ Health (1977) 0.89
Long-term continuous exposure to sulfuric acid mist in cynomolgus monkeys and guinea pigs. Arch Environ Health (1973) 0.89
Toxicity of thermal decomposition products of urea formaldehyde and phenol formaldehyde foams. Toxicol Appl Pharmacol (1979) 0.88
Dose-response analysis in animal studies: prediction of human responses. Environ Health Perspect (1981) 0.88
Sensory irritation to formaldehyde and acrolein during single and repeated exposures in mice. Am Ind Hyg Assoc J (1977) 0.88
Evaluation of sensory irritation from some common industrial solvents. Am Ind Hyg Assoc J (1980) 0.88
Distribution and reactivity of inhaled 14C-labeled toluene diisocyanate (TDI) in rats. Arch Toxicol (1994) 0.86
Irritation of the upper airways from mixtures of cumene and n-propanol. Mechanisms and their consequences for setting industrial exposure limits. Arch Toxicol (1988) 0.85
An attempt to define a just detectable effect for airborne chemicals on the respiratory tract in mice. Arch Toxicol (1996) 0.85
Autoradiographic analyses of guinea pig airway tissues following inhalation exposure to 14C-labeled methyl isocyanate. Fundam Appl Toxicol (1993) 0.85
Immunologic sensitization and pulmonary hypersensitivity by repeated inhalation of aromatic isocyanates. Toxicol Appl Pharmacol (1980) 0.84
Sensory irritation, pulmonary irritation, and respiratory stimulation by airborne benzene and alkylbenzenes: prediction of safe industrial exposure levels and correlation with their thermodynamic properties. Toxicol Appl Pharmacol (1982) 0.84
Comparison of some mono- and diisocyanates as sensory irritants. Toxicol Appl Pharmacol (1981) 0.84
Possible mechanisms for the respiratory tract effects of noncarcinogenic indoor-climate pollutants and bases for their risk assessment. Scand J Work Environ Health (1995) 0.83
Antigens which detect IgE antibodies in workers sensitive to toluene diisocyanate. Clin Allergy (1980) 0.83
Effects of R-(+)- and S-(-)-limonene on the respiratory tract in mice. Hum Exp Toxicol (2000) 0.83
Chronic exposure of cynamolgus monkeys to fly ash. Inhaled Part (1970) 0.82
A method to classify airborne chemicals which alter the normal ventilatory response induced by CO2. Toxicol Appl Pharmacol (1985) 0.82
Characterization of the effects of an airborne mixture of chemicals on the respiratory tract and smoothing polynomial spline analysis of the data. Arch Toxicol (1995) 0.82
Sister chromatid exchange in murine alveolar macrophages, regenerating liver and bone marrow cells--a simultaneous multicellular in vivo assay. Chromosoma (1979) 0.82
Stereospecificity of the sensory irritation receptor for nonreactive chemicals illustrated by pinene enantiomers. Arch Toxicol (1998) 0.81
Evaluation of the pulmonary effects of HCl using CO2 challenges in guinea pigs. Fundam Appl Toxicol (1985) 0.81
Evaluation of the pulmonary effects of wood smoke in guinea pigs by repeated CO2 challenges. Toxicol Appl Pharmacol (1984) 0.81
Airborne chemical irritants. Role of the trigeminal nerve. Arch Environ Health (1972) 0.81
Evaluation of sensory irritation of delta3-carene and turpentine, and acceptable levels of monoterpenes in occupational and indoor environment. J Toxicol Environ Health A (1999) 0.81
Performance evaluation under intoxicating atmospheres. Fundam Appl Toxicol (1987) 0.80
Uptake and distribution of 14C during and following exposure to [14C]methyl isocyanate. Toxicol Appl Pharmacol (1988) 0.80
Use of repeated CO2 challenges to evaluate the pulmonary performance of guinea pigs exposed to toluene diisocyanate. J Toxicol Environ Health (1985) 0.79
Long term pulmonary impairment following a single exposure to methyl isocyanate. Toxicol Appl Pharmacol (1991) 0.79
Induction of formaldehyde sensitivity in guinea pigs. Toxicol Appl Pharmacol (1984) 0.79
Chronic pulmonary effects in guinea pigs from prolonged inhalation of cotton dust. Toxicol Appl Pharmacol (1987) 0.78
Assessment of the cough reflex caused by inhalation of sodium lauryl sulfate and citric acid aerosols. Fundam Appl Toxicol (1983) 0.78
Evaluation of sensory irritation from acrolein-formaldehyde mixtures. Am Ind Hyg Assoc J (1978) 0.78
Pulmonary effects of a polyisocyanate aerosol: hexamethylene diisocyanate trimer (HDIt) or Desmodur-N (DES-N). Toxicol Appl Pharmacol (1987) 0.78
Improved immunosuppression with aerosolized cyclosporine in experimental pulmonary transplantation. Transplantation (1992) 0.78
Long-term continuous exposure to sulfur dioxide and fly ash mixtures in cynomolgus monkeys and guinea pigs. Arch Environ Health (1973) 0.77
Long-term continuous exposure of guinea pigs to sulfur dioxide. Arch Environ Health (1970) 0.77
The toxicity of smoke from polymeric materials during thermal decomposition. Annu Rev Pharmacol Toxicol (1985) 0.77
The Ferguson principle and an analysis of biological activity of gases and vapors. J Pharm Sci (1994) 0.76
Sensory irritation and incapacitation evoked by thermal decomposition products of polymers and comparisons with known sensory irritants. Arch Environ Health (1978) 0.76
Interactions of sulfur dioxide and acrolein as sensory irritants. Toxicol Appl Pharmacol (1979) 0.76
Toxicity of smoke during chair smoldering tests and small scale tests using the same materials. Fundam Appl Toxicol (1984) 0.76
Evaluation of sister chromatid exchange and cytotoxicity in murine tissues in vivo and lymphocytes in vitro following methyl isocyanate exposure. Environ Health Perspect (1987) 0.75
Sensory irritant receptor compartment properties. Equipotent vapour concentrations related to saturated vapour concentrations, octanol-water, and octanol-gas partition coefficients. Acta Pharm Nord (1990) 0.75
Pulmonary atelectasis following administration of halogenated hydrocarbons. Toxicol Appl Pharmacol (1975) 0.75
Presence of tolyl-specific IgE and absence of IgG antibodies in workers exposed to toluene diisocyanate. J Environ Sci Health C (1979) 0.75
Pulmonary effects of repeated exposures to paraquat aerosol in guinea pigs. Fundam Appl Toxicol (1988) 0.75
Pulmonary hypersensitivity to hexyl isocyanate-ovalbumin aerosol in guinea pigs. Toxicol Appl Pharmacol (1979) 0.75
Monitoring delayed-onset pulmonary hypersensitivity in guinea pigs. Toxicol Appl Pharmacol (1981) 0.75
Sensory irritation mechanisms investigated from model compounds: trifluoroethanol, hexafluoroisopropanol and methyl hexafluoroisopropyl ether. Arch Toxicol (1996) 0.75
Sensory irritation evoked by plastic decomposition products. Am Ind Hyg Assoc J (1974) 0.75
Development of methodologies to assess the relative hazards from thermal decomposition products of polymeric materials. Am Ind Hyg Assoc J (1979) 0.75
Mechanical properties of the lung in cynomolgus monkeys. Measurement with real-time digital computerization. Arch Environ Health (1971) 0.75
Potency of some carbamates as multiple tissue sister chromatid exchange inducers and comparison with known carcinogenic activities. Cancer Res (1981) 0.75
Evaluation of concentration-response relationships for histamine and sulfuric acid aerosols in unanesthetized guinea pigs for their effects on ventilatory response to CO2. Toxicol Appl Pharmacol (1984) 0.75
Respiratory system flow resistance with digital computer techniques. Measured in cynomolgus monkeys and guinea pigs. Arch Environ Health (1970) 0.75
A method to rapidly evaluate the acute pulmonary effects of aerosols in unanesthetized guinea pigs. Toxicol Appl Pharmacol (1983) 0.75
Reproductive toxicity of methyl isocyanate in mice. J Toxicol Environ Health (1987) 0.75
Sister chromatid exchange in murine alveolar macrophages, bone marrow, and regenerating liver cells induced by styrene inhalation. Toxicol Appl Pharmacol (1980) 0.75
Ergometer within a whole-body plethysmograph to evaluate performance of guinea pigs under toxic atmospheres. Toxicol Appl Pharmacol (1989) 0.75
Multicellular in vivo sister-chromatid exchanges induced by urethane. Mutat Res (1981) 0.75
Alteration of respiratory cycle timing by propranolol. Toxicol Appl Pharmacol (1989) 0.75
Animal assays for upper airway irritation. Screening of materials and structure-activity relations. Ann N Y Acad Sci (1992) 0.75
Distribution of ventilation in cynomolgus monkeys. Measurement with real-time digital computerization. Arch Environ Health (1971) 0.75
Sister chromatid exchange in regenerating liver and bone marrow cells of mice exposed to styrene. Toxicol Appl Pharmacol (1979) 0.75
Serologic assays for antibodies to hexamethylene diisocyanate and diphenylmethane diisocyanate. Arch Dermatol (1981) 0.75
Inhibition of methyl isocyanate toxicity in mice by starvation and dexamethasone but not by sodium thiosulfate, atropine, and ethanol. J Toxicol Environ Health (1988) 0.75
Serologic assays for antibodies to HDI and MDI. Contact Dermatitis (1981) 0.75
Concentration-dependent respiratory response of guinea pigs to paraquat aerosol. Arch Toxicol (1987) 0.75
Induction of abnormal ventilatory responses to CO2 and evaluation of agents given to prevent or reverse these responses. Fundam Appl Toxicol (1988) 0.75
IgE antibodies in TDI workers. J Allergy Clin Immunol (1980) 0.75
Sensory irritation of select experimental photochemical oxidants. Arch Environ Health (1978) 0.75
Methodologies for estimating LD50: the moving average method. Toxicol Appl Pharmacol (1985) 0.75
Toxicologic evaluation of thermoplastic resins at and above processing temperatures. Am Ind Hyg Assoc J (1981) 0.75
The effects of aerosols of carbamylcholine, serotonin and propranolol on the ventilatory response to CO2 in guinea pigs and comparison with the effects of histamine and sulfuric acid. Acta Pharmacol Toxicol (Copenh) (1985) 0.75
Single-tracer technique to evaluate pulmonary edema and its application to detect the effect of hexamethylene diisocyanate trimer aerosol exposures. Toxicol Appl Pharmacol (1983) 0.75