Published in Lancet on October 26, 1968
First-line chemotherapy with capecitabine and temozolomide in patients with metastatic pancreatic endocrine carcinomas. Cancer (2010) 2.74
Pancreatic islet beta cell tumors and hyperplasia: experience in 14 Seattle hospitals. Ann Surg (1972) 1.24
Observations on the postoperative tumor growth behavior of certain islet cell tumors. Ann Surg (1976) 1.15
Peptide-secreting tumours with special reference to the pancreas. Gut (1969) 1.03
Streptozotocin treatment of malignant islet cell tumour. Br Med J (1970) 1.00
Current diagnosis and management of Zollinger-Ellison syndrome. Ann Surg (1989) 0.99
Insulinoma in childhood. Arch Dis Child (1969) 0.99
Treatment of advanced disease in patients with well-differentiated neuroendocrine tumors. Nat Clin Pract Oncol (2009) 0.96
Outcome of peptide receptor radionuclide therapy with 177Lu-octreotate in advanced grade 1/2 pancreatic neuroendocrine tumours. Eur J Nucl Med Mol Imaging (2014) 0.94
Malignant metastatic insulinoma-postoperative treatment and follow-up. World J Surg (2005) 0.89
An active site aromatic triad in Escherichia coli DNA Pol IV coordinates cell survival and mutagenesis in different DNA damaging agents. PLoS One (2011) 0.84
Glucagonoma syndrome in a young man. Proc R Soc Med (1976) 0.83
Further studies on streptozotocin therapy for a multiple-hormone-producing islet cell carcinoma. Gut (1971) 0.82
Cancer chemotherapy: past, present, and future--Part I. J Natl Med Assoc (1984) 0.81
Subhuman primate pregnancy complicated by streptozotocin-induced diabetes mellitus. J Clin Invest (1972) 0.81
Successful treatment of a malignant gastrinoma with streptozotocin. Gut (1976) 0.81
Treatment of Zollinger-Ellison syndrome. World J Gastroenterol (2005) 0.80
Zollinger-Ellison syndrome: special considerations. Ann Surg (1977) 0.80
Insulinoma (apud cell carcinoma) in a diabetic. Br Med J (1978) 0.80
Progress report. Cytotoxic therapy for gastrointestinal carcinoma. Gut (1976) 0.79
Progress report. Diagnosis of insulinoma. Gut (1971) 0.79
Systematic Review and Meta-Analysis on the Role of Chemotherapy in Advanced and Metastatic Neuroendocrine Tumor (NET). PLoS One (2016) 0.79
Metronomic capecitabine in gastroenteropancreatic neuroendrocrine tumors: a suitable regimen and review of the literature. Onco Targets Ther (2014) 0.78
A Phase II Trial of a Histone Deacetylase Inhibitor Panobinostat in Patients With Low-Grade Neuroendocrine Tumors. Oncologist (2016) 0.76
Intra-arterial use of streptozotocin in a case of metastatic malignant gastrinoma. Can Med Assoc J (1981) 0.75
Systemic Therapies for Advanced Pancreatic Neuroendocrine Tumors. Hematol Oncol Clin North Am (2015) 0.75
Streptozotocin-associated lymphopenia in cynomolgus monkeys. Islets (2014) 0.75
Gastroenteropancreatic neuroendocrine tumors: recommendations of Turkish multidisciplinary neuroendocrine tumor study group on diagnosis, treatment and follow-up. Arch Med Sci (2017) 0.75
Design of anticancer agents utilizing streptozocin for in silico optimization of properties and pattern recognition identification of group features. Open Med Chem J (2008) 0.75
Forced diuresis to reduce nephrotoxicity of streptozotocin in the treatment of advanced metastatic insulinoma. Br Med J (Clin Res Ed) (1987) 0.75
Insulinomas in Northern Ireland between 1960 and 1980. A review of 16 cases. Ulster Med J (1981) 0.75
Electrochemical analysis of antichemotherapeutic drug zanosar in pharmaceutical and biological samples by differential pulse polarography. J Anal Methods Chem (2013) 0.75
Streptozotocin-induced renal tumours in rats. Br J Cancer (1977) 0.75
Hidden Markov models in computational biology. Applications to protein modeling. J Mol Biol (1994) 31.57
Transection of the oesophagus for bleeding oesophageal varices. Br J Surg (1973) 26.26
Dirichlet mixtures: a method for improved detection of weak but significant protein sequence homology. Comput Appl Biosci (1996) 19.74
Cofactor dynamics and sufficiency in estrogen receptor-regulated transcription. Cell (2000) 11.10
Compilation of tRNA sequences and sequences of tRNA genes. Nucleic Acids Res (1998) 10.74
International Autoimmune Hepatitis Group Report: review of criteria for diagnosis of autoimmune hepatitis. J Hepatol (1999) 9.11
Objective structured assessment of technical skill (OSATS) for surgical residents. Br J Surg (1997) 7.54
Early indicators of prognosis in fulminant hepatic failure. Gastroenterology (1989) 7.43
Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S-nitrosothiols as active intermediates. J Pharmacol Exp Ther (1981) 6.71
Cost analysis of early discharge after hip fracture. BMJ (1993) 6.64
Deaths from low dose paracetamol poisoning. BMJ (1998) 6.63
Stochastic context-free grammars for tRNA modeling. Nucleic Acids Res (1994) 6.29
Anti-tuberculous therapy and acute liver failure. Lancet (1995) 6.27
Causes and outcomes of the acute chest syndrome in sickle cell disease. National Acute Chest Syndrome Study Group. N Engl J Med (2000) 6.07
Global trends in resistance to antituberculosis drugs. World Health Organization-International Union against Tuberculosis and Lung Disease Working Group on Anti-Tuberculosis Drug Resistance Surveillance. N Engl J Med (2001) 6.05
Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses. Cell (1998) 5.92
Complementary chromatic adaptation in a filamentous blue-green alga. J Cell Biol (1973) 5.40
HTLV-III-neutralizing antibodies in patients with AIDS and AIDS-related complex. Nature (1985) 5.10
Acute liver failure: redefining the syndromes. Lancet (1993) 4.99
Vulnerability genes or plasticity genes? Mol Psychiatry (2009) 4.96
Opacity genes in Neisseria gonorrhoeae: control of phase and antigenic variation. Cell (1986) 4.89
Viral antibodies in diabetes mellitus. Br Med J (1969) 4.84
A controlled trial comparing continued zidovudine with didanosine in human immunodeficiency virus infection. The NIAID AIDS Clinical Trials Group. N Engl J Med (1992) 4.71
Hepatitis C virus antibodies in chronic active hepatitis: pathogenetic factor or false-positive result? Lancet (1990) 4.57
Urinary D-glucaric-acid excretion as a test for hepatic enzyme induction in man. Lancet (1971) 4.49
Liver transplantation in man. I. Observations on technique and organization in five cases. Br Med J (1968) 4.38
Extraction of prostaglandins from human blood. Nature (1971) 4.37
Improved outcome of paracetamol-induced fulminant hepatic failure by late administration of acetylcysteine. Lancet (1990) 4.27
A Social Study of Hospital Treatment. Br Med J (1945) 4.24
Estrogen receptor-associated proteins: possible mediators of hormone-induced transcription. Science (1994) 4.22
Seasonal incidence of diabetes mellitus. Br Med J (1969) 4.14
Subset of individuals with autism spectrum disorders and extreme macrocephaly associated with germline PTEN tumour suppressor gene mutations. J Med Genet (2005) 4.14
Long-term outcome of hepatitis C infection after liver transplantation. N Engl J Med (1996) 4.10
Daily variation of particulate air pollution and poor cardiac autonomic control in the elderly. Environ Health Perspect (1999) 4.07
The formation of a structure with the features of synovial lining by subcutaneous injection of air: an in vivo tissue culture system. J Pathol (1981) 3.99
Cell-mediated immunity to a human liver-specific antigen in patients with active chronic hepatitis and primary biliary cirrhosis. Lancet (1972) 3.90
Polarity-specific activities of retinoic acid receptors determined by a co-repressor. Nature (1995) 3.90
The association of school environments with youth physical activity. Am J Public Health (2001) 3.88
The role of virus-specific CD8(+) cells in liver damage and viral control during persistent hepatitis B virus infection. J Exp Med (2000) 3.78
Bronchoscopic lung-volume reduction with Exhale airway stents for emphysema (EASE trial): randomised, sham-controlled, multicentre trial. Lancet (2011) 3.70
Studies on prostaglandin antagonists. Br J Pharmacol (1971) 3.61
Inadequate antibody response to hBAg or suppressor T-cell defect in development of active chronic hepatitis. Lancet (1974) 3.61
Do housemen take an adequate drinking history? Br Med J (1980) 3.44
Apolipoprotein E epsilon4 associated with chronic traumatic brain injury in boxing. JAMA (1997) 3.43
Screening for type 2 diabetes: literature review and economic modelling. Health Technol Assess (2007) 3.40
Structured patient education: the diabetes X-PERT Programme makes a difference. Diabet Med (2006) 3.36
The cytotoxic T lymphocyte response to multiple hepatitis B virus polymerase epitopes during and after acute viral hepatitis. J Exp Med (1995) 3.34
lac repressor can regulate expression from a hybrid SV40 early promoter containing a lac operator in animal cells. Cell (1987) 3.33
A pharmacological study of the motility of the human gastrointestinal tract. Gut (1966) 3.32
Detection of antibodies directed against a liver-specific membrane lipoprotein in patients with acute and chronic active hepatitis. N Engl J Med (1978) 3.28
A genomewide scan for loci predisposing to type 2 diabetes in a U.K. population (the Diabetes UK Warren 2 Repository): analysis of 573 pedigrees provides independent replication of a susceptibility locus on chromosome 1q. Am J Hum Genet (2001) 3.26
Potassium ions and the secretion of insulin by islets of Langerhans incubated in vitro. Biochem J (1968) 3.26
Plasma endothelin immunoreactivity in liver disease and the hepatorenal syndrome. N Engl J Med (1992) 3.24
NHLBI Family Heart Study: objectives and design. Am J Epidemiol (1996) 3.21
Lymphocyte cytotoxicity to isolated hepatocytes in chronic active hepatitis. Nature (1974) 3.17
Prostaglandin E2 and gastric acid secretion in man. J Physiol (1973) 3.16
Antibody-dependent cell-mediated (K cell) cytotoxicity against isolated hepatocytes in chronic active hepatitis. Lancet (1976) 3.16
Purification and characterization of human liver-specific membrane lipoprotein (LSP). Clin Exp Immunol (1977) 3.13
Differential activation of peroxisome proliferator-activated receptors by eicosanoids. J Biol Chem (1995) 3.13
Cost comparison: a desflurane- versus a propofol-based general anesthetic technique. Anesth Analg (1994) 3.09
Improved survival after orthotopic liver grafting. Br Med J (Clin Res Ed) (1981) 3.09
Specificity of T lymphocyte cytotoxicity to autologous hepatocytes in chronic hepatitis B virus infection: evidence that T cells are directed against HBV core antigen expressed on hepatocytes. J Immunol (1982) 3.09
Mutations that alter the ability of the Escherichia coli cyclic AMP receptor protein to activate transcription. Nucleic Acids Res (1990) 3.08
Structural analysis of the interaction between the human immunodeficiency virus Rev protein and the Rev response element. Proc Natl Acad Sci U S A (1991) 3.06
Presence of a newly described human DNA virus (TTV) in patients with liver disease. Lancet (1998) 3.06
Nocturnal asthma and changes in circulating epinephrine, histamine, and cortisol. N Engl J Med (1980) 3.04
Liver transplantation for malignant disease. Results in 93 consecutive patients. Ann Surg (1988) 3.04
Introduction and audit of a general practice antibiotic formulary. J R Coll Gen Pract (1988) 3.00
Controlled trial of prednisone and azathioprine in active chronic hepatitis. Lancet (1973) 2.98
Use of partial cardiopulmonary bypass during the anhepatic phase of orthotopic liver grafting. Lancet (1979) 2.98
Toxicity evaluation of replication-competent herpes simplex virus (ICP 34.5 null mutant 1716) in patients with recurrent malignant glioma. Gene Ther (2000) 2.94
Intravenous acetylcysteine in paracetamol induced fulminant hepatic failure: a prospective controlled trial. BMJ (1991) 2.94
More donor organs for transplantation. Elective ventilation proposals. J R Coll Physicians Lond (1993) 2.91
Assessment of technical skills transfer from the bench training model to the human model. Am J Surg (1999) 2.90
Multisystem involvement in chronic liver disease. Studies on the incidence and pathogenesis. Am J Med (1973) 2.88
The urethral pressure profile. Br J Urol (1969) 2.88
Altered calcium metabolism in epileptic children on anticonvulsants. Br Med J (1971) 2.86
Properties of subunits and aggregates of blue-green algal biliproteins. Biochemistry (1971) 2.86
The arthropathy of idiopathic haemochromatosis. Q J Med (1968) 2.85
Hepatitis B virus infection in medical and health care personnel. Br Med J (Clin Res Ed) (1982) 2.85
Liver transplantation after paracetamol overdose. BMJ (1991) 2.81
New hepatitis C virus (HCV) genotyping system that allows for identification of HCV genotypes 1a, 1b, 2a, 2b, 3a, 3b, 4, 5a, and 6a. J Clin Microbiol (1997) 2.78
Liver disease and bile duct abnormalities in adults with cystic fibrosis. Lancet (1989) 2.76
Liver in Felty's syndrome. Br Med J (1970) 2.75
Liver disease among homosexual males. Lancet (1979) 2.74
Hepatic damage and death from overdose of paracetamol. Lancet (1973) 2.70
Extrahepatic biliary atresia versus neonatal hepatitis. Review of 137 prospectively investigated infants. Arch Dis Child (1976) 2.67
Cyclosporin A in cadaveric organ transplantation. Br Med J (Clin Res Ed) (1981) 2.67