Published in Science on November 15, 1968
Antibodies to ribonucleic acid in systemic lupus erythematosus. Proc Natl Acad Sci U S A (1969) 1.79
Foot-and-mouth disease virus inhibition induced in mice by synthetic double-stranded RNA (polyriboinosinic and polyribocytidylic acids). Proc Natl Acad Sci U S A (1969) 1.30
Protective effect of a synthetic polynucleotide complex (poly I: C) on ocular lesions produced by trachoma agent in rabbits. Infect Immun (1970) 1.26
Hyporeactivity of infection: potential limitation to therapeutic use of interferon-inducing agents. Infect Immun (1972) 1.23
Herpesvirus hominis infection in newborn mice: treatment with interferon inducer polyinosinic-polycytidylic acid. Antimicrob Agents Chemother (1975) 1.17
The role of interferon in the protective effect of a synthetic double-stranded polyribonucleotide against intranasal vesicular stomatitis virus challenge in mice. J Clin Invest (1970) 1.11
Hyporeactivity due to infection: recognition of a transferable hyporeactive factor in the serum of encephalomyocarditis virus-infected mice. Infect Immun (1974) 1.04
Inhibition of herpes simplex virus by synthetic double-stranded RNA (polyriboadenylic and polyribouridylic acids and polyriboinosinic and polyribocytidylic acids). Proc Natl Acad Sci U S A (1969) 1.04
Sensitivity of Types 1 and 2 Herpesvirus hominis to an Interferon Inducer, Poly I:C. Infect Immun (1971) 1.02
The latent herpes simplex virus. Bacteriol Rev (1974) 1.00
Herpesvirus hominis type 2 infections in rabbits: effect of prior immunization with attenuated Mycobacterium bovis (BCG) cells. Infect Immun (1972) 1.00
Dose responsiveness and variation among inbred strains of mice in production of interferon after treatment with poly (I)-poly (C) (poly-D-lysine) complexes. Appl Microbiol (1971) 0.96
Target-organ treatment of neurotropic virus disease with interferon inducers. Infect Immun (1972) 0.85
Ultrastructural changes in chick cerebellum induced by polyinosinic polycytidylic acid. Am J Pathol (1971) 0.83
Inhibition of respiratory virus infections of mice with aerosols of synthetic double-stranded ribonucleic Acid. Infect Immun (1971) 0.82
Chlorite-oxidized amylose as an adjuvant for interferon production. Infect Immun (1973) 0.82
Adjuvant effects of low doses of a nuclease-resistant derivative of polyinosinic acid . polycytidylic acid on antibody responses of monkeys to inactivated Venezuelan equine encephalomyelitis virus vaccine. Infect Immun (1979) 0.80
Role of antiviral antibodies in resistance against coxsackievirus B3 infection: interaction between preexisting antibodies and an interferon inducer. Infect Immun (1982) 0.78
Infectious diseases. Annual review of significant publications. Postgrad Med J (1969) 0.75
Inhibition of herpes simplex virus strains isolated from herpetic keratitis by polyinosinic acid-polycytidylic acid. Antimicrob Agents Chemother (1977) 0.75
Biosynthetic human interferon treatment of herpetic keratitis. Trans Am Ophthalmol Soc (1983) 0.75
Real-space observation of a two-dimensional skyrmion crystal. Nature (2010) 7.08
A pdf neuropeptide gene mutation and ablation of PDF neurons each cause severe abnormalities of behavioral circadian rhythms in Drosophila. Cell (1999) 5.14
Somatic inactivation of Pkd2 results in polycystic kidney disease. Cell (1998) 3.84
Hepatic tumors: predisposing factors for complications of transcatheter oily chemoembolization. Radiology (1996) 3.57
Relationship between muscle fiber types and sizes and muscle architectural properties in the mouse hindlimb. J Morphol (1994) 2.99
Identification and characterization of polycystin-2, the PKD2 gene product. J Biol Chem (1999) 2.74
ORE9, an F-box protein that regulates leaf senescence in Arabidopsis. Plant Cell (2001) 2.72
BNIP3 heterodimerizes with Bcl-2/Bcl-X(L) and induces cell death independent of a Bcl-2 homology 3 (BH3) domain at both mitochondrial and nonmitochondrial sites. J Biol Chem (2000) 2.68
Morphologic, cytogenetic and virologic studies in vitro of a malignant lymphoma from an African child. Int J Cancer (1966) 2.51
Neuronal expression of neural nitric oxide synthase (nNOS) protein is suppressed by an antisense RNA transcribed from an NOS pseudogene. J Neurosci (1999) 2.49
Nix and Nip3 form a subfamily of pro-apoptotic mitochondrial proteins. J Biol Chem (1999) 2.43
Power versus conventional color Doppler sonography: comparison in the depiction of vasculature in liver tumors. Radiology (1996) 2.40
Inhibition of the primary in vitro antibody response by interferon preparations. J Immunol (1975) 2.35
The pathogenesis of autoimmunity in New Zealand mice, I. Induction of antinucleic acid antibodies by polyinosinic-polycytidylic acid. Proc Natl Acad Sci U S A (1969) 2.31
Cardiac defects and renal failure in mice with targeted mutations in Pkd2. Nat Genet (2000) 2.24
A modified polyriboinosinic-polyribocytidylic acid complex that induces interferon in primates. J Infect Dis (1975) 2.14
The effect of interferon on SV-40 T antigen production in SV-40-transformed cells. Virology (1967) 2.13
Right paratracheal air cysts in the thoracic inlet: clinical and radiologic significance. AJR Am J Roentgenol (1999) 2.12
Relative ability of mitogens to stimulate production of interferon by lymphoid cells and to induce suppression of the in vitro immune response. Proc Soc Exp Biol Med (1977) 2.07
Identification of three genetic loci controlling leaf senescence in Arabidopsis thaliana. Plant J (1997) 2.06
The human acid ceramidase gene (ASAH): structure, chromosomal location, mutation analysis, and expression. Genomics (1999) 2.04
Steaming of ginseng at high temperature enhances biological activity. J Nat Prod (2000) 2.04
Bioadhesive-based dosage forms: the next generation. J Pharm Sci (2000) 2.04
Antioxidant and anti-tumor promoting activities of the methanol extract of heat-processed ginseng. Cancer Lett (2000) 2.02
Anatomical collateral ligament reconstruction in the hand using intraosseous suture anchors and a free tendon graft. J Hand Surg Eur Vol (2012) 1.98
A family of gram-negative bacterial outer membrane factors that function in the export of proteins, carbohydrates, drugs and heavy metals from gram-negative bacteria. FEMS Microbiol Lett (1997) 1.89
Acute exacerbation of idiopathic pulmonary fibrosis: frequency and clinical features. Eur Respir J (2006) 1.87
Frequent alteration of p63 expression in human primary bladder carcinomas. Cancer Res (2000) 1.80
Improved assays for a variety of interferons. 1. Proc Soc Exp Biol Med (1972) 1.79
High interferon producing line of transformed murine cells. J Gen Virol (1972) 1.79
Surfing the implicit wave. Q J Exp Psychol A (2001) 1.78
Role of interferon during viremia. II. Protective action of circulating interferon. J Immunol (1966) 1.76
Mechanism of long chain fatty acid permeation in the isolated adipocyte. J Biol Chem (1981) 1.72
Keratocytes generate traction forces in two phases. Mol Biol Cell (1999) 1.72
Temperature-sensitive mutants of influenza virus. IV. Induction of interferon in the nasopharynx by wild-type and a temperature-sensitive recombinant virus. J Infect Dis (1973) 1.70
Pharmacological preconditioning with low-dose cyclosporine or FK506 reduces subsequent ischemia/reperfusion injury in rat kidney. Transplantation (2001) 1.67
Polyunsaturated fatty acids suppress hepatic sterol regulatory element-binding protein-1 expression by accelerating transcript decay. J Biol Chem (2000) 1.66
Virus plaque-reduction assay for interferon: microplaque and regular macroplaque reduction assays. Methods Enzymol (1981) 1.62
Interleukin-2 in rheumatoid arthritis: production of and response to interleukin-2 in rheumatoid synovial fluid, synovial tissue and peripheral blood. Clin Exp Immunol (1985) 1.61
The seroepidemiology of Bordetella pertussis infection in Western Europe. Epidemiol Infect (2005) 1.60
Ectopic expression of the neuropeptide pigment-dispersing factor alters behavioral rhythms in Drosophila melanogaster. J Neurosci (2000) 1.60
TMPRSS4 promotes invasion, migration and metastasis of human tumor cells by facilitating an epithelial-mesenchymal transition. Oncogene (2007) 1.58
Multiple amidated neuropeptides are required for normal circadian locomotor rhythms in Drosophila. J Neurosci (2001) 1.56
Epidemiology of vertebral osteomyelitis (VO) in France: analysis of hospital-discharge data 2002-2003. Epidemiol Infect (2007) 1.54
Hepatocellular carcinoma and portal vein invasion: results of treatment with transcatheter oily chemoembolization. AJR Am J Roentgenol (1995) 1.53
Apoptosis in human hepatoma cell lines by chemotherapeutic drugs via Fas-dependent and Fas-independent pathways. Hepatology (1999) 1.53
Therapeutic effect of transcatheter oily chemoembolization therapy for encapsulated nodular hepatocellular carcinoma: CT and pathologic findings. Radiology (1992) 1.53
The role of interferon in the inhibition of SV40 transformation of mouse cell line 3T3. Proc Natl Acad Sci U S A (1965) 1.52
General considerations of the interferon system. Tex Rep Biol Med (1977) 1.52
IFN-beta mediates coordinate expression of antigen-processing genes in RSV-infected pulmonary epithelial cells. Am J Physiol Lung Cell Mol Physiol (2001) 1.49
European Sero-Epidemiology Network: standardisation of the assay results for pertussis. Vaccine (2003) 1.48
Environmental endotoxin measurement: interference and sources of variation in the Limulus assay of house dust. Am Ind Hyg Assoc J (1997) 1.48
The sero-epidemiology of diphtheria in Western Europe. ESEN Project. European Sero-Epidemiology Network. Epidemiol Infect (2000) 1.48
Permeation of long-chain fatty acid into adipocytes. Kinetics, specificity, and evidence for involvement of a membrane protein. J Biol Chem (1984) 1.48
Kinetics of serum interferon response in mice after single and multiple injections of polyI-poly C. Proc Soc Exp Biol Med (1971) 1.47
Involvement of two NF-kappa B binding elements in tumor necrosis factor alpha -, CD40-, and epstein-barr virus latent membrane protein 1-mediated induction of the cellular inhibitor of apoptosis protein 2 gene. J Biol Chem (2000) 1.46
Preconditioning effects of the anesthetic administered to the donor on grafted kidney function in living donor kidney transplantation recipients. Minerva Anestesiol (2013) 1.46
Celiac axis stenosis: incidence and etiologies in asymptomatic individuals. Korean J Radiol (2001) 1.45
Role of caspase-3 in apoptosis of colon cancer cells induced by nonsteroidal anti-inflammatory drugs. Int J Colorectal Dis (2000) 1.44
Change of insulin sensitivity in hepatitis C patients with normal insulin sensitivity: a 5-year prospective follow-up study variation of insulin sensitivity in HCV patients. Intern Med J (2009) 1.43
A phase I-II trial of multiple-dose polyriboinosic-polyribocytidylic acid in patieonts with leukemia or solid tumors. J Natl Cancer Inst (1976) 1.42
Identification of a subpopulation of mouse lymphoid cells required for interferon production after stimulation with mitogens. J Immunol (1974) 1.41
Unexpectedly rapid action of human interferon in physiological conditions. Nature (1975) 1.41
Hepatoprotective activity of scopoletin, a constituent of Solanum lyratum. Arch Pharm Res (1998) 1.40
Liquid chromatographic determination of less polar ginsenosides in processed ginseng. J Chromatogr A (2001) 1.40
Bronchial stenosis due to endobronchial tuberculosis: successful treatment with self-expanding metallic stent. AJR Am J Roentgenol (1992) 1.39
The changing epidemiology of hepatitis A in children and the consideration of active immunization in Korea. Yonsei Med J (2000) 1.38
Nonproteolytic neuroprotection by human recombinant tissue plasminogen activator. Science (1999) 1.37
Evaluation of an interferon inducer in viral respiratory disease. JAMA (1972) 1.37
An electron-electron double-resonance study of interactions between [14N]- and [15N]stearic acid spin-label pairs: lateral diffusion and vertical fluctuations in dimyristoylphosphatidylcholine. Biochemistry (1984) 1.36
Interleukin-1 alpha mediates the enhanced expression of intercellular adhesion molecule-1 in pulmonary epithelial cells infected with respiratory syncytial virus. Am J Respir Cell Mol Biol (1995) 1.36
Arterial manifestations of Behçet disease. AJR Am J Roentgenol (1984) 1.35
Postexposure serum prophylaxis of neonatal herpes simplex virus infection of mice. Nature (1976) 1.35
Pulmonary oil embolism after transcatheter oily chemoembolization of hepatocellular carcinoma. Radiology (1993) 1.34
Mitogenic conversion of transforming growth factor-beta1 effect by oncogenic Ha-Ras-induced activation of the mitogen-activated protein kinase signaling pathway in human prostate cancer. Cancer Res (2000) 1.33
Some factors affecting the interferon-induced antiviral state. Proc Soc Exp Biol Med (1967) 1.33
The CXCR4 antagonist AMD3100 impairs survival of human AML cells and induces their differentiation. Leukemia (2008) 1.33
Interferon-induced transfer of viral resistance between animal cells. Nature (1977) 1.31
Liver X Receptor activation downregulates AKT survival signaling in lipid rafts and induces apoptosis of prostate cancer cells. Oncogene (2010) 1.31
Mechanism of recovery from systemic vaccinia virus infection. I. The effects of cyclophosphamide. J Exp Med (1972) 1.30
Effect of interferon on early interferon production. Science (1966) 1.30
Liver abscess after transcatheter oily chemoembolization for hepatic tumors: incidence, predisposing factors, and clinical outcome. J Vasc Interv Radiol (2001) 1.30
Respiratory syncytial virus infection of human respiratory epithelial cells up-regulates class I MHC expression through the induction of IFN-beta and IL-1 alpha. J Immunol (1996) 1.29
Enhanced T cell proliferative response to type II collagen and synthetic peptide CII (255-274) in patients with rheumatoid arthritis. Arthritis Rheum (1999) 1.29
An activating mutation in a Caenorhabditis elegans Gs protein induces neural degeneration. Genes Dev (1997) 1.29
Sensitivity of common respiratory viruses to an interferon inducer in human cells. Lancet (1969) 1.29
Induction of neuronal cell death by Rab5A-dependent endocytosis of alpha-synuclein. J Biol Chem (2001) 1.28
Growth of Toxoplasma gondii in various tissue cultures treated with In-Cn or interferon. Proc Soc Exp Biol Med (1973) 1.26
Role of interferon in streptococcal infection in the mouse. Microb Pathog (1986) 1.24
Carotid artery involvement in Takayasu's arteritis: evaluation of the activity by ultrasonography. J Ultrasound Med (2001) 1.23
Characterization of the airborne concentrations of lead in U.S. industry. Am J Ind Med (1990) 1.23
Effects of interferon inducers on the intracellular growth of the protozoan parasite, Leishmania donovani. Nature (1970) 1.23
Nontumorous arterioportal shunt mimicking hypervascular tumor in cirrhotic liver: two-phase spiral CT findings. Radiology (1998) 1.23
Relationship between dose size and dose interval of polyinosinic polycytidylic acid and interferon hyporesponsiveness in mice. Proc Soc Exp Biol Med (1970) 1.22
Hmx2 homeobox gene control of murine vestibular morphogenesis. Development (2001) 1.22
Fracture of the ipsilateral neck of the femur in shaft nailing. The role of CT in diagnosis. J Bone Joint Surg Br (1998) 1.22
Ginsenoside Rg3 mediates endothelium-dependent relaxation in response to ginsenosides in rat aorta: role of K+ channels. Eur J Pharmacol (1999) 1.22
Vesicular stomatitis virus plaque production in monolayer cultures with liquid overlay medium: description and adaptation to a one-day, human interferon-plaque. J Clin Microbiol (1976) 1.22
The nature of the suppressive effect of interferon and interferon inducers on the in vitro immune response. Cell Immunol (1976) 1.21