Published in Clin Pharmacol Ther on October 01, 1974
Acute liver failure: Summary of a workshop. Hepatology (2008) 3.49
Cystinosis. Intracellular cystine depletion by aminothiols in vitro and in vivo. J Clin Invest (1976) 2.70
Treatment of acetaminophen poisoning. Can Med Assoc J (1981) 2.05
Kinetics and metabolism of paracetamol and phenacetin. Br J Clin Pharmacol (1980) 1.87
High performance liquid chromatographic estimation of paracetamol metabolites in plasma. Br J Clin Pharmacol (1978) 1.78
Effects of non-narcotic analgesics on the liver. Drugs (1986) 1.50
Inter-subject and ethnic differences in paracetamol metabolism. Br J Clin Pharmacol (1986) 1.48
Organotypic liver culture models: meeting current challenges in toxicity testing. Crit Rev Toxicol (2012) 1.46
Management of acute liver failure. Nat Rev Gastroenterol Hepatol (2009) 1.32
Mechanism of action of N-acetylcysteine in the protection against the hepatotoxicity of acetaminophen in rats in vivo. J Clin Invest (1983) 1.31
Paracetamol poisoning in children and hepatotoxicity. Br J Clin Pharmacol (1991) 1.25
Late treatment of paracetamol poisoning with mercaptamine. Br Med J (1978) 1.25
Paracetamol, alcohol and the liver. Br J Clin Pharmacol (2000) 1.19
Effects of microsomal enzyme induction on paracetamol metabolism in man. Br J Clin Pharmacol (1981) 1.12
Acetaminophen protein adduct formation following low-dose acetaminophen exposure: comparison of immediate-release vs extended-release formulations. Eur J Clin Pharmacol (2012) 1.06
Mice deficient in Cu,Zn-superoxide dismutase are resistant to acetaminophen toxicity. Biochem J (2006) 1.02
Paracetamol and phenacetin. Drugs (1986) 0.99
The role of biotransformation in chemical-induced liver injury. Environ Health Perspect (1976) 0.98
Acetaminophen: a practical pharmacologic overview. Can Med Assoc J (1984) 0.97
Paracetamol metabolites in the neonate following maternal overdose. Br J Clin Pharmacol (1984) 0.95
Selective inhibition of acetaminophen oxidation and toxicity by cimetidine and other histamine H2-receptor antagonists in vivo and in vitro in the rat and in man. J Clin Invest (1984) 0.89
Evidence for the changing regimens of acetylcysteine. Br J Clin Pharmacol (2015) 0.88
Paracetamol. Postgrad Med J (1980) 0.88
Novel acetylcysteine regimens for treatment of paracetamol overdose. Ther Adv Drug Saf (2012) 0.86
Passage of paracetamol into breast milk and its subsequent metabolism by the neonate. Br J Clin Pharmacol (1987) 0.86
Inhibition of the metabolism of paracetamol by isoniazid. Br J Clin Pharmacol (1991) 0.84
Effects of imatinib mesylate on the pharmacokinetics of paracetamol (acetaminophen) in Korean patients with chronic myelogenous leukaemia. Br J Clin Pharmacol (2011) 0.83
The third Lilly Prize Lecture. University of London, January, 1979. The nephrotoxicity and hepatotoxicity of antipyretic analgesics. Br J Clin Pharmacol (1979) 0.82
The proper use of acetaminophen. Paediatr Child Health (2011) 0.82
Lysosomal Cholesterol Accumulation Sensitizes To Acetaminophen Hepatotoxicity by Impairing Mitophagy. Sci Rep (2015) 0.81
Paracetamol poisoning: beyond the nomogram. Br J Clin Pharmacol (2015) 0.81
Acylcarnitine profiles in acetaminophen toxicity in the mouse: comparison to toxicity, metabolism and hepatocyte regeneration. Metabolites (2013) 0.81
Acetaminophen elimination half-life in humans is unaffected by short-term consumption of sulfur amino acid-free diet. J Pharmacol Exp Ther (2010) 0.80
Outcomes from massive paracetamol overdose: a retrospective observational study. Br J Clin Pharmacol (2016) 0.80
The 100 most influential publications in paracetamol poisoning treatment: a bibliometric analysis of human studies. Springerplus (2016) 0.78
Paracetamol-induced hepatotoxicity: lack of enhancement of the hepatoprotective effect of N-acetylcysteine by sodium sulphate. Inflammopharmacology (1998) 0.76
Does cytochrome P450 liver isoenzyme induction increase the risk of liver toxicity after paracetamol overdose? Open Access Emerg Med (2011) 0.75
Survival after an overdose of Distalgesic (dextropropoxyphene and paracetamol). Ulster Med J (1989) 0.75
Analgesic hepatotoxicity. West J Med (1978) 0.75
In vivo imaging of leucine aminopeptidase activity in drug-induced liver injury and liver cancer via a near-infrared fluorescent probe. Chem Sci (2017) 0.75
Is biliary excretion of paracetamol significant in man? Br J Clin Pharmacol (1986) 0.75
Drug hepatotoxicity. Br J Clin Pharmacol (1983) 0.75
Interplay of factors leading to adverse drug reactions in the liver, a personal viewpoint. Yale J Biol Med (1978) 0.75
Editorial: Paracetamol (acetaminophen) and the liver. Br Med J (1975) 0.75
Protective effect of chlormethiazole, a sedative, against acetaminophen-induced liver injury in mice. Korean J Intern Med (1999) 0.75
Hepatoprotective effects of rice-derived peptides against acetaminophen-induced damage in mice. J Clin Biochem Nutr (2016) 0.75
[Drug interactions in pain therapy]. Schmerz (2015) 0.75
Public Health: Acetaminophen (APAP) Hepatotoxicity- Isn't It Time for APAP to Go Away? J Hepatol (2017) 0.75
Relative contributions of history-taking, physical examination, and laboratory investigation to diagnosis and management of medical outpatients. Br Med J (1975) 9.18
Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione. J Pharmacol Exp Ther (1973) 5.23
Acetaminophen-induced hepatic necrosis. I. Role of drug metabolism. J Pharmacol Exp Ther (1973) 4.40
Bromobenzene-induced liver necrosis. Protective role of glutathione and evidence for 3,4-bromobenzene oxide as the hepatotoxic metabolite. Pharmacology (1974) 4.32
A randomised trial of home-versus-hospital management for patients with suspected myocardial infarction. Lancet (1978) 4.12
Acetaminophen-induced hepatic necrosis. II. Role of covalent binding in vivo. J Pharmacol Exp Ther (1973) 3.89
Interim discharge summaries: how are they best delivered to general practitioners? Br Med J (Clin Res Ed) (1987) 3.64
Effects of drugs on human blood platelet and plasma amine oxidase activity in vitro and in vivo. Biochem Pharmacol (1968) 3.62
Loss of miR-122 expression in liver cancer correlates with suppression of the hepatic phenotype and gain of metastatic properties. Oncogene (2009) 3.51
Menopausal flushing: does oestrogen therapy make sense? Lancet (1976) 3.47
Bupropion: a review of its mechanism of antidepressant activity. J Clin Psychiatry (1995) 3.30
Hepatic expression of mature transforming growth factor beta 1 in transgenic mice results in multiple tissue lesions. Proc Natl Acad Sci U S A (1995) 3.25
Self-poisoning: management of patients in Nottingham, 1976. Br Med J (1978) 3.24
A precursor-product relationship exists between oval cells and hepatocytes in rat liver. Carcinogenesis (1987) 2.98
Adenovirus-mediated in vivo gene transfer and expression in normal rat liver. Nat Genet (1992) 2.63
Cellular distribution of transforming growth factor-beta 1 and procollagen types I, III, and IV transcripts in carbon tetrachloride-induced rat liver fibrosis. J Clin Invest (1990) 2.61
Cloning, characterization, and chromosomal localization of a gene frequently deleted in human liver cancer (DLC-1) homologous to rat RhoGAP. Cancer Res (1998) 2.59
Clinical forms of gonococcal arthritis. N Engl J Med (1968) 2.58
Accumulation and elimination of poliovirus by the eastern oyster. Am J Epidemiol (1966) 2.58
In vivo differentiation of rat liver oval cells into hepatocytes. Cancer Res (1989) 2.58
Randomised placebo-controlled trial comparing oxprenolol with disopyramide phosphate in immediate treatment of suspected myocardial infarction. Lancet (1980) 2.53
A Millipore filter assay for antibodies to native DNA in sera of patients with systemic lupus erythematosus. Arthritis Rheum (1973) 2.53
Transgenic mice with increased plasma levels of TGF-beta 1 develop progressive renal disease. Lab Invest (1996) 2.42
Mutations in isocitrate dehydrogenase 1 and 2 occur frequently in intrahepatic cholangiocarcinomas and share hypermethylation targets with glioblastomas. Oncogene (2012) 2.41
Effects of xanomeline, a selective muscarinic receptor agonist, on cognitive function and behavioral symptoms in Alzheimer disease. Arch Neurol (1997) 2.35
Isoniazid liver injury: clinical spectrum, pathology, and probable pathogenesis. Ann Intern Med (1976) 2.33
Randomised trial comparing propranolol with atenolol in immediate treatment of suspected myocardial infarction. Br Med J (1980) 2.32
Guanethidine and related agents. 3. Antagonism by drugs which inhibit the norepinephrine pump in man. J Clin Invest (1970) 2.29
RNA binding domain of telomerase reverse transcriptase. Mol Cell Biol (2001) 2.27
Effect of a pyrimidopyrimidine derivative on thrombus formation in the rabbit. Nature (1965) 2.19
Is nursing any business of doctors? A simple guide to the "nursing process". Br Med J (Clin Res Ed) (1984) 2.17
Atypical ductular proliferation and its inhibition by transforming growth factor beta1 in the 3,5-diethoxycarbonyl-1,4-dihydrocollidine mouse model for chronic alcoholic liver disease. Lab Invest (1999) 2.16
Early reporting of myocardial infarction: impact of an experiment in patient education. Br Med J (Clin Res Ed) (1982) 2.11
Transgenic mouse model for synergistic effects of nuclear oncogenes and growth factors in tumorigenesis: interaction of c-myc and transforming growth factor alpha in hepatic oncogenesis. Cancer Res (1993) 2.09
Origin and structural evolution of the early proliferating oval cells in rat liver. Am J Pathol (2001) 2.07
Alterations of tumor suppressor genes and allelic losses in human hepatocellular carcinomas in China. Cancer Res (1994) 2.06
Isoniazid-associated hepatitis in 114 patients. Gastroenterology (1975) 2.02
Platelet reactivity and serum thromboxane B2 production in whole blood in gestational hypertension and pre-eclampsia. Br J Obstet Gynaecol (1991) 1.91
Acetaminophen-induced hepatic necrosis. 3. Cytochrome P-450-mediated covalent binding in vitro. J Pharmacol Exp Ther (1973) 1.90
Expression of stem cell factor and its receptor, c-kit, during liver regeneration from putative stem cells in adult rat. Lab Invest (1994) 1.90
Effect of prostaglandin E1 on platelet behaviour in vitro and in vivo. Br Med J (1967) 1.85
Dose-dependent enzyme induction. Clin Pharmacol Ther (1973) 1.84
Extracts of feverfew inhibit granule secretion in blood platelets and polymorphonuclear leucocytes. Lancet (1985) 1.84
An association between abo blood-group distribution and geographical differences in death-rates. Lancet (1977) 1.81
Expression of hepatic transcription factors during liver development and oval cell differentiation. J Cell Biol (1994) 1.80
Effect of dipyridamole on human platelet behaviour. Lancet (1965) 1.79
Plasma glutathione and glutathione disulfide in the rat: regulation and response to oxidative stress. J Pharmacol Exp Ther (1983) 1.79
Degradation of cartilage proteoglycan by human leukocyte granule neutral proteases--a model of joint injury. II. Degradation of isolated bovine nasal cartilage proteoglycan. J Clin Invest (1976) 1.77
Report of the task force on designing clinical trials in early (predementia) AD. Neurology (2010) 1.75
Increased incidence of isoniazid hepatitis in rapid acetylators: possible relation to hydranize metabolites. Clin Pharmacol Ther (1975) 1.75
Comparative and integrative functional genomics of HCC. Oncogene (2006) 1.75
Oxidation of alpha-methyldopa and other catechols by cytochrome P-450-generated superoxide anion: possible mechanism of methyldopa hepatitis. Mol Pharmacol (1976) 1.73
Dexamethasone in acute stroke. Br Med J (1978) 1.73
The Fn14 immediate-early response gene is induced during liver regeneration and highly expressed in both human and murine hepatocellular carcinomas. Am J Pathol (2000) 1.73
Acetaminophen-induced hepatic necrosis. VI. Metabolic disposition of toxic and nontoxic doses of acetaminophen. Pharmacology (1974) 1.70
Is an information booklet for patients leaving hospital helpful and useful? BMJ (1989) 1.68
Immunochemistry of cartilage proteoglycan. Immunodiffusion and gel-electrophoretic studies. Biochem J (1972) 1.67
Antagonism of the antihypertensive action of guanethidine sulfate by desipramine hydrochloride. JAMA (1967) 1.67
Origin and fate of oval cells in dipin-induced hepatocarcinogenesis in the mouse. Am J Pathol (1994) 1.67
What constitutes evidence on the dietary prevention of coronary heart disease? Cosy beliefs or harsh facts? Int J Cardiol (1984) 1.66
Changes in liver blood flow during enzyme induction. Biochem Pharmacol (1971) 1.65
The responsiveness of the Hamilton Depression Rating Scale. J Psychiatr Res (2000) 1.64
Interindividual differences in rates of drug oxidation in man. Drug Metab Dispos (1974) 1.63
Expression of acidic fibroblast growth factor in regenerating liver and during hepatic differentiation. Lab Invest (1992) 1.63
Randomised double-blind placebo-controlled trial of feverfew in migraine prevention. Lancet (1988) 1.62
Smoking and industrial pollution, and their effects on menopause and ovarian cancer. Lancet (1978) 1.59
Tissue inhibitor of metalloproteinases-1 promotes liver fibrosis development in a transgenic mouse model. Hepatology (2000) 1.59
The role of the interview in student selection. S Afr Med J (1978) 1.59
Occurrence of oval-type cells in hepatitis B virus-associated human hepatocarcinogenesis. Hepatology (1992) 1.58
Autumn Books: Who needs Clinical Pharmacology? Br Med J (Clin Res Ed) (1984) 1.57
The recombinant proregion of transforming growth factor beta1 (latency-associated peptide) inhibits active transforming growth factor beta1 in transgenic mice. Proc Natl Acad Sci U S A (1996) 1.56
"But will it help my patients with myocardial infarction?" The implications of recent trials for everyday country folk. Br Med J (Clin Res Ed) (1982) 1.55
Effect of aggregating agents on the electrophoretic mobility of human platelets. Br Med J (1966) 1.55
Prevention and diagnosis of venous thrombosis in patients with hip fractures. A survey of current practice. Lancet (1976) 1.52
Blood pressure reduction in elderly: a randomised controlled trial of methyldopa. Br Med J (Clin Res Ed) (1981) 1.52
Novel recurrent genetic imbalances in human hepatocellular carcinoma cell lines identified by comparative genomic hybridization. Hepatology (1999) 1.50
Effect of oestrogens on human platelet behaviour. Lancet (1968) 1.49
Low dose beta blockade in acute stroke ("BEST" trial): an evaluation. Br Med J (Clin Res Ed) (1988) 1.47
Use of isolated perfused organs in hypoxia and ischemia/reperfusion oxidant stress. Methods Enzymol (1990) 1.46
Patients' and general practitioners' satisfaction with information given on discharge from hospital: audit of a new information card. BMJ (1989) 1.45
Metalloproteases of human articular cartilage that digest cartilage proteoglycan at neutral and acid pH. J Clin Invest (1976) 1.43
Acetaminophen-induced hepatic necrosis. V. Correlation of hepatic necrosis, covalent binding and glutathione depletion in hamsters. Pharmacology (1974) 1.43
Differential effects of transforming growth factor-beta on proliferation of normal and malignant rat liver epithelial cells in culture. Cancer Res (1986) 1.43
The mechanisms of action of lithium. I. Effects on serotoninergic and noradrenergic systems in normal subjects. Arch Gen Psychiatry (1991) 1.42