Published in J Biol Chem on November 25, 1974
Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice. Proc Natl Acad Sci U S A (2001) 6.78
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Potency of Michael reaction acceptors as inducers of enzymes that protect against carcinogenesis depends on their reactivity with sulfhydryl groups. Proc Natl Acad Sci U S A (2001) 3.17
Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2. Proc Natl Acad Sci U S A (2005) 2.92
Identification of a novel class of insect glutathione S-transferases involved in resistance to DDT in the malaria vector Anopheles gambiae. Biochem J (2001) 2.35
Mr 26,000 antigen of Schistosoma japonicum recognized by resistant WEHI 129/J mice is a parasite glutathione S-transferase. Proc Natl Acad Sci U S A (1986) 2.35
Purification, induction, and distribution of placental glutathione transferase: a new marker enzyme for preneoplastic cells in the rat chemical hepatocarcinogenesis. Proc Natl Acad Sci U S A (1985) 2.32
An efficient system for high-level expression and easy purification of authentic recombinant proteins. Protein Sci (2004) 2.31
Exploring the molecular basis of insecticide resistance in the dengue vector Aedes aegypti: a case study in Martinique Island (French West Indies). BMC Genomics (2009) 1.98
Exposure to sublethal doses of fipronil and thiacloprid highly increases mortality of honeybees previously infected by Nosema ceranae. PLoS One (2011) 1.94
Purification and characterization of a glutathione S-transferase from benoxacor-treated maize (Zea mays). Plant Physiol (1993) 1.84
Tumor cell anti-oxidant defenses. Inhibition of the glutathione redox cycle enhances macrophage-mediated cytolysis. J Exp Med (1981) 1.71
Identification of two lithocholic acid-binding proteins. Separation of ligandin from glutathione S-transferase B. Biochem J (1979) 1.71
Glutathione S-transferase Ya subunit gene: identification of regulatory elements required for basal level and inducible expression. Proc Natl Acad Sci U S A (1988) 1.69
The Anopheles gambiae glutathione transferase supergene family: annotation, phylogeny and expression profiles. BMC Genomics (2003) 1.69
Mechanism of inactivation on prion conversion of the Saccharomyces cerevisiae Ure2 protein. Proc Natl Acad Sci U S A (2002) 1.61
Identification of a basic hybrid glutathione S-transferase from human liver. Glutathione S-transferase delta is composed of two distinct subunits (B1 and B2). Biochem J (1985) 1.57
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Rat liver glutathione S-transferases. A study of the structure of the basic YbYb-containing enzymes. Biochem J (1983) 1.50
Retracted Chicory (Cichorium intybus L.) root extract regulates the oxidative status and antioxidant gene transcripts in CCl4-induced hepatotoxicity. PLoS One (2015) 1.50
Whole-genome transcriptional analysis of heavy metal stresses in Caulobacter crescentus. J Bacteriol (2005) 1.49
A modular xylanase containing a novel non-catalytic xylan-specific binding domain. Biochem J (1995) 1.48
A novel glutathione transferase (13-13) isolated from the matrix of rat liver mitochondria having structural similarity to class theta enzymes. Biochem J (1991) 1.47
Interrelationship between anionic and cationic forms of glutathione S-transferases of human liver. Biochem J (1980) 1.47
Draft genome of the mountain pine beetle, Dendroctonus ponderosae Hopkins, a major forest pest. Genome Biol (2013) 1.46
Heterologous expression of four glutathione transferase genes genetically linked to a major insecticide-resistance locus from the malaria vector Anopheles gambiae. Biochem J (2003) 1.46
Transgenic expression of aflatoxin aldehyde reductase (AKR7A1) modulates aflatoxin B1 metabolism but not hepatic carcinogenesis in the rat. Toxicol Sci (2009) 1.45
Human glutathione S-transferases. Characterization of the anionic forms from lung and placenta. Biochem J (1984) 1.44
Aqueous extract of Terminalia arjuna prevents carbon tetrachloride induced hepatic and renal disorders. BMC Complement Altern Med (2006) 1.43
Amplification and increased expression of alpha class glutathione S-transferase-encoding genes associated with resistance to nitrogen mustards. Proc Natl Acad Sci U S A (1988) 1.43
Purification and characterization of two glutathione S-aryltransferase activities from rat liver. Biochem J (1975) 1.43
The relationships between glutathione, glutathione-S-transferase and cytotoxicity of platinum drugs and melphalan in eight human ovarian carcinoma cell lines. Br J Cancer (1991) 1.42
Adducin forms a bridge between the erythrocyte membrane and its cytoskeleton and regulates membrane cohesion. Blood (2009) 1.42
The binding and catalytic activities of forms of ligandin after modification of its thiol groups. Biochem J (1979) 1.41
Purification and characterization of glutathione S-transferases P, S and N. Isolation from rat liver of Yb1 Yn protein, the existence of which was predicted by subunit hybridization in vitro. Biochem J (1984) 1.40
Characterization of a human class-Theta glutathione S-transferase with activity towards 1-menaphthyl sulphate. Biochem J (1992) 1.40
Purification and characterization of three forms of glutathione S-transferase A. A comparative study of the major YaYa-, YbYb- and YcYc-containing glutathione S-transferases. Biochem J (1982) 1.39
Single-step purification and h.p.l.c. analysis of glutathione transferase 8-8 in rat tissues. Biochem J (1989) 1.39
Tissue distribution and subunit structures of the multiple forms of glutathione S-transferase in the rat. Biochem J (1981) 1.36
Relationship between the soluble glutathione-dependent delta 5-3-ketosteroid isomerase and the glutathione S-transferases of the liver. Proc Natl Acad Sci U S A (1977) 1.36
Purification, molecular cloning, and characterization of glutathione S-transferases (GSTs) from pigmented Vitis vinifera L. cell suspension cultures as putative anthocyanin transport proteins. J Exp Bot (2008) 1.35
Comparative study of the antioxidant and reactive oxygen species scavenging properties in the extracts of the fruits of Terminalia chebula, Terminalia belerica and Emblica officinalis. BMC Complement Altern Med (2010) 1.34
Multiple isoforms of mitochondrial glutathione S-transferases and their differential induction under oxidative stress. Biochem J (2002) 1.32
A marine oligobacterium harboring genes known to be part of aromatic hydrocarbon degradation pathways of soil pseudomonads. Appl Environ Microbiol (1996) 1.32
Cloning and characterization of two glutathione S-transferases from a DDT-resistant strain of Anopheles gambiae. Biochem J (1997) 1.32
Evaluation of Cytotoxic Effects of Dichloromethane Extract of Guduchi (Tinospora cordifolia Miers ex Hook F & THOMS) on Cultured HeLa Cells. Evid Based Complement Alternat Med (2006) 1.32
Synthesis, mechanistic studies, and anti-proliferative activity of glutathione/glutathione S-transferase-activated nitric oxide prodrugs. Bioorg Med Chem (2008) 1.31
The role of glutathione in detoxication. Environ Health Perspect (1983) 1.30
Glutathione-S-transferase P protects against endothelial dysfunction induced by exposure to tobacco smoke. Am J Physiol Heart Circ Physiol (2009) 1.30
Cytotoxicity and metabolism of 4-hydroxy-2-nonenal and 2-nonenal in H2O2-resistant cell lines. Do aldehydic by-products of lipid peroxidation contribute to oxidative stress? Biochem J (1990) 1.30
Extensive functional diversification of the Populus glutathione S-transferase supergene family. Plant Cell (2009) 1.29
A study of the structures of the YaYa and YaYc glutathione S-transferases from rat liver cytosol. Evidence that the Ya monomer is responsible for lithocholate-binding activity. Biochem J (1981) 1.29
Liver dysfunction and phosphatidylinositol-3-kinase signalling in early sepsis: experimental studies in rodent models of peritonitis. PLoS Med (2012) 1.27
The human liver glutathione S-transferase gene superfamily: expression and chromosome mapping of an Hb subunit cDNA. Nucleic Acids Res (1988) 1.27
Novel cellulose-binding domains, NodB homologues and conserved modular architecture in xylanases from the aerobic soil bacteria Pseudomonas fluorescens subsp. cellulosa and Cellvibrio mixtus. Biochem J (1995) 1.27
The carboxy-terminal 10 amino acid residues of cytochrome b5 are necessary for its targeting to the endoplasmic reticulum. EMBO J (1992) 1.26
Protective role of Scoparia dulcis plant extract on brain antioxidant status and lipidperoxidation in STZ diabetic male Wistar rats. BMC Complement Altern Med (2004) 1.26
Expression of recombinant glutathione S-transferase pi, Ya, or Yb1 confers resistance to alkylating agents. Proc Natl Acad Sci U S A (1990) 1.25
Gut pathology and responses to the microsporidium Nosema ceranae in the honey bee Apis mellifera. PLoS One (2012) 1.24
Enzymatic Mechanisms Involved in Phenanthrene Degradation by the White Rot Fungus Pleurotus ostreatus. Appl Environ Microbiol (1997) 1.24
Cholic acid binding by glutathione S-transferases from rat liver cytosol. Biochem J (1980) 1.24
Magnesium Adenosine 5[prime]-Triphosphate-Energized Transport of Glutathione-S-Conjugates by Plant Vacuolar Membrane Vesicles. Plant Physiol (1995) 1.24
Cloning and sequence analysis of a cDNA plasmid for one of the rat liver glutathione S-transferase subunits. Nucleic Acids Res (1982) 1.24
Purification and characterization of a labile rat glutathione transferase of the Mu class. Biochem J (1989) 1.23
Expression of mammalian glutathione S-transferase 5-5 in Salmonella typhimurium TA1535 leads to base-pair mutations upon exposure to dihalomethanes. Proc Natl Acad Sci U S A (1993) 1.22
Phospholipid hydroperoxide glutathione peroxidase activity of human glutathione transferases. Biochem J (1998) 1.22
Expression of human glutathione S-transferase 2 in Escherichia coli. Immunological comparison with the basic glutathione S-transferases isoenzymes from human liver. Biochem J (1987) 1.21
Hepatoprotective effects of methanol extract of Carissa opaca leaves on CCl4-induced damage in rat. BMC Complement Altern Med (2011) 1.21
Substrate specificity of rat liver glutathione S-transferase isoenzymes for a series of glutathione analogues, modified at the gamma-glutamyl moiety. Biochem J (1988) 1.20
Inhibition of hepatic deiodination of thyroxine is caused by selenium deficiency in rats. Biochem J (1987) 1.19
Molecular and enzymatic characterization of three phosphoinositide-specific phospholipase C isoforms from potato. Plant Physiol (1998) 1.19
Toxicology in the fast lane: application of high-throughput bioassays to detect modulation of key enzymes and receptors. Environ Health Perspect (2009) 1.19
Cytosolic glutathione transferases from rat liver. Primary structure of class alpha glutathione transferase 8-8 and characterization of low-abundance class Mu glutathione transferases. Biochem J (1989) 1.19
Detoxification of DNA hydroperoxide by glutathione transferases and the purification and characterization of glutathione transferases of the rat liver nucleus. Biochem J (1988) 1.19
Evaluation of Wuchereria bancrofti GST as a vaccine candidate for lymphatic filariasis. PLoS Negl Trop Dis (2009) 1.18
Antioxidant protective effect of glibenclamide and metformin in combination with honey in pancreas of streptozotocin-induced diabetic rats. Int J Mol Sci (2010) 1.18
Saccharomyces cerevisiae cells have three Omega class glutathione S-transferases acting as 1-Cys thiol transferases. Biochem J (2006) 1.18
CCl4-induced hepatotoxicity: protective effect of rutin on p53, CYP2E1 and the antioxidative status in rat. BMC Complement Altern Med (2012) 1.18
Sensitization of cells overexpressing multidrug-resistant proteins by pluronic P85. Pharm Res (2003) 1.17
Sex-specific constitutive expression of the pre-neoplastic marker glutathione S-transferase, YfYf, in mouse liver. Biochem J (1987) 1.17
Glutathione transferases. Arabidopsis Book (2010) 1.16
Expression of human glutathione S-transferases in Saccharomyces cerevisiae confers resistance to the anticancer drugs adriamycin and chlorambucil. Biochem J (1990) 1.16
Partial purification of two lithocholic acid-binding proteins from rat liver 100 000g supernatants. Biochem J (1977) 1.16
Gastroprotective activity of Nigella sativa L oil and its constituent, thymoquinone against acute alcohol-induced gastric mucosal injury in rats. World J Gastroenterol (2005) 1.16
Purification to homogeneity and the N-terminal sequence of human leukotriene C4 synthase: a homodimeric glutathione S-transferase composed of 18-kDa subunits. Proc Natl Acad Sci U S A (1993) 1.15
Biochemical study of oxidative stress markers in the liver, kidney and heart of high fat diet induced obesity in rats. Diabetol Metab Syndr (2011) 1.15
Glutathione and a UV light-induced glutathione S-transferase are involved in signaling to chalcone synthase in cell cultures. Plant Cell (2000) 1.15
The trans-stilbene oxide-active glutathione transferase in human mononuclear leucocytes is identical with the hepatic glutathione transferase mu. Biochem J (1987) 1.14
Mechanism of Wound-Healing Activity of Hippophae rhamnoides L. Leaf Extract in Experimental Burns. Evid Based Complement Alternat Med (2011) 1.14
Glutathione-s-transferase activity and metabolism of glutathione conjugates by rhizosphere bacteria. Appl Environ Microbiol (1995) 1.14
Biotransformation enzymes in human intestine: critical low levels in the colon? Gut (1991) 1.14
Expression of glutathione S-transferase during rat liver development. Biochem J (1992) 1.14
Properties of a Maize Glutathione S-Transferase That Conjugates Coumaric Acid and Other Phenylpropanoids. Plant Physiol (1995) 1.13
Isoenzymes of glutathione transferase in rat kidney cytosol. Biochem J (1985) 1.13
Proinflammatory and oxidative stress markers in patients with periodontal disease. Mediators Inflamm (2007) 1.13
Nonhistone protein BA is a glutathione S-transferase localized to interchromatinic regions of the cell nucleus. J Cell Biol (1986) 1.12
Glutathione transferases in the tapeworm Moniezia expansa. Biochem J (1989) 1.12
Endoplasmic reticulum stress induces fibrogenic activity in hepatic stellate cells through autophagy. J Hepatol (2013) 1.12
Roots of Withania somnifera Inhibit Forestomach and Skin Carcinogenesis in Mice. Evid Based Complement Alternat Med (2005) 1.11
Characteristic features in the structure and collagen-binding ability of a thermophilic collagenolytic protease from the thermophile Geobacillus collagenovorans MO-1. J Bacteriol (2006) 1.11
Preparation and purification of glucanase and chitinase from bean leaves. Plant Physiol (1971) 7.08
Assays for differentiation of glutathione S-transferases. Methods Enzymol (1981) 5.69
The glutathione S-transferases: a group of multifunctional detoxification proteins. Adv Enzymol Relat Areas Mol Biol (1978) 3.89
Removal of endotoxin from protein solutions by phase separation using Triton X-114. J Immunol Methods (1990) 3.48
Increased production of superoxide anion by macrophages exposed in vitro to muramyl dipeptide or lipopolysaccharide. J Exp Med (1980) 3.13
The identity of glutathione S-transferase B with ligandin, a major binding protein of liver. Proc Natl Acad Sci U S A (1974) 2.77
Multiple forms of human glutathione S-transferase and their affinity for bilirubin. Eur J Biochem (1975) 2.46
Enzymatic conjugation of epoxides with glutathione. J Biol Chem (1973) 2.34
Cultured human monocytes require exposure to bacterial products to maintain an optimal oxygen radical response. J Immunol (1982) 2.19
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Glutathione transferase from human erythrocytes. Nonidentity with the enzymes from liver. Arch Biochem Biophys (1978) 2.00
Binding of nonsubstrate ligands to the glutathione S-transferases. J Biol Chem (1975) 1.93
Glutathione S-transferase A. A novel kinetic mechanism in which the major reaction pathway depends on substrate concentration. J Biol Chem (1974) 1.91
Activation of macrophages for enhanced release of superoxide anion and greater killing of Candida albicans by injection of muramyl dipeptide. J Exp Med (1980) 1.79
Mechanism for the several activities of the glutathione S-transferases. J Biol Chem (1976) 1.74
Thiol S-methyltransferase: suggested role in detoxication of intestinal hydrogen sulfide. Biochem Pharmacol (1980) 1.64
Receptor-mediated endocytosis of diphtheria toxin by cells in culture. Proc Natl Acad Sci U S A (1982) 1.59
Tetanus toxin interactions with thyroid plasma membranes. Implications for structure and function of tetanus toxin receptors and potential pathophysiological significance. J Biol Chem (1977) 1.53
Lipopolysaccharide priming of human neutrophils for an enhanced respiratory burst. Role of intracellular free calcium. J Clin Invest (1989) 1.53
The structural gene for tetanus neurotoxin is on a plasmid. Science (1984) 1.51
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Glutathione S-transferase AA from rat liver. Arch Biochem Biophys (1976) 1.46
Priming of neutrophils by lipopolysaccharide for enhanced release of superoxide. Requirement for plasma but not for tumor necrosis factor-alpha. J Immunol (1990) 1.42
Relationship between the soluble glutathione-dependent delta 5-3-ketosteroid isomerase and the glutathione S-transferases of the liver. Proc Natl Acad Sci U S A (1977) 1.36
Monoclonal antibodies as probes of tetanus toxin structure and function. Infect Immun (1983) 1.34
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Mercapturic acid formation: the several glutathione transferases of rat liver. Biochem Biophys Res Commun (1973) 1.28
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Interaction of fragments B and C of tetanus toxin with neural and thyroid membranes and with gangliosides. J Biol Chem (1980) 1.18
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Activation of mouse peritoneal macrophages by lipopolysaccharide alters the kinetic parameters of the superoxide-producing NADPH oxidase. J Biol Chem (1983) 1.15
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2-Propylthiouracil does not replace glutathione for the glutathione transferases. J Biol Chem (1984) 0.88