Published in Genetics on September 01, 1973
Genetic mapping in human disease. Science (2008) 15.12
Analysis of 6,515 exomes reveals the recent origin of most human protein-coding variants. Nature (2012) 8.91
The use of restriction endonucleases to measure mitochondrial DNA sequence relatedness in natural populations. I. Population structure and evolution in the genus Peromyscus. Genetics (1979) 8.72
Dating the origin of the CCR5-Delta32 AIDS-resistance allele by the coalescence of haplotypes. Am J Hum Genet (1998) 5.24
Intrachromosomal gene conversion and the maintenance of sequence homogeneity among repeated genes. Genetics (1982) 3.70
Extent and distribution of linkage disequilibrium in three genomic regions. Am J Hum Genet (2000) 3.68
Gene losses during human origins. PLoS Biol (2006) 3.17
Evidence of positive selection acting at the human dopamine receptor D4 gene locus. Proc Natl Acad Sci U S A (2001) 2.48
Patterns of polymorphism and linkage disequilibrium suggest independent origins of the human growth hormone gene cluster. Proc Natl Acad Sci U S A (1984) 2.47
The traveling-wave approach to asexual evolution: Muller's ratchet and speed of adaptation. Theor Popul Biol (2007) 2.07
Two additional potential retrotransposons isolated from a human L1 subfamily that contains an active retrotransposable element. Proc Natl Acad Sci U S A (1993) 1.76
Intron presence-absence polymorphism in Drosophila driven by positive Darwinian selection. Proc Natl Acad Sci U S A (2002) 1.70
Cladistic structure within the human Lipoprotein lipase gene and its implications for phenotypic association studies. Genetics (2000) 1.64
Natural selection and population history in the human angiotensinogen gene (AGT): 736 complete AGT sequences in chromosomes from around the world. Am J Hum Genet (2004) 1.61
The first arrival time and mean age of a deleterious mutant gene in a finite population. Am J Hum Genet (1975) 1.55
The pattern of polymorphism on human chromosome 21. Genome Res (2003) 1.53
Mutations in KLHL40 are a frequent cause of severe autosomal-recessive nemaline myopathy. Am J Hum Genet (2013) 1.46
Sequence variation and haplotype structure at the human HFE locus. Genetics (2002) 1.44
Multilocus analysis of introgression between two sympatric sister species of Drosophila: Drosophila yakuba and D. santomea. Genetics (2005) 1.40
Adaptation and constraint at Toll-like receptors in primates. Mol Biol Evol (2010) 1.34
Distinguishing between selective sweeps from standing variation and from a de novo mutation. PLoS Genet (2012) 1.31
Measuring the rates of spontaneous mutation from deep and large-scale polymorphism data. Genetics (2009) 1.31
The evolution of isochores: evidence from SNP frequency distributions. Genetics (2002) 1.29
Demography and the age of rare variants. PLoS Genet (2014) 1.29
Recent LTR retrotransposon insertion contrasts with waves of non-LTR insertion since speciation in Drosophila melanogaster. Proc Natl Acad Sci U S A (2007) 1.20
Characterization of genetic diversity in the nematode Pristionchus pacificus from population-scale resequencing data. Genetics (2014) 1.18
Impact of population structure, effective bottleneck time, and allele frequency on linkage disequilibrium maps. Proc Natl Acad Sci U S A (2004) 1.16
Complex signatures of selection and gene conversion in the duplicated globin genes of house mice. Genetics (2007) 1.16
Detecting emerging strains of tuberculosis by using spoligotypes. Proc Natl Acad Sci U S A (2006) 1.15
Positional cloning by linkage disequilibrium. Am J Hum Genet (2004) 1.13
Complete sequence of HLA-B27 cDNA identified through the characterization of structural markers unique to the HLA-A, -B, and -C allelic series. Proc Natl Acad Sci U S A (1986) 1.13
The GenoChip: a new tool for genetic anthropology. Genome Biol Evol (2013) 1.12
Allele age and a test for selection on rare alleles. Philos Trans R Soc Lond B Biol Sci (2000) 1.11
A history of recurrent positive selection at the toll-like receptor 5 in primates. Mol Biol Evol (2009) 1.05
Selection on cis-regulatory variation at B4galnt2 and its influence on von Willebrand factor in house mice. Mol Biol Evol (2008) 1.01
Moments for sum of an arbitrary function of gene frequency along a stochastic path of gene frequency change. Proc Natl Acad Sci U S A (1975) 1.01
The joint allele-frequency spectrum in closely related species. Genetics (2007) 1.01
Genome-wide association analysis for quantitative trait loci influencing Warner-Bratzler shear force in five taurine cattle breeds. Anim Genet (2012) 0.98
Apparent variation in Neanderthal admixture among African populations is consistent with gene flow from Non-African populations. Genome Biol Evol (2013) 0.96
Surprising fitness consequences of GC-biased gene conversion: I. Mutation load and inbreeding depression. Genetics (2010) 0.94
The effect of recurrent mutation on the frequency spectrum of a segregating site and the age of an allele. Theor Popul Biol (2011) 0.94
Empirical distributions of F(ST) from large-scale human polymorphism data. PLoS One (2012) 0.94
Population distribution and ancestry of the cancer protective MDM2 SNP285 (rs117039649). Oncotarget (2014) 0.92
Linkage disequilibrium maps and association mapping. J Clin Invest (2005) 0.92
The number of alleles at a microsatellite defines the allele frequency spectrum and facilitates fast accurate estimation of theta. Mol Biol Evol (2010) 0.92
Evolutionary responses to a constructed niche: ancient Mesoamericans as a model of gene-culture coevolution. PLoS One (2012) 0.91
Disease-associated alleles in genome-wide association studies are enriched for derived low frequency alleles relative to HapMap and neutral expectations. BMC Med Genomics (2010) 0.90
Detecting disease-causing mutations in the human genome by haplotype matching. Am J Hum Genet (2006) 0.89
Tracing genetic history of modern humans using X-chromosome lineages. Hum Genet (2007) 0.88
Dating rare mutations from small samples with dense marker data. Genetics (2014) 0.86
Haplotype homozygosity and derived alleles in the human genome. Am J Hum Genet (2006) 0.86
How old is the most recent ancestor of two copies of an allele? Genetics (2004) 0.85
The sequence of the Drosophila regulatory gene Suppressor two of zeste. Nucleic Acids Res (1991) 0.85
Host microsatellite alleles in malaria predisposition? Malar J (2005) 0.83
Linkage disequilibrium decay and past population history in the human genome. PLoS One (2012) 0.82
Adaptive selection of an incretin gene in Eurasian populations. Genome Res (2010) 0.81
Founder mutation(s) in the RSPH9 gene leading to primary ciliary dyskinesia in two inbred Bedouin families. Ann Hum Genet (2010) 0.81
An age-of-allele test of neutrality for transposable element insertions. Genetics (2013) 0.80
Positive selection on the osteoarthritis-risk and decreased-height associated variants at the GDF5 gene in East Asians. PLoS One (2012) 0.79
Genetic approaches in comparative and evolutionary physiology. Am J Physiol Regul Integr Comp Physiol (2015) 0.79
Site frequency spectra from genomic SNP surveys. Theor Popul Biol (2009) 0.78
Molecular variation at the HLA-A, B, C, DRB1, DQA1, and DQB1 loci in full heritage American Indians in Arizona: private haplotypes and their evolution. Tissue Antigens (2009) 0.78
Adaptive human CDKAL1 variants underlie hormonal response variations at the enteroinsular axis. PLoS One (2014) 0.78
Rapid Expansion of Phenylthiocarbamide Non-Tasters among Japanese Macaques. PLoS One (2015) 0.78
Estimating the Ages of Selection Signals from Different Epochs in Human History. Mol Biol Evol (2015) 0.77
Europeans have a higher proportion of high‑frequency deleterious variants than Africans. Hum Genet (2016) 0.76
The utility of ancient human DNA for improving allele age estimates, with implications for demographic models and tests of natural selection. J Hum Evol (2014) 0.76
Rapid increase in southern elephant seal genetic diversity after a founder event. Proc Biol Sci (2014) 0.76
Prevalence estimation for monogenic autosomal recessive diseases using population-based genetic data. Hum Genet (2015) 0.76
Population Genomics of Daphnia pulex. Genetics (2016) 0.76
Signature of positive selection of PTK6 gene in East Asian populations: a cross talk for Helicobacter pylori invasion and gastric cancer endemicity. Mol Genet Genomics (2015) 0.76
Copy number variants in the kallikrein gene cluster. PLoS One (2013) 0.75
A single-nucleotide polymorphism of human neuropeptide s gene originated from Europe shows decreased bioactivity. PLoS One (2013) 0.75
Explosive genetic evidence for explosive human population growth. Curr Opin Genet Dev (2016) 0.75
Topologies of the conditional ancestral trees and full-likelihood-based inference in the general coalescent tree framework. Genetics (2010) 0.75
Motoo Kimura and James Crow on the Infinitely Many Alleles Model. Genetics (2016) 0.75
High mutation rates explain low population genetic divergence at copy-number-variable loci in Homo sapiens. Sci Rep (2017) 0.75
Allele Age Under Non-Classical Assumptions is Clarified by an Exact Computational Markov Chain Approach. Sci Rep (2017) 0.75
An analytical framework in the general coalescent tree setting for analyzing polymorphisms created by two mutations. J Math Biol (2014) 0.75
THE NUMBER OF ALLELES THAT CAN BE MAINTAINED IN A FINITE POPULATION. Genetics (1964) 45.28
The Average Number of Generations until Fixation of a Mutant Gene in a Finite Population. Genetics (1969) 21.57
Pattern of neutral polymorphism in a geographically structured population. Genet Res (1971) 4.65
A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences. J Mol Evol (1980) 113.75
Evolutionary rate at the molecular level. Nature (1968) 33.15
The number of heterozygous nucleotide sites maintained in a finite population due to steady flux of mutations. Genetics (1969) 22.59
The Average Number of Generations until Fixation of a Mutant Gene in a Finite Population. Genetics (1969) 21.57
Whole genome sequencing of meticillin-resistant Staphylococcus aureus. Lancet (2001) 18.55
Slightly deleterious mutant substitutions in evolution. Nature (1973) 13.79
A model of mutation appropriate to estimate the number of electrophoretically detectable alleles in a finite population. Genet Res (1973) 13.08
A stochastic model concerning the maintenance of genetic variability in quantitative characters. Proc Natl Acad Sci U S A (1965) 9.20
GENIA corpus--semantically annotated corpus for bio-textmining. Bioinformatics (2003) 8.89
Obesity, cigarette smoking, and telomere length in women. Lancet (2005) 8.59
Artemisinins target the SERCA of Plasmodium falciparum. Nature (2003) 7.72
The substitutional load in a finite population. Heredity (Edinb) (1969) 7.56
Linkage disequilibrium at steady state determined by random genetic drift and recurrent mutation. Genetics (1969) 7.33
Role of very slightly deleterious mutations in molecular evolution and polymorphism. Theor Popul Biol (1976) 6.91
The effects of social status on biological aging as measured by white-blood-cell telomere length. Aging Cell (2006) 6.80
Protein polymorphism as a phase of molecular evolution. Nature (1971) 6.68
Theoretical foundation of population genetics at the molecular level. Theor Popul Biol (1971) 6.38
The probability of consanguineous marriages. Genetics (1966) 5.85
Estimation of evolutionary distances between homologous nucleotide sequences. Proc Natl Acad Sci U S A (1981) 5.34
On the stochastic model for estimation of mutational distance between homologous proteins. J Mol Evol (1972) 5.16
On some principles governing molecular evolution. Proc Natl Acad Sci U S A (1974) 4.97
Multilayer white light-emitting organic electroluminescent device. Science (1995) 4.86
Genetic variability maintained in a finite population due to mutational production of neutral and nearly neutral isoalleles. Genet Res (1968) 4.83
The rate of molecular evolution considered from the standpoint of population genetics. Proc Natl Acad Sci U S A (1969) 4.75
Pattern of neutral polymorphism in a geographically structured population. Genet Res (1971) 4.65
The RING heterodimer BRCA1-BARD1 is a ubiquitin ligase inactivated by a breast cancer-derived mutation. J Biol Chem (2001) 4.51
On the constancy of the evolutionary rate of cistrons. J Mol Evol (1971) 4.49
Genetic variability and effective population size when local extinction and recolonization of subpopulations are frequent. Proc Natl Acad Sci U S A (1980) 4.37
The basal ganglia and adaptive motor control. Science (1994) 4.27
Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size. Nat Nanotechnol (2011) 4.22
Telomere length as an indicator of biological aging: the gender effect and relation with pulse pressure and pulse wave velocity. Hypertension (2001) 4.07
Preponderance of synonymous changes as evidence for the neutral theory of molecular evolution. Nature (1977) 4.00
Development of a pertussis component vaccine in Japan. Lancet (1984) 3.94
Complex formation and functional versatility of Mre11 of budding yeast in recombination. Cell (1998) 3.80
Distribution of allelic frequencies in a finite population under stepwise production of neutral alleles. Proc Natl Acad Sci U S A (1975) 3.64
On the evolution of multigene families. Theor Popul Biol (1983) 3.61
Population biology of antigen presentation by MHC class I molecules. Science (1996) 3.58
Linkage disequilibrium between two segregating nucleotide sites under the steady flux of mutations in a finite population. Genetics (1971) 3.51
The average number of generations until extinction of an individual mutant gene in a finite population. Genetics (1969) 3.49
Insulin resistance, oxidative stress, hypertension, and leukocyte telomere length in men from the Framingham Heart Study. Aging Cell (2006) 3.44
Effect of overall phenotypic selection on genetic change at individual loci. Proc Natl Acad Sci U S A (1978) 3.41
Telomere length inversely correlates with pulse pressure and is highly familial. Hypertension (2000) 3.32
Stepwise mutation model and distribution of allelic frequencies in a finite population. Proc Natl Acad Sci U S A (1978) 3.29
Stem-loop binding protein, the protein that binds the 3' end of histone mRNA, is cell cycle regulated by both translational and posttranslational mechanisms. Mol Cell Biol (2000) 2.90
Peptidoglycan synthetic activities in membranes of Escherichia coli caused by overproduction of penicillin-binding protein 2 and rodA protein. J Biol Chem (1986) 2.84
Mutation and evolution at the molecular level. Genetics (1973) 2.79
Allelic and nonallelic homology of a supergene family. Proc Natl Acad Sci U S A (1982) 2.72
Rad52 forms ring structures and co-operates with RPA in single-strand DNA annealing. Genes Cells (1998) 2.66
Purification and characterization of the human interleukin-18 receptor. J Biol Chem (1997) 2.58
Simulating evolution by gene duplication. Genetics (1987) 2.52
Fixation of a deleterious allele at one of two "duplicate" loci by mutation pressure and random drift. Proc Natl Acad Sci U S A (1979) 2.51
Liver tumor promotion by the cyanobacterial cyclic peptide toxin microcystin-LR. J Cancer Res Clin Oncol (1992) 2.40
Centrosomal kinase AIK1 is overexpressed in invasive ductal carcinoma of the breast. Cancer Res (1999) 2.28
Possibility of extensive neutral evolution under stabilizing selection with special reference to nonrandom usage of synonymous codons. Proc Natl Acad Sci U S A (1981) 2.23
Molecular clock of viral evolution, and the neutral theory. Proc Natl Acad Sci U S A (1990) 2.15
Responses of tonically active neurons in the primate's striatum undergo systematic changes during behavioral sensorimotor conditioning. J Neurosci (1994) 2.14
Polyallelic mutational equilibria. Genetics (1975) 2.13
Sequence variation in the 18S rRNA gene, a target for PCR-based malaria diagnosis, in Plasmodium ovale from southern Vietnam. J Clin Microbiol (1996) 2.12
Structural analysis of the dnaA and dnaN genes of Escherichia coli. Gene (1984) 2.11
Inhibitors of efflux pumps in Pseudomonas aeruginosa potentiate the activity of the fluoroquinolone antibacterial levofloxacin. J Med Chem (1999) 2.10
Triplet repeat polymorphism in the transmembrane region of the MICA gene: a strong association of six GCT repetitions with Behçet disease. Proc Natl Acad Sci U S A (1997) 2.10
The CUL1 C-terminal sequence and ROC1 are required for efficient nuclear accumulation, NEDD8 modification, and ubiquitin ligase activity of CUL1. Mol Cell Biol (2000) 2.09
The balance between different peptidoglycan precursors determines whether Escherichia coli cells will elongate or divide. J Bacteriol (1990) 2.07
The length of time required for a selectively neutral mutant to reach fixation through random frequency drift in a finite population. Genet Res (1970) 2.05
Isolation of Dictyostelium discoideum cytokinesis mutants by restriction enzyme-mediated integration of the blasticidin S resistance marker. Biochem Biophys Res Commun (1994) 2.05
A gene-counting method of maximum likelihood for estimating gene frequencies in ABO and ABO-like systems. Ann Hum Genet (1968) 2.05
Population genetics of multigene families that are dispersed into two or more chromosomes. Proc Natl Acad Sci U S A (1983) 2.05
Efficiency of truncation selection. Proc Natl Acad Sci U S A (1979) 2.00
Organization of the biosynthetic gene cluster for the polyketide anthelmintic macrolide avermectin in Streptomyces avermitilis. Proc Natl Acad Sci U S A (1999) 1.98
Selective constraint in protein polymorphism: study of the effectively neutral mutation model by using an improved pseudosampling method. Proc Natl Acad Sci U S A (1983) 1.98
Nucleotide sequence of the pbpA gene and characteristics of the deduced amino acid sequence of penicillin-binding protein 2 of Escherichia coli K12. Eur J Biochem (1986) 1.98
Simple model for treating evolution of multigene families. Nature (1976) 1.98
Details of an isolation method for hepatic lymphocytes in mice. J Immunol Methods (1992) 1.97
The effect of selected linked locus on heterozygosity of neutral alleles (the hitch-hiking effect). Genet Res (1975) 1.95
Neurons in the thalamic CM-Pf complex supply striatal neurons with information about behaviorally significant sensory events. J Neurophysiol (2001) 1.94
High prevalence of Plasmodium malariae and Plasmodium ovale in malaria patients along the Thai-Myanmar border, as revealed by acridine orange staining and PCR-based diagnoses. Trop Med Int Health (1998) 1.93
Neurons but not glial cells show reciprocal imprinting of sense and antisense transcripts of Ube3a. Hum Mol Genet (2003) 1.92
Inhibition of T helper cell type 2 cell differentiation and immunoglobulin E response by ligand-activated Valpha14 natural killer T cells. J Exp Med (1999) 1.88
New approach to cell lineage analysis in mammals using the Cre-loxP system. Mol Reprod Dev (2000) 1.88
Eukaryotes-prokaryotes divergence estimated by 5S ribosomal RNA sequences. Nat New Biol (1973) 1.88
Identification of four highly conserved genes between breakpoint hotspots BP1 and BP2 of the Prader-Willi/Angelman syndromes deletion region that have undergone evolutionary transposition mediated by flanking duplicons. Am J Hum Genet (2003) 1.82
Cell proliferative activity in intraductal papillary-mucinous neoplasms and invasive ductal adenocarcinomas of the pancreas: an immunohistochemical study. Arch Pathol Lab Med (1998) 1.81
Dominant negative umuD mutations decreasing RecA-mediated cleavage suggest roles for intact UmuD in modulation of SOS mutagenesis. Proc Natl Acad Sci U S A (1990) 1.79
Functional organization of genetic material as a product of molecular evolution. Nature (1971) 1.79
Still's disease associated with necrotizing lymphadenitis (Kikuchi's disease): report of 3 cases. J Rheumatol (1988) 1.78
Systemic toxicity and resuscitation in bupivacaine-, levobupivacaine-, or ropivacaine-infused rats. Anesth Analg (2001) 1.76
Complete nucleotide sequence of the chloroplast genome from the green alga Chlorella vulgaris: the existence of genes possibly involved in chloroplast division. Proc Natl Acad Sci U S A (1997) 1.75
Identification of type I and type II serine/threonine kinase receptors for growth/differentiation factor-5. J Biol Chem (1996) 1.72
Longitudinal versus cross-sectional evaluations of leukocyte telomere length dynamics: age-dependent telomere shortening is the rule. J Gerontol A Biol Sci Med Sci (2011) 1.72