Published in J Mol Biol on November 05, 1973
Organization of immunoglobulin genes: reiteration frequency of the mouse kappa chain constant region gene. Proc Natl Acad Sci U S A (1974) 2.00
Transcription in vitro of immunoglobulin kappa light chain genes in isolated mouse myeloma nuclei and chromatin. Proc Natl Acad Sci U S A (1976) 1.38
Translation of ovalbumin mRNA in Xenopus laevis oocytes. Characterization of the system and effects of estrogen on injected mRNA populations. J Clin Invest (1976) 0.85
Nucleotide sequence of bacteriophage phi X174 DNA. Nature (1977) 95.69
Oligonucleotide-directed mutagenesis of DNA fragments cloned into M13 vectors. Methods Enzymol (1983) 17.47
Oligonucleotide-directed mutagenesis: a simple method using two oligonucleotide primers and a single-stranded DNA template. DNA (1984) 14.55
The nucleotide sequence of bacteriophage phiX174. J Mol Biol (1978) 13.55
Oligonucleotide-directed mutagenesis using M13-derived vectors: an efficient and general procedure for the production of point mutations in any fragment of DNA. Nucleic Acids Res (1982) 13.52
A general method for defining restriction enzyme cleavage and recognition sites. Methods Enzymol (1980) 13.26
Sequence of the gene for iso-1-cytochrome c in Saccharomyces cerevisiae. Cell (1979) 10.86
Routine versus clinically driven laboratory monitoring of HIV antiretroviral therapy in Africa (DART): a randomised non-inferiority trial. Lancet (2009) 7.96
Mutagenesis at a specific position in a DNA sequence. J Biol Chem (1978) 7.56
Report of the Committee on the Genetic Constitution of Chromosomes 7, 8 and 9. Cytogenet Cell Genet (1985) 7.28
Rabbit haemoglobin synthesis in frog cells: the translation of reticulocyte 9 s RNA in frog oocytes. J Mol Biol (1971) 6.97
Use of frog eggs and oocytes for the study of messenger RNA and its translation in living cells. Nature (1971) 6.97
The specific non-symmetrical sequence recognized by restriction endonuclease MboII. J Mol Biol (1980) 6.36
Deletion mapping of sequences essential for in vivo transcription of the iso-1-cytochrome c gene. Proc Natl Acad Sci U S A (1981) 6.26
Environmental lead and children's intelligence: a systematic review of the epidemiological evidence. BMJ (1994) 5.55
The sequence of the DNAs coding for the mating-type loci of Saccharomyces cerevisiae. Cell (1981) 5.23
A position effect in the control of transcription at yeast mating type loci. Nature (1981) 5.23
The distal transcription signals of the herpesvirus tk gene share a common hexanucleotide control sequence. Cell (1984) 5.10
The alcohol use disorder and associated disabilities interview schedule (AUDADIS): reliability of alcohol and drug modules in a clinical sample. Drug Alcohol Depend (1997) 5.10
Injected nuclei in frog oocytes: fate, enlargement, and chromatin dispersal. J Embryol Exp Morphol (1976) 5.01
Four mating-type genes control sexual differentiation in the fission yeast. EMBO J (1988) 5.00
Site-specific mutagenesis using synthetic oligodeoxyribonucleotide primers: II. In vitro selection of mutant DNA. Gene (1979) 4.99
The DNA sequence and analysis of human chromosome 6. Nature (2003) 4.75
Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing. Nature (2000) 4.68
Requirement for the homeobox gene Hb9 in the consolidation of motor neuron identity. Neuron (1999) 4.68
HIV-1 protease inhibitors. A review for clinicians. JAMA (1997) 4.34
Work system design for patient safety: the SEIPS model. Qual Saf Health Care (2006) 4.21
How biomedical investigators use library books. Bull Med Libr Assoc (1966) 4.20
Diabetes-associated sustained activation of the transcription factor nuclear factor-kappaB. Diabetes (2001) 3.83
Report of the committee on the genetic constitution of chromosomes 9 and 10. Cytogenet Cell Genet (1989) 3.79
Epigenetic memory of an active gene state depends on histone H3.3 incorporation into chromatin in the absence of transcription. Nat Cell Biol (2007) 3.71
Conditions Affecting Enzyme Synthesis in Cotyledons of Germinating Seeds. Plant Physiol (1960) 3.69
Isolation and sequence of the gene for iso-2-cytochrome c in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1980) 3.62
Transcription of ribonucleic acid in isolated mouse myeloma nuclei. Biochemistry (1973) 3.59
The integration of a continuous-speech-recognition system with the QMR diagnostic program. Proc Annu Symp Comput Appl Med Care (1992) 3.55
Undergraduate research. Genomics Education Partnership. Science (2008) 3.45
Identification and isolation of the yeast cytochrome c gene. Cell (1978) 3.39
The mapping and sequence determination of the single site in phiX174am3 replicative form DNA cleaved by restriction endonuclease Pst I. FEBS Lett (1976) 3.31
Changes in somatic cell nuclei inserted into growing and maturing amphibian oocytes. J Embryol Exp Morphol (1968) 3.27
Prostate Testing for Cancer and Treatment (ProtecT) feasibility study. Health Technol Assess (2003) 3.25
Mutations in ATP2A2, encoding a Ca2+ pump, cause Darier disease. Nat Genet (1999) 3.25
Mutations of the yeast SUP4 tRNATyr locus: transcription of the mutant genes in vitro. Cell (1980) 3.24
The use of Xenopus oocytes for the expression of cloned genes. Methods Enzymol (1983) 3.23
Molecular cloning and characterization of protective outer membrane protein P.69 from Bordetella pertussis. Proc Natl Acad Sci U S A (1989) 3.13
The base-pairing specificity of cellulose-pdT9. Nucleic Acids Res (1975) 3.11
The Epstein-Barr virus BMLF1 promoter contains an enhancer element that is responsive to the BZLF1 and BRLF1 transactivators. J Virol (1989) 3.11
In vitro mutation analysis of the mating-type locus in yeast. Cell (1981) 3.09
Site-specific mutagenesis using synthetic oligodeoxyribonucleotide primers: I. Optimum conditions and minimum ologodeoxyribonucleotide length. Gene (1979) 3.05
Loss of heterozygosity on chromosome 16p13.3 in hamartomas from tuberous sclerosis patients. Nat Genet (1994) 2.93
Characterization of a short, cis-acting DNA sequence which conveys cell cycle stage-dependent transcription in Saccharomyces cerevisiae. Mol Cell Biol (1991) 2.91
Cell type-specific activation of actin genes in the early amphibian embryo. Nature (1984) 2.91
Intracellular migration of nuclear proteins in Xenopus oocytes. Nature (1978) 2.91
Multisystem involvement in chronic liver disease. Studies on the incidence and pathogenesis. Am J Med (1973) 2.88
Synthesis of a mouse immunoglobulin light chain in a rabbit reticulocyte cell-free system. Nat New Biol (1971) 2.88
Senescence of Cotyledons of Germinating Peas. Influence of Axis Tissue. Plant Physiol (1963) 2.87
The Biology of Isolated Chromatin: Chromosomes, biologically active in the test tube, provide a powerful tool for the study of gene action. Science (1968) 2.84
The cytoplasmic control of nuclear activity in animal development. Biol Rev Camb Philos Soc (1968) 2.83
Nucleotide sequence of the yeast alcohol dehydrogenase II gene. J Biol Chem (1983) 2.82
Structure of the 3' hairpin termini of four rodent parvovirus genomes: nucleotide sequence homology at origins of DNA replication. Cell (1979) 2.78
Purified DNAs are transcribed after microinjection into Xenopus oocytes. Proc Natl Acad Sci U S A (1977) 2.75
In vitro mutagenesis. Annu Rev Genet (1985) 2.72
Constitutive expression of a c-myb cDNA blocks Friend murine erythroleukemia cell differentiation. Mol Cell Biol (1988) 2.70
Hormone replacement therapy and breast cancer: what are the facts? Med J Aust (1995) 2.66
Redesigning enzyme structure by site-directed mutagenesis: tyrosyl tRNA synthetase and ATP binding. Nature (1982) 2.63
Primary sequence and immunological characterization of beta-subunit of high conductance Ca(2+)-activated K+ channel from smooth muscle. J Biol Chem (1994) 2.62
Expression cloning of Siamois, a Xenopus homeobox gene expressed in dorsal-vegetal cells of blastulae and able to induce a complete secondary axis. Cell (1995) 2.61
Reduced isotype switching in splenic B cells from mice deficient in mismatch repair enzymes. J Exp Med (1999) 2.61
Treatment decision-making at the end of life: a survey of Australian doctors' attitudes towards patients' wishes and euthanasia. Med J Aust (1996) 2.59
Oligonucleotide-directed mutagenesis: a simple method using two oligonucleotide primers and a single-stranded DNA template. Methods Enzymol (1987) 2.59
Gene transfer in amphibian eggs and oocytes. Annu Rev Genet (1981) 2.52
DNA sequences of two yeast promoter-up mutants. Nature (1983) 2.50
Regional gene assignment of human porphobilinogen deaminase and esterase A4 to chromosome 11q23 leads to 11qter. Proc Natl Acad Sci U S A (1981) 2.50
How white and African Americans view their health and social problems. Different experiences, different expectations. JAMA (1995) 2.48
Psychiatric Research Interview for Substance and Mental Disorders (PRISM): reliability for substance abusers. Am J Psychiatry (1996) 2.47
Nucleotide sequence of salmon testes and salmon liver cytoplasmic initiator tRNA. Cell (1975) 2.46
Cryptosporidiosis in hospital patients with gastroenteritis. Am J Trop Med Hyg (1983) 2.45
Interaction and functional cooperation of PEBP2/CBF with Smads. Synergistic induction of the immunoglobulin germline Calpha promoter. J Biol Chem (1999) 2.44
The role of emotionality and regulation in children's social functioning: a longitudinal study. Child Dev (1995) 2.43
Selective DNA conservation and chromatin assembly after injection of SV40 DNA into Xenopus oocytes. Dev Biol (1978) 2.43
The DNA sequence and biological annotation of human chromosome 1. Nature (2006) 2.42
High-fidelity transcription of 5S DNA injected into Xenopus oocytes. Proc Natl Acad Sci U S A (1977) 2.42
Histone-bound RNA, a component of native nucleohistone. Proc Natl Acad Sci U S A (1965) 2.41
Conversion of topoisomerase I cleavage complexes on the leading strand of ribosomal DNA into 5'-phosphorylated DNA double-strand breaks by replication runoff. Mol Cell Biol (2000) 2.41
The heat-shock response in Xenopus oocytes is controlled at the translational level. Cell (1982) 2.40
Transcription initiation of the Saccharomyces cerevisiae iso-1-cytochrome c gene. Multiple, independent T-A-T-A sequences. J Mol Biol (1986) 2.36
Structure of the Saccharomyces cerevisiae HO gene and analysis of its upstream regulatory region. Mol Cell Biol (1986) 2.36
The sequence of a region of bacteriophage phiX174 DNA coding for parts of genes A and B. J Mol Biol (1977) 2.33
Cloning of several cDNA segments coding for human liver proteins. EMBO J (1983) 2.32
Evidence of activity-dependent withdrawal of corticospinal projections during human development. Neurology (2001) 2.32
The relations of emotionality and regulation to dispositional and situational empathy-related responding. J Pers Soc Psychol (1994) 2.31
Nuclear transplantation and the control of gene activity in animal development. Proc R Soc Lond B Biol Sci (1970) 2.30
The 3' terminal sequence of chicken ovalbumin messenger RNA and its comparison with other messenger RNA molecules. J Mol Biol (1976) 2.29
Sequence organization of cloned intracisternal A particle genes. Cell (1980) 2.27
Effects of ligand activation of peroxisome proliferator-activated receptor gamma in human prostate cancer. Proc Natl Acad Sci U S A (2000) 2.23