Published in J Biol Chem on August 25, 1970
Channel-shuttle mechanism for the regulation of phenylalanine and tyrosine synthesis at a metabolic branch point in Pseudomonas aeruginosa. J Bacteriol (1973) 1.19
Purification and properties of chorismate mutase-prephenate dehydratase and prephenate dehydrogenase from Alcaligenes eutrophus. J Bacteriol (1976) 1.00
Comparison of chorismate mutase isozyme patterns in selected plants. Plant Physiol (1978) 0.93
Regulation of Chorismate mutase-prephenate dehydratase and prephenate dehydrogenase from alcaligenes eutrophus. J Bacteriol (1976) 0.78
Yeast gene TRP5: structure, function, regulation. J Biol Chem (1982) 4.48
Regulated in vitro synthesis of Escherichia coli tryptophan operon messenger ribonucleic acid and enzymes. J Biol Chem (1974) 4.25
Role of primary structure and disulfide bond formation in beta-lactamase secretion. J Bacteriol (1983) 3.26
Cloning and characterization of a 12-gene cluster from Bacillus subtilis encoding nine enzymes for de novo purine nucleotide synthesis. J Biol Chem (1987) 3.12
Histidine regulation in Salmonella typhimurium: an activator attenuator model of gene regulation. Proc Natl Acad Sci U S A (1975) 3.06
Guanosine 5'-diphosphate 3'-diphosphate (ppGpp): positive effector for histidine operon transcription and general signal for amino-acid deficiency. Proc Natl Acad Sci U S A (1975) 3.05
Crystal structure of LacI member, PurR, bound to DNA: minor groove binding by alpha helices. Science (1994) 2.95
Nucleotide sequence of Saccharomyces cerevisiae genes TRP2 and TRP3 encoding bifunctional anthranilate synthase: indole-3-glycerol phosphate synthase. J Biol Chem (1984) 2.55
Nucleotide sequence of Escherichia coli purF and deduced amino acid sequence of glutamine phosphoribosylpyrophosphate amidotransferase. J Biol Chem (1982) 2.32
Escherichia coli gene purR encoding a repressor protein for purine nucleotide synthesis. Cloning, nucleotide sequence, and interaction with the purF operator. J Biol Chem (1988) 2.21
Biochemical genetics of Neurospora crassa conidial germination. Bacteriol Rev (1976) 2.07
Regulation of histidine operon does not require hisG enzyme. Proc Natl Acad Sci U S A (1975) 2.02
Bacillus subtilis pur operon expression and regulation. J Bacteriol (1989) 1.96
Phenotypic assays and sequencing are less sensitive than point mutation assays for detection of resistance in mixed HIV-1 genotypic populations. J Acquir Immune Defic Syndr (1999) 1.88
Structure of the allosteric regulatory enzyme of purine biosynthesis. Science (1994) 1.81
The anthranilate synthetase-anthranilate-5-phosphorribosylpyrophosphate phosphoribosyltransferase aggregate. On the reaction mechanism of anthranilate synthetase from Salmonella typhimurium. J Biol Chem (1970) 1.81
HIV-associated hematologic disorders are correlated with plasma viral load and improve under highly active antiretroviral therapy. J Acquir Immune Defic Syndr (2001) 1.80
Simple DNA extraction method for dried blood spots and comparison of two PCR assays for diagnosis of vertical human immunodeficiency virus type 1 transmission in Rwanda. J Clin Microbiol (2004) 1.77
Coupled formation of an amidotransferase interdomain ammonia channel and a phosphoribosyltransferase active site. Biochemistry (1997) 1.70
Identification of the Bacillus subtilis pur operon repressor. Proc Natl Acad Sci U S A (1995) 1.67
Enzymes utilizing glutamine as an amide donor. Adv Enzymol Relat Areas Mol Biol (1998) 1.67
Positive control of lac operon expression in vitro by guanosine 5'-diphosphate 3'-diphosphate. Proc Natl Acad Sci U S A (1979) 1.66
Histidine regulation in Salmonella typhimurium. XVI. A sensitive radiochemical assay for histidinol dehydrogenase. Anal Biochem (1975) 1.64
Glutamine phosphoribosylpyrophosphate amidotransferase from Escherichia coli. Purification and properties. J Biol Chem (1979) 1.62
Anthranilate synthetase. Adv Enzymol Relat Areas Mol Biol (1973) 1.62
Quantification of HIV-1 RNA in plasma: comparable results with the NASBA HIV-1 RNA QT and the AMPLICOR HIV monitor test. J Acquir Immune Defic Syndr Hum Retrovirol (1996) 1.60
Multiple forms of anthranilate synthetase-anthranilate 5-phosphoribosylpyrophosphate phosphoribosyltransferase from Salmonella typhimurium. J Biol Chem (1971) 1.57
Glutamine nucleotide sequence of Saccharomyces cerevisiae ADE4 encoding phosphoribosylpyrophosphate amidotransferase. J Biol Chem (1984) 1.54
Purification of the Escherichia coli purine regulon repressor and identification of corepressors. J Bacteriol (1990) 1.49
Effects of the hisT mutation of Salmonella typhimurium on translation elongation rate. J Bacteriol (1983) 1.48
Anthranilate synthetase. Purification and properties of component I from Salmonella typhimurium. Biochemistry (1968) 1.48
Identification of a trpG-related glutamine amide transfer domain in Escherichia coli GMP synthetase. J Biol Chem (1985) 1.44
Cloning and structural characterization of porcine heart aconitase. J Biol Chem (1990) 1.44
Genes of the Escherichia coli pur regulon are negatively controlled by a repressor-operator interaction. J Bacteriol (1990) 1.43
Nucleotide sequence of Escherichia coli pyrG encoding CTP synthetase. J Biol Chem (1986) 1.40
Crystal structure of Bacillus subtilis YabJ, a purine regulatory protein and member of the highly conserved YjgF family. Proc Natl Acad Sci U S A (1999) 1.39
Crystal structure of glutamine phosphoribosylpyrophosphate amidotransferase from Escherichia coli. Protein Sci (1998) 1.37
Mechanism of corepressor-mediated specific DNA binding by the purine repressor. Cell (1995) 1.35
Cloning of the Bacillus subtilis glutamine phosphoribosylpyrophosphate amidotransferase gene in Escherichia coli. Nucleotide sequence determination and properties of the plasmid-encoded enzyme. J Biol Chem (1983) 1.35
A role for a highly conserved protein of unknown function in regulation of Bacillus subtilis purA by the purine repressor. J Bacteriol (1999) 1.34
Detection of pur operon-attenuated mRNA and accumulated degradation intermediates in Bacillus subtilis. J Biol Chem (1988) 1.34
Interaction of Bacillus subtilis purine repressor with DNA. J Bacteriol (1997) 1.32
Correlation between histidine operon expression and guanosine 5'-diphosphate-3'-diphosphate levels during amino acid downshift in stringent and relaxed strains of Salmonella typhimurium. J Bacteriol (1989) 1.32
Repression of Escherichia coli purB is by a transcriptional roadblock mechanism. J Bacteriol (1992) 1.30
Promoter domain mediates guanosine tetraphosphate activation of the histidine operon. Proc Natl Acad Sci U S A (1986) 1.30
Some physicochemical properties of anthranilate synthetase component I from Salmonella typhimurium. J Biol Chem (1970) 1.30
Correlation of genes and enzymes, and studies on regulation of the aromatic pathway in Salmonella. J Biol Chem (1967) 1.29
Regulation of Escherichia coli purF. Mutations that define the promoter, operator, and purine repressor gene. J Biol Chem (1988) 1.29
Regulation of the Escherichia coli glyA gene by the purR gene product. J Bacteriol (1990) 1.28
Updated European recommendations for the clinical use of HIV drug resistance testing. Antivir Ther (2004) 1.28
Study of anthranilate synthase function by replacement of cysteine 84 using site-directed mutagenesis. J Biol Chem (1985) 1.28
Glutamate synthase. Properties of the glutamine-dependent activity. J Biol Chem (1976) 1.26
Autoregulation of Escherichia coli purR requires two control sites downstream of the promoter. J Bacteriol (1990) 1.25
Chorismate mutase-prephenate dehydratase. Partial purification and properties of the enzyme from Salmonella typhimurium. Biochemistry (1969) 1.24
The amino acid sequence of D-ribose-binding protein from Escherichia coli K12. J Biol Chem (1983) 1.24
Interaction of a putative repressor protein with an extended control region of the Bacillus subtilis pur operon. J Biol Chem (1989) 1.23
Comparison of DNA sequencing and a line probe assay for detection of human immunodeficiency virus type 1 drug resistance mutations in patients failing highly active antiretroviral therapy. J Clin Microbiol (2001) 1.22
Characterization of the glutamyl-tRNA(Gln)-to-glutaminyl-tRNA(Gln) amidotransferase reaction of Bacillus subtilis. J Bacteriol (1988) 1.21
De novo purine nucleotide biosynthesis: cloning of human and avian cDNAs encoding the trifunctional glycinamide ribonucleotide synthetase-aminoimidazole ribonucleotide synthetase-glycinamide ribonucleotide transformylase by functional complementation in E. coli. Nucleic Acids Res (1990) 1.20
Evaluating Clinical Isolates for Their Phenotypic and Genotypic Resistance Against Anti-HIV Drugs. Methods Mol Med (2000) 1.19
Neurospora crassa conidial germination: role of endogenous amino acid pools. J Bacteriol (1975) 1.19
Glutamine phosphoribosylpyrophosphate amidotransferase from cloned Escherichia coli purF. NH2-terminal amino acid sequence, identification of the glutamine site, and trace metal analysis. J Biol Chem (1982) 1.19
Prevalence and characteristics of multinucleoside-resistant human immunodeficiency virus type 1 among European patients receiving combinations of nucleoside analogues. Antimicrob Agents Chemother (2000) 1.18
The anthranilate synthetase-anthranilate 5-phosphoribosylpyrophosphate phosphoribosyltransferase aggregate. Purification of the aggregate and regulatory properties of anthranilate synthetase. J Biol Chem (1970) 1.17
Regulation of Escherichia coli purF. Analysis of the control region of a pur regulon gene. J Biol Chem (1985) 1.16
Membrane-bound and soluble extracellular alpha-amylase from Bacillus subtilis. J Biol Chem (1979) 1.16
Regulation of Escherichia coli pyrC by the purine regulon repressor protein. J Bacteriol (1990) 1.16
Cloning and sequence of Bacillus subtilis purA and guaA, involved in the conversion of IMP to AMP and GMP. J Bacteriol (1992) 1.14
Evaluation of two commercial kits for the detection of genotypic drug resistance on a panel of HIV type 1 subtypes A through J. J Acquir Immune Defic Syndr (2001) 1.14
Laboratory guidelines for the practical use of HIV drug resistance tests in patient follow-up. Antivir Ther (2001) 1.14
Regulation of Escherichia coli glnB, prsA, and speA by the purine repressor. J Bacteriol (1993) 1.13
Structural characterization and corepressor binding of the Escherichia coli purine repressor. J Bacteriol (1992) 1.13
The X-ray structure of the PurR-guanine-purF operator complex reveals the contributions of complementary electrostatic surfaces and a water-mediated hydrogen bond to corepressor specificity and binding affinity. J Biol Chem (1997) 1.12
Anthranilate synthetase component II from Pseudomonas putida. Covalent structure and identification of the cysteine residue involved in catalysis. J Biol Chem (1978) 1.12
Nucleotide sequence of the guaA gene encoding GMP synthetase of Escherichia coli K12. J Biol Chem (1985) 1.11
Detection of HIV-1 RNA in plasma and serum samples using the NASBA amplification system compared to RNA-PCR. J Virol Methods (1995) 1.11
A mutation in adenylosuccinate lyase associated with mental retardation and autistic features. Nat Genet (1992) 1.11
Coexpression of two closely linked avian genes for purine nucleotide synthesis from a bidirectional promoter. Mol Cell Biol (1993) 1.11
A cysteine-histidine-aspartate catalytic triad is involved in glutamine amide transfer function in purF-type glutamine amidotransferases. J Biol Chem (1989) 1.10
Nucleotide sequence of yeast GDH1 encoding nicotinamide adenine dinucleotide phosphate-dependent glutamate dehydrogenase. J Biol Chem (1985) 1.10
Mechanism of the synergistic end-product regulation of Bacillus subtilis glutamine phosphoribosylpyrophosphate amidotransferase by nucleotides. Biochemistry (1997) 1.10
Analysis of the chicken GPAT/AIRC bidirectional promoter for de novo purine nucleotide synthesis. J Biol Chem (1995) 1.08
Mutational analysis of active site residues in pig heart aconitase. J Biol Chem (1992) 1.08
Utilization of ammonia for tryptophan synthesis. Biochem Biophys Res Commun (1975) 1.06
Structure and function of the glutamine phosphoribosylpyrophosphate amidotransferase glutamine site and communication with the phosphoribosylpyrophosphate site. J Biol Chem (1996) 1.06
Expression, purification, and kinetic characterization of recombinant human adenylosuccinate lyase. J Biol Chem (1993) 1.06
Changes in glucosamine and galactosamine levels during conidial germination in Neurospora crassa. J Bacteriol (1975) 1.05
Extracellular and membrane-bound proteases from Bacillus subtilis. J Bacteriol (1980) 1.03
Escherichia coli purB gene: cloning, nucleotide sequence, and regulation by purR. J Bacteriol (1992) 1.02
Formyltetrahydrofolate hydrolase, a regulatory enzyme that functions to balance pools of tetrahydrofolate and one-carbon tetrahydrofolate adducts in Escherichia coli. J Bacteriol (1995) 1.01
purU, a source of formate for purT-dependent phosphoribosyl-N-formylglycinamide synthesis. J Bacteriol (1993) 1.01
Dual role for the glutamine phosphoribosylpyrophosphate amidotransferase ammonia channel. Interdomain signaling and intermediate channeling. J Biol Chem (2000) 1.01
Indinavir hair concentration in highly active antiretroviral therapy-treated patients: association with viral load and drug resistance. AIDS (2001) 1.00
Mutations in the Bacillus subtilis purine repressor that perturb PRPP effector function in vitro and in vivo. Curr Microbiol (2000) 0.99
Properties of apoglutamate synthase and comparison with glutamate dehydrogenase. J Biol Chem (1976) 0.99
Mutations that render the promoter of the histidine operon of Salmonella typhimurium insensitive to nutrient-rich medium repression and amino acid downshift. J Bacteriol (1997) 0.98
NAD synthetase. Methods Enzymol (1985) 0.98
Identification of sites for feedback regulation of glutamine 5-phosphoribosylpyrophosphate amidotransferase by nucleotides and relationship to residues important for catalysis. J Biol Chem (1993) 0.97