Published in Biochemistry on November 01, 1967
The acetylation of insulin. Biochem J (1971) 1.42
Enzymatically controlled drug delivery. Proc Natl Acad Sci U S A (1988) 1.25
Semisynthesis and biological activity of porcine [LeuB24]insulin and [LeuB25]insulin. Proc Natl Acad Sci U S A (1980) 1.16
Acetoacetylation of insulin. Biochem J (1969) 0.82
Semisynthetic insulin analogues. Biochem J (1971) 0.75
Synthesis and properties of Clostridium acidi-urici (Leu2)-ferredoxin: a function of the peptide chain and evidence against the direct role of the aromatic residues in electron transfer. Proc Natl Acad Sci U S A (1974) 0.75
Prediction of coronary heart disease using risk factor categories. Circulation (1998) 48.81
Impact of atrial fibrillation on the risk of death: the Framingham Heart Study. Circulation (1998) 19.93
Independent risk factors for atrial fibrillation in a population-based cohort. The Framingham Heart Study. JAMA (1994) 11.63
Impact of high-normal blood pressure on the risk of cardiovascular disease. N Engl J Med (2001) 10.54
Survival after the onset of congestive heart failure in Framingham Heart Study subjects. Circulation (1993) 9.24
The epidemiology of heart failure: the Framingham Study. J Am Coll Cardiol (1993) 8.01
Lifetime risk of developing coronary heart disease. Lancet (1999) 7.54
Hemodynamic patterns of age-related changes in blood pressure. The Framingham Heart Study. Circulation (1997) 7.34
Prevalence, incidence, prognosis, and predisposing conditions for atrial fibrillation: population-based estimates. Am J Cardiol (1998) 6.76
Serum uric acid and risk for cardiovascular disease and death: the Framingham Heart Study. Ann Intern Med (1999) 6.72
Impact of reduced heart rate variability on risk for cardiac events. The Framingham Heart Study. Circulation (1996) 6.20
Relationship of symptom-onset-to-balloon time and door-to-balloon time with mortality in patients undergoing angioplasty for acute myocardial infarction. JAMA (2000) 6.00
Accuracy of death certificates for coding coronary heart disease as the cause of death. Ann Intern Med (1998) 5.63
Assessment of frequency of progression to hypertension in non-hypertensive participants in the Framingham Heart Study: a cohort study. Lancet (2001) 5.54
Congestive heart failure in subjects with normal versus reduced left ventricular ejection fraction: prevalence and mortality in a population-based cohort. J Am Coll Cardiol (1999) 5.43
Does the relation of blood pressure to coronary heart disease risk change with aging? The Framingham Heart Study. Circulation (2001) 5.11
Is pulse pressure useful in predicting risk for coronary heart Disease? The Framingham heart study. Circulation (1999) 5.04
Prevalence and clinical outcome of mitral-valve prolapse. N Engl J Med (1999) 5.01
Defining diastolic heart failure: a call for standardized diagnostic criteria. Circulation (2000) 4.63
Interferon-induced transcription of a gene encoding a 15-kDa protein depends on an upstream enhancer element. Proc Natl Acad Sci U S A (1987) 4.61
Echocardiographic predictors of nonrheumatic atrial fibrillation. The Framingham Heart Study. Circulation (1994) 4.52
Increased left ventricular mass and hypertrophy are associated with increased risk for sudden death. J Am Coll Cardiol (1998) 4.44
The somatic replication of DNA methylation. Cell (1981) 4.42
Risk factors for incident radiographic knee osteoarthritis in the elderly: the Framingham Study. Arthritis Rheum (1997) 4.08
Cholesterol and mortality. 30 years of follow-up from the Framingham study. JAMA (1987) 4.05
Left atrial size and the risk of stroke and death. The Framingham Heart Study. Circulation (1995) 4.04
Bone mass and the risk of breast cancer among postmenopausal women. N Engl J Med (1997) 3.96
The incidence and natural history of knee osteoarthritis in the elderly. The Framingham Osteoarthritis Study. Arthritis Rheum (1995) 3.93
Evidence for association and genetic linkage of the angiotensin-converting enzyme locus with hypertension and blood pressure in men but not women in the Framingham Heart Study. Circulation (1998) 3.89
Cancer: improving early detection and prevention. A community practice randomised trial. BMJ (1992) 3.76
An improved method for adjusting the QT interval for heart rate (the Framingham Heart Study) Am J Cardiol (1992) 3.66
Effects of ambient air pollution on nonelderly asthma hospital admissions in Seattle, Washington, 1987-1994. Epidemiology (1999) 3.57
Insulin resistance, oxidative stress, hypertension, and leukocyte telomere length in men from the Framingham Heart Study. Aging Cell (2006) 3.44
Reduced heart rate variability and mortality risk in an elderly cohort. The Framingham Heart Study. Circulation (1994) 3.44
Prevalence, clinical features and prognosis of diastolic heart failure: an epidemiologic perspective. J Am Coll Cardiol (1995) 3.19
Prognosis of left ventricular geometric patterns in the Framingham Heart Study. J Am Coll Cardiol (1995) 3.08
Impaired heart rate response to graded exercise. Prognostic implications of chronotropic incompetence in the Framingham Heart Study. Circulation (1996) 3.07
Cardiovascular disease and mortality in a community-based cohort with mild renal insufficiency. Kidney Int (1999) 2.95
Interferon-stimulated transcription: isolation of an inducible gene and identification of its regulatory region. Proc Natl Acad Sci U S A (1986) 2.92
Reduced heart rate variability and new-onset hypertension: insights into pathogenesis of hypertension: the Framingham Heart Study. Hypertension (1998) 2.86
Profile for estimating risk of heart failure. Arch Intern Med (1999) 2.81
Left ventricular dilatation and the risk of congestive heart failure in people without myocardial infarction. N Engl J Med (1997) 2.81
Mitral annular calcification and the risk of stroke in an elderly cohort. N Engl J Med (1992) 2.77
Synthetic Penicillin. Science (1946) 2.77
Clinical Advisory Statement. Importance of systolic blood pressure in older Americans. Hypertension (2000) 2.76
Echocardiographic criteria for left ventricular hypertrophy: the Framingham Heart Study. Am J Cardiol (1987) 2.60
ACC/AHA/ACP-ASIM guidelines for the management of patients with chronic stable angina: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on Management of Patients With Chronic Stable Angina). J Am Coll Cardiol (1999) 2.58
Total serum bilirubin and risk of cardiovascular disease in the Framingham offspring study. Am J Cardiol (2001) 2.57
Genetic and environmental contributions to platelet aggregation: the Framingham heart study. Circulation (2001) 2.54
Trends in the prevalence of hypertension, antihypertensive therapy, and left ventricular hypertrophy from 1950 to 1989. N Engl J Med (1999) 2.53
Prevalence and clinical determinants of mitral, tricuspid, and aortic regurgitation (the Framingham Heart Study) Am J Cardiol (1999) 2.51
Absence of association or genetic linkage between the angiotensin-converting-enzyme gene and left ventricular mass. N Engl J Med (1996) 2.49
Secular trends in the prevalence of atrial fibrillation: The Framingham Study. Am Heart J (1996) 2.47
Reconstitution of membrane proteins into liposomes: application to energy-transducing membrane proteins. Biochim Biophys Acta (1995) 2.47
Evidence for a Mendelian gene in a segregation analysis of generalized radiographic osteoarthritis: the Framingham Study. Arthritis Rheum (1998) 2.45
The impact of obesity on left ventricular mass and geometry. The Framingham Heart Study. JAMA (1991) 2.44
Association of hyperglycemia with reduced heart rate variability (The Framingham Heart Study). Am J Cardiol (2000) 2.28
Prognosis after the onset of coronary heart disease. An investigation of differences in outcome between the sexes according to initial coronary disease presentation. Circulation (1993) 2.27
Alternative lengthening of telomeres and survival in patients with glioblastoma multiforme. Lancet (2003) 2.26
Resurgence of sleeping sickness in Tambura County, Sudan. Am J Trop Med Hyg (1999) 2.24
Prognosis after first myocardial infarction. Comparison of Q-wave and non-Q-wave myocardial infarction in the Framingham Heart Study. JAMA (1992) 2.22
Echocardiographic evidence for the existence of a distinct diabetic cardiomyopathy (the Framingham Heart Study). Am J Cardiol (1991) 2.19
Natural history of progressive ischemic stroke in a population treated with heparin. Stroke (1990) 2.14
Distribution and categorization of echocardiographic measurements in relation to reference limits: the Framingham Heart Study: formulation of a height- and sex-specific classification and its prospective validation. Circulation (1997) 2.14
The association of chronic cough with the risk of myocardial infarction: the Framingham Heart Study. Am J Med (1999) 2.09
Prognostic implications of asymptomatic ventricular arrhythmias: the Framingham Heart Study. Ann Intern Med (1992) 2.08
Left ventricular mass and risk of stroke in an elderly cohort. The Framingham Heart Study. JAMA (1994) 2.03
Circadian variation in the incidence of sudden cardiac death in the Framingham Heart Study population. Am J Cardiol (1987) 2.01
Prolactin, growth hormone, erythropoietin and granulocyte-macrophage colony stimulating factor induce MGF-Stat5 DNA binding activity. EMBO J (1995) 2.00
Cooperation between STAT3 and c-jun suppresses Fas transcription. Mol Cell (2001) 1.97
Death rates from coronary disease--progress and a puzzling paradox. N Engl J Med (1998) 1.95
Bone mineral density and risk of incident and progressive radiographic knee osteoarthritis in women: the Framingham Study. J Rheumatol (2000) 1.94
FGF signaling inhibits chondrocyte proliferation and regulates bone development through the STAT-1 pathway. Genes Dev (1999) 1.94
Influence of contemporary versus 30-year blood pressure levels on left ventricular mass and geometry: the Framingham Heart Study. J Am Coll Cardiol (1991) 1.91
Transcription of interferon-stimulated genes is induced by adenovirus particles but is suppressed by E1A gene products. J Virol (1988) 1.88
Predicting survival in heart failure case and control subjects by use of fully automated methods for deriving nonlinear and conventional indices of heart rate dynamics. Circulation (1997) 1.87
Blood pressure response during treadmill testing as a risk factor for new-onset hypertension. The Framingham heart study. Circulation (1999) 1.87
Lipids and risk of coronary heart disease. The Framingham Study. Ann Epidemiol (1994) 1.86
Short stature and risk for mortality and cardiovascular disease events. The Framingham Heart Study. Circulation (1994) 1.85
Apolipoprotein E genotype and cardiovascular disease in the Framingham Heart Study. Atherosclerosis (2001) 1.84
The natural history of borderline isolated systolic hypertension. N Engl J Med (1993) 1.82
Echocardiographic features of the right heart in sleep-disordered breathing: the Framingham Heart Study. Am J Respir Crit Care Med (2001) 1.81
Defining radiographic osteoarthritis for the whole knee. Osteoarthritis Cartilage (1997) 1.80
Determinants of heart rate variability. J Am Coll Cardiol (1996) 1.79
Intermolecular cross-linking of monomeric proteins and cross-linking of oligomeric proteins as a probe of quaternary structure. Application to leucine aminopeptidase (bovine lens). J Biol Chem (1972) 1.78
Mitral valve prolapse in the general population. 1. Epidemiologic features: the Framingham Study. Am Heart J (1983) 1.72
Differential control of systolic and diastolic blood pressure : factors associated with lack of blood pressure control in the community. Hypertension (2000) 1.70
Association of blood pressure with fibrinolytic potential in the Framingham offspring population. Circulation (2000) 1.70
Immortalization of precursor cells from the mammalian CNS. Neuron (1988) 1.65
Heritability of left ventricular mass: the Framingham Heart Study. Hypertension (1997) 1.63
Hemostatic state and atrial fibrillation (the Framingham Offspring Study). Am J Cardiol (2001) 1.63
Determinants of echocardiographic aortic root size. The Framingham Heart Study. Circulation (1995) 1.61
Influence of blood pressure on left atrial size. The Framingham Heart Study. Hypertension (1995) 1.61
Differential impact of systolic and diastolic blood pressure level on JNC-VI staging. Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension (1999) 1.60
Heritability of longitudinal change in lung function. The Framingham study. Am J Respir Crit Care Med (2001) 1.60
Do antioxidant micronutrients protect against the development and progression of knee osteoarthritis? Arthritis Rheum (1996) 1.56
Daunorubicin in the treatment of acute myelocytic leukaemia. Lancet (1969) 1.56
Thrombopoietin activates a STAT5-like factor in hematopoietic cells. EMBO J (1995) 1.55
Why is left ventricular hypertrophy so predictive of morbidity and mortality? Am J Med Sci (1999) 1.54