Published in Diabetes on December 01, 1968
Retention and degradation of 125I-insulin by perfused livers from diabetic rats. J Clin Invest (1976) 2.04
Metabolism of proinsulin, insulin, and C-peptide in the rat. J Clin Invest (1973) 1.60
Human serum proinsulin. J Clin Invest (1970) 1.52
The acetylation of insulin. Biochem J (1971) 1.42
The metabolism of proinsulin and insulin by the liver. J Clin Invest (1972) 1.38
C-peptide antibodies induced by bovine insulin therapy. Clin Exp Immunol (1982) 1.20
The gastrointestinal stimulus to insulin release. II. A dual action of secretin. J Clin Invest (1970) 1.13
Characterization of circulating insulin and proinsulin-binding antibodies in autoimmune hypoglycemia. J Clin Invest (1979) 1.11
Plasma insulin: fluctuations in the "big" insulin component in man after glucose and other stimuli. J Clin Invest (1969) 1.10
A bovine pancreatic enzyme catalyzing the conversion of proinsulin to insulin. Proc Natl Acad Sci U S A (1971) 1.02
Proinsulin-like component of circulating insulin in the basal state and in patients and hamsters with islet cell tumors. J Clin Invest (1971) 1.02
Biosynthesis of insulin in bovine fetal pancreatic slices: the incorporation of tritiated leucine into a single-chain proinsulin, a double-chain intermediate, and insulin in subcellular fractions. Proc Natl Acad Sci U S A (1969) 1.00
The biological and immunological properties of pork and beef insulin, proinsulin, and connecting peptides. J Clin Invest (1970) 0.99
Biochemical and clinical implications of proinsulin conversion intermediates. J Clin Invest (1985) 0.96
Monoclonal antibodies against beta nerve growth factor and their effects on receptor binding and biological activity. Proc Natl Acad Sci U S A (1981) 0.93
Morphological and biochemical studies of B cells of fetal rat endocrine pancreas in organ culture. Evidence for (pro) insulin biosynthesis. J Cell Biol (1971) 0.92
The interactions of proinsulin with insulin receptors on the plasma membrane of the liver. J Clin Invest (1974) 0.91
Studies on the biological activity of porcine proinsulin. J Clin Invest (1970) 0.90
Adventures with insulin in the islets of Langerhans. J Biol Chem (2011) 0.88
Characterization of proinsulin-insulin intermediates in human plasma. J Clin Invest (1978) 0.88
Proinsulin: Crystallization and preliminary x-ray diffraction studies. Proc Natl Acad Sci U S A (1970) 0.86
The evolution of diabetes from prediabetes. Postgrad Med J (1970) 0.75
The source of the circulating aggregate of insulin in type I diabetic patients is therapeutic insulin. J Clin Invest (1986) 0.75
Clinical experience with the new insulins. Ulster Med J (1978) 0.75
Insulin studies in temporary neonatal hyperglycaemia. Arch Dis Child (1971) 0.75
Biosynthesis of hormonal and neural peptides. Trans Am Clin Climatol Assoc (1984) 0.75
The diagnostic evaluation and multidisciplinary management of neurofibromatosis 1 and neurofibromatosis 2. JAMA (1997) 8.30
Mission critical--integrating clinician-educators into academic medical centers. N Engl J Med (1999) 6.41
Insulin biosynthesis: evidence for a precursor. Science (1967) 5.05
Direct activation of capsaicin receptors by products of lipoxygenases: endogenous capsaicin-like substances. Proc Natl Acad Sci U S A (2000) 4.53
Processing mechanisms in the biosynthesis of proteins. Ann N Y Acad Sci (1980) 4.40
Post-translational proteolysis in polypeptide hormone biosynthesis. Annu Rev Physiol (1982) 3.43
Cell-free synthesis of rat preproinsulins: characterization and partial amino acid sequence determination. Proc Natl Acad Sci U S A (1976) 3.41
Differential effects of cytolytic T cell subsets on intracellular infection. Science (1997) 3.39
Structural basis of the redox switch in the OxyR transcription factor. Cell (2001) 3.32
Proteolytic processing in the biosynthesis of insulin and other proteins. Fed Proc (1974) 3.27
Digital dynamic telepathology--the Virtual Microscope. Proc AMIA Symp (1998) 3.01
Autologous olfactory ensheathing cell transplantation in human paraplegia: a 3-year clinical trial. Brain (2008) 2.99
Transport protein genes in the murine MHC: possible implications for antigen processing. Science (1990) 2.96
Determination of free and total insulin and C-peptide in insulin-treated diabetics. Diabetes (1977) 2.79
Identification of a human insulinoma cDNA encoding a novel mammalian protein structurally related to the yeast dibasic processing protease Kex2. J Biol Chem (1990) 2.78
Proteolytic processing in the secretory pathway. J Biol Chem (1999) 2.75
Hyperproinsulinaemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity. Nat Genet (1995) 2.73
Identification of a cDNA encoding a second putative prohormone convertase related to PC2 in AtT20 cells and islets of Langerhans. Proc Natl Acad Sci U S A (1991) 2.62
Expression of a preproinsulin-beta-galactosidase gene fusion in mammalian cells. Proc Natl Acad Sci U S A (1983) 2.57
Haemoglobin A1: An indicator of the metabolic control of diabetic patients. Lancet (1977) 2.48
Binding and degradation of 125I-insulin by rat hepatocytes. J Biol Chem (1975) 2.46
Defective prohormone processing and altered pancreatic islet morphology in mice lacking active SPC2. Proc Natl Acad Sci U S A (1997) 2.42
Insulin biosynthesis in the rat: demonstration of two proinsulins. Proc Natl Acad Sci U S A (1969) 2.41
Structure and evolution of the insulin gene. Annu Rev Genet (1985) 2.27
Construction and selection of recombinant plasmids containing full-length complementary DNAs corresponding to rat insulins I and II. Proc Natl Acad Sci U S A (1979) 2.27
Effect of improved sanitary facilities on infant diarrhea in a Hopi village. Public Health Rep (1969) 2.20
Association of depression and anxiety with reduced quality of life in patients with predialysis chronic kidney disease. Int J Clin Pract (2013) 2.15
Control of insulin gene expression in pancreatic beta-cells and in an insulin-producing cell line, RIN-5F cells. II. Regulation of insulin mRNA stability. J Biol Chem (1985) 2.09
Retention and degradation of 125I-insulin by perfused livers from diabetic rats. J Clin Invest (1976) 2.04
Congenital hypothalamic hamartoblastoma, hypopituitarism, imperforate anus and postaxial polydactyly--a new syndrome? Part I: clinical, causal, and pathogenetic considerations. Am J Med Genet (1980) 2.02
A structurally abnormal insulin causing human diabetes. Nature (1979) 1.99
Control of insulin gene expression in pancreatic beta-cells and in an insulin-producing cell line, RIN-5F cells. I. Effects of glucose and cyclic AMP on the transcription of insulin mRNA. J Biol Chem (1985) 1.95
Golgi/granule processing of peptide hormone and neuropeptide precursors: a minireview. J Cell Biochem (1984) 1.93
Plexiform neurofibromas in NF1: toward biologic-based therapy. Neurology (2002) 1.90
Kex2-like endoproteases PC2 and PC3 accurately cleave a model prohormone in mammalian cells: evidence for a common core of neuroendocrine processing enzymes. Proc Natl Acad Sci U S A (1991) 1.90
Somatostatinoma syndrome. Biochemical, morphologic and clinical features. N Engl J Med (1979) 1.88
Studies on the conversion of proinsulin to insulin. I. Conversion in vitro with trypsin and carboxypeptidase B. J Biol Chem (1971) 1.88
Nucleotide and predicted amino acid sequences of cloned human and mouse preprocathepsin B cDNAs. Proc Natl Acad Sci U S A (1986) 1.82
The current state of insect molecular systematics: a thriving Tower of Babel. Annu Rev Entomol (2000) 1.80
Proteolytic processing mechanisms in the biosynthesis of neuroendocrine peptides: the subtilisin-like proprotein convertases. Front Neuroendocrinol (1995) 1.79
Proinsulin and the biosynthesis of insulin. Recent Prog Horm Res (1969) 1.78
Isolation of a glucagon-containing peptide: primary structure of a possible fragment of proglucagon. Proc Natl Acad Sci U S A (1973) 1.73
A mutation in the B chain coding region is associated with impaired proinsulin conversion in a family with hyperproinsulinemia. Proc Natl Acad Sci U S A (1987) 1.73
Biliary atresia and reovirus type 3 infection. N Engl J Med (1982) 1.72
Translational control of insulin biosynthesis. Evidence for regulation of elongation, initiation and signal-recognition-particle-mediated translational arrest by glucose. Biochem J (1986) 1.71
High-level expression of human insulin receptor cDNA in mouse NIH 3T3 cells. Proc Natl Acad Sci U S A (1987) 1.70
Conversion of proinsulin to insulin: involvement of a 31,500 molecular weight thiol protease. Proc Natl Acad Sci U S A (1982) 1.70
Determination of the amino acid sequence of the monkey, sheep, and dog proinsulin C-peptides by a semi-micro Edman degradation procedure. J Biol Chem (1972) 1.62
Insulin-resistant diabetes due to a point mutation that prevents insulin proreceptor processing. Science (1988) 1.61
Molecular interaction of CD1b with lipoglycan antigens. Immunity (1998) 1.60
Islet-cell-surface antibodies in juvenile diabetes mellitus. N Engl J Med (1978) 1.59
Partial purification and characterization of the mRNA for rat preproinsulin. Proc Natl Acad Sci U S A (1976) 1.59
Integrating clinician-educators into Academic Medical Centers: challenges and potential solutions. Acad Med (2000) 1.57
Islet amyloid polypeptide. A new beta cell secretory product related to islet amyloid deposits. J Biol Chem (1990) 1.56
Deletions spanning the neurofibromatosis 1 gene: identification and phenotype of five patients. Am J Hum Genet (1994) 1.56
Identification of cDNA clones encoding a precursor of rat liver cathepsin B. Proc Natl Acad Sci U S A (1985) 1.55
Clinical aspects of insulin--antigenicity. Diabetes (1972) 1.55
The spontaneous reoxidation of reduced beef and rat proinsulins. Proc Natl Acad Sci U S A (1968) 1.55
An islet amyloid peptide is derived from an 89-amino acid precursor by proteolytic processing. J Biol Chem (1988) 1.53
Furin mediates enhanced production of fibrillogenic ABri peptides in familial British dementia. Nat Neurosci (1999) 1.53
Human serum proinsulin. J Clin Invest (1970) 1.52
Incomplete processing of proinsulin to insulin accompanied by elevation of Des-31,32 proinsulin intermediates in islets of mice lacking active PC2. J Biol Chem (1998) 1.51
Preparation and characterization of plasma membrane-enriched fractions from rat pancreatic islets. J Cell Biol (1976) 1.50
Effects of beta cell granule components on human islet amyloid polypeptide fibril formation. FEBS Lett (1996) 1.49
Neurological disease in xeroderma pigmentosum. Documentation of a late onset type of the juvenile onset form. Brain (1991) 1.49
Neuroprotection and neuronal differentiation studies using substantia nigra dopaminergic cells derived from transgenic mouse embryos. J Neurosci (1999) 1.47
Cathepsin B-related proteases in the insulin secretory granule. J Biol Chem (1984) 1.47
Expression profiling of pancreatic beta cells: glucose regulation of secretory and metabolic pathway genes. Proc Natl Acad Sci U S A (2000) 1.46
Conservation of PDX-1 structure, function, and expression in zebrafish. Endocrinology (1998) 1.46
Studies on the conversion of proinsulin to insulin. 3. Studies in vitro with a crude secretion granule fraction isolated from rat islets of Langerhans. J Biol Chem (1973) 1.46
Severe defect in proglucagon processing in islet A-cells of prohormone convertase 2 null mice. J Biol Chem (2001) 1.45
Myocardial micronecrosis produced by microsphere embolization. Role of an alpha-adrenergic tonic influence on the coronary microcirculation. Circ Res (1984) 1.43
Evidence for proinsulin in human urine and serum. Lancet (1968) 1.42
Evolution of early TIMI 2 flow after thrombolysis for acute myocardial infarction. GUSTO-1 Angiographic Investigators. Circulation (1996) 1.42
Isolation and characterization of proinsulin C-peptide from bovine pancreas. J Biol Chem (1971) 1.41
Microvascular spasm in the cardiomyopathic Syrian hamster: a preventable cause of focal myocardial necrosis. Circulation (1982) 1.41
A mutant human proinsulin is secreted from islets of Langerhans in increased amounts via an unregulated pathway. Proc Natl Acad Sci U S A (1988) 1.40
T-cell release of granulysin contributes to host defense in leprosy. Nat Med (2001) 1.40
Three mutant insulins in man. Nature (1983) 1.40
Association between carcinogen-DNA adducts in white blood cells and lung cancer risk in the physicians health study. Cancer Res (2001) 1.40
Cloned cell lines from a transplantable islet cell tumor are heterogeneous and express cholecystokinin in addition to islet hormones. J Cell Biol (1986) 1.39
Fostering a new relationship between departments of medicine and teaching hospitals. Acad Med (1993) 1.39
The metabolism of proinsulin and insulin by the liver. J Clin Invest (1972) 1.38
Alanine scanning mutagenesis of insulin. J Biol Chem (1997) 1.36
Peptide hormones. Annu Rev Biochem (1974) 1.33
Identification of proinsulin and C-peptide in human serum by a specific immunoassay. Proc Natl Acad Sci U S A (1970) 1.33
Loss of one but not two mdm2 null alleles alters the tumour spectrum in p53 null mice. J Pathol (1999) 1.32
The Banting Memorial Lecture 1976. Insulin today. Diabetes (1977) 1.28
Identification of a point mutation in the human insulin gene giving rise to a structurally abnormal insulin (insulin Chicago). Diabetes (1983) 1.28
Sequential changes in beta-cell function in insulin-treated diabetic patients assessed by C-peptide immunoreactivity. N Engl J Med (1973) 1.28
The limitations to and valid use of C-peptide as a marker of the secretion of insulin. Diabetes (1986) 1.27
Phylogenetic utility of elongation factor-1 alpha in noctuoidea (Insecta: Lepidoptera): the limits of synonymous substitution. Mol Biol Evol (1997) 1.26
Conservation of the sequence of islet amyloid polypeptide in five mammals is consistent with its putative role as an islet hormone. Proc Natl Acad Sci U S A (1989) 1.25
Block in insulin release from column-perifused pancreatic beta-cells induced by islet cell surface antibodies and complement. Diabetes (1981) 1.25
Guinea pig preproinsulin gene: an evolutionary compromise? Proc Natl Acad Sci U S A (1984) 1.24
Differential processing of proglucagon by the subtilisin-like prohormone convertases PC2 and PC3 to generate either glucagon or glucagon-like peptide. J Biol Chem (1995) 1.23
Selective loss of natural killer T cells by apoptosis following infection with lymphocytic choriomeningitis virus. J Virol (2001) 1.23
Biosynthesis and periplasmic segregation of human proinsulin in Escherichia coli. Proc Natl Acad Sci U S A (1981) 1.23