Published in Nature on December 25, 1965
Migration of lymphocytes and thymocytes in the rat. I. The route of migration from blood to spleen and lymph nodes. J Exp Med (1968) 4.55
Suppressor cell regulation of immune response to tumors: abrogation by adult thymectomy. Proc Natl Acad Sci U S A (1977) 1.47
Immunocompetence of spleen cells from neonatally thymectomized mice conferred in vitro by a syngeneic thymus extract. J Exp Med (1969) 1.47
Thymectomy and cancer--a follow-up study. Br J Cancer (1972) 1.40
The thymus and recovery from cyclophosphamide-induced tolerance to sheep erythrocytes. J Exp Med (1968) 1.35
Studies on delayed hypersensitivity in mice. III. Evidence for suppressive regulatory T1-cell population in delayed hypersensitivity. J Exp Med (1977) 1.31
Homeostasis and the age-associated defect of CD4 T cells. Semin Immunol (2005) 1.30
Immunological relationship between acetylcholine receptor and thymus: a possible significance in myasthenia gravis. Proc Natl Acad Sci U S A (1975) 1.03
The effect of thymic action on the precursors of antigen-sensitive cells. Proc Natl Acad Sci U S A (1967) 1.02
Thymectomy and renal homotransplantation. Clin Exp Immunol (1970) 0.98
Influence of the spleen and thymus on immune responses in ageing mice. Clin Exp Immunol (1967) 0.97
Recovery of immunological responsiveness in thymectomized mice. Clin Exp Immunol (1966) 0.92
The effect of adult thymectomy upon helper function in Xenopus laevis, the South African clawed toad. Immunology (1979) 0.88
Affinity maturation of antibodies requires integrity of the adult thymus. Eur J Immunol (2011) 0.86
Studies on thymus function. 3. Duration of thymic function. J Exp Med (1972) 0.86
The immunological effects of thymectomy in myasthenia gravis. Clin Exp Immunol (1979) 0.85
Responses to immunization in the thymus of the adult mouse. J Exp Med (1969) 0.83
Dichotomy between the induction of suppressor cells and immunologic tolerance by adult thymectomy. J Exp Med (1980) 0.82
Thymectomy in acute systemic lupus erythematosus and rheumatoid arthritis. Br Med J (1967) 0.81
Organ transplantation, past and present. Surg Clin North Am (1968) 0.79
The immunosuppressive activity of adamantoyl cytarabine. 3. Immunosuppressive specificity in rats. Immunology (1970) 0.75
The thymus, delayed hypersensitivity and autoimmunity. Proc R Soc Med (1968) 0.75
Adult and pre-adult thymectomy of mice: contrasting effects on immune responsiveness, and on numbers of mitogen-responsive and Thy-1+ lymphocytes. Immunology (1979) 0.75
Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cells. Nature (1988) 13.21
Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity. Science (1999) 11.96
The growth of mouse bone marrow cells in vitro. Aust J Exp Biol Med Sci (1966) 9.68
A family of cytokine-inducible inhibitors of signalling. Nature (1997) 9.22
Molecular cloning and expression of cDNA encoding a murine myeloid leukaemia inhibitory factor (LIF). EMBO J (1987) 7.45
Growth of factor-dependent hemopoietic precursor cell lines. J Exp Med (1980) 5.80
Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression. Genes Dev (1995) 5.51
Abnormalities of the left temporal lobe and thought disorder in schizophrenia. A quantitative magnetic resonance imaging study. N Engl J Med (1992) 4.54
The molecular biology and functions of the granulocyte-macrophage colony-stimulating factors. Blood (1986) 4.47
Molecular cloning of cDNA encoding a murine haematopoietic growth regulator, granulocyte-macrophage colony stimulating factor. Nature (1984) 4.46
Twenty proteins containing a C-terminal SOCS box form five structural classes. Proc Natl Acad Sci U S A (1998) 4.38
Ontogeny of the haemopoietic system: yolk sac origin of in vivo and in vitro colony forming cells in the developing mouse embryo. Br J Haematol (1970) 4.32
Expression of myb, myc and fos proto-oncogenes during the differentiation of a murine myeloid leukaemia. Nature (1984) 4.29
SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine. Cell (1999) 4.29
Granulocyte/macrophage colony-stimulating factor-deficient mice show no major perturbation of hematopoiesis but develop a characteristic pulmonary pathology. Proc Natl Acad Sci U S A (1994) 4.19
The granulocyte-macrophage colony-stimulating factors. Science (1985) 4.13
The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation. Proc Natl Acad Sci U S A (1999) 3.91
Purification and properties of colony-stimulating factor from mouse lung-conditioned medium. J Biol Chem (1977) 3.74
Absence of yolk sac hematopoiesis from mice with a targeted disruption of the scl gene. Proc Natl Acad Sci U S A (1995) 3.47
Constitutive Bcl-2 expression throughout the hematopoietic compartment affects multiple lineages and enhances progenitor cell survival. Proc Natl Acad Sci U S A (1999) 3.45
Structure and expression of the mRNA for murine granulocyte-macrophage colony stimulating factor. EMBO J (1985) 3.30
Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietic receptor c-Mpl. Blood (1996) 3.14
A transplantable myelomonocytic leukemia in BALB-c mice: cytology, karyotype, and muramidase content. J Natl Cancer Inst (1969) 3.06
Studies on colony formation in vitro by mouse bone marrow cells. II. Action of colony stimulating factor. J Cell Physiol (1970) 3.05
Purification of a factor inducing differentiation in murine myelomonocytic leukemia cells. Identification as granulocyte colony-stimulating factor. J Biol Chem (1983) 2.97
The nature and action of granulocyte-macrophage colony stimulating factors. Blood (1980) 2.94
Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction. EMBO J (1999) 2.80
Hematopoietic stem cell deficiencies in mice lacking c-Mpl, the receptor for thrombopoietin. Proc Natl Acad Sci U S A (1998) 2.79
Leptin can induce proliferation, differentiation, and functional activation of hemopoietic cells. Proc Natl Acad Sci U S A (1996) 2.68
Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130. Proc Natl Acad Sci U S A (2000) 2.58
Cloning and characterization of a binding subunit of the interleukin 13 receptor that is also a component of the interleukin 4 receptor. Proc Natl Acad Sci U S A (1996) 2.57
Expression of a hemopoietic growth factor cDNA in a factor-dependent cell line results in autonomous growth and tumorigenicity. Cell (1985) 2.55
Pure and mixed erythroid colony formation in vitro stimulated by spleen conditioned medium with no detectable erythropoietin. Proc Natl Acad Sci U S A (1977) 2.55
Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1. Proc Natl Acad Sci U S A (1998) 2.48
Biologic properties in vitro of a recombinant human granulocyte-macrophage colony-stimulating factor. Blood (1986) 2.45
Activation of antibody-dependent cell-mediated cytotoxicity of human neutrophils and eosinophils by separate colony-stimulating factors. J Immunol (1983) 2.44
Growth of B-lymphocyte colonies in vitro. J Exp Med (1975) 2.41
Growth of mouse megakaryocyte colonies in vitro. Proc Natl Acad Sci U S A (1975) 2.38
Malignant transformation of a growth factor-dependent myeloid cell line by Abelson virus without evidence of an autocrine mechanism. Cell (1985) 2.36
Acute antigen-induced elevation of serum colony stimulating factor (CFS) levels. Immunology (1971) 2.28
Effect of granulocyte colony stimulating factor on neutropenia induced by cytotoxic chemotherapy. Lancet (1988) 2.28
Effects of purified bacterially synthesized murine multi-CSF (IL-3) on hematopoiesis in normal adult mice. Blood (1986) 2.26
Hemopoietic responses in mice injected with purified recombinant murine GM-CSF. Exp Hematol (1987) 2.25
Effects of recombinant human granulocyte colony-stimulating factor on hematopoietic progenitor cells in cancer patients. Blood (1988) 2.24
Growth of B lymphocyte colonies in vitro from mouse lymphoid organs. Nature (1975) 2.24
Colony formation in vitro by myelomonocytic leukemic cells. J Natl Cancer Inst (1969) 2.21
A lethal myeloproliferative syndrome in mice transplanted with bone marrow cells infected with a retrovirus expressing granulocyte-macrophage colony stimulating factor. EMBO J (1989) 2.13
Routine quantitative analysis of brain and cerebrospinal fluid spaces with MR imaging. J Magn Reson Imaging (1992) 2.11
Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3. Proc Natl Acad Sci U S A (2001) 2.09
The influence of granulocyte/macrophage colony-stimulating factor on dendritic cell levels in mouse lymphoid organs. Eur J Immunol (1997) 2.08
Promoter elements of vav drive transgene expression in vivo throughout the hematopoietic compartment. Blood (1999) 2.06
Resolution and purification of three distinct factors produced by Krebs ascites cells which have differentiation-inducing activity on murine myeloid leukemic cell lines. J Biol Chem (1988) 2.05
Stimulation by human placental conditioned medium of hemopoietic colony formation by human marrow cells. Blood (1977) 2.05
Separation of functionally distinct human granulocyte-macrophage colony-stimulating factors. Blood (1979) 2.05
Production of colony-stimulating factors (CSFs) during infection: separate determinations of macrophage-, granulocyte-, granulocyte-macrophage-, and multi-CSFs. Infect Immun (1988) 2.04
Subunit promiscuity among hemopoietic growth factor receptors. Cell (1991) 2.03
Colony formation by human T lymphocytes in agar medium. Clin Exp Immunol (1977) 2.03
Production of colony-stimulating factor in mitogen-stimulated lymphocyte cultures. J Immunol (1974) 2.02
Hematopoietic and lung abnormalities in mice with a null mutation of the common beta subunit of the receptors for granulocyte-macrophage colony-stimulating factor and interleukins 3 and 5. Proc Natl Acad Sci U S A (1995) 1.97
Colony formation in agar by multipotential hemopoietic cells. J Cell Physiol (1979) 1.96
The structure and expression of the murine gene encoding granulocyte-macrophage colony stimulating factor: evidence for utilisation of alternative promoters. EMBO J (1985) 1.95
Apoptosis regulator bcl-w is essential for spermatogenesis but appears otherwise redundant. Proc Natl Acad Sci U S A (1998) 1.95
Hierarchical down-modulation of hemopoietic growth factor receptors. Cell (1985) 1.80
Removal of T cells from bone marrow for transplantation: a monoclonal antilymphocyte antibody that fixes human complement. Blood (1983) 1.80
Rel-deficient T cells exhibit defects in production of interleukin 3 and granulocyte-macrophage colony-stimulating factor. Proc Natl Acad Sci U S A (1996) 1.79
A low molecular weight factor in lung-conditioned medium stimulating granulocyte and monocyte colony formation in vitro. J Cell Physiol (1973) 1.79
Hemopoietic progenitor cells of W anemic mice studies in vivo and in vitro. J Cell Physiol (1968) 1.74
Studies on colony formation in vitro by mouse bone marrow cells. I. Continuous cluster formation and relation of clusters to colonies. J Cell Physiol (1969) 1.72
Cloning of a murine IL-11 receptor alpha-chain; requirement for gp130 for high affinity binding and signal transduction. EMBO J (1994) 1.70
Membrane receptors of mouse leukocytes. II. Sequential expression of membrane receptors and phagocytic capacity during leukocyte differentiation. J Exp Med (1978) 1.69
Granulocyte/macrophage-, megakaryocyte-, eosinophil- and erythroid-colony-stimulating factors produced by mouse spleen cells. Biochem J (1980) 1.68
Colony stimulating factor and the regulation of granulopoiesis and macrophage production. Fed Proc (1975) 1.68
Formation of eosinophilic-like granulocytic colonies by mouse bone marrow cells in vitro. J Cell Physiol (1974) 1.68
In vitro colony formation by normal and leukemic human hematopoietic cells: characterization of the colony-forming cells. J Natl Cancer Inst (1973) 1.65
Proliferative effects of purified granulocyte colony-stimulating factor (G-CSF) on normal mouse hemopoietic cells. J Cell Physiol (1983) 1.65
Agar culture studies in 127 cases of untreated acute leukemia: the prognostic value of reclassification of leukemia according to in vitro growth characteristics. Blood (1974) 1.64
Bone marrow colony-stimulating activity of serum from mice with viral-induced leukemia. J Natl Cancer Inst (1967) 1.63
Direct stimulation by purified GM-CSF of the proliferation of multipotential and erythroid precursor cells. Blood (1980) 1.62
Role of mercaptoethanol and endotoxin in stimulating B lymphocyte colony formation in vitro. J Immunol (1976) 1.62
Specific binding of murine leukemia inhibitory factor to normal and leukemic monocytic cells. Proc Natl Acad Sci U S A (1988) 1.60
Binding of the differentiation-inducer, granulocyte-colony-stimulating factor, to responsive but not unresponsive leukemic cell lines. Proc Natl Acad Sci U S A (1984) 1.59
Partial purification and some properties of the factor in normal and leukaemic human urine stimulating mouse bone marrow colony growth in vitro. Aust J Exp Biol Med Sci (1969) 1.58
Bone marrow colony stimulating activity in human sera. Results of two independent surveys in Buffalo and Melbourne. Br J Haematol (1968) 1.56
Activation of granulocyte cytotoxic function by purified mouse colony-stimulating factors. J Immunol (1983) 1.54
Similar molecular properties of granulocyte-macrophage colony-stimulating factors produced by different mouse organs in vitro and in vivo. J Biol Chem (1979) 1.53
Autoradiographic analysis of lymphopoiesis and lymphocyte migration in mice bearing multiple thymus grafts. J Exp Med (1966) 1.53
Identification of the human analogue of a regulator that induces differentiation in murine leukaemic cells. Nature (1985) 1.51
Point mutations within a dimer interface homology domain of c-Mpl induce constitutive receptor activity and tumorigenicity. EMBO J (1995) 1.50
Nonneoplastic hematopoietic myeloproliferative syndrome induced by dysregulated multi-CSF (IL-3) expression. Blood (1989) 1.46
In vitro actions on hemopoietic cells of recombinant murine GM-CSF purified after production in Escherichia coli: comparison with purified native GM-CSF. J Cell Physiol (1986) 1.44
The combined absence of the transcription factors Rel and RelA leads to multiple hemopoietic cell defects. Proc Natl Acad Sci U S A (1999) 1.43
Mononuclear cell-mediated enhancement of granulocyte function in man. J Immunol (1984) 1.42
The SOCS box of suppressor of cytokine signaling-1 is important for inhibition of cytokine action in vivo. Proc Natl Acad Sci U S A (2001) 1.40
Stimulation by leukaemic sera of colony formation in solid agar cultures by proliferation of mouse bone marrow cells. Nature (1967) 1.38
Binding of 125I-labeled granulocyte colony-stimulating factor to normal murine hemopoietic cells. J Cell Physiol (1985) 1.38
Characterization of hematopoietic progenitor cells that express the transcription factor SCL, using a lacZ "knock-in" strategy. Proc Natl Acad Sci U S A (1998) 1.37
Molecular cloning and expression of the human homologue of the murine gene encoding myeloid leukemia-inhibitory factor. Proc Natl Acad Sci U S A (1988) 1.37