Published in J Biol Chem on April 10, 1966
Interaction of insulin with the cell membrane: the primary action of insulin. Proc Natl Acad Sci U S A (1969) 3.98
The origin, hormonal nature, and action of hepatotrophic substances in portal venous blood. Surg Gynecol Obstet (1973) 3.84
Preparation and characterization of a plasma membrane fraction from isolated fat cells. J Cell Biol (1970) 2.53
Insulin-induced phosphorylation and activation of cyclic nucleotide phosphodiesterase 3B by the serine-threonine kinase Akt. Mol Cell Biol (1999) 2.37
Insulin-like activity of concanavalin A and wheat germ agglutinin--direct interactions with insulin receptors. Proc Natl Acad Sci U S A (1973) 2.19
Activation of protein kinase by physiological concentrations of cyclic AMP. Proc Natl Acad Sci U S A (1974) 1.75
Clearing-factor lipase in adipose tissue. Studies with puromycin and actinomycin. Biochem J (1968) 1.66
Role of cyclic-3',5'-amp in the response of adipose tissue to insulin. Proc Natl Acad Sci U S A (1966) 1.65
Guanosine 3':5'-cyclic monophosphate and the action of insulin and acetylcholine. Proc Natl Acad Sci U S A (1973) 1.47
Effect of insulin on the growth pattern and adenylate cyclase activity of BHK fibroblasts. Proc Natl Acad Sci U S A (1973) 1.45
Interaction of the subunits of adenosine 3':5'-cyclic monophosphate-dependent protein kinase of muscle. Proc Natl Acad Sci U S A (1971) 1.42
Putative mediators of insulin action: regulation of pyruvate dehydrogenase and adenylate cyclase activities. Proc Natl Acad Sci U S A (1982) 1.06
Clearing-factor lipase in adipose tissue. A possible role of adenosine 3',5'-(cyclic)-monophosphate in the regulation of its activity. Biochem J (1968) 1.04
The discovery of signal transduction by G proteins: a personal account and an overview of the initial findings and contributions that led to our present understanding. Biochim Biophys Acta (2006) 1.00
Coupling mode of receptors and G proteins. Naunyn Schmiedebergs Arch Pharmacol (2008) 0.96
High K+-induced contraction requires depolarization-induced Ca2+ release from internal stores in rat gut smooth muscle. Acta Pharmacol Sin (2009) 0.84
Is insulin's second messenger calcium? Proc R Soc Med (1975) 0.83
Metabolism of adenosine 3',5'-monophosphate by epithelial cells of the toad bladder. J Clin Invest (1969) 0.81
The effect of glucose, insulin and noradrenaline on lipolysis, and on the concentrations of adenosine 3':5'-cyclic monophosphate and adenosine 5'-triphosphate in adipose tissue. Biochem J (1973) 0.77
Cellular levels of feedback regulator of adenylate cyclase and the effect of epinephrine and insulin. Proc Natl Acad Sci U S A (1975) 0.76
Protein kinase inhibition differentially regulates organic cation transport. Can J Physiol Pharmacol (2009) 0.75
Clearing-factor lipase in muscle and adipose tissue of pigs. Biochem J (1973) 0.75
Cyclic AMP. Annu Rev Biochem (1968) 8.08
Adenosine 3',5'-monophosphate in biological materials. II. The measurement of adenosine 3',5'-monophosphate in tissues and the role of the cyclic nucleotide in the lipolytic response of fat to epinephrine. J Biol Chem (1965) 5.86
Adenyl cyclase as an adrenergic receptor. Ann N Y Acad Sci (1967) 4.64
The role of cyclic-3',5'-AMP in responses to catecholamines and other hormones. Pharmacol Rev (1966) 3.89
Determination of guanosine 3',5'-monophosphate in tissues and of guanyl cyclase in rat intestine. J Biol Chem (1969) 3.54
Adenosine 3',5'-monophosphate as the intracellular mediator of the action of adrenocorticotropic hormone on the adrenal cortex. J Biol Chem (1967) 3.03
Effects of lipolytic and antilipolytic substances on adenosine 3',5'-monophosphate levels in isolated fat cells. J Biol Chem (1968) 2.88
The distribution and dissociation of cyclic adenosine 3':5'-monophosphate-dependent protein kinases in adipose, cardiac, and other tissues. J Biol Chem (1975) 2.84
Studies on the mechanism of hormone action. Science (1972) 2.77
Control of gluconeogenesis in liver. I. General features of gluconeogenesis in the perfused livers of rats. J Biol Chem (1967) 2.66
Control of gluconeogenesis from amino acids in the perfused rat liver. J Biol Chem (1969) 2.64
Effects of prostaglandins on adenosine 3',5'-monophosphate levels in fat and other tissues. J Biol Chem (1968) 2.56
The effect of vasopressin and of theophylline on the concentration of adenosine 3',5'-phosphate in the urinary bladder of the toad. J Biol Chem (1965) 2.51
Control of gluconeogenesis in liver. II. Effects of glucagon, catecholamines, and adenosine 3',5'-monophosphate on gluconeogenesis in the perfused rat liver. J Biol Chem (1968) 2.40
Effects of xanthine derivatives on lipolysis and on adenosine 3',5'-monophosphate phosphodiesterase activity. Mol Pharmacol (1970) 2.33
Hydrolysis of cyclic guanosine and adenosine 3',5'-monophosphates by rat and bovine tissues. J Biol Chem (1970) 2.27
The effect of epinephrine on adenosine 3', 5'-phosphate levels in the isolated perfused rat heart. Mol Pharmacol (1965) 2.20
Effects of glucagon on cyclic AMP and carbohydrate metabolism in livers from diabetic rats. Biochim Biophys Acta (1974) 2.19
Kinetic parameters and renal clearances of plasma adenosine 3',5'-monophosphate and guanosine 3',5'-monophosphate in man. J Clin Invest (1970) 2.18
An effect of insulin on adipose-tissue adenosine 3':5'-cyclic monophosphate phosphodiesterase. Biochem J (1970) 2.07
Measurement of guanosine 3',5'-monophosphate and other cyclic nucleotides. Variations in urinary excretion with hormonal state of the rat. J Biol Chem (1966) 2.03
Guanyl cyclase, an enzyme catalyzing the formation of guanosine 3',5'-monophosphate from guanosine trihosphate. J Biol Chem (1969) 1.96
Effects of some hormonal and other factors on the excretion of guanosine 3',5'-monophosphate and adenosine 3',5'-monophosphate in rat urine. J Biol Chem (1969) 1.95
Exposing rats to a predator impairs spatial working memory in the radial arm water maze. Hippocampus (1999) 1.95
Role of adenosine 3',5'-monophosphate in the effects of insulin and anti-insulin serum on liver metabolism. J Biol Chem (1968) 1.88
Effects of parathyroid hormone on plasma and urinary adenosine 3',5'-monophosphate in man. J Clin Invest (1970) 1.86
Studies on the role of adenosine 3',5'-monophosphate in the hepatic actions of glucagon and catecholamines. J Biol Chem (1971) 1.85
The hormonal control of hepatic gluconeogenesis. Recent Prog Horm Res (1970) 1.78
The effects of the catecholamines, adrenergic blocking agents, prostaglandin E1, and insulin on cyclie AMP levels in the rat epididymal fat pad in vitro. Ann N Y Acad Sci (1967) 1.75
The importance of calcium ions for the regulation of guanosine 3':5'-cyclic monophosphage levels. Proc Natl Acad Sci U S A (1973) 1.72
Mechanism of long chain fatty acid permeation in the isolated adipocyte. J Biol Chem (1981) 1.72
Stereospecific transport of glucose in the perfused rat liver. Am J Physiol (1968) 1.67
Hormonal control of cyclic 3':5'-AMP levels and gluconeogenesis in isolated hepatocytes from fed rats. J Biol Chem (1975) 1.65
A method for deriving kinetic constants for two enzymes acting on the same substrate. Biochem J (1971) 1.63
Gluconeogenesis in the perfused liver. The effects of fasting, alloxan diabetes, glucagon, epinephrine, adenosine 3',5'-monophosphate and insulin. Am J Med (1966) 1.58
The effect of epinephrine and other agents on adenyl cyclase in the cell membrane of avian erythrocytes. Biochim Biophys Acta (1966) 1.52
Effects of catecholamines and adrenergic-blocking agents on plasma and urinary cyclic nucleotides in man. J Clin Invest (1972) 1.52
The stimulatory effect of luteinizing hormone on adenosine 3',5'-monophosphate accumulation in corpus luteum slices. J Biol Chem (1966) 1.52
Early effects of 3',5'-adenosine monophosphate on the fluxes of calcium end potassium in the perfused liver of normal and adrenalectomized rats. Proc Natl Acad Sci U S A (1968) 1.51
Effects of derivatives of adenosine 3',5'-phosphate on liver slices and intact animals. Biochim Biophys Acta (1967) 1.51
Control of gluconeogenesis in liver. 3. Effects of L-lactate, pyruvate, fructose, glucagon, epinephrine, and adenosine 3',5'-monophosphate on gluconeogenic intermediates in the perfused rat liver. J Biol Chem (1969) 1.50
The role of cyclic AMP in the control of carbohydrate metabolism. Diabetes (1969) 1.50
Stimulation of a low Km phosphodiesterase from liver by insulin and glucagon. J Biol Chem (1978) 1.49
Formation and release of a hormone antagonist by rat adipocytes. J Biol Chem (1971) 1.49
Interaction of glucocorticoids with glucagon and epinephrine in the control of gluconeogenesis and glycogenolysis in liver and of lipolysis in adipose tissue. J Biol Chem (1972) 1.49
Effects of glucagon on adenosine 3',5'-monophosphate and guanosine 3',5'-monophosphate in human plasma and urine. J Clin Invest (1970) 1.49
Cyclic nucleotides. Annu Rev Physiol (1971) 1.49
Permeation of long-chain fatty acid into adipocytes. Kinetics, specificity, and evidence for involvement of a membrane protein. J Biol Chem (1984) 1.48
Factors affecting glucose transport in heart muscle and erythrocytes. Fed Proc (1966) 1.48
THE ABSORPTION, EXCRETION, AND PHYSIOLOGICAL EFFECT OF IODINE IN NORMAL HUMAN SUBJECTS. J Clin Invest (1947) 1.44
Stimulation of adenosine 3',5'-monophosphate hydrolysis by guanosine 3',5'-monophosphate. J Biol Chem (1971) 1.41
Glycogen-storage disease in rats, a genetically determined deficiency of liver phosphorylase kinase. Biochem J (1980) 1.41
On the question of translocation of heart cAMP-dependent protein kinase. Proc Natl Acad Sci U S A (1975) 1.41
Analysis of adenosine 3',5'-monophosphate with luciferase luminescence. Anal Biochem (1970) 1.40
Regulation of adenosine 3',5'-monophosphate-dependent protein kinase. I. Preliminary characterization of the adipose tissue enzyme in crude extracts. J Biol Chem (1973) 1.38
A new enzymatic assay for guanosine 3':5'-cyclic monophosphate and its application to the ductus deferens of the rat. Proc Natl Acad Sci U S A (1973) 1.37
Detergent-dispersed adenylate cyclase from rat brain. Effects of fluoride, cations, and chelators. J Biol Chem (1973) 1.37
The role of cyclic AMP in the interaction of glucagon and insulin in the control of liver metabolism. Ann N Y Acad Sci (1971) 1.36
The role of cyclic AMP in the control of liver metabolism. Adv Enzyme Regul (1968) 1.29
Adenosine 3',5'-monophosphate (cyclic AMP) as the mediator of the actions of melanocyte stimulating hormone (MSH) and norepinephrine on the frog skin. Endocrinology (1969) 1.29
Involvement of adenosine 3',5'-monophosphate in release of ACTH. Am J Physiol (1969) 1.26
Control of gluconeogenesis in liver. IV. Differential effects of fatty acids and glucagon on ketogenesis and gluconeogenesis in the perfused rat liver. J Biol Chem (1969) 1.25
The stimulation of gluconeogenesis from lactate by epinephrine, glucagon, cyclic 3',5'-adenylate in the perfused rat liver. Pharmacol Rev (1966) 1.23
Regulation of adenosine 3',5'-monophosphate-dependent protein kinase. II. Hormonal regulation of the adipose tissue enzyme. J Biol Chem (1973) 1.23
Cyclic nucleotides in cultured cells. Adv Cyclic Nucleotide Res (1975) 1.22
Effects of glucose on glycogen synthetase, phosphorylase, and glycogen deposition in the perfused rat liver. Proc Natl Acad Sci U S A (1970) 1.22
The formation and metabolism of cyclic GMP. Ann N Y Acad Sci (1971) 1.21
The role of cyclic AMP in hormone actions. Adv Enzyme Regul (1968) 1.16
Cyclic 3',5'-nucleotide phosphodiesterase from bovine heart. Methods Enzymol (1974) 1.15
Transport of D-allose by isolated fat-cells: an effect of adenosine triphosphate on insulin stimulated transport. J Cell Physiol (1976) 1.14
The regulation of body temperature during fever. Arch Environ Health (1965) 1.12
Guanosine 3':5'-cyclic monophosphate binding proteins in rat tissues. Proc Natl Acad Sci U S A (1976) 1.12
Cyclic 3',5'-AMP and the lipolytic effects of hormones on adipose tissue. Pharmacol Rev (1966) 1.12
Abnormal regulation of adenosine 3',5'-monophosphate and corticosterone formation in an adrenocortical carcinoma. J Clin Invest (1969) 1.11
Effect of chlorophenoxyisobutyric acid (CPIB) on fat-mobilizing lipolysis and cyclic AMP levels in rat epididymal fat. Atherosclerosis (1973) 1.10
The evaluation of insulin as a metabolic signal influencing behavior via the brain. Neurosci Biobehav Rev (1996) 1.09
Effect of epinephrine on cyclic adenosine 3',5'-phosphate and hexose phosphates in intestinal smooth muscle. Biochim Biophys Acta (1966) 1.08
Interaction of adrenal steroids and glucagon on gluconeogenesis in perfused rat liver. Biochem Biophys Res Commun (1967) 1.08
Stimulation by glucagon of the incorporation of U-14C-labeled substrates into glucose by isolated hepatocytes from fed rats. Biochim Biophys Acta (1975) 1.06
Role of cyclic AMP in mediating the effects of MSH, norepinephrine, and melatonin on frog skin color. Endocrinology (1969) 1.06
Enzymes of cyclic nucleotide metabolism in invertebrate and vertebrate sperm. Arch Biochem Biophys (1976) 1.05
Control of hepatic glucose output by glucagon and insulin in the intact dog. Biochem Soc Symp (1978) 1.05
Studies on the mechanism of action of glucagon on gluconeogenesis. J Biol Chem (1973) 1.05
The effects of epinephrine and prostaglandin E-1 on cyclic adenosine 3':5'-monophosphate levels in WI-38 fibroblasts. J Biol Chem (1974) 1.04