Published in Cell on December 01, 1981
Transforming genes of human bladder and lung carcinoma cell lines are homologous to the ras genes of Harvey and Kirsten sarcoma viruses. Proc Natl Acad Sci U S A (1982) 5.39
Plasmids for the cloning and expression of full-length double-stranded cDNAs under control of the SV40 early or late gene promoter. Nucleic Acids Res (1983) 4.33
Mitotic chromosomal instability and cancer: mouse modelling of the human disease. Nat Rev Cancer (2010) 3.95
Human RAS superfamily proteins and related GTPases. Sci STKE (2004) 3.80
Analysis of the transforming potential of the human H-ras gene by random mutagenesis. Proc Natl Acad Sci U S A (1984) 3.64
Transgenic mice harboring SV40 T-antigen genes develop characteristic brain tumors. Cell (1984) 3.56
Isolation and preliminary characterization of the transforming gene of a human neuroblastoma cell line. Proc Natl Acad Sci U S A (1983) 3.52
Isolation of a genomic clone partially encoding human hypoxanthine phosphoribosyltransferase. Proc Natl Acad Sci U S A (1982) 3.49
New human transforming genes detected by a tumorigenicity assay. Mol Cell Biol (1984) 3.43
A method to detect and characterize point mutations in transcribed genes: amplification and overexpression of the mutant c-Ki-ras allele in human tumor cells. Proc Natl Acad Sci U S A (1985) 3.29
Three human transforming genes are related to the viral ras oncogenes. Proc Natl Acad Sci U S A (1983) 3.06
Isolation of amplified DNA sequences from IMR-32 human neuroblastoma cells: facilitation by fluorescence-activated flow sorting of metaphase chromosomes. Proc Natl Acad Sci U S A (1983) 2.72
Oncogenes in human tumor cell lines: molecular cloning of a transforming gene from human bladder carcinoma cells. Proc Natl Acad Sci U S A (1982) 2.55
A method for difference cloning: gene amplification following subtractive hybridization. Proc Natl Acad Sci U S A (1990) 2.53
A molecular approach to leukemogenesis: mouse lymphomas contain an activated c-ras oncogene. Proc Natl Acad Sci U S A (1984) 2.07
Transforming genes of human hematopoietic tumors: frequent detection of ras-related oncogenes whose activation appears to be independent of tumor phenotype. Proc Natl Acad Sci U S A (1983) 2.04
Transforming activity of human papillomavirus type 16 DNA sequence in a cervical cancer. Proc Natl Acad Sci U S A (1986) 1.99
Isolation of transforming sequences of two human lung carcinomas: structural and functional analysis of the activated c-K-ras oncogenes. Proc Natl Acad Sci U S A (1984) 1.89
Molecular cloning of an activated human oncogene, homologous to v-raf, from primary stomach cancer. Proc Natl Acad Sci U S A (1985) 1.83
A position 12-activated H-ras oncogene in all HS578T mammary carcinosarcoma cells but not normal mammary cells of the same patient. Proc Natl Acad Sci U S A (1984) 1.78
Transforming gene from human stomach cancers and a noncancerous portion of stomach mucosa. Proc Natl Acad Sci U S A (1986) 1.71
Concerted DNA rearrangements in Moloney murine leukemia virus-induced thymomas: a potential synergistic relationship in oncogenesis. J Virol (1985) 1.67
Detection of a raf-related and two other transforming DNA sequences in human tumors maintained in nude mice. Proc Natl Acad Sci U S A (1985) 1.61
Loss of the normal N-ras allele in a mouse thymic lymphoma induced by a chemical carcinogen. Proc Natl Acad Sci U S A (1985) 1.61
Structure and sequence of the human c-sis/platelet-derived growth factor 2 (SIS/PDGF2) transcriptional unit. Proc Natl Acad Sci U S A (1986) 1.56
Mechanism of activation of an N-ras gene in the human fibrosarcoma cell line HT1080. EMBO J (1984) 1.56
Biological role of anaplastic lymphoma kinase in neuroblastoma. Am J Pathol (2005) 1.51
Tumorigenic and metastatic properties of "normal" and ras-transfected NIH/3T3 cells. Proc Natl Acad Sci U S A (1985) 1.38
Amplification and overexpression of the met gene in spontaneously transformed NIH3T3 mouse fibroblasts. EMBO J (1986) 1.28
New acceptor cell for transfected genomic DNA: oncogene transfer into a mouse mammary epithelial cell line. Mol Cell Biol (1985) 1.26
8-Hydroxyadenine (7,8-dihydro-8-oxoadenine) induces misincorporation in in vitro DNA synthesis and mutations in NIH 3T3 cells. Nucleic Acids Res (1995) 1.26
Growth factor requirements of oncogene-transformed NIH 3T3 and BALB/c 3T3 cells cultured in defined media. Mol Cell Biol (1986) 1.25
Mechanism of activation of an N-ras oncogene of SW-1271 human lung carcinoma cells. Proc Natl Acad Sci U S A (1984) 1.23
LOH of chromosome 12p correlates with Kras2 mutation in non-small cell lung cancer. Oncogene (2003) 1.23
Activation of a human c-K-ras oncogene. Nucleic Acids Res (1984) 1.19
Transforming gene in human atherosclerotic plaque DNA. Proc Natl Acad Sci U S A (1986) 1.18
Effects of two major activating lesions on the structure and conformation of human ras oncogene products. Proc Natl Acad Sci U S A (1985) 1.17
Molecular and physical arrangements of human DNA in HRAS1-selected, chromosome-mediated transfectants. Mol Cell Biol (1986) 1.17
Inherited susceptibility to retrovirus-induced transformation of Gardner syndrome cells. Am J Hum Genet (1983) 1.17
Localization of the mcf.2 transforming sequence to the X chromosome. EMBO J (1987) 1.16
Suppression of tumorigenicity with continued expression of the c-Ha-ras oncogene in EJ bladder carcinoma-human fibroblast hybrid cells. Proc Natl Acad Sci U S A (1986) 1.16
Identification of a single chromosome in the normal human genome essential for suppression of hamster cell transformation. Proc Natl Acad Sci U S A (1985) 1.12
Partial reversion of the transformed phenotype in HRAS-transfected tumorigenic cells by transfer of a human gene. Proc Natl Acad Sci U S A (1988) 1.10
Cellular heterogeneity in a tissue culture cell line derived from a human bladder carcinoma. Br J Cancer (1983) 1.10
Retroviral oncogenes: a historical primer. Nat Rev Cancer (2012) 1.10
The biochemistry of ras p21. Biochem J (1991) 1.08
Distinctive transforming genes in x-ray-transformed mammalian cells. Proc Natl Acad Sci U S A (1987) 1.07
Human cancer and cellular oncogenes. Biochem J (1987) 1.07
Functional identification of regulatory elements within the promoter region of platelet-derived growth factor 2. Mol Cell Biol (1989) 1.05
Mutations in the K-ras oncogene induced by 1,2-dimethylhydrazine in preneoplastic and neoplastic rat colonic mucosa. J Clin Invest (1991) 1.04
Electric field-mediated gene transfer: characterization of DNA transfer and patterns of integration in lymphoid cells. Nucleic Acids Res (1988) 1.04
Close correlation between restriction fragment length polymorphism of the L-MYC gene and metastasis of human lung cancer to the lymph nodes and other organs. Proc Natl Acad Sci U S A (1988) 1.04
Molecular cloning of an oncogene from a human hepatocellular carcinoma. Proc Natl Acad Sci U S A (1986) 1.03
An abasic site analogue activates a c-Ha-ras gene by a point mutation at modified and adjacent positions. Nucleic Acids Res (1992) 1.02
Oncogene amplification during tumorigenesis of established rat fibroblasts reversibly transformed by activated human ras oncogenes. Mol Cell Biol (1986) 1.01
X-linked sideroblastic anemia and ataxia: linkage to phosphoglycerate kinase at Xq13. Am J Hum Genet (1991) 1.00
Effects of rearrangement and allelic exclusion of JJAZ1/SUZ12 on cell proliferation and survival. Proc Natl Acad Sci U S A (2007) 0.98
Topological and functional properties of the small GTPases protein interaction network. PLoS One (2012) 0.98
Bladder cancer cell line cross-contamination: identification using a locus-specific minisatellite probe. Br J Cancer (1988) 0.97
Pre-crisis mouse cells show strain-specific covariation in the amount of 54-kilodalton phosphoprotein and in susceptibility to transformation by simian virus 40. Proc Natl Acad Sci U S A (1983) 0.97
Hamster cell line suitable for transfection assay of transforming genes. Proc Natl Acad Sci U S A (1990) 0.97
Dysregulation of gene expression in the artificial human trisomy cells of chromosome 8 associated with transformed cell phenotypes. PLoS One (2011) 0.96
Molecular karyotype (amplotype) of metastatic colorectal cancer by unbiased arbitrarily primed PCR DNA fingerprinting. Proc Natl Acad Sci U S A (1998) 0.96
H-ras activation in benign and self-regressing skin tumors (keratoacanthomas) in both humans and an animal model system. Mol Cell Biol (1988) 0.96
A novel type of glutathione peroxidase: expression and regulation during wound repair. Biochem J (1997) 0.95
Validation of a high-content screening assay using whole-well imaging of transformed phenotypes. Assay Drug Dev Technol (2010) 0.94
Cell-cell contact interactions conditionally determine suppression and selection of the neoplastic phenotype. Proc Natl Acad Sci U S A (2008) 0.92
Inhibitory effect of interferon on the genetic and oncogenic transformation by viral and cellular genes. J Virol (1985) 0.92
Cyclic AMP selectively uncouples mitogen-activated protein kinase cascades from activating signals. Mol Cell Biol (2006) 0.91
Transformation of differentiated rat hepatocytes with adenovirus and adenovirus DNA. J Virol (1987) 0.91
Tumorigenicity of simian virus 40-hepatocyte cell lines: effect of in vitro and in vivo passage on expression of liver-specific genes and oncogenes. Mol Cell Biol (1988) 0.89
Identification by transfection of transforming sequences in DNA of human T-cell leukemias. Proc Natl Acad Sci U S A (1983) 0.88
Transfer and expression of the gene encoding a human myeloid membrane antigen (gp150). J Clin Invest (1985) 0.88
Loss of constitutional heterozygosity in chromosome 10 in human glioblastoma. Acta Neuropathol (1990) 0.87
Unstable transformation of mouse 3T3 cells by transfection with DNA from normal human lymphocytes. EMBO J (1984) 0.86
Resistance to anticancer drugs in NIH3T3 cells transfected with c-myc and/or c-H-ras genes. Br J Cancer (1991) 0.85
Cyclobutane thymine dimers in a ras proto-oncogene hot spot activate the gene by point mutation. Nucleic Acids Res (1993) 0.84
Growth inhibitory effect of wild-type Kras2 gene on a colonic adenocarcinoma cell line. World J Gastroenterol (2007) 0.84
Mycoplasma CG- and GATC-specific DNA methyltransferases selectively and efficiently methylate the host genome and alter the epigenetic landscape in human cells. Epigenetics (2015) 0.83
Functional expression of a human Na+/H+ antiporter gene transfected into antiporter-deficient mouse L cells. Proc Natl Acad Sci U S A (1986) 0.83
Monoclonal antibody specific for an activated RAS protein. Proc Natl Acad Sci U S A (1986) 0.82
Transfer of sensitivity to tumor promoters by transfection of DNA from sensitive into insensitive mouse JB6 epidermal cells. Mol Cell Biol (1983) 0.82
Characterization of preneoplastic and neoplastic lesions in the rat pancreas. Am J Pathol (1991) 0.82
Ras regulates kinesin 13 family members to control cell migration pathways in transformed human bronchial epithelial cells. Oncogene (2013) 0.81
Kirsten Ras* oncogene: significance of its discovery in human cancer research. Oncotarget (2016) 0.80
Presence of human papillomavirus type-6-related sequences in inverted nasal papillomas. Eur Arch Otorhinolaryngol (1990) 0.80
High-resolution HLA-DRB1 and DQB1 genotyping in Japanese patients with testicular germ cell carcinoma. Br J Cancer (1997) 0.79
The role of centrosomal Nlp in the control of mitotic progression and tumourigenesis. Br J Cancer (2011) 0.79
Clonal analysis of childhood acute lymphoblastic leukemia with "cytogenetically independent" cell populations. J Clin Invest (1989) 0.78
FXR silencing in human colon cancer by DNA methylation and KRAS signaling. Am J Physiol Gastrointest Liver Physiol (2013) 0.78
Human papillomavirus 16 DNA in NIH3T3 cells transformed by colonic cancer cellular DNA. Gut (1993) 0.78
Expression of Ha-ras oncogene p21 protein in relation to the cell cycle of cultured human tumor cells. Am J Pathol (1987) 0.77
Vascular tumors produced by NIH/3T3 cells transfected with human AIDS Kaposi's sarcoma DNA. Am J Pathol (1985) 0.77
Therapeutic Approaches to RAS Mutation. Cancer J (2016) 0.76
Oncogenic genes and human malignancy. Yale J Biol Med (1983) 0.75
Chemical carcinogens: a review of the science and its associated principles. U.S. Interagency Staff Group on Carcinogens. Environ Health Perspect (1986) 0.75
Optimisation of conditions for detection of activated oncogenes by transfection of NIH 3T3 cells. Br J Cancer (1987) 0.75
Oncogenes--implications for human cancer: a review. J R Soc Med (1984) 0.75
Molecular cloning and characterization of a new subtype of human papillomavirus 6 DNA. Eur Arch Otorhinolaryngol (1991) 0.75
DNA-mediated transfer of the adenine phosphoribosyltransferase locus into mammalian cells. Proc Natl Acad Sci U S A (1979) 21.22
Transformation of mammalian cells with genes from procaryotes and eucaryotes. Cell (1979) 21.15
Biochemical transfer of single-copy eucaryotic genes using total cellular DNA as donor. Cell (1978) 19.44
Transfer of purified herpes virus thymidine kinase gene to cultured mouse cells. Cell (1977) 18.95
International uniform response criteria for multiple myeloma. Leukemia (2006) 17.78
Functional homology of mammalian and yeast RAS genes. Cell (1985) 14.01
Purification of a RAS-responsive adenylyl cyclase complex from Saccharomyces cerevisiae by use of an epitope addition method. Mol Cell Biol (1988) 13.78
In yeast, RAS proteins are controlling elements of adenylate cyclase. Cell (1985) 11.63
Cloning the differences between two complex genomes. Science (1993) 10.60
Receptor specificity of the fibroblast growth factor family. J Biol Chem (1996) 7.58
One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice. J Natl Cancer Inst (1977) 6.91
Genes in S. cerevisiae encoding proteins with domains homologous to the mammalian ras proteins. Cell (1984) 6.87
Activation of the T24 bladder carcinoma transforming gene is linked to a single amino acid change. Nature (1982) 6.78
Genetic and physical linkage of exogenous sequences in transformed cells. Cell (1980) 6.67
Genetic analysis of yeast RAS1 and RAS2 genes. Cell (1984) 6.60
The transfer and stable integration of the HSV thymidine kinase gene into mouse cells. Cell (1978) 6.38
Three different genes in S. cerevisiae encode the catalytic subunits of the cAMP-dependent protein kinase. Cell (1987) 6.35
Structure and activation of the human N-ras gene. Cell (1983) 5.25
Cloning and characterization of BCY1, a locus encoding a regulatory subunit of the cyclic AMP-dependent protein kinase in Saccharomyces cerevisiae. Mol Cell Biol (1987) 5.03
t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1. Proc Natl Acad Sci U S A (1991) 4.96
DNA sequence and characterization of the S. cerevisiae gene encoding adenylate cyclase. Cell (1985) 4.80
The S. cerevisiae CDC25 gene product regulates the RAS/adenylate cyclase pathway. Cell (1987) 4.74
Structure of the Ki-ras gene of the human lung carcinoma cell line Calu-1. Nature (1983) 4.44
The somatic replication of DNA methylation. Cell (1981) 4.42
Isolation of the chicken thymidine kinase gene by plasmid rescue. Nature (1980) 4.37
Absence of HeLa cell contamination in 169 cell lines derived from human tumors. J Natl Cancer Inst (1977) 4.35
Complex formation between RAS and RAF and other protein kinases. Proc Natl Acad Sci U S A (1993) 4.30
Isolation and preliminary characterization of a human transforming gene from T24 bladder carcinoma cells. Nature (1982) 4.30
Differential activation of yeast adenylate cyclase by wild-type and mutant RAS proteins. Cell (1985) 4.23
The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins. Cell (1990) 4.12
cAMP-independent control of sporulation, glycogen metabolism, and heat shock resistance in S. cerevisiae. Cell (1988) 3.72
Characteristics of an SV40-plasmid recombinant and its movement into and out of the genome of a murine cell. Cell (1980) 3.66
Requirement of FGF-4 for postimplantation mouse development. Science (1995) 3.64
Analysis of the transforming potential of the human H-ras gene by random mutagenesis. Proc Natl Acad Sci U S A (1984) 3.64
RAM, a gene of yeast required for a functional modification of RAS proteins and for production of mating pheromone a-factor. Cell (1986) 3.57
Genetic relationships of Asians and Northern Europeans, revealed by Y-chromosomal DNA analysis. Am J Hum Genet (1997) 3.54
Introduction and expression of a rabbit beta-globin gene in mouse fibroblasts. Proc Natl Acad Sci U S A (1979) 3.53
Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity. Science (1994) 3.53
Isolation and preliminary characterization of the transforming gene of a human neuroblastoma cell line. Proc Natl Acad Sci U S A (1983) 3.52
Purification to homogeneity and characterization of human B-cell differentiation factor (BCDF or BSFp-2). Proc Natl Acad Sci U S A (1985) 3.46
New human transforming genes detected by a tumorigenicity assay. Mol Cell Biol (1984) 3.43
International Myeloma Working Group guidelines for serum-free light chain analysis in multiple myeloma and related disorders. Leukemia (2008) 3.41
The human FGF-5 oncogene encodes a novel protein related to fibroblast growth factors. Mol Cell Biol (1988) 3.40
Transformation of mammalian cells with an amplifiable dominant-acting gene. Proc Natl Acad Sci U S A (1980) 3.39
Initiation of mammalian liver development from endoderm by fibroblast growth factors. Science (1999) 3.30
ras proteins can induce meiosis in Xenopus oocytes. Cell (1985) 3.23
Cloning and characterization of the high-affinity cAMP phosphodiesterase of Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1986) 3.19
Three human transforming genes are related to the viral ras oncogenes. Proc Natl Acad Sci U S A (1983) 3.06
The t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcript. EMBO J (1993) 3.00
Prognostic factors of hepatocellular carcinoma in patients undergoing hepatic resection. Gastroenterology (1994) 2.99
Prevention of thalidomide- and lenalidomide-associated thrombosis in myeloma. Leukemia (2007) 2.76
Mechanism of action of globomycin. J Antibiot (Tokyo) (1978) 2.66
Comparison of aminoglycoside resistance patterns in Japan, Formosa, and Korea, Chile, and the United States. Antimicrob Agents Chemother (1985) 2.66
Isolation and characterization of a new cellular oncogene encoding a protein with multiple potential transmembrane domains. Cell (1986) 2.65
Tumour promotor induces plasminogen activator. Nature (1976) 2.60
Rigorous feedback control of cAMP levels in Saccharomyces cerevisiae. Genes Dev (1987) 2.58
Dominant yeast and mammalian RAS mutants that interfere with the CDC25-dependent activation of wild-type RAS in Saccharomyces cerevisiae. Mol Cell Biol (1989) 2.57
SCH9, a gene of Saccharomyces cerevisiae that encodes a protein distinct from, but functionally and structurally related to, cAMP-dependent protein kinase catalytic subunits. Genes Dev (1988) 2.57
Complexes between STE5 and components of the pheromone-responsive mitogen-activated protein kinase module. Proc Natl Acad Sci U S A (1994) 2.53
A method for difference cloning: gene amplification following subtractive hybridization. Proc Natl Acad Sci U S A (1990) 2.53
Genetic analysis using genomic representations. Proc Natl Acad Sci U S A (1998) 2.52
Better pulmonary function and prognosis with video-assisted thoracic surgery than with thoracotomy. Ann Thorac Surg (2000) 2.49
byr2, a Schizosaccharomyces pombe gene encoding a protein kinase capable of partial suppression of the ras1 mutant phenotype. Mol Cell Biol (1991) 2.48
Silicatein filaments and subunits from a marine sponge direct the polymerization of silica and silicones in vitro. Proc Natl Acad Sci U S A (1999) 2.47
Guanine nucleotide activation of, and competition between, RAS proteins from Saccharomyces cerevisiae. Mol Cell Biol (1987) 2.45
Genetic analysis of mammalian GAP expressed in yeast. Cell (1989) 2.44
Complex synthetic chemical libraries indexed with molecular tags. Proc Natl Acad Sci U S A (1993) 2.44
Significant association between leukoaraiosis and metabolic syndrome in healthy subjects. Neurology (2007) 2.41
A new murine model of accelerated senescence. Mech Ageing Dev (1981) 2.40
Isolation and characterization of a mammalian gene encoding a high-affinity cAMP phosphodiesterase. Proc Natl Acad Sci U S A (1989) 2.31
Production and properties of immune interferon from spleen cell cultures of Toxoplasma-infected mice. Microbiol Immunol (1980) 2.28
Serum insulin-like growth factor-1 in centenarians: implications of IGF-1 as a rapid turnover protein. J Gerontol A Biol Sci Med Sci (2001) 2.27
Cloning and characterization of the low-affinity cyclic AMP phosphodiesterase gene of Saccharomyces cerevisiae. Mol Cell Biol (1987) 2.25
A product of yeast RAS2 gene is a guanine nucleotide binding protein. Proc Natl Acad Sci U S A (1984) 2.24
Identification of the gene loci that predispose to rheumatoid arthritis. Int Immunol (1998) 2.16
The most frequent aminoglycoside resistance mechanisms--changes with time and geographic area: a reflection of aminoglycoside usage patterns? Aminoglycoside Resistance Study Groups. Clin Infect Dis (1997) 2.14
Expression and rearrangement of the ROS1 gene in human glioblastoma cells. Proc Natl Acad Sci U S A (1987) 2.11
Sequence and structure of the coding region of the human H-ras-1 gene from T24 bladder carcinoma cells. J Mol Appl Genet (1983) 2.09
Interaction and functional cooperation of the leukemia-associated factors AML1 and p300 in myeloid cell differentiation. EMBO J (1998) 2.09
Functional homology of protein kinases required for sexual differentiation in Schizosaccharomyces pombe and Saccharomyces cerevisiae suggests a conserved signal transduction module in eukaryotic organisms. Mol Biol Cell (1993) 2.09
Nucleotide sequence of a functional cDNA for human thymidylate synthase. Nucleic Acids Res (1985) 2.08
Induction of retrovirus particles in human testicular tumor (Tera-1) cell cultures: an electron microscopic study. J Natl Cancer Inst (1979) 2.08
Global metabolic response of Escherichia coli to gnd or zwf gene-knockout, based on 13C-labeling experiments and the measurement of enzyme activities. Appl Microbiol Biotechnol (2003) 2.07
Evidence for a functional link between profilin and CAP in the yeast S. cerevisiae. Cell (1991) 2.05