Published in Lancet on August 09, 1980
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"But will it help my patients with myocardial infarction?" The implications of recent trials for everyday country folk. Br Med J (Clin Res Ed) (1982) 1.55
Haemodynamic advantages of combined alpha-blockade and beta-blockade over beta-blockade alone in patients with coronary heart disease. Br Med J (Clin Res Ed) (1982) 1.50
Beta adrenoceptor antagonists after myocardial infarction--where are we now? Br Heart J (1983) 1.45
Confidence in results of beta-blocker postinfarction trials. Br Med J (Clin Res Ed) (1982) 1.28
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Limitation of myocardial infarct size in patients less than 66 years treated with alprenolol. Br Heart J (1981) 1.00
Unblocking coronary arteries. Br Med J (Clin Res Ed) (1982) 0.93
Comparative haemodynamic dose response effects of propranolol and labetalol in coronary heart disease. Br Heart J (1982) 0.92
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Reduction of infarct size. An attractive concept: useful--or possible--in humans? Br Heart J (1985) 0.87
Beta-blockade after myocardial infarction--a statistical view. Br J Clin Pharmacol (1982) 0.86
Effect of timolol on changes in serum potassium concentration during acute myocardial infarction. Br Heart J (1985) 0.85
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Comparison of haemodynamic responses to dobutamine and salbutamol in cardiogenic shock after acute myocardial infarction. Br Med J (Clin Res Ed) (1982) 0.80
Role of labetalol in acute myocardial infarction. Br J Clin Pharmacol (1982) 0.79
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The effect of chemical sympathectomy on mitochondrial function in the ischaemic and reperfused myocardium. Br J Pharmacol (1982) 0.78
Effect of metoprolol on chest pain in acute myocardial infarction. Br Heart J (1984) 0.78
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Electrocardiographic evidence of myocardial salvage after thrombolysis in acute myocardial infarction. Br Heart J (1989) 0.78
Speed of onset of pharmacodynamic activity of propranolol, practolol, oxprenolol and metoprolol after intravenous infection in man. Br J Clin Pharmacol (1981) 0.77
Combined receptor intervention and myocardial infarction. Drugs (1984) 0.76
Early intravenous beta-blockade in myocardial infarction. Br J Clin Pharmacol (1982) 0.75
Intravenous beta-blockers during unstable angina and threatened infarction. Br J Clin Pharmacol (1982) 0.75
Development of congestive heart failure after treatment with metoprolol in acute myocardial infarction. Br Heart J (1984) 0.75
The management of hypertension. Br J Clin Pharmacol (1986) 0.75
A clinician looks at the future. Br J Clin Pharmacol (1982) 0.75
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Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. analysis and examples. Br J Cancer (1977) 53.23
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Mortality in relation to smoking: 20 years' observations on male British doctors. Br Med J (1976) 28.28
The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today. J Natl Cancer Inst (1981) 25.60
Blood pressure, stroke, and coronary heart disease. Part 1, Prolonged differences in blood pressure: prospective observational studies corrected for the regression dilution bias. Lancet (1990) 25.12
Blood pressure, stroke, and coronary heart disease. Part 2, Short-term reductions in blood pressure: overview of randomised drug trials in their epidemiological context. Lancet (1990) 24.72
Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomised trials. Lancet (2005) 24.57
Mortality in relation to smoking: 40 years' observations on male British doctors. BMJ (1994) 23.80
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Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation. N Engl J Med (2001) 20.20
Beta blockade during and after myocardial infarction: an overview of the randomized trials. Prog Cardiovasc Dis (1985) 19.03
Conservatism of the approximation sigma (O-E)2-E in the logrank test for survival data or tumor incidence data. Biometrics (1973) 18.14
Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials. Lancet (2010) 18.09
Effect of rosiglitazone on the frequency of diabetes in patients with impaired glucose tolerance or impaired fasting glucose: a randomised controlled trial. Lancet (2006) 15.32
A long-term follow-up study of women using different methods of contraception--an interim report. J Biosoc Sci (1976) 13.09
The natural history of chronic airflow obstruction. Br Med J (1977) 13.04
Prevention of disabling and fatal strokes by successful carotid endarterectomy in patients without recent neurological symptoms: randomised controlled trial. Lancet (2004) 12.59
Emerging tobacco hazards in China: 1. Retrospective proportional mortality study of one million deaths. BMJ (1998) 10.71
Relevance of breast cancer hormone receptors and other factors to the efficacy of adjuvant tamoxifen: patient-level meta-analysis of randomised trials. Lancet (2011) 10.62
Intravenous and intracoronary fibrinolytic therapy in acute myocardial infarction: overview of results on mortality, reinfarction and side-effects from 33 randomized controlled trials. Eur Heart J (1985) 9.28
The relationship between glucose and incident cardiovascular events. A metaregression analysis of published data from 20 studies of 95,783 individuals followed for 12.4 years. Diabetes Care (1999) 9.16
Albuminuria and risk of cardiovascular events, death, and heart failure in diabetic and nondiabetic individuals. JAMA (2001) 8.80
Lack of effect of long-term supplementation with beta carotene on the incidence of malignant neoplasms and cardiovascular disease. N Engl J Med (1996) 8.57
Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study. Lancet (2001) 8.54
Efficacy of cholesterol-lowering therapy in 18,686 people with diabetes in 14 randomised trials of statins: a meta-analysis. Lancet (2008) 8.53
Effect of enalapril on mortality and the development of heart failure in asymptomatic patients with reduced left ventricular ejection fractions. The SOLVD Investigattors. N Engl J Med (1992) 8.38
Alcohol consumption and mortality among middle-aged and elderly U.S. adults. N Engl J Med (1997) 8.25
Comparisons between different polychemotherapy regimens for early breast cancer: meta-analyses of long-term outcome among 100,000 women in 123 randomised trials. Lancet (2011) 8.24
Differences in risk factors, atherosclerosis, and cardiovascular disease between ethnic groups in Canada: the Study of Health Assessment and Risk in Ethnic groups (SHARE) Lancet (2000) 8.01
Cigarette smoking and bronchial carcinoma: dose and time relationships among regular smokers and lifelong non-smokers. J Epidemiol Community Health (1978) 7.80
Association of fibrinogen, C-reactive protein, albumin, or leukocyte count with coronary heart disease: meta-analyses of prospective studies. JAMA (1998) 7.67
Why do we need some large, simple randomized trials? Stat Med (1985) 7.67
Menopausal hormone use and ovarian cancer risk: individual participant meta-analysis of 52 epidemiological studies. Lancet (2015) 7.29
UK and USA breast cancer deaths down 25% in year 2000 at ages 20-69 years. Lancet (2000) 7.19
Chronic infections and coronary heart disease: is there a link? Lancet (1997) 7.18
An overview of randomized trials of rehabilitation with exercise after myocardial infarction. Circulation (1989) 6.87
Effects of a polypill (Polycap) on risk factors in middle-aged individuals without cardiovascular disease (TIPS): a phase II, double-blind, randomised trial. Lancet (2009) 6.83
Mortality in relation to consumption of alcohol: 13 years' observations on male British doctors. BMJ (1994) 6.74
Ovarian cancer and oral contraceptives: collaborative reanalysis of data from 45 epidemiological studies including 23,257 women with ovarian cancer and 87,303 controls. Lancet (2008) 6.67
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Emerging epidemic of cardiovascular disease in developing countries. Circulation (1998) 6.41
Renal insufficiency as a predictor of cardiovascular outcomes and the impact of ramipril: the HOPE randomized trial. Ann Intern Med (2001) 6.38
Trials: the next 50 years. Large scale randomised evidence of moderate benefits. BMJ (1998) 6.13
An inventory to assess activities of daily living for clinical trials in Alzheimer's disease. The Alzheimer's Disease Cooperative Study. Alzheimer Dis Assoc Disord (1997) 5.94
Addition of clopidogrel to aspirin in 45,852 patients with acute myocardial infarction: randomised placebo-controlled trial. Lancet (2005) 5.86
Alcohol, tobacco and breast cancer--collaborative reanalysis of individual data from 53 epidemiological studies, including 58,515 women with breast cancer and 95,067 women without the disease. Br J Cancer (2002) 5.83
Reduction in fatal pulmonary embolism and venous thrombosis by perioperative administration of subcutaneous heparin. Overview of results of randomized trials in general, orthopedic, and urologic surgery. N Engl J Med (1988) 5.81
Early intravenous then oral metoprolol in 45,852 patients with acute myocardial infarction: randomised placebo-controlled trial. Lancet (2005) 5.50
Serum cholesterol concentration and coronary heart disease in population with low cholesterol concentrations. BMJ (1991) 5.45
150 Patients with cardiac infarction treated in a coronary unit. Lancet (1967) 5.29
Reflex regulation of arterial pressure during sleep in man. A quantitative method of assessing baroreflex sensitivity. Circ Res (1969) 5.27
Mortality in relation to smoking: 22 years' observations on female British doctors. Br Med J (1980) 5.21
Vitamin E supplementation and cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators. N Engl J Med (2000) 5.09
Effects on 11-year mortality and morbidity of lowering LDL cholesterol with simvastatin for about 5 years in 20,536 high-risk individuals: a randomised controlled trial. Lancet (2011) 5.08
The relevance in adults of air-flow obstruction, but not of mucus hypersecretion, to mortality from chronic lung disease. Results from 20 years of prospective observation. Am Rev Respir Dis (1983) 4.90
Tobacco and cancer: recent epidemiological evidence. J Natl Cancer Inst (2004) 4.83
Effect of nitric oxide synthase inhibitors on hypotension in patients with septic shock. Lancet (1992) 4.64
Mortality among doctors in different occupations. Br Med J (1977) 4.60
Emerging tobacco hazards in China: 2. Early mortality results from a prospective study. BMJ (1998) 4.51
Cause-specific mortality in long-term survivors of breast cancer who participated in trials of radiotherapy. J Clin Oncol (1994) 4.50
Sudden fall in breast cancer death rates in England and Wales. Lancet (1995) 4.50
The relationship between dysglycaemia and cardiovascular and renal risk in diabetic and non-diabetic participants in the HOPE study: a prospective epidemiological analysis. Diabetologia (2005) 4.45
Can dietary beta-carotene materially reduce human cancer rates? Nature (1981) 4.43
Pre-referral rectal artesunate to prevent death and disability in severe malaria: a placebo-controlled trial. Lancet (2008) 4.35
Tobacco--the growing epidemic. Nat Med (1999) 4.31
Risk factors for acute myocardial infarction in Indians: a case-control study. Lancet (1996) 4.28
Prevalence of HIV, hepatitis B, and hepatitis C antibodies in prisoners in England and Wales: a national survey. Commun Dis Public Health (2000) 4.25
Early health effects of the emerging tobacco epidemic in China. A 16-year prospective study. JAMA (1997) 4.09
Prediction of mortality and morbidity with a 6-minute walk test in patients with left ventricular dysfunction. SOLVD Investigators. JAMA (1993) 4.01
Reduction of cardiovascular risk by regression of electrocardiographic markers of left ventricular hypertrophy by the angiotensin-converting enzyme inhibitor ramipril. Circulation (2001) 3.96
Overcoming the limitations of current meta-analysis of randomised controlled trials. Lancet (1998) 3.79
Blood-pressure reduction and cardiovascular risk in HOPE study. Lancet (2002) 3.77
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Oxford and McKinsey: Cogwheel and beyond. Br Med J (1970) 3.50
Surface antigens common to mouse cleavage embryos and primitive teratocarcinoma cells in culture. Proc Natl Acad Sci U S A (1973) 3.37
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Effects of physiologic pacing versus ventricular pacing on the risk of stroke and death due to cardiovascular causes. Canadian Trial of Physiologic Pacing Investigators. N Engl J Med (2000) 3.32
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