Mistletoe toxicity.

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Published in Lancet on February 05, 1983

Authors

F Stirpe

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(truncated to the top 100)

The regulation of rat liver xanthine oxidase. Involvement of thiol groups in the conversion of the enzyme activity from dehydrogenase (type D) into oxidase (type O) and purification of the enzyme. Biochem J (1972) 3.29

Ribosome-inactivating proteins from plants. Biochim Biophys Acta (1993) 2.97

CD30 (Ki-1) molecule: a new cytokine receptor of the tumor necrosis factor receptor superfamily as a tool for diagnosis and immunotherapy. Blood (1995) 2.67

The regulation of rat liver xanthine oxidase. Conversion in vitro of the enzyme activity from dehydrogenase (type D) to oxidase (type O). J Biol Chem (1969) 2.65

Studies on the pathogenesis of liver necrosis by alpha-amanitin. Effect of alpha-amanitin on ribonucleic acid synthesis and on ribonucleic acid polymerase in mouse liver nuclei. Biochem J (1967) 2.24

Gelonin, a new inhibitor of protein synthesis, nontoxic to intact cells. Isolation, characterization, and preparation of cytotoxic complexes with concanavalin A. J Biol Chem (1980) 2.16

Inhibition by ricin of protein synthesis in vitro. Ribosomes as the target of the toxin. Biochem J (1973) 1.72

Ribosome-inactivating proteins up to date. FEBS Lett (1986) 1.70

Simultaneous assay of RNA polymerase I and II in nuclei isolated from resting and growing rat liver with the use of alpha-amanitin. FEBS Lett (1970) 1.67

Fructose-induced hyperuricaemia. Lancet (1970) 1.66

Ribosome-inactivating proteins from the seeds of Saponaria officinalis L. (soapwort), of Agrostemma githago L. (corn cockle) and of Asparagus officinalis L. (asparagus), and from the latex of Hura crepitans L. (sandbox tree). Biochem J (1983) 1.65

Regulation of rat liver pyruvate kinase. The effect of preincubation, pH, copper ions, fructose 1,6-diphosphate and dietary changes on enzyme activity. Biochem J (1968) 1.60

The regulation of xanthine oxidase. Inhibition by reduced nicotinamide-adenine dinucleotide of rat liver xanthine oxidase type D and of chick liver xanthine dehydrogenase. Biochem J (1970) 1.56

Inhibition by ricin of protein synthesis in vitro. Inhibition of the binding of elongation factor 2 and of adenosine diphosphate-ribosylated elongation factor 2 to ribosomes. Biochem J (1975) 1.53

Polynucleotide:adenosine glycosidase activity of ribosome-inactivating proteins: effect on DNA, RNA and poly(A). Nucleic Acids Res (1997) 1.51

Modeccin, the toxin of Adenia digitata. Purification, toxicity and inhibition of protein synthesis in vitro. Biochem J (1978) 1.46

Decreased RNA content in mouse liver nuclei after intoxication with alpha-amanitin. Biochim Biophys Acta (1966) 1.45

Selective inhibition of a nuclear RNA polymerase in cells infected with frog virus. Nature (1970) 1.44

Inhibition by ricin of protein synthesis in vitro: 60 S ribosomal subunit as the target of the toxin. Biochem J (1973) 1.42

Inhibition by alpha-amanitin of ribonucleic acid polymerase solubilized from rat liver nuclei. Biochem J (1970) 1.38

An immunotoxin composed of monoclonal anti-Thy 1.1 antibody and a ribosome-inactivating protein from Saponaria officinalis: potent antitumor effects in vitro and in vivo. J Natl Cancer Inst (1985) 1.37

Xanthine oxidase type D (dehydrogenase) in the intestine and other organs of the rat. Biochem J (1972) 1.35

Inhibition of protein synthesis in vitro by proteins from the seeds of Momordica charantia (bitter pear melon). Biochem J (1980) 1.35

Experimental conditions affecting ribonucleic acid polymerase in isolated rat liver nuclei. Effect of nucleoside triphosphate concentration, temperature, ammonium sulphate and heparin. Biochem J (1969) 1.27

Purification and partial characterization of another form of the antiviral protein from the seeds of Phytolacca americana L. (pokeweed). Biochem J (1982) 1.24

Inhibition of protein synthesis by modeccin, the toxin of Modecca digitata. FEBS Lett (1977) 1.20

Dianthins, ribosome-damaging proteins with anti-viral properties from Dianthus caryophyllus L. (carnation). Biochem J (1981) 1.18

Effect of modeccin on the steps of peptide-chain elongation. Biochem J (1978) 1.17

The regulation of rat-liver xanthine oxidase: Activation by proteolytic enzymes. FEBS Lett (1968) 1.16

Cytotoxicity acquired by conjugation of an anti-Thy1.1 monoclonal antibody and the ribosome-inactivating protein, gelonin. Eur J Biochem (1981) 1.15

Inhibition of protein synthesis by seed-extracts. A screening study. FEBS Lett (1977) 1.14

Studies on the proteins from the seeds of Croton tiglium and of Jatropha curcas. Toxic properties and inhibition of protein synthesis in vitro. Biochem J (1976) 1.14

Inhibition of protein synthesis in vitro by crotins and ricin. Effect on the steps of peptide chain elongation. Biochem J (1976) 1.12

Inhibition of protein synthesis in vitro by a lectin from Momordica charantia and by other haemagglutinins. Biochem J (1979) 1.11

Properties of the xanthine oxidase from human liver. Biochim Biophys Acta (1969) 1.11

Unexpected activity of saporins. Nature (1994) 1.10

Effect of ribosome-inactivating proteins on virus-infected cells. Inhibition of virus multiplication and of protein synthesis. Arch Virol (1982) 1.10

Modification of the carbohydrate in ricin with metaperiodate-cyanoborohydride mixtures. Effects on toxicity and in vivo distribution. Eur J Biochem (1985) 1.07

Distribution and properties of major ribosome-inactivating proteins (28 S rRNA N-glycosidases) of the plant Saponaria officinalis L. (Caryophyllaceae). Biochim Biophys Acta (1993) 1.07

Regulation of xanthine oxidase in rat liver: modifications of the enzyme activity of rat liver supernatant on storage at 20 degrees. Biochem J (1968) 1.07

Bispecific F(ab' gamma)2 antibody for the delivery of saporin in the treatment of lymphoma. J Immunol (1988) 1.02

Ribonucleic acid polymerase induced by vaccinia virus: lack of inhibition by rifampicin and alpha-amanitin. J Virol (1970) 1.01

Inhibition of protein synthesis by a toxic lectin from Viscum album L. (mistletoe). Biochem J (1980) 1.01

Regulation of xanthine dehydrogenase in chick liver. Further experiments on the effects of inosine, actinomycin D and other factors. Biochem J (1967) 1.00

Induction of apoptosis by ribosome-inactivating proteins and related immunotoxins. Int J Cancer (1996) 0.99

Some ribosome-inactivating proteins depurinate ribosomal RNA at multiple sites. Biochem J (1992) 0.99

Toxic effects of ricin: studies on the pathogenesis of liver lesions. Virchows Arch B Cell Pathol (1976) 0.98

Bryodin, a ribosome-inactivating protein from the roots of Bryonia dioica L. (white bryony). Biochem J (1986) 0.98

Polynucleotide: adenosine glycosidase activity of saporin-L1: effect on DNA, RNA and poly(A). Biochem J (1996) 0.97

Antitumor activity of anti-CD30 immunotoxin (Ber-H2/saporin) in vitro and in severe combined immunodeficiency disease mice xenografted with human CD30+ anaplastic large-cell lymphoma. Blood (1995) 0.96

Trichosanthin, alpha-momorcharin and beta-momorcharin: identity of abortifacient and ribosome-inactivating proteins. Int J Pept Protein Res (1988) 0.95

The formation of 2,3-dihydroxy-2,3-dihydro-aflatoxin B1 by the metabolism of aflatoxin B1 by liver microsomes isolated from certain avian and mammalian species and the possible role of this metabolite in the acute toxicity of aflatoxin B1. Toxicol Appl Pharmacol (1981) 0.95

Seed extracts inhibiting protein synthesis in vitro. Biochem J (1980) 0.94

Isolation and characterization of viscumin, a toxic lectin from Viscum album L. (mistletoe). J Biol Chem (1982) 0.94

Action of viscumin, a toxic lectin from mistletoe, on cells in culture. J Biol Chem (1982) 0.92

Properties of the ribosome-inactivating proteins gelonin, Momordica charantia inhibitor, and dianthins. Biochem J (1982) 0.92

The regulation of rat liver xanthine oxidase: conversion of type D (dehydrogenase) into type O (oxidase) by a thermolabile factor, and reversibility by dithioerythritol. Biochim Biophys Acta (1970) 0.92

In vitro and in vivo efficacy of heat shock protein specific immunotoxins on human tumor cells. J Biol Regul Homeost Agents (1997) 0.91

Ribosome-inactivating proteins from plants inhibit ribosome activity of Trypanosoma and Leishmania. J Protozool (1988) 0.91

The conjugate Rituximab/saporin-S6 completely inhibits clonogenic growth of CD20-expressing cells and produces a synergistic toxic effect with Fludarabine. Leukemia (2004) 0.91

Purification and properties of a new ribosome-inactivating protein with RNA N-glycosidase activity suitable for immunotoxin preparation from the seeds of Momordica cochinchinensis. Biochim Biophys Acta (1989) 0.91

Effect of protein deprivation and of starvation on DNA synthesis in resting and regenerating rat liver. J Nutr (1972) 0.90

Purification and partial characterization of a mitogenic lectin from Vicia sativa. Biochim Biophys Acta (1979) 0.90

Effect of alpha-amanitin on ribonucleic acid synthesis and on ribonucleic acid polymerase in mouse liver. Biochem J (1967) 0.90

Reduction of ricin and other plant toxins by thiol:protein disulfide oxidoreductases. Arch Biochem Biophys (1982) 0.89

Factors affecting the activity of ribonucleic acid polymerase solubilized from rat liver nuclei. Effect on ionic strength, spermine and divalent ions with native and denatured deoxyribonucleic acid. Eur J Biochem (1970) 0.89

Immunotoxins containing recombinant anti-CTLA-4 single-chain fragment variable antibodies and saporin: in vitro results and in vivo effects in an acute rejection model. J Immunol (2001) 0.89

Purification and properties of two lectins from the latex of the euphorbiaceous plants Hura crepitans L. (sand-box tree) and Euphorbia characias L. (Mediterranean spurge). Biochem J (1983) 0.89

Properties of volkensin, a toxic lectin from Adenia volkensii. J Biol Chem (1985) 0.88

Characterization of a Saponaria officinalis seed ribosome-inactivating protein: immunoreactivity and sequence homologies. Biochem Biophys Res Commun (1985) 0.88

Anti-CD30 (BER=H2) immunotoxins containing the type-1 ribosome-inactivating proteins momordin and PAP-S (pokeweed antiviral protein from seeds) display powerful antitumour activity against CD30+ tumour cells in vitro and in SCID mice. Br J Haematol (1996) 0.87

Shiga-like toxin I is a polynucleotide:adenosine glycosidase. Mol Microbiol (1998) 0.87

Specificity of ribosome-inactivating proteins with RNA N-glycosidase activity. Biochem J (1989) 0.87

Effect of ribosome-inactivating proteins on ribosomes from Tetrahymena pyriformis and Acanthamoeba castellanii. Biochem Biophys Res Commun (1987) 0.87

In vitro anti-tumour activity of anti-CD80 and anti-CD86 immunotoxins containing type 1 ribosome-inactivating proteins. Br J Haematol (2000) 0.87

A rapid and sensitive method to measure the enzymatic activity of ribosome-inactivating proteins. Nucleic Acids Res (1998) 0.87

New ribosome-inactivating proteins with polynucleotide:adenosine glycosidase and antiviral activities from Basella rubra L. and bougainvillea spectabilis Willd. Planta (1997) 0.86

Purification and properties of different forms of modeccin, the toxin of Adenia digitata. Separation of subunits with inhibitory and lectin activity. Biochem J (1980) 0.86

A comparison of the accumulation of ricin by hepatic parenchymal and non-parenchymal cells and its inhibition of protein synthesis. Biochim Biophys Acta (1981) 0.86

Trichokirin, a ribosome-inactivating protein from the seeds of Trichosanthes kirilowii Maximowicz. Purification, partial characterization and use for preparation of immunotoxins. Eur J Biochem (1988) 0.86

CD38 as a target of IB4 mAb carrying saporin-S6: design of an immunotoxin for ex vivo depletion of hematological CD38+ neoplasia. J Biol Regul Homeost Agents (2006) 0.86

Mitogenic and haemagglutinating properties of a lectinpurified from Hura crepitans seeds. Biochim Biophys Acta (1980) 0.86

Immunotoxin therapy of hematological malignancies. Haematologica (1996) 0.86

Recognition and killing of tumour cells expressing heat shock protein 65 kD with immunotoxins containing saporin. Br J Cancer (1992) 0.85

An Epstein-Barr virus-infected lymphoblastoid cell line (D430B) that grows in SCID-mice with the morphologic features of a CD30+ anaplastic large cell lymphoma, and is sensitive to anti-CD30 immunotoxins. Haematologica (1999) 0.85

Purification and partial characterization of a lectin from the seeds of Trichosanthes kirilowii Maximowicz. FEBS Lett (1989) 0.85

Ricin induces the production of tumour necrosis factor-alpha and interleukin-1 beta by human peripheral-blood mononuclear cells. Biochem J (1993) 0.85

Interaction of volkensin with HeLa cells: binding, uptake, intracellular localization, degradation and exocytosis. Cell Mol Life Sci (2004) 0.85

Adenine glycosylase activity in mammalian tissues: an equivalent of ribosome-inactivating proteins. FEBS Lett (2001) 0.84

Type 1 ribosome-inactivating proteins are the most abundant proteins in iris (Iris hollandica var. Professor Blaauw) bulbs: characterization and molecular cloning. Biochem J (1997) 0.84

On the distribution of ribosome-inactivating proteins amongst plants. J Nat Prod (1985) 0.84

Delivery of the ribosome-inactivating protein, gelonin, to lymphoma cells via CD22 and CD38 using bispecific antibodies. Br J Cancer (1995) 0.84

Polynucleotide: adenosine glycosidase activity of immunotoxins containing ribosome-inactivating proteins. J Drug Target (2000) 0.84

Effect of modeccin on rat liver ribosomes in vivo. Biochim Biophys Acta (1979) 0.84

Purification and partial characterization of single-chain ribosome-inactivating proteins from the seeds of Phytolacca dioica L. Biochim Biophys Acta (1993) 0.84

Purification and properties of new ribosome-inactivating proteins with RNA N-glycosidase activity. Biochim Biophys Acta (1990) 0.84

The effects of copper and other ions on the ribonucleic acid polymerase activity of isolated rat liver nuclei. Biochem J (1969) 0.83

Inhibition of ribonucleic acid and of protein synthesis in the organs of rats and mice poisoned with alpha-amanitin. Biochim Biophys Acta (1973) 0.83

Emergence of immunoglobulin variants following treatment of a B cell leukemia with an immunotoxin composed of antiidiotypic antibody and saporin. J Exp Med (1987) 0.83

Effect of alpha-amanitin poisoning on the synthesis of deoxyribonucleic acid and of protein in regenerating rat liver. Biochim Biophys Acta (1973) 0.82