Published in Science on March 02, 1984
Replacement of lysine residue 1030 in the putative ATP-binding region of the insulin receptor abolishes insulin- and antibody-stimulated glucose uptake and receptor kinase activity. Proc Natl Acad Sci U S A (1987) 2.99
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An antipeptide antibody that specifically inhibits insulin receptor autophosphorylation and protein kinase activity. Proc Natl Acad Sci U S A (1985) 1.11
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Insulin and rabbit anti-insulin receptor antibodies stimulate additively the intrinsic receptor kinase activity. EMBO J (1987) 0.95
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Modulation of intercellular adherens-type junctions and tyrosine phosphorylation of their components in RSV-transformed cultured chick lens cells. Cell Regul (1991) 1.53
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The role of antireceptor antibodies in stimulating phosphorylation of the insulin receptor. J Biol Chem (1984) 1.43
Expression of two human growth hormone genes in monkey cells infected by simian virus 40 recombinants. Proc Natl Acad Sci U S A (1981) 1.39
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Morphological changes of the 3T3-L1 fibroblast plasma membrane upon differentiation to the adipocyte form. J Cell Sci (1983) 1.32
Binding and internalization of 125I-LDL in normal and mutant human fibroblasts. A quantitative autoradiographic study. Exp Cell Res (1979) 1.32
Metastatic insulin-secreting carcinoma of the pancreas: clinical course and the role of surgery. Surgery (1984) 1.30
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Multisite phosphorylation of the alpha subunit of transducin by the insulin receptor kinase and protein kinase C. Proc Natl Acad Sci U S A (1986) 1.28
Surface redistribution of 125I-insulin in cultured human lymphocytes. J Cell Biol (1981) 1.27
Intraoperative ultrasonographic localization of islet cell tumors. A prospective comparison to palpation. Ann Surg (1988) 1.27
Recurrent hematuria and focal nephritis. N Engl J Med (1967) 1.27
Hypoglycemia associated with non-islet-cell tumor and insulin-like growth factors. N Engl J Med (1981) 1.26
Alpha2-HSG, a specific inhibitor of insulin receptor autophosphorylation, interacts with the insulin receptor. Mol Cell Endocrinol (2000) 1.23
Selective inhibition of protein tyrosine phosphatase activities by H2O2 and vanadate in vitro. Biochem Biophys Res Commun (1992) 1.23
Insulin stimulated phosphorylation of its own receptor. Activation of a tyrosine-specific protein kinase that is tightly associated with the receptor. J Biol Chem (1983) 1.22
Familial hyperproinsulinemia due to a proposed defect in conversion of proinsulin to insulin. N Engl J Med (1984) 1.20
Galectin-8. A new rat lectin, related to galectin-4. J Biol Chem (1995) 1.20
Effects of autonomic neuropathy on coronary blood flow in patients with diabetes mellitus. Circulation (1999) 1.19
Receptor aggregation is necessary for activation of the soluble insulin receptor kinase. J Biol Chem (1986) 1.19
A sensitive radioimmunoassay for 7S nerve growth factor antigens in serum and tissues. J Neurochem (1971) 1.19
Bovine fetuin is an inhibitor of insulin receptor tyrosine kinase. Life Sci (1997) 1.19
Galectins are differentially expressed in supratentorial pilocytic astrocytomas, astrocytomas, anaplastic astrocytomas and glioblastomas, and significantly modulate tumor astrocyte migration. Brain Pathol (2001) 1.17
Five mutant alleles of the insulin receptor gene in patients with genetic forms of insulin resistance. J Clin Invest (1990) 1.17
The insulin receptor of a human monocyte-like cell line: characterization and function. Endocrinology (1984) 1.16
Insulin and insulinomimetic agents induce activation of phosphatidylinositol 3'-kinase upon its association with pp185 (IRS-1) in intact rat livers. J Biol Chem (1992) 1.15
Hepatitis from methimazole during adrenal steroid therapy for malignant exophthalmos. JAMA (1968) 1.14
The reliability of the Diabetes Care Profile for African Americans. Eval Health Prof (1998) 1.14
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Insulin-induced surface redistribution regulates internalization of the insulin receptor and requires its autophosphorylation. Proc Natl Acad Sci U S A (1992) 1.13
Polypeptide hormone degradation and receptor regulation are coupled to ligand internalization. A direct biochemical and morphologic demonstration. J Biol Chem (1981) 1.12
Once- and twice-daily dosing with rosiglitazone improves glycemic control in patients with type 2 diabetes. Diabetes Care (2001) 1.12
Hypoglycemia in association with extrapancreatic tumors: demonstration of elevated plasma NSILA-s by a new radioreceptor assay. J Clin Endocrinol Metab (1974) 1.12
Tyrosine phosphorylation of insulin receptor substrate-1 in vivo depends upon the presence of its pleckstrin homology region. J Biol Chem (1995) 1.12
Results of a prospective strategy to diagnose, localize, and resect insulinomas. Surgery (1991) 1.11
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Intraarterial calcium stimulation and intraoperative ultrasonography in the localization and resection of insulinomas. Surgery (1997) 1.10
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Insulin resistance associated with androgen excess in women with autoantibodies to the insulin receptor. Ann Intern Med (1982) 1.09
Insulin-like growth factor-I (IGF-I) stimulates tyrosine kinase activity in purified receptors from a rat liver cell line. Biochem Biophys Res Commun (1984) 1.09
Potassium depletion and hypertonic medium reduce "non-coated" and clathrin-coated pit formation, as well as endocytosis through these two gates. J Cell Physiol (1989) 1.07
Rabbit uterus as a source of renin. Am J Physiol (1967) 1.07
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Conventional supervoltage irradiation is an effective treatment for acromegaly. J Clin Endocrinol Metab (1979) 1.07