PubRank

S J Wakil

Author PubWeight™ 119.04‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2. Science 2001 5.93
2 Fatty acid synthesis and its regulation. Annu Rev Biochem 1983 4.74
3 Control of fatty acid metabolism. I. Induction of the enzymes of fatty acid oxidation in Escherichia coli. J Bacteriol 1969 4.12
4 Control of fatty acid composition in phospholipids of Escherichia coli: response to fatty acid supplements in a fatty acid auxotroph. Proc Natl Acad Sci U S A 1969 2.38
5 The molecular organization of lipids in the membrane of Escherichia coli: phase transitions. Proc Natl Acad Sci U S A 1971 2.19
6 The subcellular localization of acetyl-CoA carboxylase 2. Proc Natl Acad Sci U S A 2000 2.10
7 Cloning of the yeast FAS3 gene and primary structure of yeast acetyl-CoA carboxylase. Proc Natl Acad Sci U S A 1992 2.10
8 Studies on the mechanism of fatty acid synthesis. XIV. The prosthetic group of acyl carrier protein and the mode of its attachment to the protein. J Biol Chem 1965 1.73
9 Human acetyl-CoA carboxylase: characterization, molecular cloning, and evidence for two isoforms. Proc Natl Acad Sci U S A 1995 1.67
10 Animal fatty acid synthetase. A novel arrangement of the beta-ketoacyl synthetase sites comprising domains of the two subunits. J Biol Chem 1981 1.61
11 Human fatty acid synthase: properties and molecular cloning. Proc Natl Acad Sci U S A 1995 1.60
12 Human acetyl-CoA carboxylase 2. Molecular cloning, characterization, chromosomal mapping, and evidence for two isoforms. J Biol Chem 1997 1.59
13 Primary structure of the multifunctional alpha subunit protein of yeast fatty acid synthase derived from FAS2 gene sequence. J Biol Chem 1988 1.56
14 Presence of two polypeptide chains comprising fatty acid synthetase. Proc Natl Acad Sci U S A 1975 1.39
15 The complete amino acid sequence of the acyl carrier protein of Escherichia coli. J Biol Chem 1968 1.38
16 Studies on the mechanism of fatty acid synthesis. 13. The role of beta-hydroxy acids in the synthesis of palmitate and cis vaccenate by the Escherichia coli enzyme system. J Biol Chem 1966 1.35
17 Studies on the control of fatty acid metabolism. 3. Incorporation of fatty acids into phospholipids and regulation of fatty acid synthetase of Escherichia coli. J Biol Chem 1971 1.33
18 A requirement for phospholipids by the microsomal reduced diphosphopyridine nucleotide-cytochrome c reductase. J Biol Chem 1967 1.32
19 Complementation of mutations and nucleotide sequence of FAS1 gene encoding beta subunit of yeast fatty acid synthase. J Biol Chem 1987 1.32
20 Physicochemical studies of the rat liver and adipose fatty acid synthetases. J Biol Chem 1979 1.29
21 The architecture of the animal fatty acid synthetase complex. IV. Mapping of active centers and model for the mechanism of action. J Biol Chem 1983 1.27
22 The isolation and characterization of fatty-acid synthetase mRNA from rat mammary gland. Eur J Biochem 1981 1.26
23 Regulation of acetyl-coenzyme A carboxylase. I. Purification and properties of two forms of acetyl-coenzyme A carboxylase from rat liver. J Biol Chem 1988 1.23
24 Studies on the mechanism of fatty acid synthesis. 18. Preparation and general properties of the enoyl acyl carrier protein reductases from Escherichia coli. J Biol Chem 1968 1.21
25 Studies on the mechanism of fatty acid synthesis. XXVI. Purification and properties of malonyl-coenzyme A--acyl carrier protein transacylase of Escherichia coli. Arch Biochem Biophys 1971 1.19
26 Acute hormonal control of acetyl-CoA carboxylase. The roles of insulin, glucagon, and epinephrine. J Biol Chem 1990 1.18
27 Studies on the mechanism of fatty acid synthesis. XVI. Preparation and general properties of acyl-malonyl acyl carrier protein-condensing enzyme from Escherichia coli. J Biol Chem 1966 1.18
28 The architecture of the animal fatty acid synthetase. I. Proteolytic dissection and peptide mapping. J Biol Chem 1983 1.17
29 Regulation of acetyl-coenzyme A carboxylase. II. Effect of fasting and refeeding on the activity, phosphate content, and aggregation state of the enzyme. J Biol Chem 1988 1.17
30 A novel cDNA extension procedure. Isolation of chicken fatty acid synthase cDNA clones. J Biol Chem 1989 1.16
31 Studies on the mechanism of fatty acid synthesis. XIX. Preparation and general properties of palmityl thioesterase. J Biol Chem 1968 1.14
32 Studies on the mechanism of fatty acid synthesis. 23. The acyl binding sites of the pigeon liver fatty acid synthetase. J Biol Chem 1970 1.14
33 Site-directed mutagenesis studies on the recombinant thioesterase domain of chicken fatty acid synthase expressed in Escherichia coli. J Biol Chem 1991 1.13
34 Studies on the yeast fatty acid synthetase. Subunit composition and structural organization of a large multifunctional enzyme complex. J Biol Chem 1978 1.10
35 Activation of acetyl-CoA carboxylase. Purification and properties of a Mn2+-dependent phosphatase. J Biol Chem 1985 1.10
36 Sterol regulation of human fatty acid synthase promoter I requires nuclear factor-Y- and Sp-1-binding sites. Proc Natl Acad Sci U S A 2000 1.08
37 Human fatty acid synthase: role of interdomain in the formation of catalytically active synthase dimer. Proc Natl Acad Sci U S A 2001 1.07
38 Structure-function relationships of the yeast fatty acid synthase: negative-stain, cryo-electron microscopy, and image analysis studies of the end views of the structure. Proc Natl Acad Sci U S A 1992 1.05
39 Isolation and mapping of the beta-hydroxyacyl dehydratase activity of chicken liver fatty acid synthase. J Biol Chem 1988 1.04
40 Requirement for reduced diphosphopyridine nucleotide-cytochrome b5 reductase in stearly coenzyme A desaturation. J Biol Chem 1970 1.03
41 A requirement for lipids by the microsomal stearyl coenzyme A desaturase. J Biol Chem 1969 1.03
42 Animal fatty acid synthase: functional mapping and cloning and expression of the domain I constituent activities. Proc Natl Acad Sci U S A 1997 1.02
43 Relation between protein synthesis and phospholipid synthesis and turnover in Escherichia coli. J Bacteriol 1972 1.01
44 Purification and properties of a palmityl thioesterase II from Escherichia coli. J Biol Chem 1970 1.00
45 Characterization of recombinant thioesterase and acyl carrier protein domains of chicken fatty acid synthase expressed in Escherichia coli. J Biol Chem 1989 1.00
46 The architecture of the animal fatty acid synthetase. II. Separation of the core and thioesterase functions and determination of the N-C orientation of the subunit. J Biol Chem 1983 0.99
47 Cloning and expression of the multifunctional human fatty acid synthase and its subdomains in Escherichia coli. Proc Natl Acad Sci U S A 1996 0.99
48 Studies on the mechanism of fatty acid synthesis. XXII. Salt activation of the fatty acid-synthesizing enzymes of Escherichia coli. J Biol Chem 1969 0.98
49 Studies on the mechanism of fatty acid synthesis. XXIV. The acetyl- and malonyltransacylase activities of pigeon liver fatty acid synthetase. J Biol Chem 1970 0.98
50 On the question of half- or full-site reactivity of animal fatty acid synthetase. J Biol Chem 1984 0.98
51 Small-angle neutron-scattering and electron microscope studies of the chicken liver fatty acid synthase. J Biol Chem 1987 0.97
52 The architecture of the animal fatty acid synthetase. III. Isolation and characterization of beta-ketoacyl reductase. J Biol Chem 1983 0.95
53 Roles of Ser101, Asp236, and His237 in catalysis of thioesterase II and of the C-terminal region of the enzyme in its interaction with fatty acid synthase. Proc Natl Acad Sci U S A 1993 0.95
54 Molecular organization of lipids in Escherichia coli membranes. II. Effect of phospholipids on succinic-ubiquinone reductase activity. J Biol Chem 1972 0.95
55 Studies on the mechanism of fatty acid synthesis. XVII. Preparation and general properties of acetyl coenzyme A and malonyl coenzyme A-acyl carrier protein transacylases. J Biol Chem 1966 0.94
56 Human fatty-acid synthase gene. Evidence for the presence of two promoters and their functional interaction. J Biol Chem 1996 0.93
57 Studies on the mechanism of fatty acid synthesis. XX. Preparation and general properties of beta-hydroxybutyryl acyl carrier protein dehydrase. J Biol Chem 1968 0.92
58 Studies on the mechanism of fatty acid synthesis. XV. Preparation and general properties of beta-ketoacyl acyl carrier protein reductase from Escherichia coli. Biochim Biophys Acta 1966 0.92
59 Positional specificities of acyl coenzyme A: glycerophosphate and acyl coenzyme A: monoacylglycerophosphate acyltransferases in Escherichia coli. J Biol Chem 1973 0.92
60 Fatty acid synthase from chicken liver. Methods Enzymol 1975 0.91
61 Factors affecting the acyl selectivities of acyltransferases in Escherichia coli. J Biol Chem 1976 0.91
62 Molecular cloning of fatty acid synthetase genes from Saccharomyces cerevisiae. J Biol Chem 1983 0.91
63 Regulation by temperature of the chain length of fatty acids in yeast. J Biol Chem 1979 0.90
64 The preparation of tryptic, peptic, thermolysin, and cyanogen bromide peptides from the acyl carrier protein of Escherichia coli. J Biol Chem 1968 0.89
65 Studies on the control of fatty acid metabolism. II. The inhibition of fatty acid synthesis in Lactobacillus plantarum by exogenous fatty acid. J Biol Chem 1970 0.89
66 Amino-terminal blocking group and sequence of the animal fatty acid synthase. Arch Biochem Biophys 1994 0.89
67 The reaction of chicken liver fatty acid synthetase with 5,5'-dithiobis(2-nitrobenzoic acid). Biochem Biophys Res Commun 1982 0.88
68 Isolation and characterization of a novel acetyl-CoA carboxylase kinase from rat liver. J Biol Chem 1994 0.88
69 Comparative studies on the kinetic parameters and product analyses of chicken and rat liver and yeast fatty acid synthetase. Comp Biochem Physiol B 1982 0.87
70 The isolation of the two subunits of yeast fatty acid synthetase. Biochem Biophys Res Commun 1978 0.87
71 Yeast fatty acid synthase: structure to function relationship. Biochemistry 1985 0.86
72 Animal fatty acid synthetase. Identification of the residues comprising the novel arrangement of the beta-ketoacyl synthetase site and their role in its cold inactivation. J Biol Chem 1982 0.86
73 Further evidence for the multifunctional enzyme characteristic of the fatty acid synthetases of animal tissues. Arch Biochem Biophys 1978 0.86
74 Identification of thyroid hormone response elements in the human fatty acid synthase promoter. Proc Natl Acad Sci U S A 1998 0.86
75 Isolation and chromosomal mapping of genomic clones encoding the human fatty acid synthase gene. Genomics 1994 0.85
76 Studies on the mechanism of fatty acid synthesis. XXV. On the mechanism of beta-ketoacylacyl carrier protein reductase from Escherichia coli. J Biol Chem 1971 0.84
77 Turnover of phospholipids in an unsaturated fatty acid auxotroph of Escherichia coli. J Bacteriol 1972 0.84
78 Complete amino acid sequence of the thioesterase domain of chicken liver fatty acid synthase. Biochemistry 1988 0.83
79 The yeast fatty acid synthetase. Structure-function relationship and the role of the active cysteine-SH and pantetheine-SH. J Biol Chem 1981 0.83
80 Studies on the mechanism of fatty acid synthesis. XXI. The role of fructose 1,6-diphosphate in the stimulation of the fatty acid synthetase from pigeon liver. J Biol Chem 1968 0.83
81 The relationship between structure and function for and the regulation of the enzymes of fatty acid synthesis. Ann N Y Acad Sci 1986 0.82
82 Yeast fatty acid synthetase: structure-function relationship and nature of the beta-ketoacyl synthetase site. Proc Natl Acad Sci U S A 1980 0.82
83 Assay for the terminal enzyme of the stearoyl coenzyme A desaturase system using chick embryo liver microsomes. J Lipid Res 1977 0.82
84 The arrangement and role of some of the amino acid residues in the beta-ketoacyl synthetase site of chicken liver fatty acid synthetase. J Biol Chem 1983 0.81
85 Complete amino acid sequence of chicken liver acyl carrier protein derived from the fatty acid synthase. Arch Biochem Biophys 1989 0.81
86 Stimulation of fatty acid biosynthesis by phosphorylated sugars. Proc Natl Acad Sci U S A 1966 0.81
87 Effect of lipids on the reconstitution of D-lactate oxidase in Escherichia coli membrane vesicles. J Biol Chem 1976 0.81
88 Increased synthesis and accumulation of phospholipids during differentiation of 3T3-L1 cells into adipocytes. J Biol Chem 1983 0.81
89 The yeast fatty acid synthase. Pathway for transfer of the acetyl group from coenzyme A to the Cys-SH of the condensation site. J Biol Chem 1990 0.81
90 Human fatty acid synthase: assembling recombinant halves of the fatty acid synthase subunit protein reconstitutes enzyme activity. Proc Natl Acad Sci U S A 1997 0.81
91 On the 4'-phosphopantetheine content of chicken and rat liver fatty acid synthetases. J Biol Chem 1976 0.80
92 A rapid purification method for rat liver pyruvate carboxylase and amino acid sequence analyses of NH2-terminal and biotin peptide. Arch Biochem Biophys 1988 0.80
93 Characterization of a genomic and cDNA clone coding for the thioesterase domain and 3' noncoding region of the chicken liver fatty acid synthase gene. Biochemistry 1988 0.80
94 Colchicine inhibition of insulin induction of stearoyl-CoA desaturase and fatty acid synthetase in cultured avian liver explants. Arch Biochem Biophys 1984 0.79
95 Comparative mitochondrial oxidation of fatty acids. Biochim Biophys Acta 1971 0.78
96 Goose fatty acid synthetase mRNA. J Biol Chem 1980 0.78
97 Separation of dimethylaminoazobenzenethiohydantoin amino acids by high-performance liquid chromatography at low picomole concentrations. Anal Biochem 1984 0.78
98 Studies on the mechanism of action of acetyl coenzyme A carboxylase. 3. Enzyme-bound 1'-N-carboxybiotin as the carboxylation intermediate. J Biol Chem 1966 0.78
99 Regulation of fatty acid synthetase in perinatal chicks. Identification of polysomes synthesizing fatty acid synthetase. J Biol Chem 1977 0.78
100 The fatty acid synthetase-structure-function relationship and mechanism of palmitate synthesis. Cardiovasc Res Cent Bull 1982 0.77
101 Induction of microsomal stearyl coenzyme A desaturase in the newly hatched chicks. Arch Biochem Biophys 1976 0.77
102 Intermediate- and long-chain beta-hydroxyacyl-ACP dehydrases from E. coli fatty acid synthetase. Biochem Biophys Res Commun 1968 0.76
103 Interaction of the fluorescent analogue stearoyl-(1,N6)-etheno coenzyme A with chicken liver acetyl coenzyme A carboxylase. J Biol Chem 1980 0.76
104 Inactivation of yeast fatty acid synthetase by modifying the beta-ketoacyl reductase active lysine residue with pyridoxal 5'-phosphate. Arch Biochem Biophys 1983 0.75
105 The role of lipids in the structure and function of E. coli membrane. Biochem Soc Symp 1972 0.75
106 Fatty acid synthesis in aorta. Isolation of fatty acid synthetase from chicken aorta. Atherosclerosis 1977 0.75
107 A micromethod for identification of hydroxy acids. Anal Biochem 1968 0.75
108 Radio-labeling of the PstI restriction fragments and improvement in the sequencing procedure. Gene 1986 0.75
109 Stearoyl-coenzyme A desaturase activity in the mammary gland and liver of lactating rats. Lipids 1982 0.75
110 In vitro synthesis of lignoceric and nervonic acids in mammalian liver and brain. Biochemistry 1970 0.75
111 Assembly of lipids and proteins in Escherichia coli membranes. J Supramol Struct 1974 0.75
112 The development and application of a novel chromophoric substrate for investigation of the mechanism of yeast fatty acid synthase. Biochem Biophys Res Commun 1985 0.75
113 Hormonal regulation of hepatic fatty acid synthetase in chick embryo. Role of insulin. J Biol Chem 1978 0.75
114 Reactions of hydroxylamine with acetoacetyl thioesters or ethyl acetoacetate. Anal Biochem 1970 0.75