Ketoconazole blocks adrenal steroid synthesis.

PubWeight™: 2.25‹?› | Rank: Top 2%

🔗 View Article (PMID 6287893)

Published in Ann Intern Med on September 01, 1982

Authors

A Pont, P L Williams, D S Loose, D Feldman, R E Reitz, C Bochra, D A Stevens

Articles citing this

Azole antifungal agents: emphasis on new triazoles. Antimicrob Agents Chemother (1988) 4.79

Overview of medically important antifungal azole derivatives. Clin Microbiol Rev (1988) 3.33

A history of prostate cancer treatment. Nat Rev Cancer (2002) 2.46

Ketoconazole blocks adrenal steroidogenesis by inhibiting cytochrome P450-dependent enzymes. J Clin Invest (1983) 2.25

Methoxycarbonyl-etomidate: a novel rapidly metabolized and ultra-short-acting etomidate analogue that does not produce prolonged adrenocortical suppression. Anesthesiology (2009) 2.19

Pharmacokinetics of fluconazole in cerebrospinal fluid and serum in human coccidioidal meningitis. Antimicrob Agents Chemother (1988) 1.85

Management of endocrine manifestations and the use of mitotane as a chemotherapeutic agent for adrenocortical carcinoma. J Clin Oncol (2009) 1.70

CYP17 inhibitors for prostate cancer therapy. J Steroid Biochem Mol Biol (2010) 1.70

Antifungal resistance and new strategies to control fungal infections. Int J Microbiol (2011) 1.44

The Treatment of Cushing's Disease. Endocr Rev (2015) 1.35

Tuberculosis of the adrenal gland: a case report and review of the literature of infections of the adrenal gland. Int J Endocrinol (2014) 1.31

Ketoconazole blocks bile acid synthesis in hepatocyte monolayer cultures and in vivo in rat by inhibiting cholesterol 7 alpha-hydroxylase. J Clin Invest (1986) 1.20

High-dose itraconazole in the treatment of severe mycoses. Antimicrob Agents Chemother (1991) 1.12

Ketoconazole inhibition of testicular secretion of testosterone and displacement of steroid hormones from serum transport proteins. Antimicrob Agents Chemother (1983) 1.09

Combined treatment with ketoconazole and luteinising hormone releasing hormone analogue: a novel approach to resistant progressive prostatic cancer. Br Med J (Clin Res Ed) (1983) 0.99

Medical management of Cushing's disease: what is the future? Pituitary (2012) 0.99

Ketoconazole binds to glucocorticoid receptors and exhibits glucocorticoid antagonist activity in cultured cells. J Clin Invest (1983) 0.98

In vitro models for studying toxicity of antifungal agents. Antimicrob Agents Chemother (1992) 0.97

Azole affinity of sterol 14α-demethylase (CYP51) enzymes from Candida albicans and Homo sapiens. Antimicrob Agents Chemother (2012) 0.97

Differential azole antifungal efficacies contrasted using a Saccharomyces cerevisiae strain humanized for sterol 14 alpha-demethylase at the homologous locus. Antimicrob Agents Chemother (2008) 0.96

Roles for the backdoor pathway of androgen metabolism in prostate cancer response to castration and drug treatment. Int J Biol Sci (2014) 0.93

Impact of fluconazole prophylaxis on cortisol levels in critically ill surgical patients. Antimicrob Agents Chemother (2004) 0.92

Current and emerging therapies for advanced adrenocortical carcinoma. Oncologist (2011) 0.92

Reversible acute adrenal insufficiency caused by fluconazole in a critically ill patient. Postgrad Med J (2006) 0.91

Drug Strategies Targeting CYP51 in Neglected Tropical Diseases. Chem Rev (2014) 0.86

Adrenal response to corticotropin during therapy with itraconazole. Antimicrob Agents Chemother (1987) 0.85

The effect of ketoconazole on post-burn inflammation, hypermetabolism and clinical outcomes. PLoS One (2012) 0.84

High dose ketoconazole: endocrine and therapeutic effects in postmenopausal breast cancer. Br J Cancer (1988) 0.83

Therapeutic potential of the inhibition of the retinoic acid hydroxylases CYP26A1 and CYP26B1 by xenobiotics. Curr Top Med Chem (2013) 0.82

Resistance to antifungals that target CYP51. J Chem Biol (2014) 0.81

Hormonal aspects of prostatic cancer: a review. J R Soc Med (1985) 0.80

Selective inhibition of steroidogenic enzymes by ketoconazole in rat ovary cells. Clin Med Insights Reprod Health (2014) 0.79

Improved responsiveness of PCOS patients to clomiphene after CYP17a inhibitor. J Assist Reprod Genet (2001) 0.79

Electrolyte disorders and renal dysfunction in acquired immunodeficiency syndrome patients. J Natl Med Assoc (1991) 0.76

Effects of ciprofloxacin on testosterone and cortisol concentrations in healthy males. Antimicrob Agents Chemother (1989) 0.75

Vitamin D3 May Ameliorate the Ketoconazole Induced Adrenal Injury: Histological and Immunohistochemical Studies on Albino Rats. Acta Histochem Cytochem (2015) 0.75

Ketoconazole in experimental vaginal candidosis in rats. Antimicrob Agents Chemother (1986) 0.75

Preoperative ketoconazole therapy for adrenocortical carcinoma. CMAJ (1989) 0.75

Non-suppression of cortisol secretion by long term treatment with ketoconazole in patients with acute leukaemia. J Clin Pathol (1985) 0.75

Articles by these authors

Application of DNA typing methods to epidemiology and taxonomy of Candida species. J Clin Microbiol (1987) 13.21

Defining opportunistic invasive fungal infections in immunocompromised patients with cancer and hematopoietic stem cell transplants: an international consensus. Clin Infect Dis (2001) 12.73

The development of androgen-independent prostate cancer. Nat Rev Cancer (2001) 11.88

Antimicrobial susceptibility testing of yeasts: a turbidimetric technique independent of inoculum size. Antimicrob Agents Chemother (1976) 8.54

The American College of Rheumatology criteria for the classification and reporting of osteoarthritis of the hip. Arthritis Rheum (1991) 7.94

A Candida albicans dispersed, repeated gene family and its epidemiologic applications. Proc Natl Acad Sci U S A (1988) 7.75

Effect of nesiritide in patients with acute decompensated heart failure. N Engl J Med (2011) 7.62

Antifungal and surgical treatment of invasive aspergillosis: review of 2,121 published cases. Rev Infect Dis (1991) 6.43

Bisphenol-A: an estrogenic substance is released from polycarbonate flasks during autoclaving. Endocrinology (1993) 6.20

Turbidimetric studies of growth inhibition of yeasts with three drugs: inquiry into inoculum-dependent susceptibility testing, time of onset of drug effect, and implications for current and newer methods. Antimicrob Agents Chemother (1978) 5.94

Direct allelic variation scanning of the yeast genome. Science (1998) 5.90

Invasive aspergillosis. Disease spectrum, treatment practices, and outcomes. I3 Aspergillus Study Group. Medicine (Baltimore) (2000) 4.98

Itraconazole resistance in Aspergillus fumigatus. Antimicrob Agents Chemother (1997) 4.75

Correlation of in vitro susceptibility test results with in vivo response: flucytosine therapy in a systemic candidiasis model. J Infect Dis (1983) 4.42

Miconazole in coccidiodomycosis. II. Therapeutic and pharmacologic studies in man. Am J Med (1976) 3.91

Susceptibility to 5-fluorocytosine and prevalence of serotype in 402 Candida albicans isolates from the United States. Antimicrob Agents Chemother (1982) 3.91

Disposition of ketoconazole, an oral antifungal, in humans. Antimicrob Agents Chemother (1982) 3.90

Treatment of invasive aspergillosis with itraconazole. Am J Med (1989) 3.87

Mouse model of pulmonary blastomycosis: utility, simplicity, and quantitative parameters. Am Rev Respir Dis (1978) 3.75

Pulmonary aspergillosis in the acquired immunodeficiency syndrome. N Engl J Med (1991) 3.69

Ketoconazole, an oral antifungal: laboratory and clinical assessment of imidazole drugs. Postgrad Med J (1979) 3.55

Advancing paternal age and the risk of schizophrenia. Arch Gen Psychiatry (2001) 3.48

The cognitive neuroscience paradigm: a unifying metatheoretical framework for the science and practice of clinical psychology. J Clin Psychol (2001) 3.45

Glucocorticoids can promote androgen-independent growth of prostate cancer cells through a mutated androgen receptor. Nat Med (2000) 3.26

Miconazole in coccidioidomycosis. I. Assays of activity in mice and in vitro. J Infect Dis (1975) 2.99

Variability of agar dilution-replicator method of yeast susceptibility testing. Antimicrob Agents Chemother (1979) 2.84

Effect of exacerbations on quality of life in patients with chronic obstructive pulmonary disease: a 2 year follow up study. Thorax (2004) 2.78

Vascular complications after percutaneous coronary interventions following hemostasis with manual compression versus arteriotomy closure devices. J Am Coll Cardiol (2001) 2.74

Restriction endonuclease analysis of total cellular DNA of Aspergillus fumigatus isolates of geographically and epidemiologically diverse origin. J Infect Dis (1990) 2.66

Lymphocyte interferon production and transformation after Herpes simplex infections in humans. J Immunol (1974) 2.64

Adverse events associated with itraconazole in 189 patients on chronic therapy. J Antimicrob Chemother (1990) 2.49

Association of heart rate variability with occupational and environmental exposure to particulate air pollution. Circulation (2001) 2.46

Genetic characterization of pathogenic Saccharomyces cerevisiae isolates. Genetics (1994) 2.41

In vitro susceptibility and synergy studies of Aspergillus species to conventional and new agents. Diagn Microbiol Infect Dis (1992) 2.41

Analysis of Candida albicans phenotypes from different geographical and anatomical sources. J Clin Microbiol (1983) 2.33

Ketoconazole blocks adrenal steroidogenesis by inhibiting cytochrome P450-dependent enzymes. J Clin Invest (1983) 2.25

The impact of culture isolation of Aspergillus species: a hospital-based survey of aspergillosis. Clin Infect Dis (2001) 2.25

Effect of cyclodextrin on the pharmacology of antifungal oral azoles. Antimicrob Agents Chemother (1992) 2.22

The decision-making value of magnetic resonance cholangiopancreatography in patients seen in a referral center for suspected biliary and pancreatic disease. Am J Gastroenterol (2001) 2.21

Treatment of systemic mycoses with ketoconazole: emphasis on toxicity and clinical response in 52 patients. National Institute of Allergy and Infectious Diseases collaborative antifungal study. Ann Intern Med (1983) 2.17

Inhibition of adrenal steroidogenesis by the anesthetic etomidate. N Engl J Med (1984) 2.16

Cognitive neuroscience and the progress of psychological science: once more with feeling (and other mental constructs). J Clin Psychol (2001) 2.16

Molecular and phenotypic characterization of genotypic Candida albicans subgroups and comparison with Candida dubliniensis and Candida stellatoidea. J Clin Microbiol (1999) 2.15

Point mutations in the human vitamin D receptor gene associated with hypocalcemic rickets. Science (1988) 2.15

Treatment of mycoses with itraconazole. Ann N Y Acad Sci (1988) 2.11

Activity of the triazole SCH 56592 against disseminated murine coccidioidomycosis. Antimicrob Agents Chemother (1997) 2.07

The presence of a polymorphism at the translation initiation site of the vitamin D receptor gene is associated with low bone mineral density in postmenopausal Mexican-American women. J Bone Miner Res (1996) 2.04

Itraconazole therapy for blastomycosis and histoplasmosis. NIAID Mycoses Study Group. Am J Med (1992) 2.01

Ketoconazole blocks testosterone synthesis. Arch Intern Med (1982) 2.01

Adjunctive therapy of allergic bronchopulmonary aspergillosis with itraconazole. Chest (1991) 2.00

1,25-dihydroxyvitamin D3 and malignant melanoma: the presence of receptors and inhibition of cell growth in culture. Endocrinology (1981) 1.95

Visceral fungal infections due to Petriellidium boydii (allescheria boydii). In vitro drug sensitivity studies. Am J Med (1976) 1.93

Is it ever safe to stop azole therapy for Coccidioides immitis meningitis? Ann Intern Med (1996) 1.91

Distribution of a corticosteroid-binding protein in Candida and other fungal genera. J Gen Microbiol (1983) 1.86

Pharmacokinetics of fluconazole in cerebrospinal fluid and serum in human coccidioidal meningitis. Antimicrob Agents Chemother (1988) 1.85

Antiproliferative effects of 1,25-dihydroxyvitamin D3 on primary cultures of human prostatic cells. Cancer Res (1994) 1.85

The vitamin D receptor and the syndrome of hereditary 1,25-dihydroxyvitamin D-resistant rickets. Endocr Rev (1999) 1.84

Recombinant and natural gamma-interferon activation of macrophages in vitro: different dose requirements for induction of killing activity against phagocytizable and nonphagocytizable fungi. Infect Immun (1985) 1.82

Interleukin-10 polymorphism in position -1082 and acute respiratory distress syndrome. Eur Respir J (2006) 1.82

Efficacy of SCH39304 and fluconazole in a murine model of disseminated coccidioidomycosis. Antimicrob Agents Chemother (1990) 1.81

Postexposure varicella management of nonimmune personnel: an alternative approach. Infect Control Hosp Epidemiol (1994) 1.77

Ulcerative and plaque-like tracheobronchitis due to infection with Aspergillus in patients with AIDS. Clin Infect Dis (1993) 1.76

Itraconazole therapy for cryptococcal meningitis and cryptococcosis. Arch Intern Med (1989) 1.76

Urinary bisphenol A concentrations and ovarian response among women undergoing IVF. Int J Androl (2009) 1.75

Adverse effect of cytosine arabinoside on disseminated zoster in a controlled trial. N Engl J Med (1973) 1.73

Selective increase in lymphocyte interferon response to vaccinia antigen after revaccination. Proc Natl Acad Sci U S A (1972) 1.73

A five-year study of needlestick injuries: significant reduction associated with communication, education, and convenient placement of sharps containers. Infect Control Hosp Epidemiol (1992) 1.72

Standardization of a fluconazole bioassay and correlation of results with those obtained by high-pressure liquid chromatography. Antimicrob Agents Chemother (1991) 1.72

Saccharomyces cerevisiae virulence phenotype as determined with CD-1 mice is associated with the ability to grow at 42 degrees C and form pseudohyphae. Infect Immun (1994) 1.72

Viral infections in man associated with acquired immunological deficiency states. Fed Proc (1972) 1.70

Comparative pathogenesis of clinical and nonclinical isolates of Saccharomyces cerevisiae. J Infect Dis (1994) 1.69

Vitamin D and prostate cancer: 1,25 dihydroxyvitamin D3 receptors and actions in human prostate cancer cell lines. Endocrinology (1993) 1.68

Studies on the "incisures" of Schmidt and Lanterman. J Cell Sci (1970) 1.65

Estrogens inhibit mycelium-to-yeast transformation in the fungus Paracoccidioides brasiliensis: implications for resistance of females to paracoccidioidomycosis. Infect Immun (1984) 1.65

Subcellular mechanisms in the action of adrenal steroids. Am J Med (1972) 1.65

Interferon, antibody, and other host factors in herpes zoster. J Clin Invest (1972) 1.64

Human renal isografts: a clinical and pathologic analysis. Medicine (Baltimore) (1968) 1.63

The prevalence of insulin receptor antibodies in patients with systemic lupus erythematosus and related conditions. J Clin Rheumatol (2001) 1.61

Pathogen factors and host factors in murine pulmonary blastomycosis. Mycopathologia (1982) 1.61

Replacement of liver function in rats by transplantation of microcarrier-attached hepatocytes. Science (1986) 1.61

Efficacy of cilofungin alone and in combination with amphotericin B in a murine model of disseminated aspergillosis. Antimicrob Agents Chemother (1991) 1.61

Experimental and clinical applications of fibrin glue. Plast Reconstr Surg (1991) 1.60

Emerging pathogens. Med Mycol (2000) 1.59

Elevated cerebrospinal fluid pressures in patients with cryptococcal meningitis and acquired immunodeficiency syndrome. Am J Med (1991) 1.58

Interaction of azoles with rifampin, phenytoin, and carbamazepine: in vitro and clinical observations. Clin Infect Dis (1992) 1.58

Comparison of oral fluconazole and itraconazole for progressive, nonmeningeal coccidioidomycosis. A randomized, double-blind trial. Mycoses Study Group. Ann Intern Med (2000) 1.58

Itraconazole treatment of phaeohyphomycosis. J Am Acad Dermatol (1990) 1.57

Treatment of fungal meningitis with miconazole. Arch Intern Med (1977) 1.57

A corticosteroid binding protein and endogenous ligand in C. albicans indicating a possible steroid-receptor system. Nature (1981) 1.55