Published in Anal Biochem on July 01, 1983
A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics (1989) 105.30
Mendelian factors underlying quantitative traits in tomato: comparison across species, generations, and environments. Genetics (1991) 17.40
Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J Exp Med (1991) 16.81
Construction of an eae deletion mutant of enteropathogenic Escherichia coli by using a positive-selection suicide vector. Infect Immun (1991) 15.39
A genetic locus of enteropathogenic Escherichia coli necessary for the production of attaching and effacing lesions on tissue culture cells. Proc Natl Acad Sci U S A (1990) 14.22
Characterization of a Mycobacterium tuberculosis insertion sequence, IS6110, and its application in diagnosis. J Clin Microbiol (1990) 13.19
Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease. Mol Cell Biol (1992) 12.96
Nucleotide sequence of the Kaposi sarcoma-associated herpesvirus (HHV8). Proc Natl Acad Sci U S A (1996) 12.89
New method for generating deletions and gene replacements in Escherichia coli. J Bacteriol (1989) 12.66
Methylation of HpaII and HhaI sites near the polymorphic CAG repeat in the human androgen-receptor gene correlates with X chromosome inactivation. Am J Hum Genet (1992) 11.38
An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Invest (1990) 10.35
Restriction Fragment Length Polymorphism Linkage Map of Arabidopsis thaliana. Plant Cell (1989) 9.98
Exploiting the triple response of Arabidopsis to identify ethylene-related mutants. Plant Cell (1990) 9.76
Safe and efficient generation of recombinant retroviruses with amphotropic and ecotropic host ranges. Proc Natl Acad Sci U S A (1988) 9.35
Acquired resistance in Arabidopsis. Plant Cell (1992) 9.22
The FLF MADS box gene: a repressor of flowering in Arabidopsis regulated by vernalization and methylation. Plant Cell (1999) 9.18
Growth and development of the axr1 mutants of Arabidopsis. Plant Cell (1990) 8.73
Alu polymerase chain reaction: a method for rapid isolation of human-specific sequences from complex DNA sources. Proc Natl Acad Sci U S A (1989) 8.68
Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease. Proc Natl Acad Sci U S A (1992) 8.59
Characterization of a continuous T-cell line susceptible to the cytopathic effects of the acquired immunodeficiency syndrome (AIDS)-associated retrovirus. Proc Natl Acad Sci U S A (1985) 8.53
Chromosomal DNA fingerprint patterns produced with IS6110 as strain-specific markers for epidemiologic study of tuberculosis. J Clin Microbiol (1991) 8.24
Cloning and expression of a high-molecular-mass major antigen of Helicobacter pylori: evidence of linkage to cytotoxin production. Infect Immun (1993) 7.75
RFLP Maps Based on a Common Set of Clones Reveal Modes of Chromosomal Evolution in Potato and Tomato. Genetics (1988) 7.68
Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4) J Exp Med (1999) 7.62
Phytochrome A null mutants of Arabidopsis display a wild-type phenotype in white light. Plant Cell (1993) 7.51
Site-specific integration by adeno-associated virus. Proc Natl Acad Sci U S A (1990) 7.06
Two-component regulatory systems responsive to environmental stimuli share strongly conserved domains with the nitrogen assimilation regulatory genes ntrB and ntrC. Proc Natl Acad Sci U S A (1986) 7.01
Genetic consequences of packaging two RNA genomes in one retroviral particle: pseudodiploidy and high rate of genetic recombination. Proc Natl Acad Sci U S A (1990) 6.66
Functional expression of a probable Arabidopsis thaliana potassium channel in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1992) 6.27
Molecular cloning and expression of glycogen synthase kinase-3/factor A. EMBO J (1990) 6.23
Saturated molecular map of the rice genome based on an interspecific backcross population. Genetics (1994) 6.22
Systematic screening of yeast artificial-chromosome libraries by use of the polymerase chain reaction. Proc Natl Acad Sci U S A (1990) 6.20
Structure and variability of human chromosome ends. Mol Cell Biol (1990) 6.18
Analysis of gene expression in single live neurons. Proc Natl Acad Sci U S A (1992) 6.15
Single-stranded DNA arising at telomeres in cdc13 mutants may constitute a specific signal for the RAD9 checkpoint. Mol Cell Biol (1995) 6.11
Phenotypic and Genetic Analysis of det2, a New Mutant That Affects Light-Regulated Seedling Development in Arabidopsis. Plant Cell (1991) 6.05
Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line. Proc Natl Acad Sci U S A (1992) 5.94
Intermediates of recombination during mating type switching in Saccharomyces cerevisiae. EMBO J (1990) 5.94
Regulation of human immunodeficiency virus env expression by the rev gene product. J Virol (1989) 5.79
Shuttle cloning and nucleotide sequences of Helicobacter pylori genes responsible for urease activity. J Bacteriol (1991) 5.72
Depletion of U3 small nucleolar RNA inhibits cleavage in the 5' external transcribed spacer of yeast pre-ribosomal RNA and impairs formation of 18S ribosomal RNA. EMBO J (1991) 5.67
Vascular endothelial growth factor/vascular permeability factor expression in a mouse model of retinal neovascularization. Proc Natl Acad Sci U S A (1995) 5.66
Human acidic ribosomal phosphoproteins P0, P1, and P2: analysis of cDNA clones, in vitro synthesis, and assembly. Mol Cell Biol (1987) 5.63
Excision of large DNA regions termed pathogenicity islands from tRNA-specific loci in the chromosome of an Escherichia coli wild-type pathogen. Infect Immun (1994) 5.56
Mutation in a heterochromatin-specific chromosomal protein is associated with suppression of position-effect variegation in Drosophila melanogaster. Proc Natl Acad Sci U S A (1990) 5.55
The LDL receptor gene: a mosaic of exons shared with different proteins. Science (1985) 5.49
Receptor editing in self-reactive bone marrow B cells. J Exp Med (1993) 5.49
Arabidopsis Flavonoid Mutants Are Hypersensitive to UV-B Irradiation. Plant Cell (1993) 5.30
Mammalian genes coordinately regulated by growth arrest signals and DNA-damaging agents. Mol Cell Biol (1989) 5.25
Reduced virulence of a defined pneumolysin-negative mutant of Streptococcus pneumoniae. Infect Immun (1989) 5.23
Isolation and expression of three gibberellin 20-oxidase cDNA clones from Arabidopsis. Plant Physiol (1995) 5.23
Connexin43: a protein from rat heart homologous to a gap junction protein from liver. J Cell Biol (1987) 5.22
p53 functions as a cell cycle control protein in osteosarcomas. Mol Cell Biol (1990) 5.20
Coordinate regulation of virulence genes in Listeria monocytogenes requires the product of the prfA gene. J Bacteriol (1992) 5.19
Amerindian mitochondrial DNAs have rare Asian mutations at high frequencies, suggesting they derived from four primary maternal lineages. Am J Hum Genet (1990) 5.17
Effects of ionizing radiation on a plant genome: analysis of two Arabidopsis transparent testa mutations. Plant Cell (1992) 5.16
Comparative genome mapping of Sorghum and maize. Genetics (1992) 5.14
Molecular bases of dominant negative and loss of function mutations at the murine c-kit/white spotting locus: W37, Wv, W41 and W. EMBO J (1990) 5.08
Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing. Proc Natl Acad Sci U S A (1991) 5.07
Primary characterization of a herpesvirus agent associated with Kaposi's sarcomae. J Virol (1996) 5.05
Two alternative pathways of double-strand break repair that are kinetically separable and independently modulated. Mol Cell Biol (1992) 4.97
A family of human cdc2-related protein kinases. EMBO J (1992) 4.96
A new mitochondrial disease associated with mitochondrial DNA heteroplasmy. Am J Hum Genet (1990) 4.96
Emergence of brown adipocytes in white fat in mice is under genetic control. Effects on body weight and adiposity. J Clin Invest (1998) 4.94
Vascular permeability factor (vascular endothelial growth factor) gene is expressed differentially in normal tissues, macrophages, and tumors. Mol Biol Cell (1992) 4.90
A novel bacterial virulence gene in Listeria monocytogenes required for host cell microfilament interaction with homology to the proline-rich region of vinculin. EMBO J (1992) 4.84
Organization and regulation of an operon that encodes a sporulation-essential sigma factor in Bacillus subtilis. J Bacteriol (1987) 4.79
Arbitrarily primed PCR fingerprinting of RNA. Nucleic Acids Res (1992) 4.78
Identification and characterization of MPG1, a gene involved in pathogenicity from the rice blast fungus Magnaporthe grisea. Plant Cell (1993) 4.78
The nonamer UUAUUUAUU is the key AU-rich sequence motif that mediates mRNA degradation. Mol Cell Biol (1995) 4.76
In situ localization of light-induced chalcone synthase mRNA, chalcone synthase, and flavonoid end products in epidermal cells of parsley leaves. Proc Natl Acad Sci U S A (1988) 4.76
Construction and analysis of TnphoA mutants of enteropathogenic Escherichia coli unable to invade HEp-2 cells. Infect Immun (1990) 4.72
Molecular cloning of cDNA for rat liver gap junction protein. J Cell Biol (1986) 4.69
Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau. Proc Natl Acad Sci U S A (1988) 4.68
Cloning of the cDNA for the human beta 1-adrenergic receptor. Proc Natl Acad Sci U S A (1987) 4.66
Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily. Proc Natl Acad Sci U S A (1991) 4.66
The Aeromonas hydrophila cphA gene: molecular heterogeneity among class B metallo-beta-lactamases. J Bacteriol (1991) 4.64
Mutation is required to activate the p53 gene for cooperation with the ras oncogene and transformation. J Virol (1989) 4.63
cDNA for the human beta 2-adrenergic receptor: a protein with multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor. Proc Natl Acad Sci U S A (1987) 4.61
Novel syntaxin homologue, Pep12p, required for the sorting of lumenal hydrolases to the lysosome-like vacuole in yeast. Mol Biol Cell (1996) 4.58
Surface location and high affinity for calcium of a 500-kd liver membrane protein closely related to the LDL-receptor suggest a physiological role as lipoprotein receptor. EMBO J (1988) 4.54
Expression cloning of a receptor for human granulocyte-macrophage colony-stimulating factor. EMBO J (1989) 4.54
Mutation in LDL receptor: Alu-Alu recombination deletes exons encoding transmembrane and cytoplasmic domains. Science (1985) 4.51
Molecular cloning of cDNA for CENP-B, the major human centromere autoantigen. J Cell Biol (1987) 4.50
Connexin46, a novel lens gap junction protein, induces voltage-gated currents in nonjunctional plasma membrane of Xenopus oocytes. J Cell Biol (1991) 4.47
An electrophoretic karyotype of Neurospora crassa. Mol Cell Biol (1988) 4.46
Conservation of gene repertoire but not gene order in pepper and tomato. Proc Natl Acad Sci U S A (1988) 4.43
Organization of replication of ribosomal DNA in Saccharomyces cerevisiae. Mol Cell Biol (1988) 4.43
Regulation of gene expression programs during Arabidopsis seed development: roles of the ABI3 locus and of endogenous abscisic acid. Plant Cell (1994) 4.41
Inheritance of the morphological differences between maize and teosinte: comparison of results for two F2 populations. Genetics (1993) 4.40
Site-specific deletion and rearrangement of integron insert genes catalyzed by the integron DNA integrase. J Bacteriol (1992) 4.39
Molecular characterization of a fimbrial adhesin, F1845, mediating diffuse adherence of diarrhea-associated Escherichia coli to HEp-2 cells. J Bacteriol (1989) 4.37
The identification of a novel synaptosomal-associated protein, SNAP-25, differentially expressed by neuronal subpopulations. J Cell Biol (1989) 4.36
Allopolyploidy-induced rapid genome evolution in the wheat (Aegilops-Triticum) group. Plant Cell (2001) 4.35
DNA damage-inducible transcripts in mammalian cells. Proc Natl Acad Sci U S A (1988) 4.30
Resolution of DNA molecules greater than 5 megabases by contour-clamped homogeneous electric fields. Nucleic Acids Res (1987) 4.28
Site-specific recombination of a transgene in fertilized eggs by transient expression of Cre recombinase. Proc Natl Acad Sci U S A (1995) 4.28
Complementation of a capsule-deficient mutation of Cryptococcus neoformans restores its virulence. Mol Cell Biol (1994) 4.22
"A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity". Addendum. Anal Biochem (1984) 66.58
Serial analysis of gene expression. Science (1995) 60.15
A genetic model for colorectal tumorigenesis. Cell (1990) 44.37
WAF1, a potential mediator of p53 tumor suppression. Cell (1993) 38.72
Surfing the p53 network. Nature (2000) 35.36
p53 mutations in human cancers. Science (1991) 31.96
Preparative and analytical purification of DNA from agarose. Proc Natl Acad Sci U S A (1979) 27.20
Lessons from hereditary colorectal cancer. Cell (1996) 25.73
Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. Science (1997) 24.61
A simplified system for generating recombinant adenoviruses. Proc Natl Acad Sci U S A (1998) 24.58
Identification of c-MYC as a target of the APC pathway. Science (1998) 24.25
Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma. Science (1997) 22.80
Genetic instabilities in human cancers. Nature (1998) 22.76
A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. Cell (1992) 19.87
Requirement for p53 and p21 to sustain G2 arrest after DNA damage. Science (1998) 17.91
Amplification of a gene encoding a p53-associated protein in human sarcomas. Nature (1992) 17.40
Participation of p53 protein in the cellular response to DNA damage. Cancer Res (1991) 16.00
Epigenetic memory in induced pluripotent stem cells. Nature (2010) 14.31
Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability. Science (1995) 13.15
Definition of a consensus binding site for p53. Nat Genet (1992) 12.76
Genetic instability in colorectal cancers. Nature (1997) 12.51
Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas. Science (1989) 11.53
Identification of FAP locus genes from chromosome 5q21. Science (1991) 11.41
A model for p53-induced apoptosis. Nature (1997) 11.38
Characterization of the yeast transcriptome. Cell (1997) 11.33
Mutations of mitotic checkpoint genes in human cancers. Nature (1998) 11.20
Suppression of human colorectal carcinoma cell growth by wild-type p53. Science (1990) 11.18
Genes expressed in human tumor endothelium. Science (2000) 10.75
Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene. Science (1992) 10.12
Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma. Proc Natl Acad Sci U S A (1998) 9.66
Gene expression profiles in normal and cancer cells. Science (1997) 9.65
APC mutations occur early during colorectal tumorigenesis. Nature (1992) 9.50
Hypomethylation distinguishes genes of some human cancers from their normal counterparts. Nature (1983) 9.28
Prevalence of ras gene mutations in human colorectal cancers. Nature (1987) 9.23
A public database for gene expression in human cancers. Cancer Res (1999) 8.81
PUMA induces the rapid apoptosis of colorectal cancer cells. Mol Cell (2001) 7.95
Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53. Nature (1993) 7.90
14-3-3 sigma is a p53-regulated inhibitor of G2/M progression. Mol Cell (1997) 7.20
Association of the APC tumor suppressor protein with catenins. Science (1993) 7.17
Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification. Proc Natl Acad Sci U S A (1987) 7.12
Oncogenic forms of p53 inhibit p53-regulated gene expression. Science (1992) 6.73
p21 is necessary for the p53-mediated G1 arrest in human cancer cells. Cancer Res (1995) 6.66
Hypermutability and mismatch repair deficiency in RER+ tumor cells. Cell (1993) 6.61
Identification of p53 as a sequence-specific DNA-binding protein. Science (1991) 6.60
Structural alterations of the epidermal growth factor receptor gene in human gliomas. Proc Natl Acad Sci U S A (1992) 6.58
Purification of DNA from formaldehyde fixed and paraffin embedded human tissue. Biochem Biophys Res Commun (1985) 6.57
Germline mutations of the gene encoding bone morphogenetic protein receptor 1A in juvenile polyposis. Nat Genet (2001) 6.36
Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers. Science (1991) 6.15
Disruption of p53 in human cancer cells alters the responses to therapeutic agents. J Clin Invest (1999) 6.13
Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21. Nature (1996) 6.11
Human Smad3 and Smad4 are sequence-specific transcription activators. Mol Cell (1998) 5.88
Cancer-susceptibility genes. Gatekeepers and caretakers. Nature (1997) 5.87
Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancer. Cancer Res (1998) 5.80
p53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis. Cancer Res (1990) 5.70
p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage. Genes Dev (1995) 5.63
14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage. Nature (1999) 5.44
Microsatellite instability and mutations of the transforming growth factor beta type II receptor gene in colorectal cancer. Cancer Res (1995) 5.26
p53 functions as a cell cycle control protein in osteosarcomas. Mol Cell Biol (1990) 5.20
Allelic loss of chromosome 18q and prognosis in colorectal cancer. N Engl J Med (1994) 5.12
PPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugs. Cell (1999) 5.12
Role of BAX in the apoptotic response to anticancer agents. Science (2000) 5.07
Analysis of mismatch repair genes in hereditary non-polyposis colorectal cancer patients. Nat Med (1996) 4.87
Familial colorectal cancer in Ashkenazim due to a hypermutable tract in APC. Nat Genet (1997) 4.86
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Clinical and pathological characteristics of sporadic colorectal carcinomas with DNA replication errors in microsatellite sequences. Am J Pathol (1994) 4.43
Anti-synthetic peptide antibody reacting at the fusion junction of deletion-mutant epidermal growth factor receptors in human glioblastoma. Proc Natl Acad Sci U S A (1990) 4.42
Mutant p53 DNA clones from human colon carcinomas cooperate with ras in transforming primary rat cells: a comparison of the "hot spot" mutant phenotypes. Cell Growth Differ (1990) 4.32
Clonal analysis using recombinant DNA probes from the X-chromosome. Cancer Res (1987) 4.25
Disruption of the APC gene by a retrotransposal insertion of L1 sequence in a colon cancer. Cancer Res (1992) 4.21
Identification of an amplified, highly expressed gene in a human glioma. Science (1987) 4.21
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Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers. Nat Genet (1996) 4.09
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Molecular diagnosis of familial adenomatous polyposis. N Engl J Med (1993) 4.07
Interleukin-2 production by tumor cells bypasses T helper function in the generation of an antitumor response. Cell (1990) 3.98
APC binds to the novel protein EB1. Cancer Res (1995) 3.98
Clonal origin bladder cancer. N Engl J Med (1992) 3.97
Relaxation of imprinted genes in human cancer. Nature (1993) 3.86
Breast cancer. What's mice got to do with it? Nature (1996) 3.86
A phosphatase associated with metastasis of colorectal cancer. Science (2001) 3.86
A fixed site of DNA replication in eucaryotic cells. Cell (1980) 3.78
Clonal analysis of human colorectal tumors. Science (1987) 3.72
Hypomethylation of DNA from benign and malignant human colon neoplasms. Science (1985) 3.72
Securin is required for chromosomal stability in human cells. Cell (2001) 3.71
Combinatorial chemoprevention of intestinal neoplasia. Nat Med (2000) 3.66
Scrambled exons. Cell (1991) 3.65
The GLI gene encodes a nuclear protein which binds specific sequences in the human genome. Mol Cell Biol (1990) 3.64
Wild-type but not mutant p53 immunopurified proteins bind to sequences adjacent to the SV40 origin of replication. Cell (1991) 3.59
Identification of ras oncogene mutations in the stool of patients with curable colorectal tumors. Science (1992) 3.58
Mismatch repair deficiency in phenotypically normal human cells. Science (1995) 3.55
Top-down morphogenesis of colorectal tumors. Proc Natl Acad Sci U S A (2001) 3.51
Cancer risk associated with germline DNA mismatch repair gene mutations. Hum Mol Genet (1997) 3.41
Mutational inactivation of transforming growth factor beta receptor type II in microsatellite stable colon cancers. Cancer Res (1999) 3.40
Identification of CDK4 as a target of c-MYC. Proc Natl Acad Sci U S A (2000) 3.38
Sequence-specific transcriptional activation is essential for growth suppression by p53. Proc Natl Acad Sci U S A (1994) 3.36
Cell surface tumor endothelial markers are conserved in mice and humans. Cancer Res (2001) 3.29
Conversion of diploidy to haploidy. Nature (2000) 3.28