Competitive inhibition by diacylglycerol of specific phorbol ester binding.

Protein kinase C: poised to signal. Am J Physiol Endocrinol Metab (2009) 2.81

Ca2+- and phospholipid-independent activation of protein kinase C by selective oxidative modification of the regulatory domain. Proc Natl Acad Sci U S A (1989) 1.96

Diacylglycerol stimulates DNA synthesis and cell division in mouse 3T3 cells: role of Ca2+-sensitive phospholipid-dependent protein kinase. Proc Natl Acad Sci U S A (1984) 1.96

PKC-delta and -eta, MEKK-1, MEK-6, MEK-3, and p38-delta are essential mediators of the response of normal human epidermal keratinocytes to differentiating agents. J Invest Dermatol (2010) 1.64

Diacylglycerols mimic phorbol diester induction of leukemic cell differentiation. Proc Natl Acad Sci U S A (1985) 1.61

Intramolecular conformational changes optimize protein kinase C signaling. Chem Biol (2014) 1.58

Analysis of the phorbol ester pharmacophore on protein kinase C as a guide to the rational design of new classes of analogs. Proc Natl Acad Sci U S A (1986) 1.39

Protein kinase C family: on the crossroads of cell signaling in skin and tumor epithelium. J Cancer Res Clin Oncol (2007) 1.36

Protein kinase C pharmacology: refining the toolbox. Biochem J (2013) 1.27

Diacylglycerol-induced translocation of diacylglycerol kinase: use of affinity-purified enzyme in a reconstitution system. Proc Natl Acad Sci U S A (1986) 1.13

Platelet-derived growth factor mimics phorbol diester action on epidermal growth factor receptor phosphorylation at threonine-654. Proc Natl Acad Sci U S A (1985) 1.12

Specific phosphorylation of proteins in pore complex-laminae from the sponge Geodia cydonium by the homologous aggregation factor and phorbol ester. Role of protein kinase C in the phosphorylation of DNA topoisomerase II. EMBO J (1987) 1.10

Role of protein kinase C in diacylglycerol-mediated induction of ornithine decarboxylase and reduction of epidermal growth factor binding. Proc Natl Acad Sci U S A (1985) 1.08

Intracellular elevations of free calcium induced by activation of histamine H1 receptors in interphase and mitotic HeLa cells: hormone signal transduction is altered during mitosis. J Cell Biol (1988) 1.08

Critical but distinct roles for the pleckstrin homology and cysteine-rich domains as positive modulators of Vav2 signaling and transformation. Mol Cell Biol (2002) 1.05

Lipid lateral heterogeneity in phosphatidylcholine/phosphatidylserine/diacylglycerol vesicles and its influence on protein kinase C activation. Biophys J (1996) 1.01

Tumor promoter-induced membrane-bound protein kinase C regulates hematogenous metastasis. Proc Natl Acad Sci U S A (1988) 0.98

Role of protein kinase C delta in reactivation of Kaposi's sarcoma-associated herpesvirus. J Virol (2004) 0.96

Screening of a PKC zeta-specific kinase inhibitor PKCzI257.3 which inhibits EGF-induced breast cancer cell chemotaxis. Invest New Drugs (2009) 0.96

A ceramide-binding C1 domain mediates kinase suppressor of ras membrane translocation. Cell Physiol Biochem (2009) 0.93

Comparison of effects of phorbol esters and glucose on protein kinase C activation and insulin secretion in pancreatic islets. Biochem J (1989) 0.92

Synergistic activation of type III protein kinase C by cis-fatty acid and diacylglycerol. Biochem J (1992) 0.92

RasGRP1 overexpression in the epidermis of transgenic mice contributes to tumor progression during multistage skin carcinogenesis. Cancer Res (2007) 0.86

Ca2+-independent binding of [3H]phorbol dibutyrate to protein kinase C is supported by protamine and other polycations. Biochem J (1988) 0.85

Chemoattractant-induced activation of c-fos gene expression in human monocytes. J Exp Med (1987) 0.83

Protein and diacylglycerol phosphorylation in the stimulus-secretion coupling of rat mast cells. Immunology (1987) 0.83

Identification of two cytosolic diacylglycerol kinase isoforms in rat brain, and in NIH-3T3 and ras-transformed fibroblasts. Biochem J (1990) 0.82

Spatiotemporal dynamics of phosphorylation in lipid second messenger signaling. Mol Cell Proteomics (2013) 0.81

Interactions of protein kinase C-α C1A and C1B domains with membranes: a combined computational and experimental study. J Am Chem Soc (2014) 0.80

Regulation of protein kinase C delta downregulation by protein kinase C epsilon and mammalian target of rapamycin complex 2. Cell Signal (2009) 0.80

Insulin receptor substrate 1 is a substrate of the Pim protein kinases. Oncotarget (2016) 0.77

Phorbol 12,13-dibutyrate binding to intact human platelets. The role of cytosolic free Ca2+. Biochem J (1991) 0.76

Oncogenicity of AKR mink cell focus-inducing murine leukemia virus correlates with induction of chronic phosphatidylinositol signal transduction. J Virol (1992) 0.76

Protein kinase C in cancer: The top five unanswered questions. Mol Carcinog (2017) 0.75

Polyphenol compounds and PKC signaling. Biochim Biophys Acta (2016) 0.75

Protein kinase C: an attractive target for cancer therapy. Cancers (Basel) (2011) 0.75

Activation of protein kinase C induces differentiation in the human T-lymphoblastic cell line MOLT-3. Br J Cancer (1989) 0.75

Role of protein kinase C in light adaptation of molluscan microvillar photoreceptors. J Physiol (2002) 0.75

Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters. J Biol Chem (1982) 16.71

Inositol phospholipids and cell surface receptor function. Biochim Biophys Acta (1975) 11.82

Phorbol diester receptor copurifies with protein kinase C. Proc Natl Acad Sci U S A (1983) 6.25

Activation of calcium and phospholipid-dependent protein kinase by diacylglycerol, its possible relation to phosphatidylinositol turnover. J Biol Chem (1980) 5.08

Inhibition of folate biosynthesis and function as a basis for chemotherapy. Adv Enzymol Relat Areas Mol Biol (1965) 4.83

Calcium-activated, phospholipid-dependent protein kinase from rat brain. Subcellular distribution, purification, and properties. J Biol Chem (1982) 3.64

Calcium-dependent protein kinase: widespread occurrence in various tissues and phyla of the animal kingdom and comparison of effects of phospholipid, calmodulin, and trifluoperazine. Proc Natl Acad Sci U S A (1980) 3.08

Specific binding of phorbol ester tumor promoters. Proc Natl Acad Sci U S A (1980) 3.07

Unsaturated diacylglycerol as a possible messenger for the activation of calcium-activated, phospholipid-dependent protein kinase system. Biochem Biophys Res Commun (1979) 2.96

Specific high affinity cell membrane receptors for biologically active phorbol and ingenol esters. Nature (1980) 2.38

Characterization of a specific phorbol ester aporeceptor in mouse brain cytosol. Proc Natl Acad Sci U S A (1983) 2.23

Tumor promoters and the mechanism of tumor promotion. Adv Cancer Res (1980) 2.11

Phospholipid-sensitive Ca2+-dependent protein kinase from heart. I. Purification and general properties. J Biol Chem (1982) 1.88

In vitro studies on the mode of action of the phorbol esters, potent tumor promoters: part 1. Crit Rev Toxicol (1980) 1.73

Cooperative roles of various membrane phospholipids in the activation of calcium-activated, phospholipid-dependent protein kinase. J Biol Chem (1981) 1.66

Identification of receptors for phorbol ester tumor promoters in intact mammalian cells and of an inhibitor of receptor binding in biologic fluids. Proc Natl Acad Sci U S A (1981) 1.59

Identification of high-affinity phorbol ester receptor in cytosol of EL4 thymoma cells: requirement for calcium, magnesium, and phospholipids. Proc Natl Acad Sci U S A (1983) 1.45

In vitro studies on the mode of action of the phorbol esters, potent tumor promoters, part 2. Crit Rev Toxicol (1981) 1.38

Identification of a calcium- and phospholipid- dependent phorbol ester binding activity in the soluble fraction of mouse tissues. Biochem Biophys Res Commun (1983) 1.34

Intermolecular hydrogen bonding between lipids: influence on organization and function of lipids in membranes. Can J Biochem (1980) 1.33

Specificity of the fatty acyl moieties of diacylglycerol for the activation of calcium-activated, phospholipid-dependent protein kinase. J Biochem (1982) 1.32

Kinetics and subcellular localization of specific [3H]phorbol 12, 13-dibutyrate binding by mouse brain. Cancer Res (1981) 1.18

Specific labeling of mouse brain membrane phospholipids with [20-3H]phorbol 12-p-azidobenzoate 13-benzoate, a photolabile phorbol ester. Proc Natl Acad Sci U S A (1983) 1.07

Specific binding of [20-3H]12-deoxyphorbol 13-isobutyrate to phorbol ester receptor subclasses in mouse skin particulate preparations. Cancer Res (1983) 1.02

Phorbol esters, fatty acids and tumour promotion. Nat New Biol (1973) 0.99

Tissue and species distribution and developmental variation of specific receptors for biologically active phorbol and ingenol esters. Carcinogenesis (1981) 0.97

Active principles of croton oil. X. Preparation of tritium labeled croton oil factor A1 and other tritium labeled phorbol derivatives. Z Krebsforsch (1970) 0.94

alpha-Bungarotoxin binding properties of a central nervous system nicotinic acetylcholine receptor. Biochim Biophys Acta (1978) 0.80

Interaction of penicillin with the bacterial cell: penicillin-binding proteins and penicillin-sensitive enzymes. Bacteriol Rev (1974) 7.49

Vanilloid (Capsaicin) receptors and mechanisms. Pharmacol Rev (1999) 7.20

Selective inhibition of protein kinase C isozymes by the indolocarbazole Gö 6976. J Biol Chem (1993) 7.16

Mechanism of action and development of resistance to a new amidino penicillin. J Bacteriol (1974) 5.47

Multiple penicillin-binding components in Bacillus subtilis, Bacillus cereus, Staphylococcus aureus, and Escherichia coli. J Biol Chem (1972) 3.32

Penicillin-sensitive enzymes and penicillin-binding components in bacterial cells. Ann N Y Acad Sci (1974) 3.16

Crystal structure of the cys2 activator-binding domain of protein kinase C delta in complex with phorbol ester. Cell (1995) 3.08

Specific binding of phorbol ester tumor promoters. Proc Natl Acad Sci U S A (1980) 3.07

Distribution of mRNA for vanilloid receptor subtype 1 (VR1), and VR1-like immunoreactivity, in the central nervous system of the rat and human. Proc Natl Acad Sci U S A (2000) 2.87

Five penicillin-binding components occur in Bacillus subtilis membranes. J Biol Chem (1972) 2.81

Inactivation of D-alanine carboxypeptidase by penicillins and cephalosporins is not lethal in Bacillus subtilis. Proc Natl Acad Sci U S A (1971) 2.80

Overexpression of protein kinase C-delta and -epsilon in NIH 3T3 cells induces opposite effects on growth, morphology, anchorage dependence, and tumorigenicity. J Biol Chem (1993) 2.62

Regulation of cell apoptosis by protein kinase c delta. Apoptosis (2003) 2.60

Analysis of the native quaternary structure of vanilloid receptor 1. J Biol Chem (2001) 2.55

RasGRP links T-cell receptor signaling to Ras. Blood (2000) 2.46

Ca(2+)-dependent and Ca(2+)-independent isozymes of protein kinase C mediate exocytosis in antigen-stimulated rat basophilic RBL-2H3 cells. Reconstitution of secretory responses with Ca2+ and purified isozymes in washed permeabilized cells. J Biol Chem (1993) 2.38

Isolation by covalent affinity chromatography of the penicillin-binding components from membranes of Bacillus subtilis. Proc Natl Acad Sci U S A (1972) 2.28

Characterization of a specific phorbol ester aporeceptor in mouse brain cytosol. Proc Natl Acad Sci U S A (1983) 2.23

How penicillin kills bacteria: progress and problems. Proc R Soc Lond B Biol Sci (1971) 2.21

The effect of phorbol diesters on chicken embryo fibroblasts. Cancer Res (1977) 2.14

Taxonomy and function of C1 protein kinase C homology domains. Protein Sci (1997) 1.98

Resiniferatoxin, a phorbol-related diterpene, acts as an ultrapotent analog of capsaicin, the irritant constituent in red pepper. Neuroscience (1989) 1.94

Ia binding ligands and cAMP stimulate nuclear translocation of PKC in B lymphocytes. Nature (1987) 1.93

DNA cross-linking and monoadduct repair in nitrosourea-treated human tumour cells. Nature (1980) 1.86

A nonpromoting phorbol from the samoan medicinal plant Homalanthus nutans inhibits cell killing by HIV-1. J Med Chem (1992) 1.80

In vitro studies on the mode of action of the phorbol esters, potent tumor promoters: part 1. Crit Rev Toxicol (1980) 1.73

Involvement of functional protein kinase C in the mitogenic response to the H-ras oncogene product. Mol Cell Biol (1987) 1.63

Ligand-induced dynamic membrane changes and cell deletion conferred by vanilloid receptor 1. J Biol Chem (2000) 1.59

Differential regulation of protein kinase C isozymes by bryostatin 1 and phorbol 12-myristate 13-acetate in NIH 3T3 fibroblasts. J Biol Chem (1994) 1.55

Phorbol ester-induced myeloid differentiation is mediated by protein kinase C-alpha and -delta and not by protein kinase C-beta II, -epsilon, -zeta, and -eta. J Biol Chem (1993) 1.51

Protein kinase Cdelta targets mitochondria, alters mitochondrial membrane potential, and induces apoptosis in normal and neoplastic keratinocytes when overexpressed by an adenoviral vector. Mol Cell Biol (1999) 1.51

Phosphorylation specificities of protein kinase C isozymes for bovine cardiac troponin I and troponin T and sites within these proteins and regulation of myofilament properties. J Biol Chem (1996) 1.49

Zinc finger domains and phorbol ester pharmacophore. Analysis of binding to mutated form of protein kinase C zeta and the vav and c-raf proto-oncogene products. J Biol Chem (1994) 1.49

Modeling of the bryostatins to the phorbol ester pharmacophore on protein kinase C. Proc Natl Acad Sci U S A (1988) 1.49

Effect of a phorbol ester on a transformation-sensitive surface protein of chick fibroblasts. Nature (1976) 1.48

Mechanism of action of the phorbol ester tumor promoters: specific receptors for lipophilic ligands. Biochem Pharmacol (1984) 1.46

Bryostatin 1, an activator of protein kinase C, inhibits tumor promotion by phorbol esters in SENCAR mouse skin. Carcinogenesis (1987) 1.44

Characterization of ligand and substrate specificity for the calcium-dependent and calcium-independent protein kinase C isozymes. Mol Pharmacol (1993) 1.40

Analysis of the phorbol ester pharmacophore on protein kinase C as a guide to the rational design of new classes of analogs. Proc Natl Acad Sci U S A (1986) 1.39

In vitro studies on the mode of action of the phorbol esters, potent tumor promoters, part 2. Crit Rev Toxicol (1981) 1.38

Differential localization of protein kinase C delta by phorbol esters and related compounds using a fusion protein with green fluorescent protein. J Biol Chem (1999) 1.36

Specific binding of phorbol ester tumor promoters to mouse skin. Cell (1980) 1.34

Residues in the second cysteine-rich region of protein kinase C delta relevant to phorbol ester binding as revealed by site-directed mutagenesis. J Biol Chem (1995) 1.33

Vanilloid (capsaicin) receptors in the rat: distribution in the brain, regional differences in the spinal cord, axonal transport to the periphery, and depletion by systemic vanilloid treatment. Brain Res (1995) 1.32

Functional analysis of capsaicin receptor (vanilloid receptor subtype 1) multimerization and agonist responsiveness using a dominant negative mutation. J Neurosci (2001) 1.32

Comparison of protein kinase C functional assays to clarify mechanisms of inhibitor action. Biochem Pharmacol (1988) 1.30

Protein kinase Calpha and protein kinase Cdelta play opposite roles in the proliferation and apoptosis of glioma cells. Cancer Res (2001) 1.30

Direct demonstration of NFATp dephosphorylation and nuclear localization in activated HT-2 cells using a specific NFATp polyclonal antibody. J Biol Chem (1995) 1.29

Differential effects of bryostatins and phorbol esters on arachidonic acid metabolite release and epidermal growth factor binding in C3H 10T1/2 cells. Cancer Res (1988) 1.28

Penicillin binding components of bacterial cells and their relationship to the mechanism of penicillin action. Ann N Y Acad Sci (1974) 1.27

Phosphorylation of protein kinase Cdelta on distinct tyrosine residues regulates specific cellular functions. J Biol Chem (2000) 1.26

Activation of the human neutrophil nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase by protein kinase C. J Clin Invest (1985) 1.25

Specific binding of resiniferatoxin, an ultrapotent capsaicin analog, by dorsal root ganglion membranes. Brain Res (1990) 1.25

Tyrosine phosphorylation-dependent and -independent associations of protein kinase C-delta with Src family kinases in the RBL-2H3 mast cell line: regulation of Src family kinase activity by protein kinase C-delta. Oncogene (1998) 1.24

The guanine nucleotide exchange factor RasGRP is a high -affinity target for diacylglycerol and phorbol esters. Mol Pharmacol (2000) 1.24

Effect of proteases on activation of resting chick embryo fibroblasts and on cell surface proteins. Cell (1975) 1.24

Phorbol esters modulate the Ras exchange factor RasGRP3. Cancer Res (2001) 1.24

Transmembrane signaling through B cell MHC class II molecules: anti-Ia antibodies induce protein kinase C translocation to the nuclear fraction. J Immunol (1987) 1.21

Characterization of functional vanilloid receptors expressed by mast cells. Blood (1998) 1.21

Differential regulation of cardiac actomyosin S-1 MgATPase by protein kinase C isozyme-specific phosphorylation of specific sites in cardiac troponin I and its phosphorylation site mutants. Biochemistry (1996) 1.20

Nonpromoting 12-deoxyphorbol 13-esters inhibit phorbol 12-myristate 13-acetate induced tumor promotion in CD-1 mouse skin. Cancer Res (1993) 1.20

Vanilloid receptors: new insights enhance potential as a therapeutic target. Pain (1996) 1.20

Non-equivalent roles for the first and second zinc fingers of protein kinase Cdelta. Effect of their mutation on phorbol ester-induced translocation in NIH 3T3 cells. J Biol Chem (1996) 1.20

The cloned rat vanilloid receptor VR1 mediates both R-type binding and C-type calcium response in dorsal root ganglion neurons. Mol Pharmacol (1999) 1.19

Mutagenicity of thymidine to cultured Chinese hamster cells. Nature (1978) 1.19

Characterization of the cysteine-rich region of the Caenorhabditis elegans protein Unc-13 as a high affinity phorbol ester receptor. Analysis of ligand-binding interactions, lipid cofactor requirements, and inhibitor sensitivity. J Biol Chem (1995) 1.19

beta2-chimaerin is a novel target for diacylglycerol: binding properties and changes in subcellular localization mediated by ligand binding to its C1 domain. Proc Natl Acad Sci U S A (1999) 1.19

Kinetics and subcellular localization of specific [3H]phorbol 12, 13-dibutyrate binding by mouse brain. Cancer Res (1981) 1.18

Measurement of DNA damage in unlabeled mammalian cells analyzed by alkaline elution and a fluorometric DNA assay. Anal Biochem (1980) 1.16

Decrease in collagen production in normal and Rous sarcoma virus-transformed chick embryo fibroblasts induced by phorbol myristate acetate. Cancer Res (1979) 1.15

Anatomic and biomechanical assessment of transarticular screw fixation for atlantoaxial instability. Spine (Phila Pa 1976) (1991) 1.15

Binding of (14C)penicillin G to the membrane-bound and the purified D-alanine carboxypeptidases from Bacillus stearothermophilus and Bacillus subtilis and its release. J Biol Chem (1974) 1.15

Characterization of the protein-protein interactions determining the heat shock protein (hsp90.hsp70.hsp56) heterocomplex. J Biol Chem (1994) 1.14

Purification and characterization of the thermophilic D-alanine carboxypeptidase from membranes of Bacillus stearothermophilus. J Biol Chem (1974) 1.14

Functional effects of overexpression of protein kinase C-alpha, -beta, -delta, -epsilon, and -eta in the mast cell line RBL-2H3. J Immunol (1997) 1.13

Different isozymes of protein kinase C mediate feedback inhibition of phospholipase C and stimulatory signals for exocytosis in rat RBL-2H3 cells. J Biol Chem (1993) 1.12

Molybdate inhibition of glucocorticoid receptor inactivation and transformation. J Biol Chem (1979) 1.12

Specific binding of [3H]resiniferatoxin by human and rat preoptic area, locus ceruleus, medial hypothalamus, reticular formation and ventral thalamus membrane preparations. Life Sci (1996) 1.10

D-alanine carboxypeptidase and cell wall cross-linking in Bacillus subtilis. J Bacteriol (1974) 1.09

Pathomechanics of closed rupture of the flexor tendon pulleys in rock climbers. J Bone Joint Surg Am (1998) 1.08

Covalent affinity chromatography of penicillin-binding components from bacterial membranes. Methods Enzymol (1974) 1.08

The cyclin-dependent kinases cdk2 and cdk5 act by a random, anticooperative kinetic mechanism. J Biol Chem (2001) 1.08

Resiniferatoxin and its analogs provide novel insights into the pharmacology of the vanilloid (capsaicin) receptor. Life Sci (1990) 1.07

Specific labeling of mouse brain membrane phospholipids with [20-3H]phorbol 12-p-azidobenzoate 13-benzoate, a photolabile phorbol ester. Proc Natl Acad Sci U S A (1983) 1.07

Characterization of specific binding of [3H]phorbol 12,13-dibutyrate and [3H]phorbol 12-myristate 13-acetate to mouse brain. Cancer Res (1980) 1.06

Relation of human neutrophil phorbol ester receptor occupancy and NADPH-oxidase activity. Blood (1982) 1.06

Strains in the metatarsals during the stance phase of gait: implications for stress fractures. J Bone Joint Surg Am (1999) 1.06

Differential inhibition of protein kinase C isozymes by UCN-01, a staurosporine analogue. Mol Pharmacol (1994) 1.05

The effect of variable size posterior wall acetabular fractures on contact characteristics of the hip joint. J Orthop Trauma (1996) 1.05

Duration of desensitization and ultrastructural changes in dorsal root ganglia in rats treated with resiniferatoxin, an ultrapotent capsaicin analog. Brain Res (1989) 1.04

Partial parallelism and partial blockade by bryostatin 1 of effects of phorbol ester tumor promoters on primary mouse epidermal cells. Cancer Res (1987) 1.04

Bryostatin 1 protects protein kinase C-delta from down-regulation in mouse keratinocytes in parallel with its inhibition of phorbol ester-induced differentiation. Mol Pharmacol (1994) 1.04

Specific protein kinase C isozymes mediate the induction of keratinocyte differentiation markers by calcium. Cell Growth Differ (1995) 1.04

The role of the acetabular labrum and the transverse acetabular ligament in load transmission in the hip. J Bone Joint Surg Am (1998) 1.04